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Learn20567-1-AP
antibody from Proteintech Group
Targeting: DICER1
Dicer, HERNA, K12H4.8-LIKE, KIAA0928, MNG1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 20567-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20567-1-AP, RRID:AB_10694287
- Product name
- DICER1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DICER1 antibody (Cat. #20567-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inducible deletion of microRNA activity in kidney mesenchymal cells exacerbates renal fibrosis.
Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.
Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis.
DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity.
ADAR1 inhibits adipogenesis and obesity by interacting with Dicer to promote the maturation of miR-155-5P.
HSP90 and Aha1 modulate microRNA maturation through promoting the folding of Dicer1.
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.
RNA structure probing reveals the structural basis of Dicer binding and cleavage.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
The Capsid Protein of Rubella Virus Antagonizes RNA Interference in Mammalian Cells.
Amyloid peptide exerts a rapid induction of Dicer1 protein in neuron via reducing phosphorylation.
The Capsid Protein of Semliki Forest Virus Antagonizes RNA Interference in Mammalian Cells.
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation.
Pseudogene RACGAP1P activates RACGAP1/Rho/ERK signalling axis as a competing endogenous RNA to promote hepatocellular carcinoma early recurrence.
Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing.
LncRNA UCA1 is necessary for TGF-β-induced epithelial-mesenchymal transition and stemness via acting as a ceRNA for Slug in glioma cells.
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling.
Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma.
Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.
Sakuma H, Maruyama K, Aonuma T, Kobayashi Y, Hayasaka T, Kano K, Kawaguchi S, Nakajima KI, Kawabe JI, Hasebe N, Nakagawa N
Scientific reports 2024 May 14;14(1):10963
Scientific reports 2024 May 14;14(1):10963
Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.
Long F, Li L, Xie C, Ma M, Wu Z, Lu Z, Liu B, Yang M, Zhang F, Ning Z, Zhong C, Yu B, Liu S, Wan L, Tian B, Yang K, Guo Y, Chen M, Chou J, Li X, Hu G, Lin C, Zhang Y
International journal of biological sciences 2023;19(12):3781-3803
International journal of biological sciences 2023;19(12):3781-3803
Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis.
Zhang M, Sun Y, Xu H, Shi Y, Shen R, Teng F, Xu J, Jia X
Acta biochimica et biophysica Sinica 2023 Apr 13;55(4):574-586
Acta biochimica et biophysica Sinica 2023 Apr 13;55(4):574-586
DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity.
Yan A, Xiong J, Zhu J, Li X, Xu S, Feng X, Ke X, Wang Z, Chen Y, Wang HW, Zhang MQ, Kee K
Nucleic acids research 2022 Oct 28;50(19):11255-11272
Nucleic acids research 2022 Oct 28;50(19):11255-11272
ADAR1 inhibits adipogenesis and obesity by interacting with Dicer to promote the maturation of miR-155-5P.
Yu Z, Luo R, Li Y, Li X, Yang Z, Peng J, Huang K
Journal of cell science 2022 Mar 1;135(5)
Journal of cell science 2022 Mar 1;135(5)
HSP90 and Aha1 modulate microRNA maturation through promoting the folding of Dicer1.
Liu X, Yang YY, Wang Y
Nucleic acids research 2022 Jul 8;50(12):6990-7001
Nucleic acids research 2022 Jul 8;50(12):6990-7001
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
Peng T, He Y, Wang T, Yu J, Ma X, Zhou Z, Sheng Y, Li L, Peng H, Li S, Zou J, Yuan Y, Zhao Y, Shi H, Li F, Liu W, Hu K, Lu X, Zhang G, Wang F
Journal of medicinal chemistry 2022 Aug 25;65(16):11010-11033
Journal of medicinal chemistry 2022 Aug 25;65(16):11010-11033
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels.
He Y, Huang M, Tang C, Yue Y, Liu X, Zheng Z, Dong H, Liu D
Virus research 2021 Jun;298:198404
Virus research 2021 Jun;298:198404
RNA structure probing reveals the structural basis of Dicer binding and cleavage.
Luo QJ, Zhang J, Li P, Wang Q, Zhang Y, Roy-Chaudhuri B, Xu J, Kay MA, Zhang QC
Nature communications 2021 Jun 7;12(1):3397
Nature communications 2021 Jun 7;12(1):3397
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
Liu X, Chen D, Chen H, Wang W, Liu Y, Wang Y, Duan C, Ning Z, Guo X, Otkur W, Liu J, Qi H, Liu X, Lin A, Xia T, Liu HX, Piao HL
Cancer communications (London, England) 2021 Jul;41(7):576-595
Cancer communications (London, England) 2021 Jul;41(7):576-595
The Capsid Protein of Rubella Virus Antagonizes RNA Interference in Mammalian Cells.
Xu J, Kong J, Lyu B, Wang X, Qian Q, Zhou X, Qiu Y
Viruses 2021 Jan 21;13(2)
Viruses 2021 Jan 21;13(2)
Amyloid peptide exerts a rapid induction of Dicer1 protein in neuron via reducing phosphorylation.
Wang Y, Xiu X, Wu S
Neurochemistry international 2021 Dec;151:105210
Neurochemistry international 2021 Dec;151:105210
The Capsid Protein of Semliki Forest Virus Antagonizes RNA Interference in Mammalian Cells.
Qian Q, Zhou H, Shu T, Mu J, Fang Y, Xu J, Li T, Kong J, Qiu Y, Zhou X
Journal of virology 2020 Jan 17;94(3)
Journal of virology 2020 Jan 17;94(3)
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation.
Song J, Zhuang Y, Zhu C, Meng H, Lu B, Xie B, Peng J, Li M, Yi C
Nature chemical biology 2020 Feb;16(2):160-169
Nature chemical biology 2020 Feb;16(2):160-169
Pseudogene RACGAP1P activates RACGAP1/Rho/ERK signalling axis as a competing endogenous RNA to promote hepatocellular carcinoma early recurrence.
Wang MY, Chen DP, Qi B, Li MY, Zhu YY, Yin WJ, He L, Yu Y, Li ZY, Lin L, Yang F, Lin ZR, Liu JQ
Cell death & disease 2019 Jun 3;10(6):426
Cell death & disease 2019 Jun 3;10(6):426
Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing.
Wei LZ, Wang YQ, Chang YL, An N, Wang X, Zhou PJ, Zhu HH, Fang YX, Gao WQ
American journal of cancer research 2018;8(2):226-244
American journal of cancer research 2018;8(2):226-244
LncRNA UCA1 is necessary for TGF-β-induced epithelial-mesenchymal transition and stemness via acting as a ceRNA for Slug in glioma cells.
Li Z, Liu H, Zhong Q, Wu J, Tang Z
FEBS open bio 2018 Nov;8(11):1855-1865
FEBS open bio 2018 Nov;8(11):1855-1865
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Zuo T, Zhu M, Xu W, Wang Z, Song H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.
Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang W, Ye L, Zhang X
Scientific reports 2017 May 18;7(1):2070
Scientific reports 2017 May 18;7(1):2070
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling.
Xu C, Zhang Y, Wang Q, Xu Z, Jiang J, Gao Y, Gao M, Kang J, Wu M, Xiong J, Ji K, Yuan W, Wang Y, Liu H
Nature communications 2016 Nov 4;7:13287
Nature communications 2016 Nov 4;7:13287
Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma.
Chen YS, Meng F, Li HL, Liu QH, Hou PF, Bai J, Zheng JN
Oncotarget 2016 Dec 20;7(51):84299-84313
Oncotarget 2016 Dec 20;7(51):84299-84313
Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.
Anglesio MS, Wang Y, Yang W, Senz J, Wan A, Heravi-Moussavi A, Salamanca C, Maines-Bandiera S, Huntsman DG, Morin GB
The Journal of pathology 2013 Feb;229(3):400-9
The Journal of pathology 2013 Feb;229(3):400-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 20567-1-AP(DICER1 antibody) at dilution of 1:200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DICER1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human DICER1. This antibody recognizes human,mouse,rat antigen. The DICER1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
