HPA008355

antibody from Atlas Antibodies

Targeting: ANKS6 ANKRD14, FLJ36928, NPHP16, SAMD6

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

HPA008355

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA008355, RRID:AB_2058277

Product name

Anti-ANKS6

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human ANKS6, Gene description: ankyrin repeat and sterile alpha motif domain containing 6, Alternative Gene Names: ANKRD14, FLJ36928, NPHP16, SAMD6, Validated applications: ICC, Uniprot ID: Q68DC2, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

Rothé B, Fortier S, Gagnieux C, Schmuziger C, Constam D
iScience 2023;26(6):106855

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Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3

Lo C, Rothé B, Ikawa Y, Zhang Z, Katoh T, Kajikawa E, Minegishi K, Xiaorei S, Fortier S, Dal Peraro M, Hamada H, Constam D
PLOS Biology 2023;21(9):e3002302

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Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse

Xu W, Li Y, Makova S, Brueckner M, Sun Z
eLife 2023;12

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Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease

Claus L, Chen C, Stallworth J, Turner J, Slaats G, Hawks A, Mabillard H, Senum S, Srikanth S, Flanagan-Steet H, Louie R, Silver J, Lerner-Ellis J, Morel C, Mighton C, Sleutels F, van Slegtenhorst M, van Ham T, Brooks A, Dorresteijn E, Barakat T, Dahan K, Demoulin N, Goffin E, Olinger E, Ambrose J, Arumugam P, Bevers R, Bleda M, Boardman-Pretty F, Boustred C, Brittain H, Caulfield M, Chan G, Elgar G, Fowler T, Giess A, Hamblin A, Henderson S, Hubbard T, Jackson R, Jones L, Kasperaviciute D, Kayikci M, Kousathanas A, Lahnstein L, Leigh S, Leong I, Lopez J, Maleady-Crowe F, McEntagart M, Minneci F, Moutsianas L, Mueller M, Murugaesu N, Need A, O’Donovan P, Odhams C, Patch C, Pereira M, Perez-Gil D, Pullinger J, Rahim T, Rendon A, Rogers T, Savage K, Sawant K, Scott R, Siddiq A, Sieghart A, Smith S, Sosinsky A, Stuckey A, Tanguy M, Taylor Tavares A, Thomas E, Thompson S, Tucci A, Welland M, Williams E, Witkowska K, Wood S, Larsen M, Hertz J, Lilien M, Obeidová L, Seeman T, Stone H, Kerecuk L, Gurgu M, Yousef Yengej F, Ammerlaan C, Rookmaaker M, Hanna C, Rogers R, Duran K, Peters E, Sayer J, van Haaften G, Harris P, Ling K, Mason J, van Eerde A, Steet R
Kidney International 2023;104(5):995-1007

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Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6

Rothé B, Leettola C, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie J, Constam D
Structure 2018;26(2):209-224.e6

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Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation

Beier D, Grampa V, Delous M, Zaidan M, Odye G, Thomas S, Elkhartoufi N, Filhol E, Niel O, Silbermann F, Lebreton C, Collardeau-Frachon S, Rouvet I, Alessandri J, Devisme L, Dieux-Coeslier A, Cordier M, Capri Y, Khung-Savatovsky S, Sigaudy S, Salomon R, Antignac C, Gubler M, Benmerah A, Terzi F, Attié-Bitach T, Jeanpierre C, Saunier S
PLOS Genetics 2016;12(3):e1005894

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The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes

Bakey Z, Bihoreau M, Piedagnel R, Delestré L, Arnould C, de Villiers A, Devuyst O, Hoffmann S, Ronco P, Gauguier D, Lelongt B
Kidney International 2015;88(2):299-310

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Mutations in ANKS6 Cause a Nephronophthisis-Like Phenotype with ESRD

Taskiran E, Korkmaz E, Gucer S, Kosukcu C, Kaymaz F, Koyunlar C, Bryda E, Chaki M, Lu D, Vadnagara K, Candan C, Topaloglu R, Schaefer F, Attanasio M, Bergmann C, Ozaltin F
Journal of the American Society of Nephrology 2014;25(8):1653-1661

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ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3

Hoff S, Halbritter J, Epting D, Frank V, Nguyen T, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto E, Eisenberger T, Elting M, van Wijk J, Bockenhauer D, Sebire N, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus T, Elshakhs N, Koon S, Harris P, Grahammer F, Huber T, Kuehn E, Kramer-Zucker A, Bolz H, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp S
Nature Genetics 2013;45(8):951-956