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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [26]
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- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 11144-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11144-1-AP, RRID:AB_2158371
- Product name
- P2RX7 antibody
- Antibody type
- Polyclonal
- Description
- P2RX7 antibody (Cat. #11144-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Jujuboside A Alleviates Facial Allodynia of CCI-ION Rats by Inhibiting the Expression of P2X7 Receptor in the Spinal Trigeminal Subnucleus Caudalis.
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage.
Protective Effect of Silymarin Against Paclitaxel-Induced Cardiotoxicity.
Rhein attenuates obesity-related glomerulopathy by inhibiting the P2X7R/NLRP3 inflammasome pathway and protecting podocytes.
Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF-κB, Bcl-2, and Caspase-3 in LPS-Induced Endotoxemia.
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Alleviation of LPS-induced acute lung injury by propolis-based nanocomposites through the TLR4/NFKB and P2X7/AKT pathways: Randomized-controlled experimental study.
Silver Nanoparticles Loaded With Oleuropein Alleviates LPS-Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor-Mediated Inflammation and Apoptosis in Rats.
Citrate-coated silver nanoparticles loaded with agomelatine provide neuronal therapy in acute cerebral ischemia/reperfusion of rats by inhibiting the oxidative stress, endoplasmic reticulum stress, and P2X7 receptor-mediated inflammasome.
Dietary composition influences sperm quality and testis damage via endoplasmic reticulum stress in lambs.
Assessment of toxicological effects of favipiravir (T-705) on the lung tissue of rats: An experimental study.
Molecular mechanisms of resveratrol and its silver nanoparticle conjugate in addressing sepsis-induced lung injury.
Blockade of P2X7 receptor-mediated purinergic signaling with A438079 protects against LPS-induced liver injury in rats.
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats.
Maternal smoking during pregnancy aggravated muscle phenotype in FHL1(-/y) offspring mice similar to congenital clubfoot through P2RX7-mediated pyroptosis.
Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells.
Muscle death participates in myofibrillar abnormalities in FHL1 knockout mice.
Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice.
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus.
Ketamine Alleviates Depressive-Like Behaviors via Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice.
The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells.
Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate.
HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation.
The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.
Zhou M, Han W, Wu Y, Ouyang Z, Zhou Y, Liu L, Qiu Y, Zhang Y, Zhang J, Pu X, Gao Y, Xiong W
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2026 Feb;55(2):232-243
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2026 Feb;55(2):232-243
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage.
Li Y, Sun J, Lyu Y, Huang M, Du C, Liang M, Chen J, Lu J, Li G, Wang Z, Han G
International immunopharmacology 2026 Feb 1;170:116080
International immunopharmacology 2026 Feb 1;170:116080
Protective Effect of Silymarin Against Paclitaxel-Induced Cardiotoxicity.
Tutar T, Yakut S, Kara A, Ulucan A, Çağlayan C
Food science & nutrition 2026 Apr;14(4):e71710
Food science & nutrition 2026 Apr;14(4):e71710
Rhein attenuates obesity-related glomerulopathy by inhibiting the P2X7R/NLRP3 inflammasome pathway and protecting podocytes.
Wei L, Zhang J, Dou L, Wu X, Xu M, Ye J, Yang Y, Zhang Y, Xiao S
Iranian journal of basic medical sciences 2025;28(12):1743-1748
Iranian journal of basic medical sciences 2025;28(12):1743-1748
Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF-κB, Bcl-2, and Caspase-3 in LPS-Induced Endotoxemia.
Ozkanlar S, Ozkanlar Y, Kara A, Dalkilinc E
Environmental toxicology 2025 Jun;40(6):924-934
Environmental toxicology 2025 Jun;40(6):924-934
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Li Z, Sun X, Wang Y, Zhang F, Wang L, Ai C, Zhang X, Yin X, Liu C, Li C, Lu C
Basic research in cardiology 2025 Dec;120(6):1225-1247
Basic research in cardiology 2025 Dec;120(6):1225-1247
Alleviation of LPS-induced acute lung injury by propolis-based nanocomposites through the TLR4/NFKB and P2X7/AKT pathways: Randomized-controlled experimental study.
Üstündağ H, Kara A, Gökhan Taş N, Danişman Kalindemi Rtaş F, Kurt N, Erbaş E, Tahir Huyut M, Gül M, Afşin Kari Per İ
Toxicon : official journal of the International Society on Toxinology 2025 Apr;258:108330
Toxicon : official journal of the International Society on Toxinology 2025 Apr;258:108330
Silver Nanoparticles Loaded With Oleuropein Alleviates LPS-Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor-Mediated Inflammation and Apoptosis in Rats.
Yakut S, Gelen V, Kara H, Özkanlar S, Yeşildağ A
Environmental toxicology 2024 Nov;39(11):4960-4973
Environmental toxicology 2024 Nov;39(11):4960-4973
Citrate-coated silver nanoparticles loaded with agomelatine provide neuronal therapy in acute cerebral ischemia/reperfusion of rats by inhibiting the oxidative stress, endoplasmic reticulum stress, and P2X7 receptor-mediated inflammasome.
Gelen V, Özkanlar S, Kara A, Yeşildağ A
Environmental toxicology 2024 Mar;39(3):1531-1543
Environmental toxicology 2024 Mar;39(3):1531-1543
Dietary composition influences sperm quality and testis damage via endoplasmic reticulum stress in lambs.
Imik A, Eren M, Can MB, Ozkanlar S, Omur AD, Aydin MA, Sunar S, Akarsu SA
Veterinary medicine and science 2024 Jul;10(4):e1504
Veterinary medicine and science 2024 Jul;10(4):e1504
Assessment of toxicological effects of favipiravir (T-705) on the lung tissue of rats: An experimental study.
Erbaş E, Celep NA, Tekiner D, Genç A, Gedikli S
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23536
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23536
Molecular mechanisms of resveratrol and its silver nanoparticle conjugate in addressing sepsis-induced lung injury.
Üstündağ H, Kara A, Doğanay S, Kurt N, Erbaş E, Kalindemirtaş FD, Kariper İA
Naunyn-Schmiedeberg's archives of pharmacology 2024 Aug;397(8):6249-6261
Naunyn-Schmiedeberg's archives of pharmacology 2024 Aug;397(8):6249-6261
Blockade of P2X7 receptor-mediated purinergic signaling with A438079 protects against LPS-induced liver injury in rats.
Kara A, Ozkanlar S
Journal of biochemical and molecular toxicology 2023 Oct;37(10):e23443
Journal of biochemical and molecular toxicology 2023 Oct;37(10):e23443
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Li F, Xu M, Miao J, Hu N, Wang Y, Wang L
Toxicology letters 2023 Jul 1;383:98-111
Toxicology letters 2023 Jul 1;383:98-111
P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats.
Ozkanlar S, Ulas N, Kaynar O, Satici E
Purinergic signalling 2023 Dec;19(4):699-707
Purinergic signalling 2023 Dec;19(4):699-707
Maternal smoking during pregnancy aggravated muscle phenotype in FHL1(-/y) offspring mice similar to congenital clubfoot through P2RX7-mediated pyroptosis.
Lou Y, Miao J, Li F, Ding J, Wang L
Toxicology letters 2021 Jul 1;345:54-60
Toxicology letters 2021 Jul 1;345:54-60
Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells.
Gong M, Ye S, Li WX, Zhang J, Liu Y, Zhu J, Lv W, Zhang H, Wang J, Lu A, He K
American journal of physiology. Cell physiology 2020 Jun 1;318(6):C1123-C1135
American journal of physiology. Cell physiology 2020 Jun 1;318(6):C1123-C1135
Muscle death participates in myofibrillar abnormalities in FHL1 knockout mice.
Ding J, Cong Y, Li F, Liu B, Wu D, Miao J, Wang L
Biochemical and biophysical research communications 2020 Feb 26;523(1):105-111
Biochemical and biophysical research communications 2020 Feb 26;523(1):105-111
Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice.
Ding J, Li F, Cong Y, Miao J, Wu D, Liu B, Wang L
Life sciences 2019 Oct 15;235:116800
Life sciences 2019 Oct 15;235:116800
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Zhang Q, Tao X, Xia S, Qu J, Song H, Liu J, Li H, Shang D
Oncology reports 2019 Jan;41(1):270-278
Oncology reports 2019 Jan;41(1):270-278
Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus.
Su WJ, Zhang T, Jiang CL, Wang W
Frontiers in cellular neuroscience 2018;12:412
Frontiers in cellular neuroscience 2018;12:412
Ketamine Alleviates Depressive-Like Behaviors via Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice.
Tan S, Wang Y, Chen K, Long Z, Zou J
Biological & pharmaceutical bulletin 2017;40(8):1260-1267
Biological & pharmaceutical bulletin 2017;40(8):1260-1267
The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells.
Weng NJ, Talbot P
Stem cell research 2017 Aug;23:39-49
Stem cell research 2017 Aug;23:39-49
Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate.
Qi B, Yu T, Wang C, Wang T, Yao J, Zhang X, Deng P, Xia Y, Junger WG, Sun D
Journal of experimental & clinical cancer research : CR 2016 Oct 3;35(1):161
Journal of experimental & clinical cancer research : CR 2016 Oct 3;35(1):161
HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation.
Liao YH, Lin YC, Tsao ST, Lin YC, Yang AJ, Huang CT, Huang KC, Lin WW
Journal of leukocyte biology 2013 Feb;93(2):289-99
Journal of leukocyte biology 2013 Feb;93(2):289-99
The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.
Kouzaki H, Iijima K, Kobayashi T, O'Grady SM, Kita H
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 1;186(7):4375-87
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 1;186(7):4375-87
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The P2RX7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human P2RX7. This antibody recognizes human,mouse,rat antigen. The P2RX7 antibody has been validated for the following applications: ELISA, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 11144-1-AP(P2RX7 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
