28207-1-AP

antibody from Proteintech Group

Targeting: P2RX7 MGC20089, P2X7

Provider product page for 28207-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [37]
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Product number: 28207-1-AP - Provider product page
Provider: Proteintech Group
Product name: P2RX7 antibody
Antibody type: Polyclonal
Description: P2RX7 antibody (Cat. #28207-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

P2RX7 protein structure - 28207-1-AP shown in red.

Submitted references The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.

Zhuang Z, Han C, Cai M, Li M, Lin S, Chen L, Zhu Z, Zhang H, Xing C, Han B, Yang R
Journal of advanced research 2026 Mar;81:349-364

Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor.

Wang C, Hao J, Liu Y, Shen H
Purinergic signalling 2026 Mar 3;22(2)

Recombinant SARS-Cov-2 spike protein S1 subunit upregulates P2 × 7-NLRP3 leading to macrophage pyroptosis promoting acute lung injury.

Lu M, Li M, Zhou H, Zhu J, Jiao Q, Liu X, Wu J, Xu G, Lv C, Fan Y, Zhang B, Pan L
Respiratory research 2026 Jan 23;27(1):76

Islet regeneration protein Reg3g promotes macrophage clearance of β cell-derived dysfunctional mitochondria-rich vesicles to mitigate T2DM.

Li S, Wang M, Zhou H, Liu J, Wang M, Yuan H, Zheng M, Li X, Zhu X, Xiang M
Redox biology 2026 Feb;89:103996

Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.

Li H, Zhao R, Wan L, Yuan Y, Ma E, Li Y, Chen Z, Liu B, Song Y, Cao Z, Jiao X, Wang Y, Wu P, Jin H, Li J, Yang X, Huang L, Zhang Y, Yang K, Huo J, Jin H, Zhong H, Min M, Zhang S, Cao Y, Li W, Zhang R, Wei C
Nature aging 2026 Apr 6;

Deciphering the Therapeutic Mechanisms of Banxia Xiexin Decoction Against Ulcerative Colitis: Targeting Pyroptosis and Necroptosis.

Lu J, Liang K, Zhang L, Cui B, You L, An R, Hu C, Wang X
Journal of inflammation research 2025;18:17537-17560

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel.

Liu Y, Han X, Zhang W, Pei Q, Xu S, Wang H
Frontiers in immunology 2025;16:1712759

Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF-κB, Bcl-2, and Caspase-3 in LPS-Induced Endotoxemia.

Ozkanlar S, Ozkanlar Y, Kara A, Dalkilinc E
Environmental toxicology 2025 Jun;40(6):924-934

P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma.

Sharma S, Ghimeray K, Rahman MM, Upadrasta A, Akundi RS
Purinergic signalling 2025 Jun;21(3):447-464

Visualization of P2X7 Receptors in Living Human Gliomas: An 18F-GSK1482160 PET Imaging and Neuropathology Study.

Zhou W, Yue Q, Yuan Y, Huang Q, He K, Hua T, Han J, He Y, Guan Y, Chen L, Xie F, Mao Y
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Jun 3;31(11):2183-2195

Pannexin1 via P2rx7/amphiregulin contributes to cardiac fibrosis post myocardial infarction.

Deng N, You L, Guo H, Wei Y, Xu F, Chen D, Luo S, Huang S, Zuo S, Li W, Si X
Journal of molecular histology 2025 Jul 15;56(4):230

Protective effect of lappaconitine on Freund's complete adjuvant-induced arthritis exerted through P2X7 receptor-mediated regulation of M1/M2 balance in rats.

Pengqiang Z, Qi F, Weiyan H, Shan OU
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Feb;45(1):39-48

The P2X7-Mediated Mitochondrial ROS as an Emerging Core Target of Tuftsin Nanoparticles in Severe Acute Pancreatitis Therapy via Regulating Mitophagy.

Wen E, Tian Y, Fang M, Zhang Y, Zhao H, Wang Z, Zhang L, Li X
ACS applied materials & interfaces 2025 Feb 5;17(5):7521-7538

Activation of Adenosine Triphosphate-Gated Purinergic 2 Receptor Channels by Transient Receptor Potential Vanilloid Subtype 4 in Cough Hypersensitivity.

Li W, Wang S, Zhang T, Zhu Y, Yu L, Xu X
Biomolecules 2025 Feb 14;15(2)

Network Pharmacology and Experimental Validation Reveal Wu Miao Pill's Therapeutic Effects on Acute Gouty Arthritis Through P2X7R Regulation.

Gao WQ, Gong XZ, Chang C, Li L, Gu YY, He DY
Biochemical genetics 2025 Dec 6;

P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage.

Ding PF, Zhang JT, Zhu XL, Cui Y, Chen CL, Liu XZ, Shen JD, Zou LX, Lu Y, Zhuang Z, Hang CH, Li W
Journal of neuroinflammation 2025 Aug 28;22(1):208

KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications.

Zhang T, Hu H, Jiang H, Wang Z, Lin J, Cheng Y, Guo W, Ke D, Hang H, Ta M, Ou-Yang J, Zhai J, Yang X, Wang S, Zhu B
Nature communications 2025 Aug 2;16(1):7120

Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH.

Liu Y, Yao C, Sheng B, Zhi S, Chen X, Ding P, Zhang J, Tao Z, Li W, Zhuang Z, Mao J, Peng Z, Yan H, Jin W
Translational stroke research 2025 Apr;16(2):448-466

Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice.

Dang R, Liu A, Zhou Y, Li X, Wu M, Cao K, Meng Y, Zhang H, Gan G, Xie W, Jia Z
Nature communications 2024 Oct 5;15(1):8639

The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress.

Li X, Quan P, Si Y, Liu F, Fan Y, Ding F, Sun L, Liu H, Huang S, Sun L, Yang F, Yao L
Journal of neuroinflammation 2024 Jan 8;21(1):13

Role of P2X7 receptor in the progression and clinicopathological characteristics of gastric cancer.

Zhang WJ, Pi XW, Le YG, Li TZ
Scientific reports 2024 Dec 30;14(1):31673

Quercetin Mitigates Lysophosphatidylcholine (LPC)-Induced Neutrophil Extracellular Traps (NETs) Formation through Inhibiting the P2X7R/P38MAPK/NOX2 Pathway.

Liu S, Wang Y, Ying L, Li H, Zhang K, Liang N, Luo G, Xiao L
International journal of molecular sciences 2024 Aug 30;25(17)

Activation of P2X7 Receptor Mediates the Abnormal Ovulation Induced by Chronic Restraint Stress and Chronic Cold Stress.

Fan X, Wang J, Ma Y, Chai D, Han S, Xiao C, Huang Y, Wang X, Wang J, Wang S, Xiao L, Zhang C
Biology 2024 Aug 15;13(8)

Baicalin inhibits monosodium urate crystal-induced pyroptosis in renal tubular epithelial cell line through Panx-1/P2X7 pathways: Molecular docking, molecular dynamics, and in vitro experiments.

Fu W, Liu Z, Wang Y, Li X, Yu X, Li Y, Yu Z, Qiu Y, Mei Z, Xu L
Chemical biology & drug design 2024 Apr;103(4):e14522

P2X(7)R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.

Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, Ruepp MD, Jimenez-Sanchez M, Perkinton MS, Kassiou M, Golde TE, Hanger DP, Verkhratsky A, Perez-Nievas BG, Noble W
Brain, behavior, and immunity 2023 Nov;114:414-429

Asiaticoside hampers epithelial-mesenchymal transition by promoting PPARG expression and suppressing P2RX7-mediated TGF-β/Smad signaling in triple-negative breast cancer.

Huang X, Jia Z, Li X, Hu Z, Yu X, Xia J
Phytotherapy research : PTR 2023 May;37(5):1771-1786

Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.

Sun W, Wang Q, Zhang R, Zhang N
Food & function 2023 Jul 31;14(15):7247-7269

Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.

Zhu X, Hao W, Liu Z, Song Y, Hao C, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Jan 1;249:114373

Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.

Liu C, Tian Q, Wang J, He P, Han S, Guo Y, Yang C, Wang G, Wei H, Li M
Molecular neurobiology 2023 Feb;60(2):460-479

Co-exposure to cadmium and microplastics promotes liver fibrosis through the hemichannels -ATP-P2X7 pathway.

Sun J, Qu H, Ali W, Chen Y, Wang T, Ma Y, Yuan Y, Gu J, Bian J, Liu Z, Zou H
Chemosphere 2023 Dec;344:140372

Purinergic receptor P2X7 activates NOX2/JNK signaling to participate in granulosa cell inflammation and apoptosis in polycystic ovary syndrome.

Shen C, Jiang Y, Lin J, He Y, Liu Y, Fang D
Journal of bioenergetics and biomembranes 2023 Aug;55(4):313-322

Microglial NLRP3 inflammasome activation mediates diabetes-induced depression-like behavior via triggering neuroinflammation.

Su WJ, Li JM, Zhang T, Cao ZY, Hu T, Zhong SY, Xu ZY, Gong H, Jiang CL
Progress in neuro-psychopharmacology & biological psychiatry 2023 Aug 30;126:110796

Progesterone Reduces ATP-Induced Pyroptosis of SH-SY5Y Cells.

Cui C, Wang X, Zhang S, Wu H, Li M, Dong L, Yan C, Li D
BioMed research international 2022;2022:4827444

Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.

Chai Y, Cai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in pharmacology 2022;13:812362

Apelin-13/APJ induces cardiomyocyte hypertrophy by activating the Pannexin-1/P2X7 axis and FAM134B-dependent reticulophagy.

Yang Y, Zhang K, Huang S, Chen W, Mao H, Ouyang X, Chen L, Li L
Journal of cellular physiology 2022 Apr;237(4):2230-2248

A438079 affects colorectal cancer cell proliferation, migration, apoptosis, and pyroptosis by inhibiting the P2X7 receptor.

Zhang Y, Li F, Wang L, Lou Y
Biochemical and biophysical research communications 2021 Jun 18;558:147-153

The role of P2X7 receptor in prognosis and metastasis of colorectal cancer.

Zhang Y, Ding J, Wang L
Advances in medical sciences 2019 Sep;64(2):388-394

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