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LearnABIN108736
antibody from antibodies-online
Targeting: FPR2
ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH2, FPRL1, HM63, LXA4R
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Immunocytochemistry [1]
- Flow cytometry [1]
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- Product number
- ABIN108736 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN108736, RRID:AB_10952146
- Product name
- anti-Formyl Peptide Receptor 2 (FPR2) antibody
- Antibody type
- Monoclonal
- Antigen
- Genetic immunisation with cDNA encoding human Crisp3
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- GM1D6
- Vial size
- 100 ug
- Storage
- Store the antibody at 4°C. Avoid repeated freezing and thawing.
Submitted references Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands.
Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression.
Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor.
Annexin A1 N-terminal derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions.
Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease.
Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils.
Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity.
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.
Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.
Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets.
Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis.
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1.
Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells.
Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.
A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor.
Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease.
[Divided nevus--an embryological experiment of nature].
1;16 tandem translocation with trisomy 16 in a Brown Swiss bull.
Lethal intrauterine fetal trauma.
He HQ, Troksa EL, Caltabiano G, Pardo L, Ye RD
The Journal of biological chemistry 2014 Jan 24;289(4):2295-306
The Journal of biological chemistry 2014 Jan 24;289(4):2295-306
Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression.
Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B, Perretti M
Circulation research 2014 Jan 17;114(2):242-8
Circulation research 2014 Jan 17;114(2):242-8
Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor.
Dalli J, Consalvo AP, Ray V, Di Filippo C, D'Amico M, Mehta N, Perretti M
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):6478-87
Journal of immunology (Baltimore, Md. : 1950) 2013 Jun 15;190(12):6478-87
Annexin A1 N-terminal derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions.
Bizzarro V, Fontanella B, Carratù A, Belvedere R, Marfella R, Parente L, Petrella A
PloS one 2012;7(9):e45639
PloS one 2012;7(9):e45639
Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease.
Dakin SG, Dudhia J, Werling NJ, Werling D, Abayasekara DR, Smith RK
PloS one 2012;7(11):e48978
PloS one 2012;7(11):e48978
Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils.
Dalli J, Montero-Melendez T, McArthur S, Perretti M
Frontiers in pharmacology 2012;3:28
Frontiers in pharmacology 2012;3:28
Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity.
Simiele F, Recchiuti A, Mattoscio D, De Luca A, Cianci E, Franchi S, Gatta V, Parolari A, Werba JP, Camera M, Favaloro B, Romano M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Mar;26(3):1323-33
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Mar;26(3):1323-33
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
Bena S, Brancaleone V, Wang JM, Perretti M, Flower RJ
The Journal of biological chemistry 2012 Jul 13;287(29):24690-7
The Journal of biological chemistry 2012 Jul 13;287(29):24690-7
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.
Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M
Arteriosclerosis, thrombosis, and vascular biology 2012 Aug;32(8):1970-8
Arteriosclerosis, thrombosis, and vascular biology 2012 Aug;32(8):1970-8
Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.
Nadkarni S, Cooper D, Brancaleone V, Bena S, Perretti M
Arteriosclerosis, thrombosis, and vascular biology 2011 Nov;31(11):2749-59
Arteriosclerosis, thrombosis, and vascular biology 2011 Nov;31(11):2749-59
Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets.
Spurr L, Nadkarni S, Pederzoli-Ribeil M, Goulding NJ, Perretti M, D'Acquisto F
International immunopharmacology 2011 Jan;11(1):55-66
International immunopharmacology 2011 Jan;11(1):55-66
Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G, Perretti M
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4905-14
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4905-14
ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis.
Martins V, Valença SS, Farias-Filho FA, Molinaro R, Simões RL, Ferreira TP, e Silva PM, Hogaboam CM, Kunkel SL, Fierro IM, Canetti C, Benjamim CF
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5374-81
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5374-81
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.
Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD
American journal of respiratory and critical care medicine 2008 Sep 15;178(6):574-82
American journal of respiratory and critical care medicine 2008 Sep 15;178(6):574-82
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1.
Björkman L, Karlsson J, Karlsson A, Rabiet MJ, Boulay F, Fu H, Bylund J, Dahlgren C
Journal of leukocyte biology 2008 Feb;83(2):245-53
Journal of leukocyte biology 2008 Feb;83(2):245-53
Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells.
Viswanathan A, Painter RG, Lanson NA Jr, Wang G
Stem cells (Dayton, Ohio) 2007 May;25(5):1263-9
Stem cells (Dayton, Ohio) 2007 May;25(5):1263-9
Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.
Migeotte I, Communi D, Parmentier M
Cytokine & growth factor reviews 2006 Dec;17(6):501-19
Cytokine & growth factor reviews 2006 Dec;17(6):501-19
A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor.
Elagoz A, Henderson D, Babu PS, Salter S, Grahames C, Bowers L, Roy MO, Laplante P, Grazzini E, Ahmad S, Lembo PM
British journal of pharmacology 2004 Jan;141(1):37-46
British journal of pharmacology 2004 Jan;141(1):37-46
Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease.
Cui Y, Le Y, Yazawa H, Gong W, Wang JM
Journal of leukocyte biology 2002 Oct;72(4):628-35
Journal of leukocyte biology 2002 Oct;72(4):628-35
[Divided nevus--an embryological experiment of nature].
John SM, Hamm H, Happle R
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1990 Dec;41(12):696-8
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1990 Dec;41(12):696-8
1;16 tandem translocation with trisomy 16 in a Brown Swiss bull.
Kovács A, Foote RH, Lein DH
The Veterinary record 1990 Aug 25;127(8):205
The Veterinary record 1990 Aug 25;127(8):205
Lethal intrauterine fetal trauma.
Stafford PA, Biddinger PW, Zumwalt RE
American journal of obstetrics and gynecology 1988 Aug;159(2):485-9
American journal of obstetrics and gynecology 1988 Aug;159(2):485-9
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Spectral Confocal Microscopy of CHO cells using GM1-D6. CHO cells were transiently transfected with an expression vector encoding FPRL1. Binding of D6 was visualized with a FITC-conjugated secondary antibody (green). Actin filaments are labeled with Alexa Fluor-555 Phalloidin (red). Cell nuclei are stained with DAPI (blue).
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FACS analysis of BOSC23 cells using D6 GM0601. BOSC23 cells were transiently transfected with an expression vector encoding either FPRL1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of D6 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with FPRL1 transfected cells.
