11549-1-AP

antibody from Proteintech Group

Targeting: CAMKK2 CAMKK, CAMKKB, KIAA0787, MGC15254

Provider product page for 11549-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [42]
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Validations
Western blot [1]

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Product number: 11549-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11549-1-AP, RRID:AB_2259441
Product name: CAMKK2 antibody
Antibody type: Polyclonal
Description: KD/KO validated CAMKK2 antibody (Cat. #11549-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CAMKK2 protein structure - 11549-1-AP shown in red.

Submitted references Methyl Cinnamate (MC) Alleviates Free Fatty Acids (FFAs) Induced Lipid Accumulation Through the AMPK Pathway in HepG2 Cells.

Fu Y, Li G, Feng Z, Liu J, Wang X, Wang T, Liu J
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:1183-1197

An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.

Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H
Journal of pharmacological sciences 2024 Jan;154(1):37-46

Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids.

Ohtsuka S, Miyai Y, Mima H, Magari M, Chiba Y, Suizu F, Sakagami H, Ueno M, Tokumitsu H
Cell calcium 2024 Jan;117:102820

β-Hydroxybutyrate Protects Against Cisplatin-Induced Renal Damage via Regulating Ferroptosis.

Tian R, Tang S, Zhao J, Hao Y, Zhao L, Han X, Wang X, Zhang L, Li R, Zhou X
Renal failure 2024 Dec;46(1):2354918

OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.

Liu N, Fan Y, Li Y, Zhang Y, Li J, Wang Y, Wang Z, Liu Y, Li Y, Kang Z, Peng Y, Ru Z, Yang M, Feng C, Wang Y, Yang X
Current neuropharmacology 2023;21(12):2550-2562

A high-concentrate diet induces inflammatory injury via regulating Ca(2+)/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows.

Meng M, Li X, Wang Z, Huo R, Ma N, Chang G, Shen X
Frontiers in immunology 2023;14:1186170

Wang H, Jia Y, Gu J, Chen O, Yue S
Frontiers in pharmacology 2023;14:1087557

A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.

Jiang W, Zhang M, Gao C, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J
The EMBO journal 2023 Oct 16;42(20):e113743

Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells.

Akasaka Y, Hasei S, Ohata Y, Kanna M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Ono H, Matsubara A, Hinata N, Asano T, Yamamotoya T
International journal of molecular sciences 2023 Nov 6;24(21)

CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.

Li C, Hao J, Qiu H, Xin H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425

Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.

Ma S, Xu J, Zheng Y, Li Y, Wang Y, Li H, Fang Z, Li J
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115878

Dihydroartemisinin inhibits liver cancer cell migration and invasion by reducing ATP synthase production through CaMKK2/NCLX.

Chang J, Xin C, Wang Y, Wang Y
Oncology letters 2023 Dec;26(6):540

Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.

Chen M, Zhu JY, Mu WJ, Luo HY, Li Y, Li S, Yan LJ, Li RY, Guo L
Nature communications 2023 Dec 18;14(1):8391

Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt/β-catenin signal pathway.

Zhang H, Dong X, Ding X, Liu G, Yang F, Song Q, Sun H, Chen G, Li S, Li Y, Wang M, Guo T, Zhang Z, Li B, Yang L
Journal of translational medicine 2023 Dec 11;21(1):900

Physical exercise attenuates age-related muscle atrophy and exhibits anti-ageing effects via the adiponectin receptor 1 signalling.

Chen YL, Ma YC, Tang J, Zhang D, Zhao Q, Liu JJ, Tang HS, Zhang JY, He GH, Zhong CH, Wu YT, Wen HR, Ma LQ, Zou CG
Journal of cachexia, sarcopenia and muscle 2023 Aug;14(4):1789-1801

Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics.

Zhong Y, Jin R, Luo R, Liu J, Ren L, Zhang Y, Shan Z, Peng X
Nutrients 2023 Aug 11;15(16)

Transient Ca(2+) entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity.

Honsho M, Mawatari S, Fujino T
Frontiers in molecular biosciences 2022;9:1008626

Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control.

Yan M, Jin S, Liu Y, Wang L, Wang Z, Xia T, Chang Q
Frontiers in pharmacology 2022;13:824138

Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells.

Dai S, Venturini E, Yadav S, Lin X, Clapp D, Steckiewicz M, Gocher-Demske AM, Hardie DG, Edelman AM
Biochimica et biophysica acta. Molecular cell research 2022 Jul;1869(7):119252

Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.

Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697

CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway.

Wang S, Yi X, Wu Z, Guo S, Dai W, Wang H, Shi Q, Zeng K, Guo W, Li C
The Journal of investigative dermatology 2022 Jan;142(1):189-200.e8

β-carotene alleviates LPS-induced inflammation through regulating STIM1/ORAI1 expression in bovine mammary epithelial cells.

Meng M, Huo R, Ma N, Chang G, Shen X
International immunopharmacology 2022 Dec;113(Pt A):109377

Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.

Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809

CARS senses cysteine deprivation to activate AMPK for cell survival.

Yuan M, Yan R, Zhang Y, Qiu Y, Jiang Z, Liu H, Wang Y, Sun L, Zhang H, Gao P
The EMBO journal 2021 Nov 2;40(21):e108028

Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness.

Zhang Y, Recouvreux MV, Jung M, Galenkamp KMO, Li Y, Zagnitko O, Scott DA, Lowy AM, Commisso C
Cancer discovery 2021 Jul;11(7):1808-1825

Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx.

Qu Z, Liu A, Liu C, Tang Q, Zhan L, Xiao W, Huang J, Liu Z, Zhang S
Journal of agricultural and food chemistry 2021 Jul 28;69(29):8144-8159

m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X
Autophagy 2021 Feb;17(2):457-475

Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine.

Zheng Y, Guan H, Yang J, Cai J, Liu Q, Zhang Z
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2021 Dec;7(4):997-1008

Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca(2+) Homeostasis, and Bcl2 Expression.

Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Zhang Y, Peng X
Molecular nutrition & food research 2021 Aug;65(15):e2001202

A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.

Medchalmi S, Tare P, Sayyad Z, Swarup G
The FEBS journal 2021 Aug;288(15):4576-4595

Yi-Zhi-Fang-Dai Formula Exerts a Protective Effect on the Injury of Tight Junction Scaffold Proteins in Vitro and in Vivo by Mediating Autophagy through Regulation of the RAGE/CaMKKβ/AMPK/mTOR Pathway.

Chan Y, Chen W, Chen Y, Lv Z, Wan W, Li Y, Zhang C
Biological & pharmaceutical bulletin 2020;43(12):1847-1858

Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.

Li W, Jiang YH, Wang Y, Zhao M, Hou GJ, Hu HZ, Zhou L
Chinese journal of integrative medicine 2020 Jan;26(1):46-53

Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1α pathway in mice.

Li Y, Wang B, Shen J, Bai M, Xu E
Pharmaceutical biology 2020 Dec;58(1):385-392

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.

Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.

Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7

Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy.

Wen J, Xu B, Sun Y, Lian M, Li Y, Lin Y, Chen D, Diao Y, Almoiliqy M, Wang L
Pharmacological research 2019 Aug;146:104308

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.

Li YC, Qiao JY, Wang BY, Bai M, Shen JD, Cheng YX
Nutrients 2018 Aug 5;10(8)

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC
Nature 2017 Aug 3;548(7665):112-116

Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.

Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J, Lei M
Oncotarget 2016 Feb 2;7(5):5366-82

Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.

Wang S, Chen Y, Kou R, Wang Y, Zeng T, Xie K, Song F
Toxicology 2016 Aug 10;368-369:19-27

Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway.

Xi Y, Wu M, Li H, Dong S, Luo E, Gu M, Shen X, Jiang Y, Liu Y, Liu H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;35(6):2349-59

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.

Knight JR, Bastide A, Roobol A, Roobol J, Jackson TJ, Utami W, Barrett DA, Smales CM, Willis AE
The Biochemical journal 2015 Jan 15;465(2):227-38

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CAMKK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CAMKK2. This antibody recognizes human, mouse antigen. The CAMKK2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 11549-1-AP.pdf

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