ORC1

gene product
HSORC1, ORC1L, PARC1
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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198 antibodies from 28 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
20 antibodies
antibodies-online
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Affinity Biosciences
1 antibody
Bethyl Laboratories
1 antibody
Abnova Corporation
5 antibodies
Atlas Antibodies
1 antibody
GeneTex
5 antibodies
LifeSpan BioSciences, Inc.
14 antibodies
Biorbyt
11 antibodies
Creative Biolabs
8 antibodies
Invitrogen Antibodies
5 antibodies
Acris Antibodies GmbH
3 antibodies
OriGene
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Bioworld Technology, Inc
1 antibody
St John's Laboratory
2 antibodies
Boster Biological Technology
1 antibody
Cell Signaling Technology, Inc
1 antibody
Creative Diagnostics
3 antibodies
MyBioSource
3 antibodies
GenWay
4 antibodies
EMD Millipore
1 antibody
RayBiotech, Inc.
1 antibody
Sigma-Aldrich
1 antibody
United States Biological
13 antibodies
Arigo
1 antibody
Aviva Systems Biology
1 antibody