Antibody data

Product number
NBP2-48345 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal beta 2-Microglobulin Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Reactivity
Human, Simian
Host
Mouse
Isotype
IgG
Vial size
7 ml
Storage
Store at 4C.
B2M protein structure - NBP2-48345 shown in red.