Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 316304 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#316304, RRID:AB_492837
- Product name
- FITC anti-human 2-microglobulin
- Antibody type
- Monoclonal
- Antigen
- Purified human β2-microglobulin
- Description
- β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.
- Reactivity
- Human, Porcine
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references The β2-microglobulin-free heterodimerization of rhesus monkey MHC class I A with its normally spliced variant reduces the ubiquitin-dependent degradation of MHC class I A.
Differential cell fates induced by all-trans retinoic acid-treated HL-60 human leukemia cells.
Dai ZX, Zhang GH, Zhang XH, Xia HJ, Li SY, Zheng YT
Journal of immunology (Baltimore, Md. : 1950) 2012 Mar 1;188(5):2285-96
Journal of immunology (Baltimore, Md. : 1950) 2012 Mar 1;188(5):2285-96
Differential cell fates induced by all-trans retinoic acid-treated HL-60 human leukemia cells.
Ozeki M, Shively JE
Journal of leukocyte biology 2008 Sep;84(3):769-79
Journal of leukocyte biology 2008 Sep;84(3):769-79
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with 2M2 FITC
- Conjugate
- Green dye