23006-1-AP

antibody from Proteintech Group

Targeting: SCP2

Provider product page for 23006-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations
Western blot [1]

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Product number: 23006-1-AP - Provider product page
Provider: Proteintech Group
Product name: SCP2 antibody
Antibody type: Polyclonal
Description: KD/KO validated SCP2 antibody (Cat. #23006-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SCP2 protein structure - 23006-1-AP shown in red.

Submitted references Membrane editing with proximity labeling reveals regulators of lipid homeostasis.

Tei R, Li XL, Luan L, Baskin JM
Nature chemical biology 2026 May;22(5):728-739

Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high-frequency PIK3CA mutations revealed by molecular and immunohistochemical analysis.

Nakamura H, Kukita Y, Kittaka N, Kusama H, Nakayama T, Tamaki Y, Yoshida KI, Kunimasa K, Imamura F, Yagi T
Histopathology 2026 Mar;88(4):790-809

Celastrol triggers CAV-1-mediated mitochondrion cholesterol metabolism and mitophagy to suppress liver cancer.

Li HF, Zhang CJ, Shi YN, Zhu N, Yang Q, Long JP, Liang YT, Qin L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157989

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy.

Li S, Liu M, Chen C, Li X, Yan X, Zhu W, Qiu W, Li Q, Sun X, Huang C, Yin M, Chen Z, Lu Y, Ge J, Kong X, Qian J, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e21997

YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates.

Zhang J, Hu J, Liu R, Zhou T, Luo X, Liang P, Xie Z, Zhao Q, Chen Y, Du D, Liu C, Zheng Y, Li D, Wang B
Nature cell biology 2025 Jul;27(7):1148-1160

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway.

Zhen Q, Xu Y, Xu Y, Liu X, Zhang Y, Ye D, Han S, Liu S, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e12599

PEX39 facilitates the peroxisomal import of PTS2-containing proteins.

Chen WW, Rodrigues TA, Wendscheck D, Pedrosa AG, Yang C, Francisco T, Möcklinghoff T, Zografakis A, Nunes-Silva B, Avraham RE, Silva AR, Ferreira MJ, Das H, Koster J, Neuwirth S, Bender J, Oeljeklaus S, Sondhi V, Gatsogiannis C, Schuldiner M, Zalckvar E, Hofmann K, Waterham HR, DeBerardinis RJ, Azevedo JE, Warscheid B
Nature cell biology 2025 Aug;27(8):1256-1271

A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.

Wu J, Jin X, Li W, Liu E
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280

Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.

Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655

Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells.

Chen M, Wen J, Qiu Y, Gao X, Zhang J, Lin Y, Wu Z, Lin X, Zhu A
Toxins 2024 Aug 24;16(9)

Immunomodulation in Endometriosis: Investigating the interrelationship between VISTA expression and Escherichia.Shigella-Associated metabolites.

Chen Y, Che X, Rong Y, Zhu J, Yu Y, Xu H, Sun Y, Chen H, Yan L, Chen L, Xu Y, Zhang J
International immunopharmacology 2024 Aug 20;137:112366

Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.

Fu Y, Li L, Zhang X, Deng Z, Wu Y, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH, Zhang L
Nature communications 2024 Apr 6;15(1):2974

SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis.

Dai T, Xue X, Huang J, Yang Z, Xu P, Wang M, Xu W, Feng Z, Zhu W, Xu Y, Chen J, Li S, Meng Q
Cell death discovery 2023 Jul 8;9(1):234

Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.

Landowski M, Bhute VJ, Grindel S, Haugstad Z, Gyening YK, Tytanic M, Brush RS, Moyer LJ, Nelson DW, Davis CR, Yen CE, Ikeda S, Agbaga MP, Ikeda A
Communications biology 2023 Jan 4;6(1):8

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells.

Ray GJ, Boydston EA, Shortt E, Wyant GA, Lourido S, Chen WW, Sabatini DM
iScience 2020 May 22;23(5):101109

Sterol carrier protein-2 deficiency attenuates diet-induced dyslipidemia and atherosclerosis in mice.

He H, Wang J, Yannie PJ, Kakiyama G, Korzun WJ, Ghosh S
The Journal of biological chemistry 2018 Jun 15;293(24):9223-9231

Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells.

Li NC, Fan J, Papadopoulos V
PloS one 2016;11(2):e0149728

Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation.

Wani S, Sugita A, Ohkuma Y, Hirose Y
Journal of biochemistry 2016 Aug;160(2):111-20

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SCP2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SCP2. This antibody recognizes human, mouse antigen. The SCP2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 23006-1-AP.pdf

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