abx117048

antibody from Abbexa

Targeting: SMPD2 ISC1, nSMase

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx117048

Provider

Abbexa

Product name

Sphingomyelin Phosphodiesterase 2 (SMPD2) Antibody

Antibody type

Polyclonal

Description

SMPD2 Antibody is a Rabbit Polyclonal antibody against SMPD2. Sphingomyelinases (SMases) catalyze the hydrolysis of sphingomyelin to produce ceramide and phosphocholineCeramide is an important bioactive lipid triggering signal transduction involved in cell prolifeRation, apoptosis and differentiationA number of SMases have been described and categorized based on their optimum pH activity, cation dependence, tissue distribution, and subcellular localizationThese include a lysosomal acid SMase, a Zn++-dependent secreted acid SMase, a membrane-bound Mg++-dependent neutral SMase, a Mg++-independent neutral SMase, and an alkaline SMasenSMase1 (also termed SMPD2) is a Mg++-dependent neutral SMase that is widely expressed and predominantly localized to the endoplasmic reticulumThis protein has also been shown to have lyso-platelet activating factor (PAF) phospholipase C activityA second neutral SMase, nSMase2 (also termed SMPD3) is predominantly expressed in the brainThe activity of neutral SMases is regulated by oxidative stress, chemotherapeutic drugs, inflammatory cytokines, and apoptotic stimuliAnalysis of single and double knockouts of the SMPD2 and SMPD3 has revealed that loss of both genes leads to complete loss of neutral SMase activity with developmental defects observed with loss of nSMase2.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µg

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.