16036-1-AP

antibody from Proteintech Group

Targeting: AREG AREGB, SDGF

Provider product page for 16036-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [21]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 16036-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16036-1-AP, RRID:AB_2227602
Product name: Amphiregulin antibody
Antibody type: Polyclonal
Description: KD/KO validated Amphiregulin antibody (Cat. #16036-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AREG protein structure - 16036-1-AP shown in red.

Submitted references Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS).

Zhou L, Tan J, Dai Y, Zhu K, Xiao Y, Wu D, Wang Z, Tan Y, Qin Y
Drug design, development and therapy 2023;17:3085-3101

Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.

Kambey PA, Liu WY, Wu J, Tang C, Buberwa W, Saro A, Nyalali AMK, Gao D
CNS neuroscience & therapeutics 2023 Oct;29(10):2925-2939

Dapagliflozin delays renal fibrosis in diabetic kidney disease by inhibiting YAP/TAZ activation.

Feng L, Chen Y, Li N, Yang X, Zhou L, Li H, Wang T, Xie M, Liu H
Life sciences 2023 Jun 1;322:121671

Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.

Wang Q, Wang F, Li X, Ma Z, Jiang D
Phytotherapy research : PTR 2023 Jan;37(1):111-123

TPM2 attenuates progression of prostate cancer by blocking PDLIM7-mediated nuclear translocation of YAP1.

Wu Z, Ge L, Ma L, Lu M, Song Y, Deng S, Duan P, Du T, Wu Y, Zhang Z, Zhang S
Cell & bioscience 2023 Feb 23;13(1):39

Schwann cell-derived amphiregulin enhances nerve regeneration via supporting the proliferation and migration of Schwann cells and the elongation of axons.

Chen S, Chen Q, Zhang X, Shen Y, Shi X, Dai X, Yi S
Journal of neurochemistry 2023 Aug;166(4):678-691

miR-33a-3p regulates METTL3-mediated AREG stability and alters EMT to inhibit pancreatic cancer invasion and metastasis.

Su X, Lai T, Tao Y, Zhang Y, Zhao C, Zhou J, Chen E, Zhu M, Zhang S, Wang B, Mao Y, Hu H
Scientific reports 2023 Aug 21;13(1):13587

Adaptive transcriptomic and immune infiltrate responses in the tumor immune microenvironment following neoadjuvant chemotherapy in high grade serous ovarian cancer reveal novel prognostic associations and activation of pro-tumorigenic pathways.

James NE, Woodman M, De La Cruz P, Eurich K, Ozsoy MA, Schorl C, Hanley LC, Ribeiro JR
Frontiers in immunology 2022;13:965331

Establishment of a patient-derived mucoepidermoid carcinoma cell line with the CRTC1-MAML2 fusion gene.

Noguchi K, Kanda S, Yoshida K, Funaoka Y, Yamanegi K, Yoshikawa K, Takaoka K, Kishimoto H, Nakano Y
Molecular and clinical oncology 2022 Mar;16(3):75

Luteinizing hormone stimulates the expression of amphiregulin in human theca cells.

Liu Y, Zhong Y, Shen X, Guo X, Wu R, Yang T, Chen M
Journal of ovarian research 2022 Dec 7;15(1):129

AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells.

Xiao Z, Hammes SR
iScience 2021 Nov 19;24(11):103270

Extracellular Matrix-Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer.

DiGiacomo JW, Godet I, Trautmann-Rodriguez M, Gilkes DM
Molecular cancer research : MCR 2021 Jan;19(1):136-149

IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway.

Cai H, Yan L, Liu N, Xu M, Cai H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109790

CBX2 Regulates Proliferation and Apoptosis via the Phosphorylation of YAP in Hepatocellular Carcinoma.

Mao J, Tian Y, Wang C, Jiang K, Li R, Yao Y, Zhang R, Sun D, Liang R, Gao Z, Wang Q, Wang L
Journal of Cancer 2019;10(12):2706-2719

CD317 Activates EGFR by Regulating Its Association with Lipid Rafts.

Zhang G, Li X, Chen Q, Li J, Ruan Q, Chen YH, Yang X, Wan X
Cancer research 2019 May 1;79(9):2220-2231

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.

Kubli SP, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, Jafari SM, Snow B, Jones L, Palomero L, Thu KL, Cassetta L, Soong D, Berger T, Ramachandran P, Baniasadi SP, Duncan G, Lindzen M, Yarden Y, Herranz C, Lazaro C, Chu MF, Haight J, Tinto P, Silvester J, Cescon DW, Petit A, Pettersson S, Pollard JW, Mak TW, Pujana MA, Cappello P, Gorrini C
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 26;116(9):3604-3613

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.

Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y
Aging cell 2019 Dec;18(6):e13027

Loss of KIBRA function activates EGFR signaling by inducing AREG.

Mussell AL, Denson KE, Shen H, Chen Y, Yang N, Frangou C, Zhang J
Oncotarget 2018 Jul 6;9(52):29975-29984

Membrane-Tethered Intracellular Domain of Amphiregulin Promotes Keratinocyte Proliferation.

Stoll SW, Stuart PE, Lambert S, Gandarillas A, Rittié L, Johnston A, Elder JT
The Journal of investigative dermatology 2016 Feb;136(2):444-452

The EGF receptor ligand amphiregulin controls cell division via FoxM1.

Stoll SW, Stuart PE, Swindell WR, Tsoi LC, Li B, Gandarillas A, Lambert S, Johnston A, Nair RP, Elder JT
Oncogene 2016 Apr 21;35(16):2075-86

TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin.

Yang N, Morrison CD, Liu P, Miecznikowski J, Bshara W, Han S, Zhu Q, Omilian AR, Li X, Zhang J
Cell cycle (Georgetown, Tex.) 2012 Aug 1;11(15):2922-30

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 16036-1-AP(AREG antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using AREG antibody 16036-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 16036-1-AP(AREG antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 16036-1-AP(AREG antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue