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- Antibody Data
- Antigen structure
- References [23]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 12595-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12595-1-AP, RRID:AB_2159186
- Product name
- PANX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PANX1 antibody (Cat. #12595-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport.
Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis.
Exploring the pathophysiology underlying clozapine-induced enhancement of glutamatergic transmission through L-glutamate and D-serine release associated with pannexin1 hemichannels.
Subcortical Circuits Among Pedunculopontine Nucleus, Thalamus and Basal Ganglia Play Important Roles in Paroxysmal Arousal in Genetic Rat Models of Autosomal Dominant Sleep-Related Hypermotor Epilepsy.
Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer.
Hypoxia induces robust ATP release from erythrocytes in ApoE-LDLR double-deficient mice.
PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis.
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats.
Construction of a Novel Damage-Associated Molecular-Pattern-Related Signature to Assess Lung Adenocarcinoma's Prognosis and Immune Landscape.
Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.
Dipyridamole activates adenosine A2B receptor and AMPK/cAMP signaling and promotes myogenic differentiation of myoblastic C2C12 cells.
Construction of a Novel Ferroptosis-Related Gene Signature for Predicting Survival of Patients With Lung Adenocarcinoma.
TGF-β2 increases cell-cell communication in chondrocytes via p-Smad3 signalling.
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.
H2O2 gel bleaching induces cytotoxicity and pain conduction in dental pulp stem cells via intracellular reactive oxygen species on enamel/dentin disc.
TRPA1 triggers hyperalgesia and inflammation after tooth bleaching.
Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
Defining the proteolytic landscape during enterovirus infection.
Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models.
Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis.
Involvement of interstitial cells of Cajal in bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
Tsuruda T, Kodama M, Nakayama KI
Cancer science 2026 May;117(5):1333-1345
Cancer science 2026 May;117(5):1333-1345
Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis.
Liu Z, Yang Y, Song L, Ruan X, Li X, He Y, Zou Y, Ding S, Sun Y
Journal of innate immunity 2025;17(1):539-565
Journal of innate immunity 2025;17(1):539-565
Exploring the pathophysiology underlying clozapine-induced enhancement of glutamatergic transmission through L-glutamate and D-serine release associated with pannexin1 hemichannels.
Okada M, Okubo R, Motomura E
British journal of pharmacology 2025 Oct;182(19):4710-4728
British journal of pharmacology 2025 Oct;182(19):4710-4728
Subcortical Circuits Among Pedunculopontine Nucleus, Thalamus and Basal Ganglia Play Important Roles in Paroxysmal Arousal in Genetic Rat Models of Autosomal Dominant Sleep-Related Hypermotor Epilepsy.
Okubo R, Motomura E, Okada M
International journal of molecular sciences 2025 Jun 9;26(12)
International journal of molecular sciences 2025 Jun 9;26(12)
Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer.
Zhang C, Zhang Z, Wu Y, Wu Y, Cheng J, Luo K, Li Z, Zhang M, Wang J, Zhang X, Li Y
eLife 2025 Jul 24;13
eLife 2025 Jul 24;13
Hypoxia induces robust ATP release from erythrocytes in ApoE-LDLR double-deficient mice.
Alcicek FC, Dybas J, Bulat K, Mohaissen T, Szczesny-Malysiak E, Franczyk-Zarow M, Marzec KM
Frontiers in physiology 2024;15:1497346
Frontiers in physiology 2024;15:1497346
PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis.
Hu CQ, Hou T, Xiang R, Li X, Li J, Wang TT, Liu WJ, Hou S, Wang D, Zhao QH, Yu XX, Xu M, Liu XK, Chi YJ, Yang JC
Military Medical Research 2024 Jun 27;11(1):41
Military Medical Research 2024 Jun 27;11(1):41
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
Xiong Y, Luo J, Hong ZY, Zhu WZ, Hu A, Song BL
Journal of lipid research 2024 Jul;65(7):100579
Journal of lipid research 2024 Jul;65(7):100579
Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats.
Fukuyama K, Motomura E, Okada M
International journal of molecular sciences 2024 Jan 28;25(3)
International journal of molecular sciences 2024 Jan 28;25(3)
Construction of a Novel Damage-Associated Molecular-Pattern-Related Signature to Assess Lung Adenocarcinoma's Prognosis and Immune Landscape.
Liu X, Yao S, Feng Y, Li P, Li Y, Xia S
Biomolecules 2024 Jan 15;14(1)
Biomolecules 2024 Jan 15;14(1)
Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.
Ding F, Zhu J, Hu Y
Acta cirurgica brasileira 2023;38:e380323
Acta cirurgica brasileira 2023;38:e380323
Dipyridamole activates adenosine A2B receptor and AMPK/cAMP signaling and promotes myogenic differentiation of myoblastic C2C12 cells.
Marco-Bonilla M, Herencia R, Fresnadillo M, Huete-Toral F, Carracedo G, Largo R, Herrero-Beaumont G, Mediero A
Frontiers in pharmacology 2023;14:1247664
Frontiers in pharmacology 2023;14:1247664
Construction of a Novel Ferroptosis-Related Gene Signature for Predicting Survival of Patients With Lung Adenocarcinoma.
Song X, Wu L, Wang G, Liu B, Zhu W
Frontiers in oncology 2022;12:810526
Frontiers in oncology 2022;12:810526
TGF-β2 increases cell-cell communication in chondrocytes via p-Smad3 signalling.
Duan M, Liu Y, Guo D, Kan S, Niu Z, Pu X, Bai M, Zhang D, Du W, Xie J
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119175
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119175
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Science signaling 2022 Feb 8;15(720):eabg6941
Science signaling 2022 Feb 8;15(720):eabg6941
H2O2 gel bleaching induces cytotoxicity and pain conduction in dental pulp stem cells via intracellular reactive oxygen species on enamel/dentin disc.
Chen C, Huang X, Zhu W, Ding C, Huang P, Li R
PloS one 2021;16(9):e0257221
PloS one 2021;16(9):e0257221
TRPA1 triggers hyperalgesia and inflammation after tooth bleaching.
Chen C, Huang X, Zhu W, Ding C, Huang P, Li R
Scientific reports 2021 Aug 31;11(1):17418
Scientific reports 2021 Aug 31;11(1):17418
Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
Wang Q, Li M, Gan Y, Jiang S, Qiao J, Zhang W, Fan Y, Shen Y, Song Y, Meng Z, Yao M, Gu J, Zhang Z, Tu H
Theranostics 2020;10(5):2141-2157
Theranostics 2020;10(5):2141-2157
Defining the proteolytic landscape during enterovirus infection.
Saeed M, Kapell S, Hertz NT, Wu X, Bell K, Ashbrook AW, Mark MT, Zebroski HA, Neal ML, Flodström-Tullberg M, MacDonald MR, Aitchison JD, Molina H, Rice CM
PLoS pathogens 2020 Sep;16(9):e1008927
PLoS pathogens 2020 Sep;16(9):e1008927
Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models.
Liu D, Dong Z, Xiang F, Liu H, Wang Y, Wang Q, Rao J
Neurochemical research 2020 Feb;45(2):437-454
Neurochemical research 2020 Feb;45(2):437-454
Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis.
Huang G, Bao J, Shao X, Zhou W, Wu B, Ni Z, Wang L
Life sciences 2020 Aug 1;254:117791
Life sciences 2020 Aug 1;254:117791
Involvement of interstitial cells of Cajal in bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
Jin Z, Ding Y, Xue R, Jia Z, Huang Z, Ding Y, Gu C, Yang J
International urology and nephrology 2017 Aug;49(8):1353-1359
International urology and nephrology 2017 Aug;49(8):1353-1359
Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H
PloS one 2015;10(6):e0127919
PloS one 2015;10(6):e0127919
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 12595-1-AP(PANX1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-PANX1 (IP:12595-1-AP, 3ug; Detection:12595-1-AP 1:400) with HeLa cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PANX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PANX1. This antibody recognizes human antigen. The PANX1 antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.
