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- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- HPA016930 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA016930, RRID:AB_1854954
- Product name
- Anti-PANX1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human PANX1, Gene description: pannexin 1, Alternative Gene Names: MRS1, PX1, UNQ2529, Validated applications: WB, IHC, ICC, Uniprot ID: Q96RD7, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.2 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice
Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma
A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands
Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength
Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis
The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells.
Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells
Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves
Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity
Freeman E, Langlois S, Leyba M, Ammar T, Léger Z, McMillan H, Renaud J, Jasmin B, Cowan K
Skeletal Muscle 2024;14(1)
Skeletal Muscle 2024;14(1)
Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
Jiménez-Madrona E, Morado-Díaz C, Talaverón R, Tabernero A, Pastor A, Sáez J, Matarredona E
Frontiers in Neuroscience 2023;17
Frontiers in Neuroscience 2023;17
Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma
Langlois S, St-Pierre M, Holland S, Xiang X, Freeman E, Mohamed H, Dural A, Hammad A, Karami S, van de Panne C, Cowan K
Journal of Cancer 2023;14(5):689-706
Journal of Cancer 2023;14(5):689-706
A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands
Mauduit O, Aure M, Delcroix V, Basova L, Srivastava A, Umazume T, Mays J, Bellusci S, Tucker A, Hajihosseini M, Hoffman M, Makarenkova H
Cell Reports 2022;39(2):110663
Cell Reports 2022;39(2):110663
Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength
Aguilar-Perez A, Pacheco-Costa R, Atkinson E, Deosthale P, Davis H, Essex A, Dilley J, Gomez L, Rupert J, Zimmers T, Thompson R, Allen M, Plotkin L
Scientific Reports 2019;9(1)
Scientific Reports 2019;9(1)
Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis
Boucher J, Simonneau C, Denet G, Clarhaut J, Balandre A, Mesnil M, Cronier L, Monvoisin A
International Journal of Molecular Sciences 2018;19(6):1558
International Journal of Molecular Sciences 2018;19(6):1558
The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells.
Tozzi M, Larsen AT, Lange SC, Giannuzzo A, Andersen MN, Novak I
Scientific reports 2018 Jun 12;8(1):8926
Scientific reports 2018 Jun 12;8(1):8926
Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells
Basova L, Tang X, Umazume T, Gromova A, Zyrianova T, Shmushkovich T, Wolfson A, Hawley D, Zoukhri D, Shestopalov V, Makarenkova H
Investigative Opthalmology & Visual Science 2017;58(13):5654
Investigative Opthalmology & Visual Science 2017;58(13):5654
Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves
Horton S, Luna Lopez C, Blevins E, Howarth H, Weisberg J, Shestopalov V, Makarenkova H, Shah S
Frontiers in Cellular Neuroscience 2017;11
Frontiers in Cellular Neuroscience 2017;11
Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity
Maes M, McGill M, da Silva T, Abels C, Lebofsky M, Weemhoff J, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter J, Penuela S, Jaeschke H, Cogliati B, Vinken M
Archives of Toxicology 2016;91(5):2245-2261
Archives of Toxicology 2016;91(5):2245-2261
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in U-138MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-PANX1 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
Enhanced validation
- Submitted by
- 55af80e3e0991
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Confocal images of immunofluorescently stained human U-2 OS cells.The protein PANX1 is shown in green. The image to the left show cells transfected with control siRNA and the image to the right show cells where PANX1 has been downregulated with specific siRNA.
- Sample type
- U-2 OS cells
- Primary Ab dilution
- 1:60
- Secondary Ab
- Secondary Ab
- Secondary Ab dilution
- 1:800
- Knockdown/Genetic Approaches Application
- Immunocytochemistry
