BPTF

gene product
FAC1, FALZ, NURF301
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
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91 antibodies from 24 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
4 antibodies
antibodies-online
36 antibodies
LifeSpan BioSciences, Inc.
8 antibodies
Biorbyt
9 antibodies
Invitrogen Antibodies
2 antibodies
Bethyl Laboratories
2 antibodies
NovoPro Bioscience Inc.
1 antibody
Abnova Corporation
2 antibodies
Atlas Antibodies
2 antibodies
Acris Antibodies GmbH
1 antibody
GeneTex
1 antibody
OriGene
1 antibody
Affinity Biosciences
1 antibody
Creative Biolabs
8 antibodies
Abgent
2 antibodies
United States Biological
2 antibodies
Abiocode, Inc.
1 antibody
Boster Biological Technology
1 antibody
St John's Laboratory
1 antibody
MyBioSource
2 antibodies
Creative Diagnostics
1 antibody
Sigma-Aldrich
1 antibody
EMD Millipore
1 antibody
GenWay
1 antibody