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- References [322]
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- Product number
- 20665-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20665-1-AP, RRID:AB_2687961
- Product name
- PSD95-Specific,DLG4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PSD95-Specific,DLG4 antibody (Cat. #20665-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Novel LncRNA Gm44763 Regulates Morphine-Induced Reward Memory via MiR-298-5p-Mediated eIF4E Translation Control.
Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress.
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Insulin-like growth factor 2 alleviates metabolic inflammation and associated cognitive impairment in diet-induced obesity mice.
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder.
Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.
Discovery of Novel Pyrano[3,2-a]carbazole Alkaloid Derivatives against Ischemic Stroke by Targeting ADGRL3.
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
Neuronal Differentiation of GBM-Initiating Cells Combined with Elimination of Undifferentiated Cells Preserves Motor Function.
Antisense oligonucleotide of cargo adaptor BICD2 long-term effectively alleviates neuropathic pain via activation of PSD95 in the mouse spinal dorsal horn.
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Modified Kai-Xin-San ameliorates cognitive impairment in Alzheimer's disease model mice by regulating neuroinflammation and synaptic dysfunction.
Celastrol ameliorates depressive-like behaviors in a rat model of post-stroke depression and is associated with reduced neuroinflammation and restoration of serotonergic- and synaptic-related proteins.
Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia.
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy.
Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
Environmental enrichment differentially regulates synaptic plasticity of hippocampal mature and newborn dentate granule cells and attenuates methamphetamine-induced behaviors.
Mechanistic insights into the effects of Norisoboldine on intestinal immunity and neuroinflammation in a mouse model of slow transit constipation with depression.
Fibrinogen drives neuroinflammation and neuropathology in perioperative neurocognitive disorders.
Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.
IL-17A-mediated copper accumulation participates in chronic neuropathic pain-induced cognitive impairment by enhancing microglial synaptic pruning.
Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation.
Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.
The role of TIPE2 in alleviating alcohol-related cognitive impairment via suppression of neuroinflammation.
Yueju pill exerts rapid antidepressant effects via sequential activation of hippocampal GLP-1 receptor and PACAP signaling in mice.
Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude.
Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice.
Multi-omics reveal the neuroprotective mechanisms of Xinshubao tablet against scopolamine-induced cognitive dysfunction in mice.
Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition.
The regulation and mechanism of the cAMP-PKA pathway on PTSD-like behaviors exacerbated by alcohol exposure.
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Sigma-1 receptor activation by PRE-084 attenuates sepsis-associated encephalopathy by targeting microglial p38 MAPK-mediated neuroinflammation and neuronal endoplasmic reticulum stress.
Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway.
Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota.
Inhibition of phosphodiesterase-4 by rolipram alleviates anxiety-like behavior in mice with PTSD by modulating neuroinflammation and synaptic plasticity via cAMP signaling.
3-hydroxykynurenine increase in kynurenine pathway driven bisphenol F induced anxiety- and depression-like behaviors.
Cognitive impairment induced by psychological stress is time-of-day of exposure dependent in female rats.
Microglia in the Rostral Ventromedial Medulla Mediate Synaptic Pruning via the C1q/C3-CR3 Signaling Pathway-A Mechanism for the Chronic Orofacial Pain.
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.
C/EBP β/AEP pathway mediates hippocampal mitochondrial damage in a mouse model of sepsis encephalopathy.
Blood flow restriction training attenuates stroke-induced hippocampal ferroptosis, synaptic damage, and cognitive impairment via upregulating SIRT1 pathway.
Geniposide attenuates obesity-related depression: involvement of decreased neuroinflammation and synaptic engulfment.
Electroacupuncture reduces microglial hyperactivity and synaptic phagocytosis in the medial prefrontal cortex to treat chronic pain comorbid with anxiety and depression.
Urolithin A improves Parkinson's disease-associated cognitive impairment through modulation of neuroinflammation and neuroplasticity.
Xanthouhumol relieves stress-induced depressive-like behaviors through the Sirt1/NF-κB/NLRP3 pathway.
Inhibition of spreading depolarizations by targeting GABA(A) receptors and voltage-gated sodium channels improves neurological deficits in rats with traumatic brain injury.
Nose-to-Brain Delivery of Chlorella vulgaris Extracellular Vesicles for Antidepressant Effects.
UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome.
Astragalin rescues Cadmium-induced cognitive decline by revering glial metabolic reprogramming and neuroinflammation via the mTOR/HIF-1α axis.
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
MiR-29a-3p ameliorate behavioral deficiency in hypoxia-ischemia brain damage in neonatal mice by inhibiting BTG2.
Astrocyte-derived CCL5-mediated CCR5(+) neutrophil infiltration drives depression pathogenesis.
Melatonin Alleviates Behavioral and Neurodevelopmental Abnormalities in Offspring Caused by Prenatal Stress.
FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model.
The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption.
Suppression of KDM5C mitigates the symptoms of Alzheimer's disease by up-regulating BDNF expression.
Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors.
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Human neural stem cell-derived small extracellular vesicles enhance functional recovery after ischemic stroke through the miR-362-3p/MCAM/Wnt/β-catenin axis.
FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment.
CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target.
Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1.
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
Flavonoids from Shiliangcha (Chimonanthus salicifolius) Alleviate Brain Aging in d-Galactose-Induced Senescent Mice through Gut Microbiota.
Effects of Angiotensin II Receptor 1 Inhibition by LCZ696 on the Acquisition and Relapse of Methamphetamine-Associated Contextual Memory.
The expression profile of type 1 equilibrative nucleoside transporter in aged C57BL/6J mouse brain.
Pro-Inflammatory Microglia Exacerbate High-Altitude-Induced Cognitive Impairment by Driving Lipid Droplet Accumulation in Astrocytes.
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Kai-Xin-San ameliorates fluoxetine-resistant depressive-like behaviors by modulating tryptophan-kynurenine metabolic homeostasis in a rodent model.
Electroacupuncture treatment enhances synaptic plasticity in middle cerebral artery occlusion mice via the miR-670-3p/HMGB1 axis.
Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway.
Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway.
Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice.
Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme.
Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.
Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis.
Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway.
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis.
Dihuang Yinzi improves scopolamine-induced learning and memory impairment by regulating plasma exosome-derived BDNF.
Exploring the effect and mechanism of action of Jinlida granules (JLD) in the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation.
Bioengineering an improved three-dimensional vascularized co-culture model for studying Neuron-Microglia interactions.
Estrogen Alleviates Sevoflurane-Induced Neurotoxicity by Inhibiting ERα-Tau Binding.
Scopolamine exerted antidepressant-like behavioral effects via restoring the synaptic plasticity in CRS-treated mice.
Yueju pill and its active component- Myricetin attenuate the reinstatement of methamphetamine-seeking behavior in mice.
Repetitive unidirectional spinal tactile stimulation engages microglial Bmal1 pathways to promote synaptic remodeling in the mPFC of adolescent VPA-exposed mice.
Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors.
Tenuifolin Attenuates Methamphetamine-Induced Reinstatement in Mice by Regulating Hippocampal Postsynaptic BDNF Signaling.
Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy.
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning.
PPARα deletion induces depressive-like behaviors by impairing neuronal synaptic plasticity and transmission.
ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice.
17β-Trenbolone modulates anxiety-related synaptic plasticity by affecting the interaction between hippocampal TACR3 and systemic testosterone in male mice.
Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission.
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke.
Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons.
Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance.
Effect of histone demethylase KDM5B on long-term cognitive impairment in neonatal rats induced by sevoflurane.
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy.
Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice.
(+)-catechin protects PC12 cells against CORT-induced oxidative stress and pyroptosis through the pathways of PI3K/AKT and Nrf2/HO-1/NF-κB.
CircSEC24B activates autophagy and induces chemoresistance of colorectal cancer via OTUB1-mediated deubiquitination of SRPX2.
Monitoring of activity-driven trafficking of endogenous synaptic proteins through proximity labeling.
Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model.
WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis.
Corilagin improves cognitive impairment in APP/PS1 mice by reducing Aβ generation and enhancing synaptic plasticity.
Dynamic changes in Beclin-1, LC3B, and p62 in aldose reductase-knockout mice at different time points after ischemic stroke.
3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.
Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
GABA(B) modulate NF-κB/NLRP3 pathways in electroacupuncture prevention of depression in CUMS rats.
S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress.
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Mitigates Neuroinflammation and Cognitive Impairment by Modulating Glial Activation in Sepsis-Associated Encephalopathy.
Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota.
The effect of paeoniflorin on the rewarding effect of methamphetamine and the associated cognitive impairment in mice.
Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats.
Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair.
The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury.
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids.
NUFIP1-engineered exosomes derived from hUMSCs regulate apoptosis and neurological injury induced by propofol in newborn rats.
Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity.
Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury.
Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder.
Bavachin ameliorates neuroinflammation and depressive-like behaviors in streptozotocin-induced diabetic mice through the inhibition of PKCδ.
Kaempferol improves Pb-induced cognitive impairments via inhibiting autophagy.
Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice.
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease.
SEP-363856 exerts neuroprotection through the PI3K/AKT/GSK-3β signaling pathway in a dual-hit neurodevelopmental model of schizophrenia-like mice.
Alcohol Consumption During Adolescence Alters the Cognitive Function in Adult Male Mice by Persistently Increasing Levels of DUSP6.
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice.
Molecular profiling of the hippocampus of children with autism spectrum disorder.
PM2.5 triggers tau aggregation in a mouse model of tauopathy.
Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP(+) PD model.
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy.
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway.
Pyrolae herba alleviates cognitive impairment via hippocampal TREM2 signaling modulating neuroinflammation and neurogenesis in lipopolysaccharide-treated mice.
Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice.
YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.
GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring.
Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.
PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex.
Early life stress enhances the susceptibility to depression and interferes with neuroplasticity in the hippocampus of adolescent mice via regulating miR-34c-5p/SYT1 axis.
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.
Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity.
Dysregulation of the Gut Microbiota Contributes to Sevoflurane-Induced Cognitive Dysfunction in Aged Mice by Activating the NLRP3 Inflammasome.
Taohe Chengqi decoction improves diabetic cognitive dysfunction by alleviating neural stem cell senescence through HIF1α-driven metabolic signaling.
Tong-Qiao-Huo-Xue Decoction promotes synaptic remodeling via cAMP/PKA/CREB pathway in vascular dementia rats.
Exacerbated mitochondrial dynamic abnormalities without evident tau pathology in rapidly progressive Alzheimer's disease.
Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.
Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice.
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.
Low-dose diazepam improves cognitive function in APP/PS1 mouse models: Involvement of AMPA receptors.
Zexieyin formula alleviates Alzheimer's disease via post-synaptic CaMKII modulating AMPA receptor: Involved in promoting neurogenesis to strengthen synaptic plasticity in mice hippocampus.
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring.
Acute elevated dietary fat alone is not sufficient to decrease AgRP projections in the paraventricular nucleus of the hypothalamus in mice.
Psoralen protects neurons and alleviates neuroinflammation by regulating microglial M1/M2 polarization via inhibition of the Fyn-PKCδ pathway.
The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol.
Huanglian Jiedu decoction alleviates neurobehavioral damage in mice with chronic alcohol exposure through the RAS-RAF-MEK-ERK pathway.
Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats.
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
Chlorpyrifos-induced dysregulation of synaptic plasticity in rat hippocampal neurons.
Effects of perfluorooctane sulfonate (PFOS) on cognitive behavior and autophagy of male mice.
Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats.
Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy.
Sialic Acid Enhanced the Antistress Capability under Challenging Situations by Increasing Synaptic Transmission.
Spinosin protects Neuro-2a/APP695 cells from oxidative stress damage by inactivating p38.
USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2.
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway.
Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation.
ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model.
Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice.
Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation.
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model.
Amyloid futures in the expanding pathology of brain aging and dementia.
Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Prevotella histicola Transplantation Ameliorates Cognitive Impairment and Decreases Oxidative Stress in Vascular Dementia Rats.
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Protective Effect of 20(S)-Protopanaxadiol on D-Gal-Induced Cognitively Impaired Mice Based on Its Target Protein Brain-type Creatine Kinase.
Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway.
Salidroside Alleviates Diabetic Cognitive Dysfunction Via B3galt2/F3/Contactin Signaling Pathway in Mice.
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling.
Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons.
Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S mice.
The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.
Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain.
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Benzene, 1,2,4-Trimethoxy-5-(2-Methyl-1-Propen-1-yl) Attenuates D-galactose/AlCl(3)-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and improving Expression of Memory-Related Proteins.
A terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity.
Evaluation of BDE-47-induced neurodevelopmental toxicity in zebrafish embryos.
NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice.
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter.
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
MicroRNA-124/Death-Associated Protein Kinase 1 Signaling Regulates Neuronal Apoptosis in Traumatic Brain Injury via Phosphorylating NR2B.
Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner.
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Hypoxia-pretreated mesenchymal stem cell-derived exosomes-loaded low-temperature extrusion 3D-printed implants for neural regeneration after traumatic brain injury in canines.
Transplantation of Astrocytic Mitochondria Modulates Neuronal Antioxidant Defense and Neuroplasticity and Promotes Functional Recovery after Intracerebral Hemorrhage.
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Evaluation of Neurotoxicity in BALB/c Mice following Chronic Exposure to Polystyrene Microplastics.
LRFN2 binding to NMDAR inhibits the progress of ESCC via regulating the Wnt/β-Catenin and NF-κB signaling pathway.
Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn.
Electroacupuncture remodels the extracellular matrix and promotes synaptic plasticity in a mouse model of depression.
Promoted CD4(+) T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice.
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin.
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway.
Arsenic exposure via drinking water during pregnancy and lactation induces autism-like behaviors in male offspring mice.
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model.
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice.
Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.
A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.
MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice.
Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats.
The circRNA circ-Nbea participates in regulating diabetic encephalopathy.
Polygonatum sibiricum ameliorated cognitive impairment of naturally aging rats through BDNF-TrkB signaling pathway.
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway.
Resveratrol attenuates methylmercury-induced neurotoxicity by modulating synaptic homeostasis.
Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress-Induced Depression.
Ketamine Induces Lasting Antidepressant Effects by Modulating the NMDAR/CaMKII-Mediated Synaptic Plasticity of the Hippocampal Dentate Gyrus in Depressive Stroke Model.
Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells.
Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder.
Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice.
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.
The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice.
Novel Botanical Therapeutic NB-02 Effectively Treats Alzheimer's Neuropathophysiology in an APP/PS1 Mouse Model.
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway.
Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies.
hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats.
Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling Pathway.
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.
Spinosin protects N2a cells from H(2) O(2) -induced neurotoxicity through inactivation of p38MAPK.
The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice.
The novel GLP-1/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD.
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase.
Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA(2) phosphorylation in experimental ischemic stroke.
Ferrostatin-1 mitigates cognitive impairment of epileptic rats by inhibiting P38 MAPK activation.
Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway.
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves.
Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5-choice serial reaction time task.
The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma.
Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.
Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA(2) phosphorylation.
Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: Role of GSK-3β/β-catenin pathway.
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
The memory improving effects of round scad (Decapterus maruadsi) hydrolysates on sleep deprivation-induced memory deficits in rats via antioxidant and neurotrophic pathways.
Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease.
The protective mechanism underlying phenylethanoid glycosides (PHG) actions on synaptic plasticity in rat Alzheimer's disease model induced by beta amyloid 1-42.
Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise.
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain.
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death.
Regulation of hippocampal long term depression by Neuroligin 1.
Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model.
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1-42)-Induced Rat Model of Alzheimer's Disease.
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease.
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c.
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
Gao F, Yang X, Yang Z, Yu D, Zhang B, Wang Y, Yao Z, Chen J, Liao Q, Li L, Hou B, Wang D, Zhang Y, Yan C
Research (Washington, D.C.) 2026;9:1032
Research (Washington, D.C.) 2026;9:1032
Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress.
Liu W, Wang Y, Zhao Y, Song B, Luo L, Zahir KM, Song M, Wang Y, Zhang L, Zuo Z, Yao L
Redox biology 2026 May;92:104137
Redox biology 2026 May;92:104137
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Yu H, Wang F, Yuan JQ, Chen J, Zhang KY, Jia D, Gong J, Mao Y, Bi S, Zhang YQ, Lan ZC, Yu HY, Chai GS
Experimental & molecular medicine 2026 Mar;58(3):813-831
Experimental & molecular medicine 2026 Mar;58(3):813-831
Insulin-like growth factor 2 alleviates metabolic inflammation and associated cognitive impairment in diet-induced obesity mice.
Liu X, Chen L, Chen Y, Huang Y, Xiao X, Zhong X
Diabetes, obesity & metabolism 2026 Mar;28(3):1800-1816
Diabetes, obesity & metabolism 2026 Mar;28(3):1800-1816
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder.
Gai W, Wu M, Wu A, Jing Z, Ye Z, Jin J, Zhang Y, Zhao M, Liu G, Wang X, Yang X, Dong J, Xu Y, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e05906
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e05906
Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.
Zhuang H, Cao X, Tang X, Liang Z, Wang H, Liu Q, Yan X, Lin X, Su X, Wang M, Huang Y, Lu D, Wang Y, Chen H, Shen L
Translational psychiatry 2026 Mar 30;16(1)
Translational psychiatry 2026 Mar 30;16(1)
Discovery of Novel Pyrano[3,2-a]carbazole Alkaloid Derivatives against Ischemic Stroke by Targeting ADGRL3.
Tao A, Lin Y, Feng J, Luo H, Qu K, Kang Y, Yu H, Chuangjun L, Ma J, Huang W, Sheng L, Zhang D, Zang Y, Peng Y
Journal of medicinal chemistry 2026 Mar 26;69(6):7012-7031
Journal of medicinal chemistry 2026 Mar 26;69(6):7012-7031
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control.
Gao L, Shen J, Gao J, Li T, Yan D, Zeng X, Meng J, Li H, Chen D, Wu J
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
Antioxidants (Basel, Switzerland) 2026 Mar 23;15(3)
Neuronal Differentiation of GBM-Initiating Cells Combined with Elimination of Undifferentiated Cells Preserves Motor Function.
Chen Z, Zou P, Kondo T
Cells 2026 Mar 18;15(6)
Cells 2026 Mar 18;15(6)
Antisense oligonucleotide of cargo adaptor BICD2 long-term effectively alleviates neuropathic pain via activation of PSD95 in the mouse spinal dorsal horn.
Wu ZX, Xu Y, Xie J, Ma G, Li YX, Yang T, Liang JH, Yang L, Wang QH, Hao LY, Zhang Y, Meng J, Pan ZQ, Wang HJ
Neuropharmacology 2026 Mar 1;285:110793
Neuropharmacology 2026 Mar 1;285:110793
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Wang J, Chen P, Li Y, Wang R, Ding W, Yu R, Qin Q, Wu R, Wei W, Shi J, Yuan H, Zhuang C, Sun Y
Free radical biology & medicine 2026 Jun;249:165-179
Free radical biology & medicine 2026 Jun;249:165-179
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Zhang W, Wu G, Wang L, Ren S
Neurochemistry international 2026 Jun;196:106150
Neurochemistry international 2026 Jun;196:106150
Modified Kai-Xin-San ameliorates cognitive impairment in Alzheimer's disease model mice by regulating neuroinflammation and synaptic dysfunction.
Liu XY, Wang K, Zhong JJ, Lin CL, Zhu JR, Wang PP, Guo R, Shao SS, Lim HSD, Siow KL, Shan Kek R, Ng YH, Chen M, Han RC, Yao H, Zheng GQ, Wen L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158102
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158102
Celastrol ameliorates depressive-like behaviors in a rat model of post-stroke depression and is associated with reduced neuroinflammation and restoration of serotonergic- and synaptic-related proteins.
Zheng Y, Zhang P, Xie Q, Cao F, Xu L
Brain research bulletin 2026 Jun 1;239:111855
Brain research bulletin 2026 Jun 1;239:111855
Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia.
Zhang S, Zang L, Li Y, Zhang Y, Chen X, Xin Y, He G, Zhou Z, Halalmeh I, Liang Y, Li W, Yang J, Geng J, Xiong X
Neurobiology of disease 2026 Jun 1;223:107386
Neurobiology of disease 2026 Jun 1;223:107386
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Yao SX, Luo SY, Zhao HQ, Tan H, Liu PA, Liu J
International immunopharmacology 2026 Jul 15;181:116693
International immunopharmacology 2026 Jul 15;181:116693
Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Guo S, Wei F, Sun H, Jin H, Cheng W, Fu C, Wang H, Yin Y
Glia 2026 Jan;74(1):e70087
Glia 2026 Jan;74(1):e70087
Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy.
Deng J, Zhang Y, Xie W, Li L, Li Q
The journal of spinal cord medicine 2026 Jan;49(1):95-106
The journal of spinal cord medicine 2026 Jan;49(1):95-106
Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.
Cheng H, Gao Y, Shang H, Han W, Zhang X, Gao R, Dang W, Ma Z, Liu X, Gao Y
Scientific reports 2026 Jan 5;16(1):1091
Scientific reports 2026 Jan 5;16(1):1091
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
Song Y, Lin W, Yuan H, Hu H, Wu S, Lu Y, Li D, Jing L, Tu S, Zhu W
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
Environmental enrichment differentially regulates synaptic plasticity of hippocampal mature and newborn dentate granule cells and attenuates methamphetamine-induced behaviors.
Li J, Xu J, Xu Y, Li S, Ma W, Yin F, Fan S, Zhang F, Cheng YF, Ma T, Zhou J, Zhou L
European journal of pharmacology 2026 Jan 20;1012:178496
European journal of pharmacology 2026 Jan 20;1012:178496
Mechanistic insights into the effects of Norisoboldine on intestinal immunity and neuroinflammation in a mouse model of slow transit constipation with depression.
Wu B, Wu J, Bai X, Zhou Q, Wang X
Journal of ethnopharmacology 2026 Jan 10;354:120479
Journal of ethnopharmacology 2026 Jan 10;354:120479
Fibrinogen drives neuroinflammation and neuropathology in perioperative neurocognitive disorders.
Wang X, Jiang S, Di L, Li S, Chen H, Huang P, Cao T, Jin W, Huang L
International immunopharmacology 2026 Jan 1;168(Pt 2):115906
International immunopharmacology 2026 Jan 1;168(Pt 2):115906
Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.
Xiao Q, Zhou S, Tang B, Zhu Y
CNS neuroscience & therapeutics 2026 Feb;32(2):e70770
CNS neuroscience & therapeutics 2026 Feb;32(2):e70770
IL-17A-mediated copper accumulation participates in chronic neuropathic pain-induced cognitive impairment by enhancing microglial synaptic pruning.
Liu J, Li Z, Peng X, Zhao W, Chu T, Ju J, Ren J, Gao F
Brain, behavior, and immunity 2026 Feb;132:106208
Brain, behavior, and immunity 2026 Feb;132:106208
Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation.
Chen X, Yuan C, Li Z, Zhao T, Yang Y, Wang Y, Qiao C, Liu Z, Li X
NPJ microgravity 2026 Feb 26;12(1)
NPJ microgravity 2026 Feb 26;12(1)
Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.
Liu Z, Shen Y, Luo AD, Ao WL, Guan SQ, Lei F, Xu ZC, Yu CY, Xu P, Huang H
Neurochemical research 2026 Feb 17;51(2):74
Neurochemical research 2026 Feb 17;51(2):74
The role of TIPE2 in alleviating alcohol-related cognitive impairment via suppression of neuroinflammation.
Ruan M, Ma S, Wang X, Zhang F, Zhang H
Neuropharmacology 2026 Aug 15;294:110968
Neuropharmacology 2026 Aug 15;294:110968
Yueju pill exerts rapid antidepressant effects via sequential activation of hippocampal GLP-1 receptor and PACAP signaling in mice.
Xing S, Peng Y, Wang Y, Wu C, Han M, Xie H, Chen G, Zhang H
Journal of ethnopharmacology 2026 Aug 10;367:121767
Journal of ethnopharmacology 2026 Aug 10;367:121767
Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude.
Zeng F, Li H, Ma Y, Ma S
Frontiers in neuroscience 2025;19:1600069
Frontiers in neuroscience 2025;19:1600069
Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice.
Maruko A, Ito N, Oshima K, Nishi A, Kobayashi Y, Okada N
Frontiers in pharmacology 2025;16:1600176
Frontiers in pharmacology 2025;16:1600176
Multi-omics reveal the neuroprotective mechanisms of Xinshubao tablet against scopolamine-induced cognitive dysfunction in mice.
Yang Z, Zhang FR, Ren L, Bai JM, Wang SC, Li XY, Yang HJ, Xiao HH
Frontiers in pharmacology 2025;16:1596728
Frontiers in pharmacology 2025;16:1596728
Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition.
Zhang Y, Zhang X, Shi X, Liao W, Lin J
Frontiers in pharmacology 2025;16:1594283
Frontiers in pharmacology 2025;16:1594283
The regulation and mechanism of the cAMP-PKA pathway on PTSD-like behaviors exacerbated by alcohol exposure.
Zhao S, Zhao W, Wang Z, Chen X, Zong F, Zhang H
Frontiers in pharmacology 2025;16:1592187
Frontiers in pharmacology 2025;16:1592187
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Xu P, Zhou W, Wang S, Wang L, Bai Y, Xing S, Xue W, Li M, Shi J, Wu H
Theranostics 2025;15(18):9415-9446
Theranostics 2025;15(18):9415-9446
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Wang M, Huang C, Ai S, Xia Y, Li C, Zhi Y, Wang K, Nie M, Gu X, Xu Y, Zhang H, Wang HL
Journal of hazardous materials 2025 Sep 5;495:138818
Journal of hazardous materials 2025 Sep 5;495:138818
Sigma-1 receptor activation by PRE-084 attenuates sepsis-associated encephalopathy by targeting microglial p38 MAPK-mediated neuroinflammation and neuronal endoplasmic reticulum stress.
Zeng X, Kang W, Zhou Q, Pan X, Wang L
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Sep 4;74(1):117
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Sep 4;74(1):117
Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway.
Tang YN, Bai YF, Dong A, Rao QL, Wu HH, Wang CG, Xu YT
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120423
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120423
Umbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota.
Jiang Y, Ni Z, Dai H, Luo X, Xing J, Wang R, Zhang X
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24155-24168
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24155-24168
Inhibition of phosphodiesterase-4 by rolipram alleviates anxiety-like behavior in mice with PTSD by modulating neuroinflammation and synaptic plasticity via cAMP signaling.
Lin Y, Ma S, Sun R, Ruan M, Zhang F, Zhang HT
International immunopharmacology 2025 Sep 23;162:115116
International immunopharmacology 2025 Sep 23;162:115116
3-hydroxykynurenine increase in kynurenine pathway driven bisphenol F induced anxiety- and depression-like behaviors.
Lin Y, Wang L, Meng S, Liu J, Li X, Wang W, Hu M, Wang X, Duan W, Xu S, Wang J, Gao R
The Science of the total environment 2025 Sep 15;995:180073
The Science of the total environment 2025 Sep 15;995:180073
Cognitive impairment induced by psychological stress is time-of-day of exposure dependent in female rats.
Wang X, Gao S, Chen L, Zhang L, Liu X, Yin C, Xiao X, Xiong X, Yang J
Brain research 2025 Sep 15;1863:149837
Brain research 2025 Sep 15;1863:149837
Microglia in the Rostral Ventromedial Medulla Mediate Synaptic Pruning via the C1q/C3-CR3 Signaling Pathway-A Mechanism for the Chronic Orofacial Pain.
Huang X, Zeng J, Hu Z, Wu Y, Zhang G, Zhang C, Yu C, Song M
Molecular neurobiology 2025 Oct;62(10):13338-13351
Molecular neurobiology 2025 Oct;62(10):13338-13351
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes.
Ding Z, Liu Q, Zhang J
Molecular neurobiology 2025 Oct;62(10):12523-12538
Molecular neurobiology 2025 Oct;62(10):12523-12538
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Yang J, Zhang H, Wang Y, Luo Y, Zheng W, Liu Y, Jiang Q, Deng J, Liu Q, Zhang P, Huang H, Yu C, Xu Z, Chen Y
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Yan S, Liu J, Zhang T, Li J, Zeng J, Li M, Aslam MS, Shen J, Tong T, You Z, Liu S, Li P, Li J, Gong K, Wei S, Hao C, Meng X
Molecular brain 2025 Oct 8;18(1):77
Molecular brain 2025 Oct 8;18(1):77
Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.
Godoy-Lugo JA, Hicks D, Durra S, Massey ER, Shkirkova K, Sauri AI, Kerstiens E, Chen S, Zhao L, Sioutas C, Mack WJ, Finch CE, Thorwald MA
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845
C/EBP β/AEP pathway mediates hippocampal mitochondrial damage in a mouse model of sepsis encephalopathy.
Shi Z, Peng Q, Sun S, Xiong M, Zhu X, Wang H, Liu S, Li Z, Wang L, Li G, Zhan L
International immunopharmacology 2025 Oct 10;163:115275
International immunopharmacology 2025 Oct 10;163:115275
Blood flow restriction training attenuates stroke-induced hippocampal ferroptosis, synaptic damage, and cognitive impairment via upregulating SIRT1 pathway.
Zhou F, Zhu X, Zhang X, Lin C, Ma Y, Lin Q, Li X
Neuroscience 2025 Oct 1;584:295-310
Neuroscience 2025 Oct 1;584:295-310
Geniposide attenuates obesity-related depression: involvement of decreased neuroinflammation and synaptic engulfment.
Yan Z, Chang L, Sun S, Sun Z
Neuroreport 2025 Oct 1;36(15):927-937
Neuroreport 2025 Oct 1;36(15):927-937
Electroacupuncture reduces microglial hyperactivity and synaptic phagocytosis in the medial prefrontal cortex to treat chronic pain comorbid with anxiety and depression.
Li W, Chang W, Cui K, Shen Z, Yin X, Xu S
Brain research bulletin 2025 Oct 1;230:111521
Brain research bulletin 2025 Oct 1;230:111521
Urolithin A improves Parkinson's disease-associated cognitive impairment through modulation of neuroinflammation and neuroplasticity.
Xu N, Du C, Yu Y, Li Y, Gao S, Yu S, Sun B, Lou H
Experimental neurology 2025 Nov;393:115395
Experimental neurology 2025 Nov;393:115395
Xanthouhumol relieves stress-induced depressive-like behaviors through the Sirt1/NF-κB/NLRP3 pathway.
Lin G, Zhang Y, Qin J, He Y, Fan L, Tan Q, Xie P
Psychopharmacology 2025 Nov;242(11):2579-2590
Psychopharmacology 2025 Nov;242(11):2579-2590
Inhibition of spreading depolarizations by targeting GABA(A) receptors and voltage-gated sodium channels improves neurological deficits in rats with traumatic brain injury.
Yan R, Liu Q, Zhang D, Li K, Li Y, Nie Y, Zhang Y, Li P, Mao S, Li H
British journal of pharmacology 2025 Nov;182(21):5247-5268
British journal of pharmacology 2025 Nov;182(21):5247-5268
Nose-to-Brain Delivery of Chlorella vulgaris Extracellular Vesicles for Antidepressant Effects.
Jin K, Wang R, Chen B, Zhong D, Cheng S, Tong A, Qi Y, Lu J, Zhou M
Journal of extracellular vesicles 2025 Nov;14(11):e70198
Journal of extracellular vesicles 2025 Nov;14(11):e70198
UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome.
Yang X, Huang YA, Marshall J
Molecular autism 2025 Nov 27;16(1):60
Molecular autism 2025 Nov 27;16(1):60
Astragalin rescues Cadmium-induced cognitive decline by revering glial metabolic reprogramming and neuroinflammation via the mTOR/HIF-1α axis.
Huang Q, Wang J, Cao MM, Ma HY, Qin XY, Hu Y, Lan R
Neuroscience 2025 Nov 19;588:31-39
Neuroscience 2025 Nov 19;588:31-39
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
Ni Z, Li Y, Wang G, Wang S, Chen H, Hou H, Hu Q
Molecular neurobiology 2025 Nov 14;63(1):38
Molecular neurobiology 2025 Nov 14;63(1):38
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
Sun Y, Wang J, Ding W, Qin Q, Wang R, Yu R, Yan J, Hou R, Liu G, Cai X, Qu Z, Zhang W, Yu J, Xing C, Zhuang C
Redox biology 2025 May;82:103620
Redox biology 2025 May;82:103620
MiR-29a-3p ameliorate behavioral deficiency in hypoxia-ischemia brain damage in neonatal mice by inhibiting BTG2.
Luo Q, Xing X, Song Y, Gu B, Hu Q, Liu W, Xiao Y, Wang Z
Behavioural brain research 2025 May 28;486:115552
Behavioural brain research 2025 May 28;486:115552
Astrocyte-derived CCL5-mediated CCR5(+) neutrophil infiltration drives depression pathogenesis.
Yao H, Jiang SY, Jiao YY, Zhou ZY, Zhu Z, Wang C, Zhang KZ, Ma TF, Hu G, Du RH, Lu M
Science advances 2025 May 23;11(21):eadt6632
Science advances 2025 May 23;11(21):eadt6632
Melatonin Alleviates Behavioral and Neurodevelopmental Abnormalities in Offspring Caused by Prenatal Stress.
Wu D, Du J, Zhao T, Li N, Qiao X, Peng F, Wang D, Shi J, Zhang S, Diao C, Wang L, Zhou W, Hao A
CNS neuroscience & therapeutics 2025 Mar;31(3):e70347
CNS neuroscience & therapeutics 2025 Mar;31(3):e70347
FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model.
Chen L, Cui W, Qin J, Zhu M, Zhang H, Yang J, Xu Z, Huang H
Journal of integrative neuroscience 2025 Mar 19;24(3):25710
Journal of integrative neuroscience 2025 Mar 19;24(3):25710
The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption.
Guo M, Zhang F, Liu S, Zhang Y, Wang L, Song J, Wei W, Li X
Cell insight 2025 Jun;4(3):100240
Cell insight 2025 Jun;4(3):100240
Suppression of KDM5C mitigates the symptoms of Alzheimer's disease by up-regulating BDNF expression.
Han J, Hong R, Cao C, Zhang L, Sun A, Li Y, Chi Y, Zhang L, Yang Y, Qu X
Neurochemistry international 2025 Jun;186:105975
Neurochemistry international 2025 Jun;186:105975
Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors.
Gao F, Zhang Z, Ju M, Bian L, Wang H, Zhao S, Cai N, Wang Y, Jia Y, Shen L, Zhang Y, Yao H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2414559
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2414559
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Zhao H, Zhang S, Gong Z, Chen T, Guo H, Yang M, Wang L, Zhou X, Xie J, Li H, Lu Y, Zhu Z
Journal of ethnopharmacology 2025 Jun 26;350:120036
Journal of ethnopharmacology 2025 Jun 26;350:120036
Human neural stem cell-derived small extracellular vesicles enhance functional recovery after ischemic stroke through the miR-362-3p/MCAM/Wnt/β-catenin axis.
Zhu Z, Zhang G, Ahmed W, Feng J, Wang C, Zhang Y, Wu G, Hong C, Zhang Q, Feng T, Liu J, Zhao A, Chen L
International immunopharmacology 2025 Jun 17;158:114826
International immunopharmacology 2025 Jun 17;158:114826
FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment.
Li M, Yang Y, Chen T, Luo Y, Zhang Y, Liu H, Maes M
Behavioral and brain functions : BBF 2025 Jun 15;21(1):18
Behavioral and brain functions : BBF 2025 Jun 15;21(1):18
CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target.
Zhang C, Zhu X, Gao R, Chen H, Yan C, Liu W, Yang L, Zeng X, Yang H, Liu J, Li Q, Ma D, Zhu T, Chen C
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102555
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102555
Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1.
Shi XX, Tian XF, He B, Liu SN, Shi CG, Shi Y, Yang YS
Brain research bulletin 2025 Jun 1;225:111346
Brain research bulletin 2025 Jun 1;225:111346
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
Jiang Z, Liu D, Li T, Gai C, Xin D, Zhao Y, Song Y, Cheng Y, Li T, Wang Z
Neural regeneration research 2025 Jun 1;20(6):1776-1788
Neural regeneration research 2025 Jun 1;20(6):1776-1788
Flavonoids from Shiliangcha (Chimonanthus salicifolius) Alleviate Brain Aging in d-Galactose-Induced Senescent Mice through Gut Microbiota.
Liu S, Wang M, Meng X, Pan J, Fang J, Cheng W, Zhang X, Cheng K
Journal of agricultural and food chemistry 2025 Jul 9;73(27):16890-16905
Journal of agricultural and food chemistry 2025 Jul 9;73(27):16890-16905
Effects of Angiotensin II Receptor 1 Inhibition by LCZ696 on the Acquisition and Relapse of Methamphetamine-Associated Contextual Memory.
Li X, Zou Z, Yang X, Lü J, Zhang X, Zhou J, Zhu D, Gong X, Lin S, Yu Z, Si Z, Wei W, Xie Y, Liu Y
Pharmaceuticals (Basel, Switzerland) 2025 Jul 8;18(7)
Pharmaceuticals (Basel, Switzerland) 2025 Jul 8;18(7)
The expression profile of type 1 equilibrative nucleoside transporter in aged C57BL/6J mouse brain.
Zhang XY, Ma Z, Jin YH, Long Z, Tang Q, He G, Jia YF
Acta biochimica et biophysica Sinica 2025 Jul 28;58(4):780-91
Acta biochimica et biophysica Sinica 2025 Jul 28;58(4):780-91
Pro-Inflammatory Microglia Exacerbate High-Altitude-Induced Cognitive Impairment by Driving Lipid Droplet Accumulation in Astrocytes.
Fan X, Cao S, Fang Y, Zhu L, Wang X
Antioxidants (Basel, Switzerland) 2025 Jul 26;14(8)
Antioxidants (Basel, Switzerland) 2025 Jul 26;14(8)
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Liu S, Yang Y, Zong Y, Chen W, Geng J, Zhao Y, Du R, He Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Kai-Xin-San ameliorates fluoxetine-resistant depressive-like behaviors by modulating tryptophan-kynurenine metabolic homeostasis in a rodent model.
Yao L, Jing R, Wang C, Wang Y, Li X, Wu X, Wang Y, Liu L, Mu L, Liu P, Hu Y
Journal of ethnopharmacology 2025 Jul 24;351:120011
Journal of ethnopharmacology 2025 Jul 24;351:120011
Electroacupuncture treatment enhances synaptic plasticity in middle cerebral artery occlusion mice via the miR-670-3p/HMGB1 axis.
Cheng J, Pan G, Wang Z, Chu H, Pu Y
Journal of the Chinese Medical Association : JCMA 2025 Jul 1;88(7):520-529
Journal of the Chinese Medical Association : JCMA 2025 Jul 1;88(7):520-529
Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway.
Xie H, Jiang Y, Zhang X, Min X, Zeng J, Chen L, Zeng N, Liu R
Neurobiology of stress 2025 Jan;34:100708
Neurobiology of stress 2025 Jan;34:100708
Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway.
Xu H, Wang Y, Geng D, Chen F, Chen Y, Niwenahisemo LC, Shi L, Du N, He Z, Xu X, Kuang L
Food science & nutrition 2025 Jan;13(1):e70003
Food science & nutrition 2025 Jan;13(1):e70003
Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice.
Zhang S, Wang X, Liu S, Hu C, Meng Y
Brain, behavior, and immunity 2025 Jan;123:193-210
Brain, behavior, and immunity 2025 Jan;123:193-210
Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme.
Zhang Y, Duan W, Chen L, Chen J, Xu W, Fan Q, Li S, Liu Y, Wang S, He Q, Li X, Huang Y, Peng H, Zhao J, Zhang Q, Qiu Z, Shao Z, Zhang B, Wang Y, Tian Y, Shu Y, Qin Z, Chi Y
Neuron 2025 Jan 22;113(2):225-243.e10
Neuron 2025 Jan 22;113(2):225-243.e10
Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.
Pan D, Hu G, Li J, Wang Z, Chen Y, Cao J
Investigative ophthalmology & visual science 2025 Jan 2;66(1):3
Investigative ophthalmology & visual science 2025 Jan 2;66(1):3
Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis.
Ma J, Liu Y, Hu J, Liu X, Xia Y, Xia W, Shen Z, Kong X, Wu X, Mao L, Li Q
Endocrine 2025 Feb;87(2):486-497
Endocrine 2025 Feb;87(2):486-497
Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway.
Wu Q, Zhou Y, Ou C, Gao Z, Wu X, Zhao Y, Wang Y, Wu Z, Yu H
Brain and behavior 2025 Feb;15(2):e70328
Brain and behavior 2025 Feb;15(2):e70328
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Wang J, Zhang J, Li J, Gao Q, Chen J, Jia C, Gu X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis.
Chen L, Luo S, Liu T, Shuai Z, Song Y, Yang Q, Wang Y, Huang H, Luo Y
Journal of neuroinflammation 2025 Feb 21;22(1):44
Journal of neuroinflammation 2025 Feb 21;22(1):44
Dihuang Yinzi improves scopolamine-induced learning and memory impairment by regulating plasma exosome-derived BDNF.
Su W, Du Y, Wang W, Li Q, Zhang J, He W
Journal of ethnopharmacology 2025 Feb 11;341:119322
Journal of ethnopharmacology 2025 Feb 11;341:119322
Exploring the effect and mechanism of action of Jinlida granules (JLD) in the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation.
Gu H, Zhang Y, Sun J, Liu L, Liu Z
Annals of medicine 2025 Dec;57(1):2445181
Annals of medicine 2025 Dec;57(1):2445181
Bioengineering an improved three-dimensional vascularized co-culture model for studying Neuron-Microglia interactions.
Han Y, Guo L, Wang M, Cao Z, Zheng X, Wang X, Jin L, Wei X, Wang X, Zhao J
Bioactive materials 2025 Dec;54:813-828
Bioactive materials 2025 Dec;54:813-828
Estrogen Alleviates Sevoflurane-Induced Neurotoxicity by Inhibiting ERα-Tau Binding.
Li F, Gong B, Song Z, Yang N, Liu Y, Zhang J, Li D, Yang Y, Yu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e08568
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e08568
Scopolamine exerted antidepressant-like behavioral effects via restoring the synaptic plasticity in CRS-treated mice.
Bi PW, Sun SR, Zhao JN, Zhang HY, Lv Z, Yin YY, Li YF
Metabolic brain disease 2025 Dec 9;40(8):332
Metabolic brain disease 2025 Dec 9;40(8):332
Yueju pill and its active component- Myricetin attenuate the reinstatement of methamphetamine-seeking behavior in mice.
Du Y, Fan S, Yang X, Ma W, Li S, Xu Y, Li C, Chen S, Wang Y, Wang M, Ma T, Zhang J
International immunopharmacology 2025 Dec 3;166:115601
International immunopharmacology 2025 Dec 3;166:115601
Repetitive unidirectional spinal tactile stimulation engages microglial Bmal1 pathways to promote synaptic remodeling in the mPFC of adolescent VPA-exposed mice.
Chen YN, Zhao ST, Hu MA, Li W, Yu J, Ma MJ, Tang LY, Feng X, Li JS, Zhang YX
Journal of neuroinflammation 2025 Dec 11;23(1):23
Journal of neuroinflammation 2025 Dec 11;23(1):23
Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors.
Matthews B, Steeves SA, Akefe IO, Ahmed NY, Gormal RS, Dehorter N, Wallis TP, Meunier FA
The EMBO journal 2025 Aug;44(15):4196-4221
The EMBO journal 2025 Aug;44(15):4196-4221
Tenuifolin Attenuates Methamphetamine-Induced Reinstatement in Mice by Regulating Hippocampal Postsynaptic BDNF Signaling.
Qi Y, Fan S, Sun Y, Shi H, Li H, Xiao G, Shen Q
CNS neuroscience & therapeutics 2025 Aug;31(8):e70588
CNS neuroscience & therapeutics 2025 Aug;31(8):e70588
Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy.
Xia C, Zuo G, Wang M, Wang Y, Guo Y, Han Y, Xiang H, Cheng Y, Xu J, He J, Zhang W
Molecular psychiatry 2025 Aug;30(8):3695-3707
Molecular psychiatry 2025 Aug;30(8):3695-3707
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning.
Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, Luo S, Zhang C, Peng G, Li J, Yu J, Ling Y, Fan Z, Mo W, Yang Y, Zhang J
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Aug;21(8):e70331
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Aug;21(8):e70331
PPARα deletion induces depressive-like behaviors by impairing neuronal synaptic plasticity and transmission.
Zhuo R, Cheng X, Yang L, Wang C, Yang L, Zhang Y, Zeng Y, Li Y
Neuroscience 2025 Aug 30;582:82-93
Neuroscience 2025 Aug 30;582:82-93
ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice.
Lenoel I, Ribon M, Lorenc F, Diebold A, Philibert CE, Robaldo D, Badsi M, Perronnet J, Lameth J, Berriat F, Misawa H, Coutelier M, Cassel R, Sarrazin N, Jost-Mousseau C, Bohl D, Millecamps S, Mallat M, Brenner D, Weishaupt JH, Boillée S, Lobsiger CS
Nature communications 2025 Aug 26;16(1):7951
Nature communications 2025 Aug 26;16(1):7951
17β-Trenbolone modulates anxiety-related synaptic plasticity by affecting the interaction between hippocampal TACR3 and systemic testosterone in male mice.
Zuo X, Bai H, Qiu J, Li R, Kuang X, Zhao Y, Tuo J, Zhao Q, Zhao X, Feng X
Environmental research 2025 Aug 15;279(Pt 1):121796
Environmental research 2025 Aug 15;279(Pt 1):121796
Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile.
Huang SY, Yang ZJ, Cheng J, Li HY, Chen S, Huang ZH, Chen JD, Xiong RG, Yang MT, Wang C, Li MC, Song S, Huang WG, Wang DL, Li HB, Lan QY
Redox biology 2025 Apr;81:103578
Redox biology 2025 Apr;81:103578
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
Li J, Wu X, Yan S, Shen J, Tong T, Aslam MS, Zeng J, Chen Y, Chen W, Li M, You Z, Gong K, Yang J, Zhu M, Meng X
Molecular neurobiology 2025 Apr;62(4):4221-4236
Molecular neurobiology 2025 Apr;62(4):4221-4236
Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission.
Fan H, Yuan M, Wang S, Yang X, Shu L, Pu Y, Zou Q, Zhang X, Wang C, Cai Z
Molecular and cellular biochemistry 2025 Apr;480(4):2345-2360
Molecular and cellular biochemistry 2025 Apr;480(4):2345-2360
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke.
Mei F, Deng D, Cao Z, Lou L, Chen K, Hu M, Zhu Z, Shen J, Zhang J, Liang J, Huang J, Bao M, Waisman A, Wang X
EMBO molecular medicine 2025 Apr;17(4):679-695
EMBO molecular medicine 2025 Apr;17(4):679-695
Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons.
Zhong Z, Liu J, Luo Y, Wu M, Qiu F, Zhao H, Liu Y, Wang Y, Long H, Zhao L, Wang Y, Han Y, Meng P
Drug design, development and therapy 2024;18:4565-4584
Drug design, development and therapy 2024;18:4565-4584
Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance.
Wu HM, Yang YV, Huang NJ, Fan LP, Dai YY, Hu KT, Tang TY, Liu L, Xu Y, Liu DT, Cai ZX, Niu XY, Ren XY, Yao ZH, Qin HY, Chen JZ, Huang X, Zhang C, You X, Wang C, He Y, Hong W, Sun YX, Zhan YH, Lin SY
Frontiers in neuroscience 2024;18:1368552
Frontiers in neuroscience 2024;18:1368552
Effect of histone demethylase KDM5B on long-term cognitive impairment in neonatal rats induced by sevoflurane.
Wang Y, Chen Y, Zhang M, Yuan C, Zhang Y, Liu X, Zhang Y, Liang X
Frontiers in molecular neuroscience 2024;17:1459358
Frontiers in molecular neuroscience 2024;17:1459358
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy.
Wang S, Chen B, Yuan M, Liu S, Fan H, Yang X, Zou Q, Pu Y, Cai Z
Frontiers in aging neuroscience 2024;16:1340117
Frontiers in aging neuroscience 2024;16:1340117
Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice.
Zou Y, Wang C, Li H, Zhong M, Lin J, Hu Y, Chen Z, Gan CL
Frontiers in pharmacology 2024;15:1500105
Frontiers in pharmacology 2024;15:1500105
(+)-catechin protects PC12 cells against CORT-induced oxidative stress and pyroptosis through the pathways of PI3K/AKT and Nrf2/HO-1/NF-κB.
Chencen L, Shuo Z, Zhiyu C, Xiaoyu F, Min Z, Pengjiao W, Xiuli G
Frontiers in pharmacology 2024;15:1450211
Frontiers in pharmacology 2024;15:1450211
CircSEC24B activates autophagy and induces chemoresistance of colorectal cancer via OTUB1-mediated deubiquitination of SRPX2.
Wang D, Li Y, Chang W, Feng M, Yang Y, Zhu X, Liu Z, Fu Y
Cell death & disease 2024 Sep 27;15(9):693
Cell death & disease 2024 Sep 27;15(9):693
Monitoring of activity-driven trafficking of endogenous synaptic proteins through proximity labeling.
Pascual-Caro C, de Juan-Sanz J
PLoS biology 2024 Oct;22(10):e3002860
PLoS biology 2024 Oct;22(10):e3002860
Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model.
Chen B, Jin K, Dong J, Cheng S, Kong L, Hu S, Chen Z, Lu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2405354
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2405354
WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis.
Tan L, Fan Y, Xu X, Zhang T, Cao X, Zhang C, Liang J, Hou Y, Dou H
Arthritis research & therapy 2024 Oct 23;26(1):183
Arthritis research & therapy 2024 Oct 23;26(1):183
Corilagin improves cognitive impairment in APP/PS1 mice by reducing Aβ generation and enhancing synaptic plasticity.
Chen L, Zhuang Z, Duan H, Lv D, Hong S, Chen P, He B, Shen Z
European journal of pharmacology 2024 Oct 15;981:176893
European journal of pharmacology 2024 Oct 15;981:176893
Dynamic changes in Beclin-1, LC3B, and p62 in aldose reductase-knockout mice at different time points after ischemic stroke.
Li J, Ning Z, Zhong X, Hu D, Wang Y, Cheng X, Deng M
Heliyon 2024 Oct 15;10(19):e38068
Heliyon 2024 Oct 15;10(19):e38068
3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.
Qi Y, Zhou Y, Li J, Zhu F, Guo G, Wang C, Yu M, Wang Y, Ma T, Feng S, Zhou L
Neural regeneration research 2024 Oct 1;19(10):2270-2280
Neural regeneration research 2024 Oct 1;19(10):2270-2280
Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease.
Ye Y, Fu C, Li Y, Sun J, Li X, Chai S, Li S, Hou M, Cai H, Wang Z, Wu M
Experimental neurology 2024 Nov;381:114920
Experimental neurology 2024 Nov;381:114920
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
GABA(B) modulate NF-κB/NLRP3 pathways in electroacupuncture prevention of depression in CUMS rats.
Li J, Yao D, Zhang T, Tong T, Shen J, Yan S, Zeng J, Aslam MS, Li M, You Z, Li J, Li Z, Li Y, Hao C, Meng X
Brain research bulletin 2024 Nov;218:111108
Brain research bulletin 2024 Nov;218:111108
S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress.
Zhang Y, Wei CK, Wang P, Zheng LC, Cheng Y, Ren ZH, Jin YH, Yao YY, Liu HZ
Scientific reports 2024 Nov 6;14(1):26929
Scientific reports 2024 Nov 6;14(1):26929
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Mitigates Neuroinflammation and Cognitive Impairment by Modulating Glial Activation in Sepsis-Associated Encephalopathy.
Liu S, Wang Y, Zhang Y, Wang X, Wang L
Neurochemical research 2024 Nov 29;50(1):39
Neurochemical research 2024 Nov 29;50(1):39
Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota.
Cai Y, Liu S, Ge X, Cheng L, Zhang X
Food & function 2024 Nov 25;15(23):11444-11457
Food & function 2024 Nov 25;15(23):11444-11457
The effect of paeoniflorin on the rewarding effect of methamphetamine and the associated cognitive impairment in mice.
Gong XS, Wang HX, Yang XD, Yu ZY, Lin SJ, Zou ZT, Lv JN, Qian LY, Ruan YE, Si ZZ, Zhou Y, Liu Y
Metabolic brain disease 2024 Nov 20;40(1):27
Metabolic brain disease 2024 Nov 20;40(1):27
Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats.
Liu M, Li L, Chen R, Wang Q, Zeng T, Hu J, Yan C, Xiao J, Xia X
Biogerontology 2024 Nov 15;26(1):11
Biogerontology 2024 Nov 15;26(1):11
Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair.
Wu Z, Zhou Y, Hou X, Liu W, Yin W, Wang L, Cao Y, Jiang Z, Guo Y, Chen Q, Xie W, Wang Z, Shi N, Liu Y, Gao X, Luo L, Dai J, Ren C, Jiang X
Bioactive materials 2024 May;35:242-258
Bioactive materials 2024 May;35:242-258
The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury.
Zhao Y, Li T, Jiang Z, Gai C, Yu S, Xin D, Li T, Liu D, Wang Z
Neural regeneration research 2024 May;19(5):1084-1094
Neural regeneration research 2024 May;19(5):1084-1094
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids.
Chen A, Yangzom T, Hong Y, Lundberg BC, Sullivan GJ, Tzoulis C, Bindoff LA, Liang KX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307136
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307136
NUFIP1-engineered exosomes derived from hUMSCs regulate apoptosis and neurological injury induced by propofol in newborn rats.
Sun W, Zhao P, Hu S, Zhao Z, Liu B, Yang X, Yang J, Fu Z, Li S, Yu W
Neurotoxicology 2024 May;102:81-95
Neurotoxicology 2024 May;102:81-95
Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity.
Zhao M, Ren Z, Zhao A, Tang Y, Kuang J, Li M, Chen T, Wang S, Wang J, Zhang H, Wang J, Zhang T, Zeng J, Liu X, Xie G, Liu P, Sun N, Bao T, Nie T, Lin J, Liu P, Zheng Y, Zheng X, Liu T, Jia W
Cell metabolism 2024 May 7;36(5):1000-1012.e6
Cell metabolism 2024 May 7;36(5):1000-1012.e6
Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury.
Ling T, Yin A, Cao Y, Li J, Li H, Zhou Y, Guo X, Li J, Zhang R, Wu H, Li P
Neuroscience 2024 May 3;545:31-46
Neuroscience 2024 May 3;545:31-46
Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder.
Song Z, Ho CT, Zhang X
Journal of agricultural and food chemistry 2024 May 29;72(21):12184-12197
Journal of agricultural and food chemistry 2024 May 29;72(21):12184-12197
Bavachin ameliorates neuroinflammation and depressive-like behaviors in streptozotocin-induced diabetic mice through the inhibition of PKCδ.
Zhang Z, Sun L, Guo Y, Zhao J, Li J, Pan X, Li Z
Free radical biology & medicine 2024 Mar;213:52-64
Free radical biology & medicine 2024 Mar;213:52-64
Kaempferol improves Pb-induced cognitive impairments via inhibiting autophagy.
Wang M, Xia Y, Ai S, Gu X, Wang HL
The Journal of nutritional biochemistry 2024 Mar;125:109556
The Journal of nutritional biochemistry 2024 Mar;125:109556
Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice.
Zhao J, Luo J, Deng C, Fan Y, Liu N, Cao J, Chen D, Diao Y
Journal of ethnopharmacology 2024 Mar 25;322:117621
Journal of ethnopharmacology 2024 Mar 25;322:117621
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Li XY, Yin X, Lu JJ, Li QR, Xing WQ, Han Q, Ji H, Li SZ, Yang HM, Guo JR, Wang ZQ, Xu B
Cells 2024 Mar 25;13(7)
Cells 2024 Mar 25;13(7)
The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease.
Liu K, Aierken A, Liu M, Parhat N, Kong W, Yin X, Liu G, Yu D, Hong J, Ni J, Quan Z, Liu X, Ji S, Mao J, Peng W, Chen C, Yan Y, Qing H
iScience 2024 Mar 15;27(3):109281
iScience 2024 Mar 15;27(3):109281
SEP-363856 exerts neuroprotection through the PI3K/AKT/GSK-3β signaling pathway in a dual-hit neurodevelopmental model of schizophrenia-like mice.
Li M, Liu Y, Sun M, Yang Y, Zhang L, Liu Y, Li F, Liu H
Drug development research 2024 Jun;85(4):e22225
Drug development research 2024 Jun;85(4):e22225
Alcohol Consumption During Adolescence Alters the Cognitive Function in Adult Male Mice by Persistently Increasing Levels of DUSP6.
Sun M, Zheng Q, Wang L, Wang R, Cui H, Zhang X, Xu C, Yin F, Yan H, Qiao X
Molecular neurobiology 2024 Jun;61(6):3161-3178
Molecular neurobiology 2024 Jun;61(6):3161-3178
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Cheng J, Yuan L, Yu S, Gu B, Luo Q, Wang X, Zhao Y, Gai C, Li T, Liu W, Wang Z, Liu D, Ho RCM, Ho CSH
Behavioural brain research 2024 Jun 25;468:115028
Behavioural brain research 2024 Jun 25;468:115028
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice.
Zhao W, Zhao S, Wei R, Wang Z, Zhang F, Zong F, Zhang HT
International immunopharmacology 2024 Jun 15;134:112185
International immunopharmacology 2024 Jun 15;134:112185
Molecular profiling of the hippocampus of children with autism spectrum disorder.
Rexrode LE, Hartley J, Showmaker KC, Challagundla L, Vandewege MW, Martin BE, Blair E, Bollavarapu R, Antonyraj RB, Hilton K, Gardiner A, Valeri J, Gisabella B, Garrett MR, Theoharides TC, Pantazopoulos H
Molecular psychiatry 2024 Jul;29(7):1968-1979
Molecular psychiatry 2024 Jul;29(7):1968-1979
PM2.5 triggers tau aggregation in a mouse model of tauopathy.
Liu C, Meng L, Gao Y, Chen J, Zhu M, Xiong M, Xiao T, Gu X, Liu C, Li T, Zhang Z
JCI insight 2024 Jul 22;9(14)
JCI insight 2024 Jul 22;9(14)
Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.
Zhang W, Zhong Y, Wang Z, Tang F, Zheng C
Scientific reports 2024 Jul 13;14(1):16215
Scientific reports 2024 Jul 13;14(1):16215
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.
Li P, Wang T, Guo H, Liu Y, Zhao H, Ren T, Tang Y, Wang Y, Zou M
Journal of affective disorders 2024 Jul 1;356:586-596
Journal of affective disorders 2024 Jul 1;356:586-596
CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP(+) PD model.
Ren Y, Wu X, Bai T, Yang N, Yuan Y, Xu L, Wen Y, Wen Y, Wang Z, Zhou L, Zou F, Li W
Ecotoxicology and environmental safety 2024 Jul 1;279:116446
Ecotoxicology and environmental safety 2024 Jul 1;279:116446
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy.
Yi W, Chen F, Yuan M, Wang C, Wang S, Wen J, Zou Q, Pu Y, Cai Z
Experimental neurology 2024 Jan;371:114591
Experimental neurology 2024 Jan;371:114591
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838
Brain research bulletin 2024 Jan;206:110838
β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway.
Ning Z, Zhong X, Wu Y, Wang Y, Hu D, Wang K, Deng M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155215
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155215
Pyrolae herba alleviates cognitive impairment via hippocampal TREM2 signaling modulating neuroinflammation and neurogenesis in lipopolysaccharide-treated mice.
Sun Y, Zhang H, Liu R, Huang R, Zhang X, Zhou S, Wu L, Zhu B, Wu H
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117214
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117214
Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice.
Wang X, Hu M, Chen J, Lou X, Zhang H, Li M, Cheng J, Ma T, Xiong J, Gao R, Chen X, Wang J
Molecular medicine (Cambridge, Mass.) 2024 Jan 3;30(1):4
Molecular medicine (Cambridge, Mass.) 2024 Jan 3;30(1):4
YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.
Lu L, Shi Y, Wei B, Li W, Yu X, Zhao Y, Yu D, Sun M
iScience 2024 Jan 19;27(1):108703
iScience 2024 Jan 19;27(1):108703
GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring.
Wei B, Shi H, Yu X, Shi Y, Zeng H, Zhao Y, Zhao Z, Song Y, Sun M, Wang B
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):20
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):20
Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.
Prakash N, Matos HY, Sebaoui S, Tsai L, Tran T, Aromolaran A, Atrachji I, Campbell N, Goodrich M, Hernandez-Pineda D, Herrero MJ, Hirata T, Lischinsky J, Martinez W, Torii S, Yamashita S, Hosseini H, Sokolowski K, Esumi S, Kawasawa YI, Hashimoto-Torii K, Jones KS, Corbin JG
The Journal of comparative neurology 2024 Feb;532(2):e25545
The Journal of comparative neurology 2024 Feb;532(2):e25545
PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex.
Cui W, Chen C, Gong L, Wen J, Yang S, Zheng M, Gao B, You J, Lin X, Hao Y, Chen Z, Wu Z, Gao L, Tang J, Yuan Z, Sun X, Jing L, Wen G
CNS neuroscience & therapeutics 2024 Feb;30(2):e14377
CNS neuroscience & therapeutics 2024 Feb;30(2):e14377
Early life stress enhances the susceptibility to depression and interferes with neuroplasticity in the hippocampus of adolescent mice via regulating miR-34c-5p/SYT1 axis.
Yu S, Zhao Y, Luo Q, Gu B, Wang X, Cheng J, Wang Z, Liu D, Ho RCM, Ho CSH
Journal of psychiatric research 2024 Feb;170:262-276
Journal of psychiatric research 2024 Feb;170:262-276
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Zhou Y, Zhao Q, Zhang Y, Di L, Xue F, Xu W, Gao W, Guo Y, He Y, Kou J, Qin Y, Xie X, Du L, Han G, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.
Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy T, Wood MA, Luptak A
eLife 2024 Feb 6;13
eLife 2024 Feb 6;13
Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.
Wang W, Li J, Cui S, Li J, Ye X, Wang Z, Zhang T, Jiang X, Kong Y, Chen X, Chen YQ, Zhu S
Science advances 2024 Feb 2;10(5):eadj7813
Science advances 2024 Feb 2;10(5):eadj7813
Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity.
Yang K, Wei R, Liu Q, Tao Y, Wu Z, Yang L, Wang QH, Wang H, Pan Z
Neuropharmacology 2024 Feb 15;244:109799
Neuropharmacology 2024 Feb 15;244:109799
Dysregulation of the Gut Microbiota Contributes to Sevoflurane-Induced Cognitive Dysfunction in Aged Mice by Activating the NLRP3 Inflammasome.
Han S, Bian R, Chen Y, Liang J, Zhao P, Gu Y, Zhang D
Molecular neurobiology 2024 Dec;61(12):10500-10516
Molecular neurobiology 2024 Dec;61(12):10500-10516
Taohe Chengqi decoction improves diabetic cognitive dysfunction by alleviating neural stem cell senescence through HIF1α-driven metabolic signaling.
Qin T, He Z, Hassan HM, Wang Q, Shi L, Yu Y, Zhou Y, Zhang W, Yuan Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156219
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156219
Tong-Qiao-Huo-Xue Decoction promotes synaptic remodeling via cAMP/PKA/CREB pathway in vascular dementia rats.
Li J, Ye H, Xu F, Yang Y, Ge C, Yao M, Huang P, Wang L, Wang N, Zhou X, Chang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156166
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156166
Exacerbated mitochondrial dynamic abnormalities without evident tau pathology in rapidly progressive Alzheimer's disease.
Xiyang Y, Gao J, Ding M, Ren X, Appleby BS, Leverenz JB, Miyagi M, Pillai JA, Perry G, Wang X
Journal of Alzheimer's disease : JAD 2024 Dec;102(4):1074-1083
Journal of Alzheimer's disease : JAD 2024 Dec;102(4):1074-1083
Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.
Mo J, Liao W, Du J, Huang X, Li Y, Su A, Zhong L, Gong M, Wang P, Liu Z, Kuang H, Wang L
Journal of ethnopharmacology 2024 Dec 5;335:118636
Journal of ethnopharmacology 2024 Dec 5;335:118636
Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice.
Ning Z, Zhong X, Wang Y, Hu D, Tang X, Deng M
International immunopharmacology 2024 Dec 25;143(Pt 3):113581
International immunopharmacology 2024 Dec 25;143(Pt 3):113581
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.
Ramani A, Pasquini G, Gerkau NJ, Jadhav V, Vinchure OS, Altinisik N, Windoffer H, Muller S, Rothenaigner I, Lin S, Mariappan A, Rathinam D, Mirsaidi A, Goureau O, Ricci-Vitiani L, D'Alessandris QG, Wollnik B, Muotri A, Freifeld L, Jurisch-Yaksi N, Pallini R, Rose CR, Busskamp V, Gabriel E, Hadian K, Gopalakrishnan J
Nature communications 2024 Dec 19;15(1):10703
Nature communications 2024 Dec 19;15(1):10703
Low-dose diazepam improves cognitive function in APP/PS1 mouse models: Involvement of AMPA receptors.
Chen J, Zhang M, Shen Z, Tang M, Zeng Y, Bai D, Zhao P, Jiang G
Brain research 2024 Dec 15;1845:149207
Brain research 2024 Dec 15;1845:149207
Zexieyin formula alleviates Alzheimer's disease via post-synaptic CaMKII modulating AMPA receptor: Involved in promoting neurogenesis to strengthen synaptic plasticity in mice hippocampus.
Sun Y, Zhang H, Liu R, Wang Y, Zhang X, Huang R, Zhu B, Wu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155802
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155802
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring.
Tian L, Zhang Y, Chen J, Liu X, Nie H, Li K, Liu H, Lai W, Shi Y, Xi Z, Lin B
Journal of hazardous materials 2024 Aug 5;474:134800
Journal of hazardous materials 2024 Aug 5;474:134800
Acute elevated dietary fat alone is not sufficient to decrease AgRP projections in the paraventricular nucleus of the hypothalamus in mice.
Yagoub S, Chesters RA, Ott J, Zhu J, Cantacorps L, Ritter K, Lippert RN
Scientific reports 2024 Aug 29;14(1):20043
Scientific reports 2024 Aug 29;14(1):20043
Psoralen protects neurons and alleviates neuroinflammation by regulating microglial M1/M2 polarization via inhibition of the Fyn-PKCδ pathway.
Guo Y, Xu S, Pan X, Xin W, Cao W, Ma W, Li L, Shen Q, Li Z
International immunopharmacology 2024 Aug 20;137:112493
International immunopharmacology 2024 Aug 20;137:112493
The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol.
Tang H, Hou H, Song L, Tian Z, Liu W, Xia T, Wang A
Journal of hazardous materials 2024 Apr 5;467:133634
Journal of hazardous materials 2024 Apr 5;467:133634
Huanglian Jiedu decoction alleviates neurobehavioral damage in mice with chronic alcohol exposure through the RAS-RAF-MEK-ERK pathway.
Chen Y, Jiang L, Li M, Shen Y, Liu S, Yang D
Heliyon 2024 Apr 30;10(8):e29556
Heliyon 2024 Apr 30;10(8):e29556
Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats.
Fan B, Lin J, Luo Q, Liao W, Hao C
Neurotoxicity research 2024 Apr 2;42(2):22
Neurotoxicity research 2024 Apr 2;42(2):22
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
Hu Y, Hu C, Yin J, Zhong J, Deng Y, Yang G
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
Chlorpyrifos-induced dysregulation of synaptic plasticity in rat hippocampal neurons.
Zhou W, Zhang C, Wang P, Deng Y, Dai H, Tian J, Wu G, Zhao L
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 2023;58(2):100-109
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 2023;58(2):100-109
Effects of perfluorooctane sulfonate (PFOS) on cognitive behavior and autophagy of male mice.
Zhou A, Wang L, Pi X, Fan C, Chen W, Wang Z, Rong S, Wang T
The Journal of toxicological sciences 2023;48(9):513-526
The Journal of toxicological sciences 2023;48(9):513-526
Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats.
Yang L, Zhang Y, Yu X, Li D, Liu N, Xue X, Fu J
Journal of immunology research 2023;2023:5149306
Journal of immunology research 2023;2023:5149306
Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy.
Wen J, Wang Y, Wang C, Yuan M, Chen F, Zou Q, Cai Z, Zhao B
Oxidative medicine and cellular longevity 2023;2023:4822767
Oxidative medicine and cellular longevity 2023;2023:4822767
Sialic Acid Enhanced the Antistress Capability under Challenging Situations by Increasing Synaptic Transmission.
Huang C, Wang R, Wang Y, Liu H, Chen XT, Gu X, Wang HL
The Journal of nutrition 2023 Sep;153(9):2561-2570
The Journal of nutrition 2023 Sep;153(9):2561-2570
Spinosin protects Neuro-2a/APP695 cells from oxidative stress damage by inactivating p38.
Xiaoying Z, Ruixuan W, Yiqing W, Fanxing XU, Tingxu Y, Bo WU, Ming Z, Ying J
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(5):868-875
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(5):868-875
USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2.
Li Z, Liu B, Lambertsen KL, Clausen BH, Zhu Z, Du X, Xu Y, Poulsen FR, Halle B, Bonde C, Chen M, Wang X, Schlüter D, Huang J, Waisman A, Song W, Wang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(28):e2301641
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(28):e2301641
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes.
Li SJ, Ma MH, Li JM, Lu XY, Lu CB, Zhou SF, Zhang LX, Li MQ, Shao TZ, Bai SP, Yan XX, Li F, Li CQ
Aging and disease 2023 Oct 1;14(5):1853-1869
Aging and disease 2023 Oct 1;14(5):1853-1869
The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway.
Zhao N, Zhu X, Xie L, Guan X, Tang L, Jiang G, Pang T
Cellular and molecular neurobiology 2023 Nov;43(8):4261-4277
Cellular and molecular neurobiology 2023 Nov;43(8):4261-4277
Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation.
Ma L, Wu Q, Yuan J, Wang Y, Zhang P, Liu Q, Tan D, Liang M, Chen Y
CNS neuroscience & therapeutics 2023 Nov;29(11):3644-3656
CNS neuroscience & therapeutics 2023 Nov;29(11):3644-3656
ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.
Zhang Y, Zhang J, Zhao Y, Zhang Y, Liu L, Xu X, Wang X, Fu J
Cell death & disease 2023 Nov 6;14(11):721
Cell death & disease 2023 Nov 6;14(11):721
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.
Meng L, Liu C, Li Y, Chen G, Xiong M, Yu T, Pan L, Zhang X, Zhou L, Guo T, Yuan X, Liu C, Zhang Z, Zhang Z
Science advances 2023 Nov 3;9(44):eadj1092
Science advances 2023 Nov 3;9(44):eadj1092
The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.
Meng L, Liu C, Liu M, Chen J, Liu C, Zhang Z, Chen G, Zhang Z
Cell reports 2023 Nov 28;42(11):113342
Cell reports 2023 Nov 28;42(11):113342
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Li W, Shen Z, Yin X, Chang W, Chen X, Yu J, Xu S
Translational psychiatry 2023 Nov 22;13(1):359
Translational psychiatry 2023 Nov 22;13(1):359
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Meng Q, Chao Y, Zhang S, Ding X, Feng H, Zhang C, Liu B, Zhu W, Li Y, Zhang Q, Tong H, Wu L, Bian H
Molecular brain 2023 Nov 20;16(1):80
Molecular brain 2023 Nov 20;16(1):80
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Sun X, Huang LY, Pan HX, Li LJ, Wang L, Pei GQ, Wang Y, Zhang Q, Cheng HX, He CQ, Wei Q
Neural regeneration research 2023 May;18(5):1067-1075
Neural regeneration research 2023 May;18(5):1067-1075
Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model.
Xie XM, Hao JJ, Shi JZ, Zhou YF, Liu PF, Wang F, Zheng XM, Yu XY, Wang CC, Yan Y, Du GH, Song JK, He YY, Pang XB
International immunopharmacology 2023 May;118:109994
International immunopharmacology 2023 May;118:109994
Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice.
Dai J, Xie R, Sun ZN, Kou XL, Zhang JQ, Qi C, Liu R, Gao X, Wang J, Gao J
Cerebral cortex (New York, N.Y. : 1991) 2023 May 24;33(11):6594-6607
Cerebral cortex (New York, N.Y. : 1991) 2023 May 24;33(11):6594-6607
Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation.
Liang J, Han S, Ye C, Zhu H, Wu J, Nie Y, Chai G, Zhao P, Zhang D
Brain sciences 2023 Mar 19;13(3)
Brain sciences 2023 Mar 19;13(3)
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Yao H, Wang C, Xia Z
Journal of affective disorders 2023 Mar 1;324:143-152
Journal of affective disorders 2023 Mar 1;324:143-152
Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model.
Wang J, Men Y, Wang Z
ACS chemical neuroscience 2023 Mar 1;14(5):977-987
ACS chemical neuroscience 2023 Mar 1;14(5):977-987
Amyloid futures in the expanding pathology of brain aging and dementia.
Thorwald MA, Silva J, Head E, Finch CE
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Jun;19(6):2605-2617
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Jun;19(6):2605-2617
Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.
Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy TW, Wood MA, Lupták A
bioRxiv : the preprint server for biology 2023 Jun 9;
bioRxiv : the preprint server for biology 2023 Jun 9;
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Meng P, Zhang X, Liu TT, Liu J, Luo Y, Xie MX, Yang H, Fang R, Guo DW, Zhong ZY, Wang YH, Ge JW
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.
Meng L, Li Y, Liu C, Zhang G, Chen J, Xiong M, Pan L, Zhang X, Chen G, Xiong J, Liu C, Xu X, Bu L, Zhang Z, Zhang Z
Progress in neurobiology 2023 Jul;226:102462
Progress in neurobiology 2023 Jul;226:102462
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Liu P, Zhou Y, Shi J, Wang F, Yang X, Zheng X, Wang Y, He Y, Xie X, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Prevotella histicola Transplantation Ameliorates Cognitive Impairment and Decreases Oxidative Stress in Vascular Dementia Rats.
Duan R, Hou J, Wang X, Huang Z, Cao H, Hu J, Peng Q, Duan H, Wang Q, Chen X
Brain sciences 2023 Jul 29;13(8)
Brain sciences 2023 Jul 29;13(8)
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Chang Y, Wang C, Zhu J, Zheng S, Sun S, Wu Y, Jiang X, Li L, Ma R, Li G
Journal of translational medicine 2023 Jul 22;21(1):494
Journal of translational medicine 2023 Jul 22;21(1):494
Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.
Yang ZH, Cai X, Ding ZL, Li W, Zhang CY, Huo JH, Zhang Y, Wang L, Zhang LM, Li SW, Li M, Zhang C, Chang H, Xiao X
BMC medicine 2023 Jul 13;21(1):254
BMC medicine 2023 Jul 13;21(1):254
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Zhang H, Xie X, Shi J, Zhao Q, Luo D, Hao J, Zhou Y, Han G, Pang X
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Protective Effect of 20(S)-Protopanaxadiol on D-Gal-Induced Cognitively Impaired Mice Based on Its Target Protein Brain-type Creatine Kinase.
Zhang H, Chen F, Xu S, Zhang W, Li R, Yao Q, Zhao Y, Zhu Z, Chen L
Journal of agricultural and food chemistry 2023 Feb 8;
Journal of agricultural and food chemistry 2023 Feb 8;
Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway.
Tan X, Wang J, Yao J, Yuan J, Dai Y, Sun M, Zhang T, Yang J, Cai W, Qiu L, Sun J
Neuroscience letters 2023 Feb 6;796:137049
Neuroscience letters 2023 Feb 6;796:137049
Salidroside Alleviates Diabetic Cognitive Dysfunction Via B3galt2/F3/Contactin Signaling Pathway in Mice.
Lv P, Zuo Z, Liu W, Zhao L, Wang Y, Wang X, Yu S, Yu H, Zhang T, Bi J, Liu X
Neuroscience 2023 Feb 21;512:47-58
Neuroscience 2023 Feb 21;512:47-58
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling.
Zhang Y, Zhou Q, Lu L, Su Y, Shi W, Zhang H, Liu R, Pu Y, Yin L
Nutrients 2023 Feb 15;15(4)
Nutrients 2023 Feb 15;15(4)
Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons.
Ma Z, Liu K, Zhang RF, Xie ZX, Liu W, Deng Y, Li X, Xu B
The Science of the total environment 2023 Feb 1;858(Pt 1):159753
The Science of the total environment 2023 Feb 1;858(Pt 1):159753
Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.
Li Y, Li J, Yang L, Ren F, Dong K, Zhao Z, Duan W, Wei W, Guo R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155083
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155083
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
Sun Y, Xu L, Zheng D, Wang J, Liu G, Mo Z, Liu C, Zhang W, Yu J, Xing C, He L, Zhuang C
Redox biology 2023 Aug;64:102793
Redox biology 2023 Aug;64:102793
Complement C3a receptor antagonist alleviates tau pathology and ameliorates cognitive deficits in P301S mice.
Yao Y, Chang Y, Li S, Zhu J, Wu Y, Jiang X, Li L, Liu R, Ma R, Li G
Brain research bulletin 2023 Aug;200:110685
Brain research bulletin 2023 Aug;200:110685
The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.
Tong T, Chen Y, Hao C, Shen J, Chen W, Cheng W, Yan S, Li J, Li Y, Gulizhaerkezi T, Zeng J, Meng X
Behavioural brain research 2023 Aug 5;451:114509
Behavioural brain research 2023 Aug 5;451:114509
Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain.
Li Y, Khan N, Ritzel RM, Lei Z, Allen S, Faden AI, Wu J
Journal of neuroinflammation 2023 Aug 31;20(1):197
Journal of neuroinflammation 2023 Aug 31;20(1):197
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Zhou Y, Luo D, Shi J, Yang X, Xu W, Gao W, Guo Y, Zhao Q, Xie X, He Y, Du G, Pang X
Journal of ethnopharmacology 2023 Aug 10;312:116455
Journal of ethnopharmacology 2023 Aug 10;312:116455
Benzene, 1,2,4-Trimethoxy-5-(2-Methyl-1-Propen-1-yl) Attenuates D-galactose/AlCl(3)-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and improving Expression of Memory-Related Proteins.
Yang P, Liao C, Hu Q, Zhang J, Yang H, Xian S, Mao S
Neuroscience 2023 Aug 1;524:242-255
Neuroscience 2023 Aug 1;524:242-255
A terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity.
Gao S, Zhang L, Wang X, Li R, Han L, Xiong X, Jiang Q, Cheng D, Xiao X, Li H, Yang J
Brain research 2023 Aug 1;1812:148419
Brain research 2023 Aug 1;1812:148419
Evaluation of BDE-47-induced neurodevelopmental toxicity in zebrafish embryos.
Zhuang J, Pan ZJ, Qin Y, Liang H, Zhang WF, Sun ZY, Shi HB
Environmental science and pollution research international 2023 Apr;30(18):54022-54034
Environmental science and pollution research international 2023 Apr;30(18):54022-54034
NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice.
Zhang R, Mao W, Niu L, Bao W, Wang Y, Wang Y, Zhu Y, Yang Z, Chen J, Dong J, Cai M, Yuan Z, Song H, Li G, Zhang M, Xiong N, Wei J, Dong Z
eLife 2023 Apr 27;12
eLife 2023 Apr 27;12
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter.
Li B, Chang X, Liang X, Liu T, Shen Y, Zhang Q, Yang X, Lyu Y, Liu L, Guo J, Wu M, Gao Y, Yan X, Wang T, Zhang W, Qiu Y, Zheng J
The Science of the total environment 2023 Apr 1;867:161416
The Science of the total environment 2023 Apr 1;867:161416
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
Luo K, Wang Y, Chen WS, Feng X, Liao Y, Chen S, Liu Y, Liao C, Chen M, Ao L
Neural plasticity 2022;2022:5241449
Neural plasticity 2022;2022:5241449
MicroRNA-124/Death-Associated Protein Kinase 1 Signaling Regulates Neuronal Apoptosis in Traumatic Brain Injury via Phosphorylating NR2B.
Shi Y, Cui W, Wang Q, Zhou J, Wu X, Wang J, Zhang S, Hu Q, Han L, Du Y, Ge S, Liu H, Qu Y
Frontiers in cellular neuroscience 2022;16:892197
Frontiers in cellular neuroscience 2022;16:892197
Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.
Wang Y, Luo K, Li J, Liao Y, Liao C, Chen WS, Chen M, Ao L
Frontiers in cellular neuroscience 2022;16:884788
Frontiers in cellular neuroscience 2022;16:884788
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ
Drug design, development and therapy 2022;16:843-861
Drug design, development and therapy 2022;16:843-861
Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner.
Yang J, Dong HQ, Liu YH, Ji MH, Zhang X, Dai HY, Sun ZC, Liu L, Zhou J, Sha HH, Qian YN, Li QG, Yao H, Li NN
Frontiers in cellular neuroscience 2022;16:771156
Frontiers in cellular neuroscience 2022;16:771156
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Fan XX, Sun WY, Li Y, Tang Q, Li LN, Yu X, Wang SY, Fan AR, Xu XQ, Chang HS
Frontiers in pharmacology 2022;13:968124
Frontiers in pharmacology 2022;13:968124
Hypoxia-pretreated mesenchymal stem cell-derived exosomes-loaded low-temperature extrusion 3D-printed implants for neural regeneration after traumatic brain injury in canines.
Liu X, Wang J, Wang P, Zhong L, Wang S, Feng Q, Wei X, Zhou L
Frontiers in bioengineering and biotechnology 2022;10:1025138
Frontiers in bioengineering and biotechnology 2022;10:1025138
Transplantation of Astrocytic Mitochondria Modulates Neuronal Antioxidant Defense and Neuroplasticity and Promotes Functional Recovery after Intracerebral Hemorrhage.
Tashiro R, Bautista-Garrido J, Ozaki D, Sun G, Obertas L, Mobley AS, Kim GS, Aronowski J, Jung JE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Sep 7;42(36):7001-7014
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Sep 7;42(36):7001-7014
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Ma P, Wan LP, Li Y, He CH, Song NN, Zhao S, Wang H, Ding YQ, Mao B, Sheng N
Science advances 2022 Sep 30;8(39):eabq4736
Science advances 2022 Sep 30;8(39):eabq4736
Evaluation of Neurotoxicity in BALB/c Mice following Chronic Exposure to Polystyrene Microplastics.
Jin H, Yang C, Jiang C, Li L, Pan M, Li D, Han X, Ding J
Environmental health perspectives 2022 Oct;130(10):107002
Environmental health perspectives 2022 Oct;130(10):107002
LRFN2 binding to NMDAR inhibits the progress of ESCC via regulating the Wnt/β-Catenin and NF-κB signaling pathway.
Zhou Y, Xu L, Wang J, Ge B, Wang Q, Wang T, Liu C, Wei B, Wang Q, Gao Y
Cancer science 2022 Oct;113(10):3566-3578
Cancer science 2022 Oct;113(10):3566-3578
Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn.
Wang Q, Yang Z, Wu X, Zhang X, Geng F, Wang Q, Geng Z, Yu C, Li Z
International immunopharmacology 2022 Oct;111:109118
International immunopharmacology 2022 Oct;111:109118
Electroacupuncture remodels the extracellular matrix and promotes synaptic plasticity in a mouse model of depression.
Feng Y, Zhu G, Chen R, Shi G, Peng M, Zhou Y, Fu W, Zhou P
Biochemical and biophysical research communications 2022 Oct 20;626:44-50
Biochemical and biophysical research communications 2022 Oct 20;626:44-50
Promoted CD4(+) T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice.
Wu X, Shen Q, Chang H, Li J, Xing D
Journal of neuroinflammation 2022 Oct 10;19(1):253
Journal of neuroinflammation 2022 Oct 10;19(1):253
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545
Aging and disease 2022 Oct 1;13(5):1532-1545
Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin.
Cheng Y, Wang X, Yu Y, Gu J, Zhao M, Fu Q, Song Y, Liu Y
Neurochemical research 2022 Nov;47(11):3318-3330
Neurochemical research 2022 Nov;47(11):3318-3330
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Yuan C, Zheng L, Zhao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
Deng Y, Zou J, Hong Y, Peng Q, Fu X, Duan R, Chen J, Chen X
Cells 2022 Nov 17;11(22)
Cells 2022 Nov 17;11(22)
Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway.
Ma C, Zhou Y, Yi W, Zhou X, Guo W, Xu X, Luo J, Luo Z, Liu A, Chen D
Annals of translational medicine 2022 May;10(10):540
Annals of translational medicine 2022 May;10(10):540
Arsenic exposure via drinking water during pregnancy and lactation induces autism-like behaviors in male offspring mice.
Zhang X, Mei D, Li Y, You M, Wang D, Yao D, Xu Y, Zhai L, Wang Y
Chemosphere 2022 Mar;290:133338
Chemosphere 2022 Mar;290:133338
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model.
Shen Q, Wu X, Zhang Z, Zhang D, Yang S, Xing D
Aging cell 2022 Mar;21(3):e13573
Aging cell 2022 Mar;21(3):e13573
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Wang L, Chen J, Hu Y, Liao A, Zheng W, Wang X, Lan J, Shen J, Wang S, Yang F, Wang Y, Li Y, Chen D
Translational psychiatry 2022 Mar 22;12(1):114
Translational psychiatry 2022 Mar 22;12(1):114
Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice.
Sun Z, Zhao S, Suo X, Dou Y
BMC neuroscience 2022 Jun 6;23(1):33
BMC neuroscience 2022 Jun 6;23(1):33
Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.
Yang L, Yu X, Zhang Y, Liu N, Li D, Xue X, Fu J
CNS neuroscience & therapeutics 2022 Jul;28(7):1019-1032
CNS neuroscience & therapeutics 2022 Jul;28(7):1019-1032
A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.
Qin Y, Du Y, Chen L, Liu Y, Xu W, Liu Y, Li Y, Leng J, Wang Y, Zhang XY, Feng J, Zhang F, Jin L, Qiu Z, Gong X, Wang H
Molecular psychiatry 2022 Jul;27(7):2985-2998
Molecular psychiatry 2022 Jul;27(7):2985-2998
MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice.
Zhang Y, Deng W, Wang W, Song A, Mukama O, Deng S, Han X, De Dieu Habimana J, Peng K, Ni B, Zhang S, Huang J, Yan XX, Li Z
Cell death discovery 2022 Jul 4;8(1):304
Cell death discovery 2022 Jul 4;8(1):304
Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.
Li W, Lu L, Zhu D, Liu J, Shi Y, Zeng H, Yu X, Guo J, Wei B, Cai Y, Sun M
Ecotoxicology and environmental safety 2022 Jul 1;239:113682
Ecotoxicology and environmental safety 2022 Jul 1;239:113682
Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats.
Ren Z, Wang M, Aldhabi M, Zhang R, Liu Y, Liu S, Tang R, Chen Z
Neurobiology of stress 2022 Jan;16:100422
Neurobiology of stress 2022 Jan;16:100422
The circRNA circ-Nbea participates in regulating diabetic encephalopathy.
Liu J, Deng Z, Yu Z, Zhou W, Yuan Q
Brain research 2022 Jan 1;1774:147702
Brain research 2022 Jan 1;1774:147702
Polygonatum sibiricum ameliorated cognitive impairment of naturally aging rats through BDNF-TrkB signaling pathway.
Zhang X, Ni L, Hu S, Yue B, Chen X, Yuan D, Wang T, Zhou Z
Journal of food biochemistry 2022 Dec;46(12):e14510
Journal of food biochemistry 2022 Dec;46(12):e14510
Cornuside Is a Potential Agent against Alzheimer's Disease via Orchestration of Reactive Astrocytes.
Shi JZ, Zheng XM, Zhou YF, Yun LY, Luo DM, Hao JJ, Liu PF, Zhang WK, Xu JK, Yan Y, Xie XM, He YY, Pang XB
Nutrients 2022 Aug 3;14(15)
Nutrients 2022 Aug 3;14(15)
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.
Liang W, Hou Y, Huang W, Wang Y, Jiang T, Huang X, Wang Z, Wu F, Zheng J, Zhang J, Ou H, Li S, Ping J, Zhang Y, Ye J, Li Z, Yang Q, Zhang J, Zheng X, Li S, Zhu XH, Chen R, Zhao C
Science advances 2022 Aug 19;8(33):eabn7357
Science advances 2022 Aug 19;8(33):eabn7357
sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway.
Lu L, Liu X, Fu J, Liang J, Hou Y, Dou H
Scientific reports 2022 Apr 29;12(1):7047
Scientific reports 2022 Apr 29;12(1):7047
Resveratrol attenuates methylmercury-induced neurotoxicity by modulating synaptic homeostasis.
Wang W, Deng C, Chen F, Zhang L, Hu Y, Lu Q, Zhang A
Toxicology and applied pharmacology 2022 Apr 1;440:115952
Toxicology and applied pharmacology 2022 Apr 1;440:115952
Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress-Induced Depression.
Zhang D, Shen Q, Wu X, Xing D
Oxidative medicine and cellular longevity 2021;2021:6678276
Oxidative medicine and cellular longevity 2021;2021:6678276
Ketamine Induces Lasting Antidepressant Effects by Modulating the NMDAR/CaMKII-Mediated Synaptic Plasticity of the Hippocampal Dentate Gyrus in Depressive Stroke Model.
Abdoulaye IA, Wu SS, Chibaatar E, Yu DF, Le K, Cao XJ, Guo YJ
Neural plasticity 2021;2021:6635084
Neural plasticity 2021;2021:6635084
Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells.
Bodnar B, Zhang Y, Liu J, Lin Y, Wang P, Wei Z, Saribas S, Zhu Y, Li F, Wang X, Yang W, Li Q, Ho WZ, Hu W
Frontiers in cellular neuroscience 2021;15:682272
Frontiers in cellular neuroscience 2021;15:682272
Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder.
Zhang S, Jiang M, Yan S, Liang M, Wang W, Yuan B, Xu Q
Frontiers in pharmacology 2021;12:793012
Frontiers in pharmacology 2021;12:793012
Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice.
Zhou L, Tao X, Pang G, Mu M, Sun Q, Liu F, Hu Y, Tao H, Li B, Xu K
Frontiers in pharmacology 2021;12:661304
Frontiers in pharmacology 2021;12:661304
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66
Molecular neurodegeneration 2021 Sep 22;16(1):66
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Lan J, Hu Y, Wang X, Zheng W, Liao A, Wang S, Li Y, Wang Y, Yang F, Chen D
Neuropharmacology 2021 Sep 15;196:108689
Neuropharmacology 2021 Sep 15;196:108689
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
Lu C, Liu X, Li J, Huang Y, Huang X, Dai G, Wu L
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
ACS chemical neuroscience 2021 Oct 20;12(20):3939-3946
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.
Lu L, Wang H, Liu X, Tan L, Qiao X, Ni J, Sun Y, Liang J, Hou Y, Dou H
Journal of neuroinflammation 2021 Oct 13;18(1):229
Journal of neuroinflammation 2021 Oct 13;18(1):229
The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice.
Guo H, Deji C, Peng H, Zhang J, Chen Y, Zhang Y, Wang Y
Genes, brain, and behavior 2021 Nov;20(8):e12765
Genes, brain, and behavior 2021 Nov;20(8):e12765
Novel Botanical Therapeutic NB-02 Effectively Treats Alzheimer's Neuropathophysiology in an APP/PS1 Mouse Model.
Lee YF, Lariviere L, Russ AN, Choi SZ, Bacskai BJ, Kastanenka KV
eNeuro 2021 May-Jun;8(3)
eNeuro 2021 May-Jun;8(3)
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM
Neuron 2021 May 19;109(10):1657-1674.e7
Neuron 2021 May 19;109(10):1657-1674.e7
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Xia B, Huang X, Sun G, Tao W
Journal of ethnopharmacology 2021 Mar 25;268:113665
Journal of ethnopharmacology 2021 Mar 25;268:113665
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway.
Wang R, Zhou Z, Wang D, Zhao Q, Zhang C, Liu C, Zhao H, Yuan C, Yuan D, Wang T
Food & function 2021 Jul 21;12(14):6464-6478
Food & function 2021 Jul 21;12(14):6464-6478
Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission.
Wu L, Zhang T, Chen K, Lu C, Liu XF, Zhou JL, Huang YK, Yan H, Chen Y, Zhang CJ, Li JF, Shi SQ, Ren P, Huang X
Phytotherapy research : PTR 2021 Jan;35(1):404-414
Phytotherapy research : PTR 2021 Jan;35(1):404-414
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies.
Li Y, Fan C, Wang L, Lan T, Gao R, Wang W, Yu SY
The Journal of clinical investigation 2021 Aug 16;131(16)
The Journal of clinical investigation 2021 Aug 16;131(16)
hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
Akinyemi AR, Li D, Zhang J, Liu Q
Neuroscience letters 2021 Apr 23;751:135824
Neuroscience letters 2021 Apr 23;751:135824
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
Liao D, Lv C, Cao L, Yao D, Wu Y, Long M, Liu N, Jiang P
Oxidative medicine and cellular longevity 2020;2020:9268083
Oxidative medicine and cellular longevity 2020;2020:9268083
Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats.
Zhu S, Min D, Zeng J, Ju Y, Liu Y, Chen X
Stem cells international 2020;2020:6393075
Stem cells international 2020;2020:6393075
Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling Pathway.
Dong Y, Hong W, Tang Z, Gao Y, Wu X, Liu H
Mediators of inflammation 2020;2020:5458061
Mediators of inflammation 2020;2020:5458061
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
Liu D, Bai X, Ma W, Xin D, Chu X, Yuan H, Qiu J, Ke H, Yin S, Chen W, Wang Z
Frontiers in pharmacology 2020;11:204
Frontiers in pharmacology 2020;11:204
Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.
Dong Y, Hong W, Tang Z, Gao Y, Wu X, Liu H
Neurochemistry international 2020 Oct;139:104789
Neurochemistry international 2020 Oct;139:104789
Spinosin protects N2a cells from H(2) O(2) -induced neurotoxicity through inactivation of p38MAPK.
Xu F, Zhang X, Wang J, Li X, He B, Xiao F, Yan T, Wu B, Jia Y, Wang Z
The Journal of pharmacy and pharmacology 2020 Nov;72(11):1607-1614
The Journal of pharmacy and pharmacology 2020 Nov;72(11):1607-1614
The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
Niu L, Luo SS, Xu Y, Wang Z, Luo D, Yang H, Li W, He J, Zhong XL, Liu ZH, Zeng JY, Cao WY, Wan W
Neurobiology of learning and memory 2020 Nov;175:107301
Neurobiology of learning and memory 2020 Nov;175:107301
Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice.
Kukharsky MS, Ninkina NN, An H, Telezhkin V, Wei W, Meritens CR, Cooper-Knock J, Nakagawa S, Hirose T, Buchman VL, Shelkovnikova TA
Translational psychiatry 2020 May 28;10(1):171
Translational psychiatry 2020 May 28;10(1):171
The novel GLP-1/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD.
Li C, Liu W, Li X, Zhang Z, Qi H, Liu S, Yan N, Xing Y, Hölscher C, Wang Z
Brain and behavior 2020 Mar;10(3):e01505
Brain and behavior 2020 Mar;10(3):e01505
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
Zhang X, Zhao D, Wu W, Ali Shah SZ, Lai M, Yang D, Li J, Guan Z, Li W, Gao H, Zhao H, Zhou X, Yang L
Aging 2020 Jun 10;12(11):11139-11151
Aging 2020 Jun 10;12(11):11139-11151
Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase.
Wu Z, Zhang Y, Yang X, Zhao P
Neurochemical research 2020 Jul;45(7):1626-1635
Neurochemical research 2020 Jul;45(7):1626-1635
Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA(2) phosphorylation in experimental ischemic stroke.
Cao C, Zhou J, Wu X, Qian Y, Hong Y, Mu J, Jin L, Zhu C, Li S
Cellular signalling 2020 Feb;66:109467
Cellular signalling 2020 Feb;66:109467
Ferrostatin-1 mitigates cognitive impairment of epileptic rats by inhibiting P38 MAPK activation.
Ye Q, Zeng C, Luo C, Wu Y
Epilepsy & behavior : E&B 2020 Feb;103(Pt A):106670
Epilepsy & behavior : E&B 2020 Feb;103(Pt A):106670
Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway.
Yang F, Zhang Y, Tang Z, Shan Y, Wu X, Liu H
Life sciences 2020 Feb 1;242:117151
Life sciences 2020 Feb 1;242:117151
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves.
Shi B, Luo J, Fang Y, Liu X, Rao Z, Liu R, Zeng N
Frontiers in pharmacology 2019;10:1324
Frontiers in pharmacology 2019;10:1324
Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5-choice serial reaction time task.
Guo H, Xie Q, Cui J, Xu D, Deji C, Chen Y, Wang Y, Lai J
Journal of neuroscience research 2019 Sep;97(9):1051-1065
Journal of neuroscience research 2019 Sep;97(9):1051-1065
The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma.
Cheng Y, Yin B, Hou T, Chen T, Ping J
Journal of cellular physiology 2019 Sep;234(9):16215-16225
Journal of cellular physiology 2019 Sep;234(9):16215-16225
Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.
Zhou C, Sun X, Hu Y, Song J, Dong S, Kong D, Wang Y, Hua X, Han J, Zhou Y, Jin G, Yang X, Shi H, Zhang Z, Hua F
Aging 2019 Sep 11;11(17):7257-7273
Aging 2019 Sep 11;11(17):7257-7273
Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats.
Li PJ, Guo YQ, Ding PY, Liu RB, Deng F, Feng XX, Yan WJ
Neurological research 2019 Oct;41(10):867-874
Neurological research 2019 Oct;41(10):867-874
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q
Cell reports 2019 Jul 2;28(1):78-90.e6
Cell reports 2019 Jul 2;28(1):78-90.e6
CAMK2-Dependent Signaling in Neurons Is Essential for Survival.
Kool MJ, Proietti Onori M, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439
S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA(2) phosphorylation.
Cao C, Dai L, Mu J, Wang X, Hong Y, Zhu C, Jin L, Li S
Cellular signalling 2019 Jan;53:151-161
Cellular signalling 2019 Jan;53:151-161
Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: Role of GSK-3β/β-catenin pathway.
Jiang P, Li G, Zhou X, Wang C, Qiao Y, Liao D, Shi D
Chemosphere 2019 Jan;214:430-435
Chemosphere 2019 Jan;214:430-435
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
Wang Y, Liu Y, Li Y, Liu B, Wu P, Xu S, Shi H
Acta histochemica 2019 Jan;121(1):56-63
Acta histochemica 2019 Jan;121(1):56-63
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Mo J, Wang B, Zhu X, Wu X, Liu Y
Neurobiology of disease 2019 Jan;121:274-285
Neurobiology of disease 2019 Jan;121:274-285
The memory improving effects of round scad (Decapterus maruadsi) hydrolysates on sleep deprivation-induced memory deficits in rats via antioxidant and neurotrophic pathways.
Zhang Q, Su G, Zhao T, Wang S, Sun B, Zheng L, Zhao M
Food & function 2019 Dec 11;10(12):7733-7744
Food & function 2019 Dec 11;10(12):7733-7744
Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease.
Yan XS, Yang ZJ, Jia JX, Song W, Fang X, Cai ZP, Huo DS, Wang H
Neural regeneration research 2019 Apr;14(4):649-657
Neural regeneration research 2019 Apr;14(4):649-657
The protective mechanism underlying phenylethanoid glycosides (PHG) actions on synaptic plasticity in rat Alzheimer's disease model induced by beta amyloid 1-42.
Jia JX, Yan XS, Song W, Fang X, Cai ZP, Huo DS, Wang H, Yang ZJ
Journal of toxicology and environmental health. Part A 2018;81(21):1098-1107
Journal of toxicology and environmental health. Part A 2018;81(21):1098-1107
Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise.
Wu Z, Li X, Zhang Y, Tong D, Wang L, Zhao P
Frontiers in cellular neuroscience 2018;12:122
Frontiers in cellular neuroscience 2018;12:122
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain.
Raihan O, Brishti A, Molla MR, Li W, Zhang Q, Xu P, Khan MI, Zhang J, Liu Q
Neuroscience 2018 Oct 15;390:160-173
Neuroscience 2018 Oct 15;390:160-173
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
Zhu B, Zhao L, Luo D, Xu D, Tan T, Dong Z, Tang Y, Min Z, Deng X, Sun F, Yan Z, Chen G
Cellular and molecular life sciences : CMLS 2018 Jul;75(13):2473-2488
Cellular and molecular life sciences : CMLS 2018 Jul;75(13):2473-2488
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Cell death & disease 2018 Jul 23;9(8):795
Cell death & disease 2018 Jul 23;9(8):795
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Aging cell 2018 Feb;17(1)
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BioMed research international 2017;2017:7464872
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Frontiers in molecular neuroscience 2017;10:128
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Nature neuroscience 2016 Nov;19(11):1513-1522
Nature neuroscience 2016 Nov;19(11):1513-1522
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Scientific reports 2016 Nov 23;6:37713
Scientific reports 2016 Nov 23;6:37713
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Oncotarget 2016 Mar 15;7(11):12035-52
Oncotarget 2016 Mar 15;7(11):12035-52
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 20665-1-AP( PSD95-Specific,DLG4 Antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PSD95-Specific,DLG4 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PSD95-Specific,DLG4. This antibody recognizes human,mouse,rat antigen. The PSD95-Specific,DLG4 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
