BS64008

antibody from Bioworld Technology, Inc
Targeting: TLK1 KIAA0137, PKU-BETA
Provider product page for BS64008

Antibody data

Product number
BS64008 - Provider product page
Provider
Bioworld Technology, Inc
Product name
TLK1 (phospho S743) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human TLK1 around the phosphorylation site of Serine 743.
Description
The Tousled-like kinases (TLK1 and TLK2, also designated PKU-ÉÇ and PKU-Ï«, respectively) are the human homologs of the Tousled gene from Arabidopsis thaliana, which encodes a Serine/Threonine kinase that is necessary for proper organ morphogenesis. Both TLKs contain a nuclear localization signal and a predicted coiled-coil region in the N-terminal domain. TLK is ubiquitously expressed, and is prevalent in mouse testis, especially in pachytene spermatocytes and round spermatids. It displays a propensity to dimerize through an interaction between its coiled-coil structure and is able to autophosphorylate, as well as phosphorylate exogenous substrates. TLK1 and TLK2 are regulated by the cell cycle, showing maximum activity during S phase. Subsequently, they are thought to regulate the development of multicellular organisms, including playing a key role in spermatogenesis, through a series of phosphorylations.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TLK1 protein structure - BS64008 shown in red.