Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7753 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL1RAP polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL1RAP.
- Description
- ?Interleukin-1 (IL-1) is a key pro-inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation. Two major agonists, IL-1Ï« and IL-1ÉÇ, bind to a single known functional type-1 IL-1 receptor (IL-1RI), which associates with the accessory protein (IL-1RAcP), resulting in signal transduction. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1RAcP to activate NF?B. The membrane bound form of IL-1RAcP (mIL-1RAcP) facilitates signal transduction. Two alternatively spliced isoforms, soluble IL-1RAcP (sIL-1RAcP) and sIL-1RAcP-ÉÇ, which lack transmembrane and intracellular domains, can inhibit IL-1 signaling. Although both mIL-1RAcP and sIL-1RAcP mRNAs are widely expressed in human tissue, their relative proportions differ significantly in a tissue-specific manner.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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