Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
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- Product number
- NB100-64340 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-64340, RRID:AB_960759
- Product name
- Mouse Monoclonal Complement C8A/B/G Antibody
- Antibody type
- Monoclonal
- Description
- Protein A purified. This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyzes the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.05 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.
Human complement protein C8 gamma.
Human complement protein C8 gamma.
Rosa DD, Pasqualotto AC, de Quadros M, Prezzi SH
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2004 Aug;8(4):328-30
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2004 Aug;8(4):328-30
Human complement protein C8 gamma.
Schreck SF, Parker C, Plumb ME, Sodetz JM
Biochimica et biophysica acta 2000 Oct 18;1482(1-2):199-208
Biochimica et biophysica acta 2000 Oct 18;1482(1-2):199-208
Human complement protein C8 gamma.
Schreck SF, Parker C, Plumb ME, Sodetz JM
Biochimica et biophysica acta 2000 Oct 18;1482(1-2):199-208
Biochimica et biophysica acta 2000 Oct 18;1482(1-2):199-208
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