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- References [19]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 11432-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11432-1-AP, RRID:AB_2116435
- Product name
- HAT1 antibody
- Antibody type
- Polyclonal
- Description
- HAT1 antibody (Cat. #11432-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references HAT1 as a Lactyltransferase to Promote DNA Repair Through RPA1 Lactylation in Glioblastoma.
Regulation of Histone Acetylation During Inflammation Resolution.
Histone acetyltransferase 1 promotes postinfarction inflammatory response by regulation of monocyte histone succinylation.
HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma.
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.
Histone acetyltransferase 1 promotes ovarian cancer progression by regulating cell proliferation and the cell cycle.
Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation.
Bevacizumab induces ferroptosis and enhances CD8(+) T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9.
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
A druggable copper-signalling pathway that drives inflammation.
Predisposition to cortical neurodegenerative changes in brains of hypertension prone rats.
Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors.
Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
New Cortical Neurodegenerative Pathways in the Hypertensive Rat Brain.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
Identification and characterization of an endoplasmic reticulum localization motif.
Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).
Zhao Y, He J, Zhou Z, Lai T, Zeng S, Li N, He Y, Zhou W, Wu Y, Xu B
International journal of biological sciences 2026;22(4):1906-1919
International journal of biological sciences 2026;22(4):1906-1919
Regulation of Histone Acetylation During Inflammation Resolution.
Gong L, Lei J, Zhou Y, Zhang J, Wu L, Chen Y, Liu X, Li Y
ImmunoTargets and therapy 2025;14:1145-1158
ImmunoTargets and therapy 2025;14:1145-1158
Histone acetyltransferase 1 promotes postinfarction inflammatory response by regulation of monocyte histone succinylation.
Guo Y, Xiong J, Li Z, Bai L, Wang B, Guo B, Tang H, Li G, Qiu Y, Lv L, Dong Z, Tu Y
Nature communications 2025 Nov 28;16(1):11718
Nature communications 2025 Nov 28;16(1):11718
HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma.
He J, Lai T, Zhao Y, Zhou Z, Zhou L, Tao D, Yang H, Li N, He Y, Yang S, Tang Z, Zeng S, Munai E, Liu Y, Tan Y, Zhou W, Wu Y
Cell death & disease 2025 Nov 21;16(1):851
Cell death & disease 2025 Nov 21;16(1):851
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma.
Zhou P, Peng X, Zhang K, Cheng J, Tang M, Shen L, Zhou Q, Li D, Yang L
Cell death & disease 2025 Mar 6;16(1):160
Cell death & disease 2025 Mar 6;16(1):160
Histone acetyltransferase 1 promotes ovarian cancer progression by regulating cell proliferation and the cell cycle.
Han X, Liu L, Li J, Zhi Y, Zhao L, Yuan L, Ouyang X, Liu J
Oncology letters 2025 Dec;30(6):539
Oncology letters 2025 Dec;30(6):539
Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation.
Srivastava S, Samaniego-Castruita D, Srivastava S, Khurana S, Rehman J, Shukla V, Ben-Sahra I, Foltz DR
Molecular cell 2025 Dec 18;85(24):4510-4525.e8
Molecular cell 2025 Dec 18;85(24):4510-4525.e8
Bevacizumab induces ferroptosis and enhances CD8(+) T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9.
Hou CY, Lv P, Yuan HF, Zhao LN, Wang YF, Zhang HH, Yang G, Zhang XD
Acta pharmacologica Sinica 2024 Sep;45(9):1951-1963
Acta pharmacologica Sinica 2024 Sep;45(9):1951-1963
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
Guo B, Zhang S, Wang S, Zhang H, Fang J, Kang N, Zhen X, Zhang Y, Zhou J, Yan G, Sun H, Ding L, Liu C
Reproductive biology and endocrinology : RB&E 2023 Oct 31;21(1):103
Reproductive biology and endocrinology : RB&E 2023 Oct 31;21(1):103
A druggable copper-signalling pathway that drives inflammation.
Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, Péricat D, Näser E, Cougoule C, Meunier E, Bègue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R
Nature 2023 May;617(7960):386-394
Nature 2023 May;617(7960):386-394
Predisposition to cortical neurodegenerative changes in brains of hypertension prone rats.
Ben-Shabat M, Awad-Igbaria Y, Sela S, Gross B, Yagil Y, Yagil C, Palzur E
Journal of translational medicine 2023 Jan 27;21(1):51
Journal of translational medicine 2023 Jan 27;21(1):51
Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ
eLife 2023 Apr 24;12
eLife 2023 Apr 24;12
Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors.
George J, Chen Y, Abdelfattah N, Yamamoto K, Gallup TD, Adamson SI, Rybinski B, Srivastava A, Kumar P, Lee MG, Baskin DS, Jiang W, Choi JM, Flavahan W, Chuang JH, Kim BY, Xu J, Jung SY, Yun K
Cancer research communications 2022 Jun;2(6):402-416
Cancer research communications 2022 Jun;2(6):402-416
Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
Sun Y, Ren D, Zhou Y, Shen J, Wu H, Jin X
Cell death & disease 2021 Sep 25;12(10):878
Cell death & disease 2021 Sep 25;12(10):878
New Cortical Neurodegenerative Pathways in the Hypertensive Rat Brain.
Moti BS, Oz E, Olga A, Bella G, Shifra S, Eilam P
Cerebral cortex (New York, N.Y. : 1991) 2021 Oct 22;31(12):5487-5496
Cerebral cortex (New York, N.Y. : 1991) 2021 Oct 22;31(12):5487-5496
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
Yang G, Yuan Y, Yuan H, Wang J, Yun H, Geng Y, Zhao M, Li L, Weng Y, Liu Z, Feng J, Bu Y, Liu L, Wang B, Zhang X
EMBO reports 2021 Feb 3;22(2):e50967
EMBO reports 2021 Feb 3;22(2):e50967
Identification and characterization of an endoplasmic reticulum localization motif.
Nie YW, Wang M, Zhang P, Huan L, Liu DJ
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).
Yu H, Diao H, Wang C, Lin Y, Yu F, Lu H, Xu W, Li Z, Shi H, Zhao S, Zhou Y, Zhang Y
Molecular & cellular proteomics : MCP 2015 Apr;14(4):1009-23
Molecular & cellular proteomics : MCP 2015 Apr;14(4):1009-23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 11432-1-AP(HAT1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using HAT1 antibody 11432-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 11432-1-AP(HAT1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
