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- References [14]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 23778-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ADAM8 antibody
- Antibody type
- Polyclonal
- Description
- ADAM8 antibody (Cat. #23778-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ADAM8 Destroys the Endothelial Barrier and Promotes Leukocyte Extravasation to Aggravate Hepatic Ischemia-Reperfusion Injury.
Disulfidptosis-based molecular clustering and prognostic signatures predict patient survival and the immune landscape in patients with colon cancer.
Roles of Adam8 in Neuroinflammation in experimental ischemic Stroke: Insights from single-cell and ribosome-bound mRNA sequencing.
Long noncoding RNA GCH1 mediates mitophagy via the PTEN-induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis.
Assessing the predictive potential of ADAM8 for disease control in chronic rhinosinusitis with nasal polyps.
Identification of a novel macrophage-related prognostic signature in colorectal cancer.
The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways.
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.
ADAM8 Activates NLRP3 Inflammasome to Promote Cerebral Ischemia-Reperfusion Injury.
Matrix metalloprotease-mediated cleavage of neural glial-related cell adhesion molecules activates quiescent olfactory stem cells via EGFR.
ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways.
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
High ADAM8 expression is associated with poor prognosis in patients with hepatocellular carcinoma.
Li J, Zhang W, Zhang Y, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71217
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71217
Disulfidptosis-based molecular clustering and prognostic signatures predict patient survival and the immune landscape in patients with colon cancer.
Wen L, Ma Y, Li J, Chen D, Huang C, Wang P, Wen S, Wen G, Guo J, Zhang G, Wang J, Yao X
Discover oncology 2025 Mar 18;16(1):354
Discover oncology 2025 Mar 18;16(1):354
Roles of Adam8 in Neuroinflammation in experimental ischemic Stroke: Insights from single-cell and ribosome-bound mRNA sequencing.
Liu J, Xu L, Lu J, Shen X, Li D, Bai L, Li X Jr, Yu Z, Li H
Experimental neurology 2025 Jun;388:115207
Experimental neurology 2025 Jun;388:115207
Long noncoding RNA GCH1 mediates mitophagy via the PTEN-induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis.
Zeng G, Sun Y, Liu T, Liu W, Chen Y, Wu J, Zheng J, Song W, Ding Y
Animal models and experimental medicine 2025 Jul;8(7):1253-1267
Animal models and experimental medicine 2025 Jul;8(7):1253-1267
Assessing the predictive potential of ADAM8 for disease control in chronic rhinosinusitis with nasal polyps.
Liu P, Liu M, Sun Y, Lei W, Xu Y
Frontiers in allergy 2024;5:1488441
Frontiers in allergy 2024;5:1488441
Identification of a novel macrophage-related prognostic signature in colorectal cancer.
Lin D, Zheng T, Huang S, Liu R, Guan S, Zhang Z
Scientific reports 2024 Feb 2;14(1):2767
Scientific reports 2024 Feb 2;14(1):2767
The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.
Liu X, Huang Y, Qi Y, Wu S, Hu F, Wang J, Shu K, Zhang H, Bartsch JW, Nimsky C, Dong F, Lei T
Cancers 2022 Oct 7;14(19)
Cancers 2022 Oct 7;14(19)
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways.
Yao L, Shao W, Chen Y, Wang S, Huang D
Experimental animals 2022 Feb 9;71(1):90-99
Experimental animals 2022 Feb 9;71(1):90-99
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.
Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, Rost F, Dahl A, Rauch E, Kattner L, Weber S, Mirtschink P, Kopaliani I, Guan K, Lorenz K, Saftig P, Wagner M, El-Armouche A
Nature communications 2022 Dec 10;13(1):7648
Nature communications 2022 Dec 10;13(1):7648
ADAM8 Activates NLRP3 Inflammasome to Promote Cerebral Ischemia-Reperfusion Injury.
Lu H, Meng Y, Han X, Zhang W
Journal of healthcare engineering 2021;2021:3097432
Journal of healthcare engineering 2021;2021:3097432
Matrix metalloprotease-mediated cleavage of neural glial-related cell adhesion molecules activates quiescent olfactory stem cells via EGFR.
Chen ZH, Luo XC, Yu CR, Huang L
Molecular and cellular neurosciences 2020 Oct;108:103552
Molecular and cellular neurosciences 2020 Oct;108:103552
ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways.
Li W, Wang D, Sun X, Zhang Y, Wang L, Suo J
International journal of molecular medicine 2019 Feb;43(2):914-926
International journal of molecular medicine 2019 Feb;43(2):914-926
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D
Nature medicine 2019 Feb;25(2):301-311
Nature medicine 2019 Feb;25(2):301-311
High ADAM8 expression is associated with poor prognosis in patients with hepatocellular carcinoma.
Zhang Y, Tan YF, Jiang C, Zhang K, Zha TZ, Zhang M
Pathology oncology research : POR 2013 Jan;19(1):79-88
Pathology oncology research : POR 2013 Jan;19(1):79-88
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- BxPC-3 cells were subjected to SDS PAGE followed by western blot with 23778-1-AP( ADAM8 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ADAM8 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ADAM8. This antibody recognizes human, mouse antigen. The ADAM8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
