DPAB-DC2661

RAN antibody from Creative Diagnostics
ARA24, Gsp1, TC4
Western blot
Recommended by provider
ELISA
Recommended by provider

Antibody data

Product number
DPAB-DC2661
Provider
Creative Diagnostics
Proper citation
Creative Diagnostics Cat#DPAB-DC2661, RRID:AB_2499949
Product name
Anti-RAN (full length) polyclonal antibody
Provider product page
Creative Diagnostics - DPAB-DC2661
Antibody type
Polyclonal
Description
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedys disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Vial size
50  ml
Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Handling
The antibody solution should be gently mixed before use.
Provider Type Product Number
- No reagents -