DPAB-DC2661

RAN antibody from Creative Diagnostics

ARA24, Gsp1, TC4

Western blot

Recommended by provider

ELISA

Recommended by provider

Provider product page for DPAB-DC2661

Antibody Data

Product number

DPAB-DC2661

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPAB-DC2661, RRID:AB_2499949

Product name

Anti-RAN (full length) polyclonal antibody

Provider product page

Antibody type

Polyclonal

Description

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedys disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedys disease.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Vial size

50  ml

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Handling

The antibody solution should be gently mixed before use.