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- Antibody Data
- Antigen structure
- References [19]
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- Product number
- MAB1850 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human NKp46/NCR1 Monoclonal Antibody (Clone 195314)
- Antibody type
- Monoclonal
- Antigen
- Mouse T cell hybridoma transfected with human NKp46/NCR1
- Description
- Protein A or G purified from hybridoma culture supernatant
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 500 µg
Submitted references Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for EGFR-Amplified Gastroesophageal Adenocarcinoma.
Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity.
Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients.
Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models.
NKp30 isoforms and NKp46 transcripts in metastatic melanoma patients: Unique NKp30 pattern in rare melanoma patients with favorable evolution.
Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome.
Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection.
Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways.
Characterization of the Microenvironment in Positive and Negative Sentinel Lymph Nodes from Melanoma Patients.
A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells.
CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph.
Natural killer cells are characterized by the concomitantly increased interferon-γ and cytotoxicity in acute resolved hepatitis B patients.
Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1).
Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma.
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
A novel binding assay to assess specificity of monoclonal antibodies.
Maron SB, Alpert L, Kwak HA, Lomnicki S, Chase L, Xu D, O'Day E, Nagy RJ, Lanman RB, Cecchi F, Hembrough T, Schrock A, Hart J, Xiao SY, Setia N, Catenacci DVT
Cancer discovery 2018 Jun;8(6):696-713
Cancer discovery 2018 Jun;8(6):696-713
Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity.
Trotta AM, Santagata S, Zanotta S, D'Alterio C, Napolitano M, Rea G, Camerlingo R, Esposito F, Lamantia E, Anniciello A, Botti G, Longo N, Botti G, Pignata S, Perdonà S, Scala S
Journal of experimental & clinical cancer research : CR 2018 Dec 4;37(1):297
Journal of experimental & clinical cancer research : CR 2018 Dec 4;37(1):297
Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients.
Shi J, Zhao J, Zhang X, Cheng Y, Hu J, Li Y, Zhao X, Shang Q, Sun Y, Tu B, Shi L, Gao B, Wang FS, Zhang Z
Scientific reports 2017 Mar 14;7:44544
Scientific reports 2017 Mar 14;7:44544
Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models.
Feng Y, Liao S, Wei C, Jia D, Wood K, Liu Q, Wang X, Shi FD, Jin WN
Journal of neuroinflammation 2017 Dec 15;14(1):248
Journal of neuroinflammation 2017 Dec 15;14(1):248
NKp30 isoforms and NKp46 transcripts in metastatic melanoma patients: Unique NKp30 pattern in rare melanoma patients with favorable evolution.
Messaoudene M, Fregni G, Enot D, Jacquelot N, Neves E, Germaud N, Garchon HJ, Boukouaci W, Tamouza R, Chanal J, Avril MF, Toubert A, Zitvogel L, Rusakiewicz S, Caignard A
Oncoimmunology 2016;5(12):e1154251
Oncoimmunology 2016;5(12):e1154251
Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome.
Hervier B, Perez M, Allenbach Y, Devilliers H, Cohen F, Uzunhan Y, Ouakrim H, Dorgham K, Méritet JF, Longchampt E, Stenzel W, Cremer I, Benveniste O, Vieillard V
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 1;197(5):1621-30
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 1;197(5):1621-30
Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection.
Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan Z
Immunity 2016 Jul 19;45(1):131-44
Immunity 2016 Jul 19;45(1):131-44
Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways.
Hudspeth K, Donadon M, Cimino M, Pontarini E, Tentorio P, Preti M, Hong M, Bertoletti A, Bicciato S, Invernizzi P, Lugli E, Torzilli G, Gershwin ME, Mavilio D
Journal of autoimmunity 2016 Jan;66:40-50
Journal of autoimmunity 2016 Jan;66:40-50
Characterization of the Microenvironment in Positive and Negative Sentinel Lymph Nodes from Melanoma Patients.
Messaoudene M, Périer A, Fregni G, Neves E, Zitvogel L, Cremer I, Chanal J, Sastre-Garau X, Deschamps L, Marinho E, Larousserie F, Maubec E, Avril MF, Caignard A
PloS one 2015;10(7):e0133363
PloS one 2015;10(7):e0133363
A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells.
Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA
mAbs 2014 May-Jun;6(3):728-39
mAbs 2014 May-Jun;6(3):728-39
CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph.
Carrega P, Bonaccorsi I, Di Carlo E, Morandi B, Paul P, Rizzello V, Cipollone G, Navarra G, Mingari MC, Moretta L, Ferlazzo G
Journal of immunology (Baltimore, Md. : 1950) 2014 Apr 15;192(8):3805-15
Journal of immunology (Baltimore, Md. : 1950) 2014 Apr 15;192(8):3805-15
Natural killer cells are characterized by the concomitantly increased interferon-γ and cytotoxicity in acute resolved hepatitis B patients.
Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang FS
PloS one 2012;7(11):e49135
PloS one 2012;7(11):e49135
Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1).
Durrenberger PF, Ettorre A, Kamel F, Webb LV, Sim M, Nicholas RS, Malik O, Reynolds R, Boyton RJ, Altmann DM
Journal of neuroinflammation 2012 Jan 2;9:1
Journal of neuroinflammation 2012 Jan 2;9:1
Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
Keim S, Zoernig I, Spille A, Lahrmann B, Brand K, Herpel E, Grabe N, Jäger D, Halama N
Oncoimmunology 2012 Aug 1;1(5):593-599
Oncoimmunology 2012 Aug 1;1(5):593-599
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.
Yu J, Mitsui T, Wei M, Mao H, Butchar JP, Shah MV, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G Jr, Benson DM, Loughran TP Jr, Tridandapani S, Caligiuri MA
The Journal of clinical investigation 2011 Apr;121(4):1456-70
The Journal of clinical investigation 2011 Apr;121(4):1456-70
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma.
Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD Jr, Barlogie B, van Rhee F
Blood 2008 Feb 1;111(3):1309-17
Blood 2008 Feb 1;111(3):1309-17
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socié G, Toubert A
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):2227-37
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):2227-37
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socié G, Toubert A
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):2227-37
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):2227-37
A novel binding assay to assess specificity of monoclonal antibodies.
Warren HS, Bettadapura J
Journal of immunological methods 2005 Oct 20;305(1):33-8
Journal of immunological methods 2005 Oct 20;305(1):33-8
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