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Learn15182-1-AP
antibody from Proteintech Group
Targeting: NLRP2
CLR19.9, FLJ20510, NALP2, NBS1, PAN1, PYPAF2
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15182-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15182-1-AP, RRID:AB_2298531
- Product name
- NLRP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NLRP2 antibody (Cat. #15182-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Macrophage IL-1β contributes to tumorigenesis through paracrine AIM2 inflammasome activation in the tumor microenvironment.
Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.
Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation.
Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimer's disease by suppressing NLRP2 activation in astrocytes.
A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease.
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression.
NLRP2 negatively regulates antiviral immunity by interacting with TBK1.
Chew ZH, Cui J, Sachaphibulkij K, Tan I, Kar S, Koh KK, Singh K, Lim HM, Lee SC, Kumar AP, Gasser S, Lim LHK
Frontiers in immunology 2023;14:1211730
Frontiers in immunology 2023;14:1211730
Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.
Jin L, Li T, Hong Y, Mao R, Li X, Zhu C, Mu J, Zhou J, Pan L, Que Y, Xia Y, Zhang Y, Li S
Biochemical pharmacology 2023 Sep;215:115703
Biochemical pharmacology 2023 Sep;215:115703
Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation.
Zhu H, Xiao F, Xiao Y, Guo Y, Shan X, Zhang Z, Zhang L, Guo H
Journal of neuroinflammation 2023 Dec 19;20(1):304
Journal of neuroinflammation 2023 Dec 19;20(1):304
Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimer's disease by suppressing NLRP2 activation in astrocytes.
Zhang M, Wu Y, Gao R, Chen X, Chen R, Chen Z
Molecular and cellular endocrinology 2022 Feb 15;542:111529
Molecular and cellular endocrinology 2022 Feb 15;542:111529
A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease.
Huang S, Chen Z, Fan B, Chen Y, Zhou L, Jiang B, Long H, Zhong W, Li X, Li Y
Journal of neuroimmunology 2021 May 15;354:577543
Journal of neuroimmunology 2021 May 15;354:577543
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Ding PH, Yang MX, Wang NN, Jin LJ, Dong Y, Cai X, Chen LL
Frontiers in microbiology 2020;11:1881
Frontiers in microbiology 2020;11:1881
Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression.
Zhang Q, Sun Y, He Z, Xu Y, Li X, Ding J, Lu M, Hu G
Brain, behavior, and immunity 2020 Aug;88:471-481
Brain, behavior, and immunity 2020 Aug;88:471-481
NLRP2 negatively regulates antiviral immunity by interacting with TBK1.
Yang Y, Lang X, Sun S, Gao C, Hu J, Ding S, Li J, Li Y, Wang F, Gong T
European journal of immunology 2018 Nov;48(11):1817-1825
European journal of immunology 2018 Nov;48(11):1817-1825
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 15182-1-AP(NLRP2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 15182-1-AP(NLRP2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NLRP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NLRP2. This antibody recognizes human, mouse antigen. The NLRP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
