abx015864

antibody from Abbexa

Targeting: FOXD3 Genesis, HFH2

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx015864

Provider

Abbexa

Product name

Forkhead Box D3 (FOXD3) Antibody

Antibody type

Monoclonal

Description

FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development.This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation.FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3 (-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures.FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells.Promotes development of neural crest cells from neural tube progenitors.Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation.Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.

Reactivity

Human, Mouse, Simian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.