EVX2

This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]

Description

Even-skipped homeobox 2

Tissue specificity

Tissue enhanced (brain, prostate, seminal vesicle, testis, vagina)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

2 (176077472 - 176083913)

Ensembl ID

ENSG00000174279  (ver. 103.38)

Orthologs

Mouse Evx2: ENSMUSG00000001815

UniProt

Q03828

neXtProt

NX_Q03828

Human splice variants
Mouse splice variants

Protein structure