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- Antibody Data
- Antigen structure
- References [14]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 15759-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15759-1-AP, RRID:AB_2296904
- Product name
- LHPP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LHPP antibody (Cat. #15759-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
Correlated with better prognosis, CSTA inhibits metastasis of nasopharyngeal carcinoma cells via suppressing AKT signaling through promoting METTL3 degradation.
LHPP suppresses proliferation, migration, and invasion in hepatocellular carcinoma and pancreatic cancer by inhibiting EGFR signaling pathway.
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.
Colitis Is Associated with Loss of the Histidine Phosphatase LHPP and Upregulation of Histidine Phosphorylation in Intestinal Epithelial Cells.
LHPP suppresses gastric cancer progression via the PI3K/AKT/mTOR signaling pathway.
Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines.
Does the LHPP gene share a common biological function in pancancer progression?
The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis.
The Significance of Circular RNA DDX17 in Prostate Cancer.
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.
LHPP inhibits hepatocellular carcinoma cell growth and metastasis.
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway.
Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L
Cancer letters 2023 May 28;562:216158
Cancer letters 2023 May 28;562:216158
Correlated with better prognosis, CSTA inhibits metastasis of nasopharyngeal carcinoma cells via suppressing AKT signaling through promoting METTL3 degradation.
Liu ZJ, Zheng LS, Li CZ, Peng LX, Mei Y, Lang YH, Xu L, Meng DF, Peng XS, Wang MD, Xie DH, Guo LL, Ding LY, Huang BJ, Qian CN
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166696
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166696
LHPP suppresses proliferation, migration, and invasion in hepatocellular carcinoma and pancreatic cancer by inhibiting EGFR signaling pathway.
Zhu H, Song C, Li J, Liu Q, Liu M, Fu L
Medical oncology (Northwood, London, England) 2023 Jul 31;40(9):257
Medical oncology (Northwood, London, England) 2023 Jul 31;40(9):257
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.
Sha L, Li J, Shen H, Wang Q, Meng P, Zhang X, Deng Y, Zhu W, Xu Q
Cell reports 2023 Aug 29;42(8):112975
Cell reports 2023 Aug 29;42(8):112975
Colitis Is Associated with Loss of the Histidine Phosphatase LHPP and Upregulation of Histidine Phosphorylation in Intestinal Epithelial Cells.
Linder M, Liko D, Kancherla V, Piscuoglio S, Hall MN
Biomedicines 2023 Aug 1;11(8)
Biomedicines 2023 Aug 1;11(8)
LHPP suppresses gastric cancer progression via the PI3K/AKT/mTOR signaling pathway.
Wang D, Li J, Li W
Journal of Cancer 2022;13(14):3584-3592
Journal of Cancer 2022;13(14):3584-3592
Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines.
Ma L, Sun H, Xu X, Chen Y, Zhang L, Li S, Tang L
Journal of physiology and biochemistry 2022 Nov;78(4):807-817
Journal of physiology and biochemistry 2022 Nov;78(4):807-817
Does the LHPP gene share a common biological function in pancancer progression?
Guo K, Tian W, Wang H, Chang D, Dou Y, Yuan J, Chen Y, Hou B
BMC medical genomics 2022 Nov 14;15(1):239
BMC medical genomics 2022 Nov 14;15(1):239
The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis.
Yang X, Meng L, Zhong Y, Hu F, Wang L, Wang M
Aging 2021 Jan 8;13(2):2864-2884
Aging 2021 Jan 8;13(2):2864-2884
The Significance of Circular RNA DDX17 in Prostate Cancer.
Lin Q, Cai J, Wang QQ
BioMed research international 2020;2020:1878431
BioMed research international 2020;2020:1878431
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.
Li J, Xie H, Ying Y, Chen H, Yan H, He L, Xu M, Xu X, Liang Z, Liu B, Wang X, Zheng X, Xie L
Molecular cancer 2020 Oct 29;19(1):152
Molecular cancer 2020 Oct 29;19(1):152
LHPP inhibits hepatocellular carcinoma cell growth and metastasis.
Liao L, Duan D, Liu Y, Chen L
Cell cycle (Georgetown, Tex.) 2020 Jul;19(14):1846-1854
Cell cycle (Georgetown, Tex.) 2020 Jul;19(14):1846-1854
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Hou B, Li W, Li J, Ma J, Xia P, Liu Z, Zeng Q, Zhang X, Chang D
Oncology reports 2020 Feb;43(2):536-548
Oncology reports 2020 Feb;43(2):536-548
LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway.
Li Y, Zhang X, Zhou X, Zhang X
Bioscience reports 2019 Jul 31;39(7)
Bioscience reports 2019 Jul 31;39(7)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 15759-1-AP(LHPP antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using LHPP antibody 15759-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15759-1-AP(LHPP antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15759-1-AP(LHPP antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
