55169-1-AP

antibody from Proteintech Group

Targeting: IL11 AGIF, IL-11

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Antibody Data

Product number

55169-1-AP

Provider

Proteintech Group

Product name

IL-11 antibody

Antibody type

Polyclonal

Description

KD/KO validated IL-11 antibody (Cat. #55169-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

TGF-β1/IL-11 positive loop between renal tubular epithelial cell and fibroblast promotes the ectopic calcification of renal interstitial fibroblasts in rats.

Zhong J, Duan X, Yang H, Liu Z, Zhong W, Zhang Z, Huang Y, Zeng H, Zhao H, Liu Y, Liu Y, Zeng G, Zhao Z
Biochemical pharmacology 2025 Oct;240:117074

---

Targeting VSIG4(+) tissue-resident macrophages enhances T cell cytotoxicity and immunotherapy efficacy in cancer.

Ma Z, Wang Y, Wang W, Wei C, Liu Z, Li Z, Ye Y, Mao Y, Yuan Y, Huang Z, Zhang J, Cao Y, Mao X, Zhang Y, Jin X, Yin J, Li G, Zheng L, Liu Z, Li X, Liang X, Liu Z
Developmental cell 2025 Oct 6;60(19):2594-2610.e5

---

Integrative analysis of the therapeutic mechanisms of Astragaloside IV in idiopathic pulmonary fibrosis via network pharmacology and molecular validation.

Chen S, Yan J, Zhang J, Ma Y, Su Y, Yu Y
Scientific reports 2025 Nov 12;15(1):39624

---

Identification and validation of a novel lymph node metastasis-related model for papillary thyroid carcinoma to predict the prognosis.

Xie CR, Zhang XW, Chen Q, Zhao LF, Huang KM, Wang Y, Yu X
Gland surgery 2025 Aug 31;14(8):1456-1472

---

ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.

Zhuang T, Chen MH, Wu RX, Wang J, Hu XD, Meng T, Wu AH, Li Y, Yang YF, Lei Y, Hu DH, Li YX, Zhang L, Sun AJ, Lu W, Zhang GN, Zuo JL, Ruan CC
Nature communications 2024 Mar 5;15(1):1995

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Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape.

Tang M, Xu M, Wang J, Liu Y, Liang K, Jin Y, Duan W, Xia S, Li G, Chu H, Liu W, Wang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2306348

---

Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy.

Bai X, Chen Q, Li F, Teng Y, Tang M, Huang J, Xu X, Zhang XQ
Nature communications 2024 Aug 10;15(1):6844

---

IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.

Zhao Q, Qian L, Guo Y, Lü J, Li D, Xie H, Wang Q, Ma W, Liu P, Liu Y, Wang T, Wu X, Han J, Yu Z
Theranostics 2023;13(7):2337-2349

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The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis.

Jiang LF, Yang M, Meng HW, Jia PC, Du CL, Liu JY, Lv XW, Cheng-Huang, Li J
Life sciences 2023 Oct 1;330:121974

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Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells.

Zhang C, Teng Y, Li F, Ho W, Bai X, Xu X, Zhang XQ
ACS nano 2023 Aug 8;17(15):14852-14870

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Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.

Bai X, Zhao G, Chen Q, Li Z, Gao M, Ho W, Xu X, Zhang XQ
Science advances 2022 Jun 24;8(25):eabn7162

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Carbon disulfide induced decidualization disorder in the mice uterus at the window of implantation.

Huang F, Wu Y, Zhang D, Liu X, Wang Z
Ecotoxicology and environmental safety 2020 Mar 1;190:110069

---

Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infection.

Li Y, Wu Q, Jin Y, Yang Q
Veterinary research 2019 Dec 21;50(1):111

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human plasma tissue were subjected to SDS PAGE followed by western blot with 55169-1-AP( IL11 Antibody) at dilution of 1:300

Other comments

WB

Appendix

55169-1-AP.pdf

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