Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB218 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal IL-11 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human IL-11 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse IL-11 is observed and no cross-reactivity with recombinant human (rh) IL-6, rhCNTF, rhLIF, rhOSM, rhCLC, or rhCT-1 is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression.
Upregulation of IL-11, an IL-6 Family Cytokine, Promotes Tumor Progression and Correlates with Poor Prognosis in Non-Small Cell Lung Cancer.
Production and characterization of genetically modified human IL-11 variants.
MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.
IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells.
Chen Z, Chen X, Xie R, Huang M, Dong W, Han J, Zhang J, Zhou Q, Li H, Huang J, Lin T
Molecular therapy : the journal of the American Society of Gene Therapy 2019 Feb 6;27(2):326-341
Molecular therapy : the journal of the American Society of Gene Therapy 2019 Feb 6;27(2):326-341
Upregulation of IL-11, an IL-6 Family Cytokine, Promotes Tumor Progression and Correlates with Poor Prognosis in Non-Small Cell Lung Cancer.
Zhao M, Liu Y, Liu R, Qi J, Hou Y, Chang J, Ren L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(6):2213-2224
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(6):2213-2224
Production and characterization of genetically modified human IL-11 variants.
Sano E, Takei T, Ueda T, Tsumoto K
Biochimica et biophysica acta. General subjects 2017 Feb;1861(2):205-217
Biochimica et biophysica acta. General subjects 2017 Feb;1861(2):205-217
MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.
Zhou C, Ji J, Cai Q, Shi M, Chen X, Yu Y, Zhu Z, Zhang J
BMC cancer 2015 May 2;15:343
BMC cancer 2015 May 2;15:343
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.
Bockhorn J, Dalton R, Nwachukwu C, Huang S, Prat A, Yee K, Chang YF, Huo D, Wen Y, Swanson KE, Qiu T, Lu J, Park SY, Dolan ME, Perou CM, Olopade OI, Clarke MF, Greene GL, Liu H
Nature communications 2013;4:1393
Nature communications 2013;4:1393
IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.
Kim JY, Kim M, Ham A, Brown KM, Greene RW, D'Agati VD, Lee HT
Journal of the American Society of Nephrology : JASN 2013 Oct;24(10):1558-70
Journal of the American Society of Nephrology : JASN 2013 Oct;24(10):1558-70
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells.
Onnis B, Fer N, Rapisarda A, Perez VS, Melillo G
The Journal of clinical investigation 2013 Apr;123(4):1615-29
The Journal of clinical investigation 2013 Apr;123(4):1615-29
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by IL-11 and Neutralization by Human IL-11 Antibody. Recombinant Human IL-11 (Catalog # 218-IL) stimulates proliferation in the T11 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-11 (1 ng/mL) is neutralized (green line) by increasing concen-trations of Mouse Anti-Human IL-11 Monoclonal Antibody (Catalog # MAB218). The ND50 is typically 5-15 µg/mL.