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- References [85]
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- Product number
- 10957-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10957-1-AP, RRID:AB_2221670
- Product name
- ACOX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ACOX1 antibody (Cat. #10957-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity.
Gestational supplementation of Bifidobacterium, Lactobacillus, and Streptococcus thermophilus attenuates hepatic steatosis in offspring mice through promoting fatty acid β-oxidation.
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia.
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions.
Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data.
Loss of ACOX1 in clear cell renal cell carcinoma and its correlation with clinical features.
Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice.
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
TM4SF5-mediated abnormal food-intake behavior and apelin expression facilitate non-alcoholic fatty liver disease features.
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy.
Proteomics reveals defective peroxisomal fatty acid oxidation during the progression of acute kidney injury and repair.
Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway.
Hepatic DKK1-driven steatosis is CD36 dependent.
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.
A cottonseed oil-enriched diet improves liver and plasma lipid levels in a male mouse model of fatty liver.
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.
MAPL loss dysregulates bile and liver metabolism in mice.
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
RASAL2 Deficiency Attenuates Hepatic Steatosis by Promoting Hepatic VLDL Secretion via the AKT/TET1/MTTP Axis.
The Adaptive Characteristics of Cholesterol and Bile Acid Metabolism in Nile Tilapia Fed a High-Fat Diet.
Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARα Signaling Pathway.
Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma.
CD147 Mediates 5-Fluorouracil Resistance in Colorectal Cancer by Reprogramming Glycolipid Metabolism.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma.
FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling.
Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect.
Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice.
Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell.
Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease.
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
The Impaired Bioenergetics of Diabetic Cardiac Microvascular Endothelial Cells.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity.
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.
Elucidation of the mechanism of NEFA-induced PERK-eIF2α signaling pathway regulation of lipid metabolism in bovine hepatocytes.
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα.
Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation.
Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".
TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
Impact of discontinuation of fish oil after pioglitazone-fish oil combination therapy in diabetic KK mice.
Hypertensive Rats Treated Chronically With N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology.
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission.
miR-222 targets ACOX1, promotes triglyceride accumulation in hepatocytes.
Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.
MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2.
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase.
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation.
p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure.
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.
Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice.
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.
Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats.
Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells.
Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice.
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.
Yang Y, Yuan W, He K, Lin C, Du S, Kou Y, Nie B
Frontiers in pharmacology 2024;15:1366479
Frontiers in pharmacology 2024;15:1366479
Gestational supplementation of Bifidobacterium, Lactobacillus, and Streptococcus thermophilus attenuates hepatic steatosis in offspring mice through promoting fatty acid β-oxidation.
Chen H, Wu Q, Chen X, Yu X, Zhao H, Huang Q, Huang Y, Wang J, Huang X, Wei J, Wu F, Xiao X, Wang L
Journal of food science 2024 May;89(5):3064-3077
Journal of food science 2024 May;89(5):3064-3077
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia.
Tannoury M, Ayoub M, Dehgane L, Nemazanyy I, Dubois K, Izabelle C, Brousse A, Roos-Weil D, Maloum K, Merle-Béral H, Bauvois B, Saubamea B, Chapiro E, Nguyen-Khac F, Garnier D, Susin SA
Leukemia 2024 Feb;38(2):302-317
Leukemia 2024 Feb;38(2):302-317
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions.
Manandhar L, Dutta RK, Devkota P, Chhetri A, Wei X, Park C, Kwon HM, Park R
Cell communication and signaling : CCS 2024 Feb 21;22(1):142
Cell communication and signaling : CCS 2024 Feb 21;22(1):142
Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data.
Zhao S, Zhang P, Niu S, Xie J, Liu Y, Liu Y, Zhao N, Cheng C, Lu P
Functional & integrative genomics 2024 Apr 10;24(2):72
Functional & integrative genomics 2024 Apr 10;24(2):72
Loss of ACOX1 in clear cell renal cell carcinoma and its correlation with clinical features.
Mo Y, Zhao J, Zhao R, Huang Y, Liang Z, Zhou X, Chu J, Pan X, Duan S, Chen S, Mo L, Huang B, Huang Z, Wei J, Zheng Q, Luo W
Open life sciences 2023;18(1):20220696
Open life sciences 2023;18(1):20220696
Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice.
Gao J, Wang A, Bu X, Jia W
Frontiers in immunology 2023;14:1169869
Frontiers in immunology 2023;14:1169869
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Yamashita A, Ignatenko O, Nguyen M, Lambert R, Watt K, Daneault C, Robillard-Frayne I, Topisirovic I, Rosiers CD, McBride HM
Biology direct 2023 Sep 22;18(1):60
Biology direct 2023 Sep 22;18(1):60
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804
Nature communications 2023 Sep 19;14(1):5804
TM4SF5-mediated abnormal food-intake behavior and apelin expression facilitate non-alcoholic fatty liver disease features.
Pinanga YD, Lee HA, Shin EA, Lee H, Pyo KH, Kim JE, Lee EH, Kim W, Kim S, Kim HY, Lee JW
iScience 2023 Sep 15;26(9):107625
iScience 2023 Sep 15;26(9):107625
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J, Guo J, Zhao J, Hou Y, Ding C
Nature communications 2023 Sep 13;14(1):5670
Nature communications 2023 Sep 13;14(1):5670
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy.
Chaves-Filho AB, Peixoto AS, Castro É, Oliveira TE, Perandini LA, Moreira RJ, da Silva RP, da Silva BP, Moretti EH, Steiner AA, Miyamoto S, Yoshinaga MY, Festuccia WT
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Mar;1868(3):159264
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Mar;1868(3):159264
Proteomics reveals defective peroxisomal fatty acid oxidation during the progression of acute kidney injury and repair.
Chen J, Zheng QY, Wang LM, Luo J, Chen KH, He YN
Heliyon 2023 Jul;9(7):e18134
Heliyon 2023 Jul;9(7):e18134
Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway.
Ding M, Zhou F, Li Y, Liu C, Gu Y, Wu J, Fan G, Li Y, Li X
Chinese herbal medicines 2023 Jul;15(3):421-429
Chinese herbal medicines 2023 Jul;15(3):421-429
Hepatic DKK1-driven steatosis is CD36 dependent.
Yang Z, Huang X, Zhang J, You K, Xiong Y, Fang J, Getachew A, Cheng Z, Yu X, Wang Y, Wu F, Wang N, Feng S, Lin X, Yang F, Chen Y, Wei H, Li YX
Life science alliance 2023 Jan;6(1)
Life science alliance 2023 Jan;6(1)
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
Landowski M, Bhute VJ, Grindel S, Haugstad Z, Gyening YK, Tytanic M, Brush RS, Moyer LJ, Nelson DW, Davis CR, Yen CE, Ikeda S, Agbaga MP, Ikeda A
Communications biology 2023 Jan 4;6(1):8
Communications biology 2023 Jan 4;6(1):8
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.
Bai M, Wu M, Jiang M, He J, Deng X, Xu S, Fan J, Miao M, Wang T, Li Y, Yu X, Wang L, Zhang Y, Huang S, Yang L, Jia Z, Zhang A
EMBO molecular medicine 2023 Feb 8;15(2):e16581
EMBO molecular medicine 2023 Feb 8;15(2):e16581
A cottonseed oil-enriched diet improves liver and plasma lipid levels in a male mouse model of fatty liver.
Son Y, Shockey J, Dowd MK, Shieh JG, Cooper JA, Paton CM
American journal of physiology. Regulatory, integrative and comparative physiology 2023 Feb 1;324(2):R171-R182
American journal of physiology. Regulatory, integrative and comparative physiology 2023 Feb 1;324(2):R171-R182
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.
Yuan T, Xia Y, Pan S, Li B, Ye Z, Yan X, Hu W, Li L, Song B, Yu W, Li H, Rao T, Lin F, Zhou X, Cheng F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Dec;72(12):2111-2126
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Dec;72(12):2111-2126
MAPL loss dysregulates bile and liver metabolism in mice.
Goyon V, Besse-Patin A, Zunino R, Ignatenko O, Nguyen M, Coyaud É, Lee JM, Nguyen BN, Raught B, McBride HM
EMBO reports 2023 Dec 6;24(12):e57972
EMBO reports 2023 Dec 6;24(12):e57972
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Chen H, Ma Y, Qi X, Tian J, Ma Y, Niu T
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Li Y, Liu Y, Chen Z, Tang K, Yang L, Jiang Y, Wang J, Huang P, Wang J, Zheng P, Song H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114319
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Chen H, Qi X, Guan K, Wang R, Li Q, Ma Y
Journal of dairy science 2023 Apr;106(4):2271-2288
Journal of dairy science 2023 Apr;106(4):2271-2288
RASAL2 Deficiency Attenuates Hepatic Steatosis by Promoting Hepatic VLDL Secretion via the AKT/TET1/MTTP Axis.
Ding H, Yu JH, Ge G, Ma YY, Wang JC, Zhang J, Liu J
Journal of clinical and translational hepatology 2023 Apr 28;11(2):261-272
Journal of clinical and translational hepatology 2023 Apr 28;11(2):261-272
The Adaptive Characteristics of Cholesterol and Bile Acid Metabolism in Nile Tilapia Fed a High-Fat Diet.
Li RX, Qian YF, Zhou WH, Wang JX, Zhang YY, Luo Y, Qiao F, Chen LQ, Zhang ML, Du ZY
Aquaculture nutrition 2022;2022:8016616
Aquaculture nutrition 2022;2022:8016616
Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARα Signaling Pathway.
Huang P, Yang L, Liu Y, Jiang Y, Li Y, Chen Z, Song H, Zheng P
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1124901
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1124901
Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice.
Shimizu K, Nishimuta S, Fukumura Y, Michinaga S, Egusa Y, Hase T, Terada T, Sakurai F, Mizuguchi H, Tomita K, Nishinaka T
PloS one 2022;17(9):e0274297
PloS one 2022;17(9):e0274297
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma.
Zhao Z, Zhao Z, Wang J, Zhang H, Xi Z, Xia Q
Frontiers in oncology 2022;12:840287
Frontiers in oncology 2022;12:840287
CD147 Mediates 5-Fluorouracil Resistance in Colorectal Cancer by Reprogramming Glycolipid Metabolism.
Dong S, Li S, Wang X, Liang S, Zhang W, Li L, Xu Q, Shi B, Cheng Z, Zhang X, Zhong M, Zhang G, Hu S
Frontiers in oncology 2022;12:813852
Frontiers in oncology 2022;12:813852
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma.
Tong Y, Sun M, Chen L, Wang Y, Li Y, Li L, Zhang X, Cai Y, Qie J, Pang Y, Xu Z, Zhao J, Zhang X, Liu Y, Tian S, Qin Z, Feng J, Zhang F, Zhu J, Xu Y, Lou W, Ji Y, Zhao J, He F, Hou Y, Ding C
Journal of hematology & oncology 2022 Nov 25;15(1):168
Journal of hematology & oncology 2022 Nov 25;15(1):168
FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling.
Kong Y, Zhao C, Tan P, Liu S, Huang Y, Zeng F, Ma P, Guo Y, Zhao B, Wang J
Animals : an open access journal from MDPI 2022 Apr 6;12(7)
Animals : an open access journal from MDPI 2022 Apr 6;12(7)
Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect.
Klouwer FCC, Falkenberg KD, Ofman R, Koster J, van Gent D, Ferdinandusse S, Wanders RJA, Waterham HR
Frontiers in cell and developmental biology 2021;9:661298
Frontiers in cell and developmental biology 2021;9:661298
Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice.
Lei SS, Zhang NY, Zhou FC, He X, Wang HY, Li LZ, Zheng X, Dong YJ, Luo R, Li B, Jin HY, Yu QX, Lv GY, Chen SH
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6689727
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6689727
Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell.
Mu Y, Maharjan Y, Kumar Dutta R, Wei X, Kim JH, Son J, Park C, Park R
PloS one 2021;16(2):e0245799
PloS one 2021;16(2):e0245799
Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease.
Guo W, Zhong W, Hao L, Dong H, Sun X, Yue R, Li T, Zhou Z
Cellular and molecular gastroenterology and hepatology 2021;12(5):1599-1615
Cellular and molecular gastroenterology and hepatology 2021;12(5):1599-1615
High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease.
Zou M, Chen Y, Zheng Z, Sheng S, Jia Y, Wang X, Ren S, Yang Y, Li X, Dong W, Guan M, Zhang Q, Xue Y
Frontiers in pharmacology 2021;12:741087
Frontiers in pharmacology 2021;12:741087
The Impaired Bioenergetics of Diabetic Cardiac Microvascular Endothelial Cells.
Zhang H, Shen Y, Kim IM, Weintraub NL, Tang Y
Frontiers in endocrinology 2021;12:642857
Frontiers in endocrinology 2021;12:642857
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
Ma C, Wang Z, Xia R, Wei L, Zhang C, Zhang J, Zhao L, Wu H, Kang L, Yang S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity.
Xiong Y, Chen Y, Huang X, Yang Z, Zhang J, Yu X, Fang J, Tao J, You K, Cheng Z, Tan S, Xu Y, Yuan F, Liu Y, Zhuang Y, Yang F, Li Y
Life sciences 2021 Mar 1;268:119000
Life sciences 2021 Mar 1;268:119000
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.
Chen X, Xu Y, Denning KL, Grigore A, Lu Y
Free radical biology & medicine 2021 Jun;169:283-293
Free radical biology & medicine 2021 Jun;169:283-293
Elucidation of the mechanism of NEFA-induced PERK-eIF2α signaling pathway regulation of lipid metabolism in bovine hepatocytes.
Huang Y, Zhao C, Kong Y, Tan P, Liu S, Liu Y, Zeng F, Yuan Y, Zhao B, Wang J
The Journal of steroid biochemistry and molecular biology 2021 Jul;211:105893
The Journal of steroid biochemistry and molecular biology 2021 Jul;211:105893
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Chen N, Mu L, Yang Z, Du C, Wu M, Song S, Yuan C, Shi Y
Journal of cellular physiology 2021 Jan;236(1):625-640
Journal of cellular physiology 2021 Jan;236(1):625-640
CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα.
Zayed MA, Jin X, Yang C, Belaygorod L, Engel C, Desai K, Harroun N, Saffaf O, Patterson BW, Hsu FF, Semenkovich CF
Diabetes 2021 Feb;70(2):549-561
Diabetes 2021 Feb;70(2):549-561
Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation.
Cholico GN, Fling RR, Zacharewski NA, Fader KA, Nault R, Zacharewski TR
Scientific reports 2021 Aug 3;11(1):15689
Scientific reports 2021 Aug 3;11(1):15689
Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".
Han C, Jiang YH, Li W, Liu Y
Journal of ethnopharmacology 2021 Apr 6;269:113768
Journal of ethnopharmacology 2021 Apr 6;269:113768
TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter.
Wang J, Zhang Y, Zhuo Q, Tseng Y, Wang J, Ma Y, Zhang J, Liu J
Nutrition & metabolism 2020;17:46
Nutrition & metabolism 2020;17:46
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
Shen S, Faouzi S, Souquere S, Roy S, Routier E, Libenciuc C, André F, Pierron G, Scoazec JY, Robert C
Cell reports 2020 Nov 24;33(8):108421
Cell reports 2020 Nov 24;33(8):108421
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Xu L, Xia H, Ni D, Hu Y, Liu J, Qin Y, Zhou Q, Yi Q, Xie Y
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
Miyamoto T, Hosoba K, Itabashi T, Iwane AH, Akutsu SN, Ochiai H, Saito Y, Yamamoto T, Matsuura S
The EMBO journal 2020 Jun 17;39(12):e103499
The EMBO journal 2020 Jun 17;39(12):e103499
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ
Molecular cell 2020 Jul 2;79(1):30-42.e4
Molecular cell 2020 Jul 2;79(1):30-42.e4
Impact of discontinuation of fish oil after pioglitazone-fish oil combination therapy in diabetic KK mice.
Iizuka Y, Chiba K, Kim H, Hirako S, Wada M, Matsumoto A
The Journal of nutritional biochemistry 2020 Feb;76:108265
The Journal of nutritional biochemistry 2020 Feb;76:108265
Hypertensive Rats Treated Chronically With N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology.
Li B, He X, Lei SS, Zhou FC, Zhang NY, Chen YH, Wang YZ, Su J, Yu JJ, Li LZ, Zheng X, Luo R, Kołodyńska D, Xiong S, Lv GY, Chen SH
Frontiers in pharmacology 2019;10:1677
Frontiers in pharmacology 2019;10:1677
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4
Gastroenterology 2019 Sep;157(3):744-759.e4
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.
Kumar S, Rani R, Karns R, Gandhi CR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):3825-3840
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):3825-3840
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Luo M, Huang S, Zhang J, Zhang L, Mehmood K, Jiang J, Zhang N, Zhou D
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission.
Park H, He A, Tan M, Johnson JM, Dean JM, Pietka TA, Chen Y, Zhang X, Hsu FF, Razani B, Funai K, Lodhi IJ
The Journal of clinical investigation 2019 Feb 1;129(2):694-711
The Journal of clinical investigation 2019 Feb 1;129(2):694-711
miR-222 targets ACOX1, promotes triglyceride accumulation in hepatocytes.
Wang JJ, Zhang YT, Tseng YJ, Zhang J
Hepatobiliary & pancreatic diseases international : HBPD INT 2019 Aug;18(4):360-365
Hepatobiliary & pancreatic diseases international : HBPD INT 2019 Aug;18(4):360-365
Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.
Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y
American journal of physiology. Gastrointestinal and liver physiology 2019 Apr 1;316(4):G527-G538
American journal of physiology. Gastrointestinal and liver physiology 2019 Apr 1;316(4):G527-G538
MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2.
Lai YH, Liu H, Chiang WF, Chen TW, Chu LJ, Yu JS, Chen SJ, Chen HC, Tan BC
Theranostics 2018;8(2):486-504
Theranostics 2018;8(2):486-504
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase.
Ferdinandusse S, Denis S, van Roermund CWT, Preece MA, Koster J, Ebberink MS, Waterham HR, Wanders RJA
Biochimica et biophysica acta. Molecular basis of disease 2018 Mar;1864(3):952-958
Biochimica et biophysica acta. Molecular basis of disease 2018 Mar;1864(3):952-958
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2018 Jan 11;8(1):408
Scientific reports 2018 Jan 11;8(1):408
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
Lyu Z, Mao Z, Li Q, Xia Y, Liu Y, He Q, Wang Y, Zhao H, Lu Z, Zhou Q
EBioMedicine 2018 Dec;38:178-190
EBioMedicine 2018 Dec;38:178-190
PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation.
Eun SY, Lee JN, Nam IK, Liu ZQ, So HS, Choe SK, Park R
Experimental & molecular medicine 2018 Apr 6;50(4):1-12
Experimental & molecular medicine 2018 Apr 6;50(4):1-12
p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure.
Xiao Y, Wang J, Yan W, Zhou K, Cao Y, Cai W
Cell death & disease 2017 Oct 12;8(10):e3110
Cell death & disease 2017 Oct 12;8(10):e3110
SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.
Sun LN, Zhi Z, Chen LY, Zhou Q, Li XM, Gan WJ, Chen S, Yang M, Liu Y, Shen T, Xu Y, Li JM
Cancer letters 2017 Nov 28;409:104-115
Cancer letters 2017 Nov 28;409:104-115
Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2017 Aug 21;7(1):8976
Scientific reports 2017 Aug 21;7(1):8976
Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice.
Sun Q, Zhang W, Zhong W, Sun X, Zhou Z
Alcoholism, clinical and experimental research 2016 Oct;40(10):2076-2084
Alcoholism, clinical and experimental research 2016 Oct;40(10):2076-2084
Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
Niewiadomski J, Zhou JQ, Roman HB, Liu X, Hirschberger LL, Locasale JW, Stipanuk MH
Annals of the New York Academy of Sciences 2016 Jan;1363(1):99-115
Annals of the New York Academy of Sciences 2016 Jan;1363(1):99-115
Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.
Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Müller C, Calkhoven CF
EMBO reports 2015 Aug;16(8):1022-36
EMBO reports 2015 Aug;16(8):1022-36
Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
Wang Y, Kou Y, Wang X, Cederbaum A, Wang R
PloS one 2014;9(3):e92504
PloS one 2014;9(3):e92504
Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats.
Li Q, Xie G, Zhang W, Zhong W, Sun X, Tan X, Sun X, Jia W, Zhou Z
Alcoholism, clinical and experimental research 2014 Jul;38(7):1982-92
Alcoholism, clinical and experimental research 2014 Jul;38(7):1982-92
Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells.
Kamli MR, Kim J, Pokharel S, Jan AT, Lee EJ, Choi I
Biochemical and biophysical research communications 2014 Aug 8;450(4):1291-6
Biochemical and biophysical research communications 2014 Aug 8;450(4):1291-6
Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice.
Sun X, Tang Y, Tan X, Li Q, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z
American journal of physiology. Gastrointestinal and liver physiology 2012 Mar 1;302(5):G548-57
American journal of physiology. Gastrointestinal and liver physiology 2012 Mar 1;302(5):G548-57
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6739-44
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6739-44
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
Kassmann CM, Quintes S, Rietdorf J, Möbius W, Sereda MW, Nientiedt T, Saher G, Baes M, Nave KA
FEBS letters 2011 Jul 21;585(14):2205-11
FEBS letters 2011 Jul 21;585(14):2205-11
Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.
Guo Y, Zhang X, Huang J, Zeng Y, Liu W, Geng C, Li KW, Yang D, Wu S, Wei H, Han Z, Qian X, Jiang Y, He F
PloS one 2009 Oct 28;4(10):e7641
PloS one 2009 Oct 28;4(10):e7641
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 10957-1-AP(AOX antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 10957-1-AP(AOX antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ACOX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ACOX1. This antibody recognizes human,mouse,rat antigen. The ACOX1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
