BS7916

antibody from Bioworld Technology, Inc
Targeting: CTH
Provider product page for BS7916
Western blot
Immunohistochemistry

Antibody data

Product number
BS7916 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CTH polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CTH.
Description
CTH (cystathionine ÎÛ-lyase), also known as CSE or ÎÛ-cystathionase, is a member of the trans-sulfuration enzyme family and participates in the trans-sulfuration pathway. CTH is a cytoplasmic enzyme produced in the cytosol and is responsible for catalyzing the pyridoxal phosphate-dependent ÉÇ-disulfide elimination reaction resulting in ammonium, pyruvate and thiocysteine. The thiocysteine that is produced may then react with other thiols (or cysteine) and form hydrogen sulfide (H2S). Thus, CTH is the major H2S-producing enzyme in kidney, liver, vascular smooth muscle cells and enterocytes. The endogenous production of H2S plays a significant role in the regulation of cellular functions, including cell growth, hyperpolarization of cell membranes, modulation of neuronal excitability and relaxation of smooth muscle cells. Mutations in the gene encoding CTH can result in the autosomal recessive disease cystathioninuria; a disorder characterized by the unusual accumulation of plasma cystathionine causing increased urinary excretion.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CTH protein structure - BS7916 shown in red.