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- References [29]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 60234-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Gamma Cystathionase antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Gamma Cystathionase antibody (Cat. #60234-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2C7F9
- Vial size
- 20ul, 150ul
Submitted references Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation.
Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.
Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H(2)S levels and further modulating m(6)A.
Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells.
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760.
Hydrogen sulfide attenuates TMAO‑induced macrophage inflammation through increased SIRT1 sulfhydration.
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE(-/-) mice corpus cavernosum microcirculation.
Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy.
Hydrogen sulfide ameliorated preeclampsia via suppression of toll-like receptor 4-activated inflammation in the rostral ventrolateral medulla of rats.
Endogenous and exogenous hydrogen sulfide modulates urothelial bladder carcinoma development in human cell lines.
Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases.
Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.
Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H(2)S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization.
Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.
In vitro evidence for the involvement of H(2)S pathway in the effect of clodronate during inflammatory response.
The Vasoactive Role of Perivascular Adipose Tissue and the Sulfide Signaling Pathway in a Nonobese Model of Metabolic Syndrome.
Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?
Fructose Intake Impairs the Synergistic Vasomotor Manifestation of Nitric Oxide and Hydrogen Sulfide in Rat Aorta.
Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.
Arterial Hypertension and Plasma Glucose Modulate the Vasoactive Effects of Nitroso-Sulfide Coupled Signaling in Human Intrarenal Arteries.
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Decreased Expression of Cystathionine β-Synthase Exacerbates Intestinal Barrier Injury in Ulcerative Colitis.
Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.
Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.
Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.
The novel H(2)S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoK(ATP) channels and reduction of oxidative stress.
Smimmo M, Casale V, Casillo GM, Mitidieri E, d'Emmanuele di Villa Bianca R, Bello I, Schettino A, Montanaro R, Brancaleone V, Indolfi C, Cirino G, Di Lorenzo A, Bucci M, Panza E, Vellecco V
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116466
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116466
Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.
von Mässenhausen A, Schlecht MN, Beer K, Maremonti F, Tonnus W, Belavgeni A, Gavali S, Flade K, Riley JS, Zamora Gonzalez N, Brucker A, Becker JN, Tmava M, Meyer C, Peitzsch M, Hugo C, Gembardt F, Angeli JPF, Bornstein SR, Tait SWG, Linkermann A
Science advances 2024 Mar 15;10(11):eadk7329
Science advances 2024 Mar 15;10(11):eadk7329
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.
Liu M, Zeng C, Zhang Y, Xin Y, Deng S, Hu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116613
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116613
Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H(2)S levels and further modulating m(6)A.
Cui J, Wang X, Dong L, Wang Q
Molecular biology reports 2024 Apr 20;51(1):558
Molecular biology reports 2024 Apr 20;51(1):558
Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells.
Rydz L, Wróbel M, Janik K, Jurkowska H
Biomolecules 2023 Oct 7;13(10)
Biomolecules 2023 Oct 7;13(10)
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760.
Cacanyiova S, Cebova M, Simko F, Baka T, Bernatova I, Kluknavsky M, Zorad S, Krskova K, Shaman E, Zemancikova A, Barta A, Aydemir BG, Berenyiova A
Biological research 2023 Oct 25;56(1):55
Biological research 2023 Oct 25;56(1):55
Hydrogen sulfide attenuates TMAO‑induced macrophage inflammation through increased SIRT1 sulfhydration.
Liu MH, Lin XL, Xiao LL
Molecular medicine reports 2023 Jul;28(1)
Molecular medicine reports 2023 Jul;28(1)
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
Huang S, Chen X, Pan J, Zhang H, Ke J, Gao L, Yu Chang AC, Zhang J, Zhang H
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.
Stokes ME, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, Shen L, Gasparek J, Betzenhauser M, Taylor SJ, Staschke KA, Rigby AC, Mulvihill MJ, Bose N, Lightcap ES, Surguladze D
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Dec 1;29(23):4870-4882
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Dec 1;29(23):4870-4882
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE(-/-) mice corpus cavernosum microcirculation.
Olivencia MA, Esposito E, Brancaleone V, Castaldo S, Cirino G, Pérez-Vizcaino F, Sorrentino R, d'Emmanuele di Villa Bianca R, Mitidieri E
Pharmacological research 2023 Aug;194:106834
Pharmacological research 2023 Aug;194:106834
Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy.
Chen Z, Ouyang C, Zhang H, Gu Y, Deng Y, Du C, Cui C, Li S, Wang W, Kong W, Chen J, Cai J, Geng B
Autophagy 2022 Oct;18(10):2270-2287
Autophagy 2022 Oct;18(10):2270-2287
Hydrogen sulfide ameliorated preeclampsia via suppression of toll-like receptor 4-activated inflammation in the rostral ventrolateral medulla of rats.
Du J, Wang P, Gou Q, Jin S, Xue H, Li D, Tian D, Sun J, Zhang X, Teng X, Wu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113018
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113018
Endogenous and exogenous hydrogen sulfide modulates urothelial bladder carcinoma development in human cell lines.
Panza E, Bello I, Smimmo M, Brancaleone V, Mitidieri E, Bucci M, Cirino G, Sorrentino R, D Emmanuele di Villa Bianca R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113137
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113137
Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases.
Badiei A, Beltran WA, Aguirre GD
Experimental eye research 2022 Feb;215:108902
Experimental eye research 2022 Feb;215:108902
Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.
von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, Beer K, Hannani MT, Lau A, Peitzsch M, Hoppenz P, Locke S, Chavakis T, Kramann R, Muruve DA, Hugo C, Bornstein SR, Linkermann A
Science advances 2022 Feb 4;8(5):eabl8920
Science advances 2022 Feb 4;8(5):eabl8920
Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H(2)S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization.
Berenyiova A, Cebova M, Aydemir BG, Golas S, Majzunova M, Cacanyiova S
International journal of molecular sciences 2022 Aug 16;23(16)
International journal of molecular sciences 2022 Aug 16;23(16)
Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.
Chen S, Bu D, Zhu J, Yue T, Guo S, Wang X, Pan Y, Liu Y, Wang P
Neoplasia (New York, N.Y.) 2021 May;23(5):461-472
Neoplasia (New York, N.Y.) 2021 May;23(5):461-472
In vitro evidence for the involvement of H(2)S pathway in the effect of clodronate during inflammatory response.
Montanaro R, D'Addona A, Izzo A, Ruosi C, Brancaleone V
Scientific reports 2021 Jul 20;11(1):14811
Scientific reports 2021 Jul 20;11(1):14811
The Vasoactive Role of Perivascular Adipose Tissue and the Sulfide Signaling Pathway in a Nonobese Model of Metabolic Syndrome.
Cacanyiova S, Golas S, Zemancikova A, Majzunova M, Cebova M, Malinska H, Hüttl M, Markova I, Berenyiova A
Biomolecules 2021 Jan 15;11(1)
Biomolecules 2021 Jan 15;11(1)
Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?
Berenyiova A, Bernatova I, Zemancikova A, Drobna M, Cebova M, Golas S, Balis P, Liskova S, Valaskova Z, Krskova K, Zorad S, Dayar E, Cacanyiova S
Biomedicines 2021 Dec 24;10(1)
Biomedicines 2021 Dec 24;10(1)
Fructose Intake Impairs the Synergistic Vasomotor Manifestation of Nitric Oxide and Hydrogen Sulfide in Rat Aorta.
Berenyiova A, Golas S, Drobna M, Cebova M, Cacanyiova S
International journal of molecular sciences 2021 Apr 30;22(9)
International journal of molecular sciences 2021 Apr 30;22(9)
Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.
Zhong L, Ding W, Zeng Q, He B, Zhang H, Wang L, Fan J, He S, Zhang Y, Wei A
Oxidative medicine and cellular longevity 2020;2020:7286958
Oxidative medicine and cellular longevity 2020;2020:7286958
Arterial Hypertension and Plasma Glucose Modulate the Vasoactive Effects of Nitroso-Sulfide Coupled Signaling in Human Intrarenal Arteries.
Cacanyiova S, Krskova K, Zorad S, Frimmel K, Drobna M, Valaskova Z, Misak A, Golas S, Breza J, Breza J Jr, Berenyiova A
Molecules (Basel, Switzerland) 2020 Jun 23;25(12)
Molecules (Basel, Switzerland) 2020 Jun 23;25(12)
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
Wang L, Shi H, Liu Y, Zhang W, Duan X, Li M, Shi X, Wang T
International journal of oncology 2019 Aug;55(2):473-487
International journal of oncology 2019 Aug;55(2):473-487
Decreased Expression of Cystathionine β-Synthase Exacerbates Intestinal Barrier Injury in Ulcerative Colitis.
Chen S, Zuo S, Zhu J, Yue T, Bu D, Wang X, Wang P, Pan Y, Liu Y
Journal of Crohn's & colitis 2019 Aug 14;13(8):1067-1080
Journal of Crohn's & colitis 2019 Aug 14;13(8):1067-1080
Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina.
Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD
Experimental eye research 2019 Apr;181:72-84
Experimental eye research 2019 Apr;181:72-84
Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.
Chen X, Zhao X, Lan F, Zhou T, Cai H, Sun H, Kong W, Kong W
Scientific reports 2017 Oct 16;7(1):13248
Scientific reports 2017 Oct 16;7(1):13248
Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.
Leucker TM, Nomura Y, Kim JH, Bhatta A, Wang V, Wecker A, Jandu S, Santhanam L, Berkowitz D, Romer L, Pandey D
American journal of physiology. Heart and circulatory physiology 2017 Apr 1;312(4):H711-H720
American journal of physiology. Heart and circulatory physiology 2017 Apr 1;312(4):H711-H720
The novel H(2)S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoK(ATP) channels and reduction of oxidative stress.
Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Di Cesare Mannelli L, Martelli A, Citi V, Breschi MC, Levi R, Gargini C, Bucci M, Cirino G, Ghelardini C, Calderone V
Pharmacological research 2016 Nov;113(Pt A):290-299
Pharmacological research 2016 Nov;113(Pt A):290-299
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 60234-1-Ig(CSE antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Gamma cystathionase antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human Gamma cystathionase. This antibody recognizes human,mouse, rat antigen. The Gamma cystathionase antibody has been validated for the following applications: ELISA, WB, IHC analysis.
