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Western blotAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- 658302 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#658302, RRID:AB_2562878
- Product name
- Purified anti-SPHK1
- Antibody type
- Monoclonal
- Antigen
- SPHK1 peptide-KLH
- Description
- SPHK1 is a lipid kinase that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P) which is a key sphingolipid signaling molecule involved in cell growth, survival, differentiation, and motility. As an important regulator of ceramide, sphingosine, and S1P, SPHK1 plays important roles in immunological, inflammatory diseases, and cancer. SPHK1 is overexpressed in various types of cancers, and upregulation of SPHK1 has been associated with tumor angiogenesis and resistance to radiation and chemotherapy. Agents targeting the SPHK1 have the potential as therapeutics for cancer, immunological, and inflammatory disorders.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 1A5SC
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Western blot analysis of extracts from Hela (lane 1) and PC-3 (lane 2) cells using anti-SPHK1 antibody (1A5SC). β-actin was used as loading control.
- Conjugate
- Unconjugated
