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- Product number
- 10670-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10670-1-AP, RRID:AB_2195809
- Product name
- SPHK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SPHK1 antibody (Cat. #10670-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury.
Integrated network pharmacology and Chinmedomics reveal the molecular mechanisms of aqueous extract of Eleutherococcus senticosus fruit for treating essential hypertension.
Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization.
Cry2 deficiency leads to cognitive impairment through the microbiota-gut-brain axis mediated S1P/NLRP3/IL-1β pathway in mice.
Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics.
Kummerowia striata extract protects paracetamol-induced liver injury by modulating the S1P/Nrf2/Keap1 pathway.
Evaluation and Characterization of Acute respiratory distress syndrome in tree shrews through TMT proteomic method.
SPHK1-mediated M2 macrophage polarization drives TGF-β1-dependent thrombus fibrosis.
Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor.
The Combination of PF-543 and TRAIL Effectively Induces Apoptotic Cell Death and Inhibits Stem Cell-Like Properties Through the SPHK1/S1PR1/STAT3 Pathway in TRAIL-Resistant Colorectal Cancer Cells.
HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17.
Identification and Validation of a Macrophage Phagocytosis-Related Gene Signature for Prognostic Prediction in Colorectal Cancer (CRC).
Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis.
Mitophagy-mediated S1P facilitates muscle adaptive responses to endurance exercise through SPHK1-S1PR1/S1PR2 in slow-twitch myofibers.
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway.
Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer.
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.
Exosomal SphK1 from colorectal cancer cells promotes cancer cell migration and activates hepatic stellate cells.
Efficient Fabrication of Human Corneal Stromal Cell Spheroids and Promoting Cell Stemness Based on 3D-Printed Derived PDMS Microwell Platform.
Integrative multi-omics reveals the mechanism of ulcerative colitis treated with Ma-Mu-Ran antidiarrheal capsules.
The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling.
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
SPHK1 enhances olaparib resistance in ovarian cancer through the NFκB/NRF2/ferroptosis pathway.
SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatment.
Hypoxia-inducible factor 2α overexpression in podocytes ameliorates lipid metabolism disorders in diabetic kidney disease by inhibiting S1P.
Autophagy-dependent secretion of ENO1 mediates chemoresistance of glioblastoma and tumor microenvironment remodeling.
CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis.
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Hydroxyl safflower yellow A regulates bone-fat balance in osteoporosis by SphK1/S1P/S1PR signaling pathway.
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids.
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization.
Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography.
Rosmarinic Acid Alleviates Radiation-Induced Pulmonary Fibrosis by Downregulating the tRNA N7-Methylguanosine Modification-Regulated Fibroblast-to-Myofibroblast Transition Through the Exosome Pathway.
Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia.
An inducible sphingosine kinase 1 in hepatic stellate cells potentiates liver fibrosis.
Hydroxysafflor yellow A, a natural food pigment, ameliorates atherosclerosis in ApoE(-/-) mice by inhibiting the SphK1/S1P/S1PR3 pathway.
Hepatitis B Virus Increases SphK1-S1P Synthesis by Promoting the Availability of the Transcription Factor USF1.
The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse.
SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.
Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.
Protocol for the isolation of tumor cell-derived extracellular vesicles followed by in vivo metastasis assessment in a murine ovarian cancer model.
SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.
A role for plasma membrane Ca(2+) ATPases in regulation of cellular Ca(2+) homeostasis by sphingosine kinase-1.
Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia-reperfusion injury and remodels sphingosine metabolism.
A multi-omics approach identifies the key role of disorders of sphingolipid metabolism in Ang II-induced hypertensive cardiomyopathy myocardial remodeling.
Sphk1/S1P pathway promotes blood-brain barrier breakdown after intracerebral hemorrhage through inducing Nlrp3-mediated endothelial cell pyroptosis.
ATF3 regulates SPHK1 in cardiomyocyte injury via endoplasmic reticulum stress.
UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1.
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia Cells.
Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer.
A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain.
The preventive effect of mussel oil on gestational diabetes mellitus in pregnant mice fed by a high-fat and high-sucrose diet.
A comprehensive multiomics approach reveals that high levels of sphingolipids in cardiac cachexia adipose tissue are associated with inflammatory and fibrotic changes.
Establishment of a Rat Model of Liver Venous Deprivation: Simultaneous Portal and Hepatic Vein Ligation.
LASS2 impairs proliferation of glioma stem cells and migration and invasion of glioma cells mainly via inhibition of EMT and apoptosis promotion.
Clonorchis sinensis infection induces hepatobiliary injury via disturbing sphingolipid metabolism and activating sphingosine 1-phosphate receptor 2.
Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice.
Metabolomic Analysis Reveals that SPHK1 Promotes Oral Squamous Cell Carcinoma Progression through NF-κB Activation.
Ginkgolide B targets and inhibits creatine kinase B to regulate the CCT/TRiC-SK1 axis and exerts pro-angiogenic activity in middle cerebral artery occlusion mice.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Identifying the mechanisms and molecular targets of Hongjingtian injection on treatment of TGFβ1-induced HK-2 cells: coupling network pharmacology with experimental verification.
Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse Model.
CeO(2) nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics.
Potential of a sphingosine 1-phosphate receptor antagonist and sphingosine kinase inhibitors as targets for multiple myeloma treatment.
Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture.
SphK2/S1P Promotes Metastasis of Triple-Negative Breast Cancer Through the PAK1/LIMK1/Cofilin1 Signaling Pathway.
SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis.
Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation.
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.
POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling.
Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice.
Decreased S1P and SPHK2 are involved in pancreatic acinar cell injury.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages.
SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner.
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2α and sphingosine kinase 1.
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Huang Y, Zhao E, Zhao G, Zhuo W, Zhao Y, Wang H, Lv G, Hu R, Zeng Z, Han S, Hu Y, Zhao G
Theranostics 2026;16(9):4768-4786
Theranostics 2026;16(9):4768-4786
Integrated network pharmacology and Chinmedomics reveal the molecular mechanisms of aqueous extract of Eleutherococcus senticosus fruit for treating essential hypertension.
Li Z, Yang L, Kong L, Sun H, Sun Y, Yin F, Yan G, Wang X
Journal of ethnopharmacology 2026 Jul 15;366:121619
Journal of ethnopharmacology 2026 Jul 15;366:121619
Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization.
Saito J, Dave JM, Gallardo-Vara E, Sadagopan N, Kabir I, Tellides G, Riemer RK, Urban Z, Spiegel S, Hla T, Greif DM
Nature cardiovascular research 2026 Jan;5(1):34-50
Nature cardiovascular research 2026 Jan;5(1):34-50
Cry2 deficiency leads to cognitive impairment through the microbiota-gut-brain axis mediated S1P/NLRP3/IL-1β pathway in mice.
Geng F, Zhao N, Zhou L, Liu XT, Chen X, Wang ZT, Zhang ZJ, Ren QG
Journal of neuroinflammation 2026 Jan 26;23(1):71
Journal of neuroinflammation 2026 Jan 26;23(1):71
Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics.
Chai D, Sun Y, Lu J, Yao Y, Jiang C, Wu L, Cai Q
Neuropsychiatric disease and treatment 2025;21:2035-2052
Neuropsychiatric disease and treatment 2025;21:2035-2052
Kummerowia striata extract protects paracetamol-induced liver injury by modulating the S1P/Nrf2/Keap1 pathway.
Qin H, Chen R, Xie Y, Liu H, Xiao Y, Li L
PloS one 2025;20(8):e0329837
PloS one 2025;20(8):e0329837
Evaluation and Characterization of Acute respiratory distress syndrome in tree shrews through TMT proteomic method.
Xiong J, Zhang L, Xing J, Huang W, Wang N, Lin X, He S, Liao M, He J
PloS one 2025;20(4):e0319752
PloS one 2025;20(4):e0319752
SPHK1-mediated M2 macrophage polarization drives TGF-β1-dependent thrombus fibrosis.
Chen X, Li F, Ma G, Qiang H, Chen M, Chen S, Huang Y, Lai X, Lin Q, Deng C
Frontiers in immunology 2025;16:1681485
Frontiers in immunology 2025;16:1681485
Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor.
Wu F, Feng Z, Wang X, Guo Y, Wu B, Bai S, Lan N, Chen M, Ren J
Frontiers in immunology 2025;16:1564213
Frontiers in immunology 2025;16:1564213
The Combination of PF-543 and TRAIL Effectively Induces Apoptotic Cell Death and Inhibits Stem Cell-Like Properties Through the SPHK1/S1PR1/STAT3 Pathway in TRAIL-Resistant Colorectal Cancer Cells.
Kim SL, Shin MW, Jin BC, Seo SY, Kim SW
Digestive diseases and sciences 2025 Sep;70(9):3041-3055
Digestive diseases and sciences 2025 Sep;70(9):3041-3055
HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17.
Zhang K, Peng X, Zhou P, Li X, Shen L, Yang L, Zhou Q
Oncogene 2025 Sep;44(35):3183-3198
Oncogene 2025 Sep;44(35):3183-3198
Identification and Validation of a Macrophage Phagocytosis-Related Gene Signature for Prognostic Prediction in Colorectal Cancer (CRC).
Zhao X, Tan B, Yang J, Liu S
Current issues in molecular biology 2025 Sep 29;47(10)
Current issues in molecular biology 2025 Sep 29;47(10)
Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis.
Zhan Y, Xu J, Zhang Z, Hu Y, Li Y, Qian J, Ling Y, Wu D, Deng H, Li G, Shen Z, Fang Y
Cancer communications (London, England) 2025 Oct;45(10):1203-1228
Cancer communications (London, England) 2025 Oct;45(10):1203-1228
Mitophagy-mediated S1P facilitates muscle adaptive responses to endurance exercise through SPHK1-S1PR1/S1PR2 in slow-twitch myofibers.
Leng M, Yang F, Zhao J, Xiong Y, Zhou Y, Zhao M, Jia S, Liu L, Zheng Q, Gan L, Ye J, Zheng M
Autophagy 2025 Oct;21(10):2111-2129
Autophagy 2025 Oct;21(10):2111-2129
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
Yuan YX, Chen RJ, Tu GH, Li CQ, Xu LL, Lu YL, Wu LX
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway.
Yao GW, Li CX, Fan YX, Zhuo YZ, Zhang SK, Cui LH
Journal of natural medicines 2025 May;79(3):706-720
Journal of natural medicines 2025 May;79(3):706-720
Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer.
Price ZK, Lokman NA, Morrison J, Mhlanga SN, Sugiyama M, Koya Y, Davies LT, Pitson SM, Oehler MK, Pitman MR, Yoshihara M, Kajiyama H, Ricciardelli C
Journal of cellular and molecular medicine 2025 May;29(9):e70574
Journal of cellular and molecular medicine 2025 May;29(9):e70574
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.
Rao X, Allison DB, Flight RM, Lin P, He D, Li Z, Zhang Y, Wang R, Li C, Wang J, Wang X, Peng J, Fong KW, Shao Q, Wang C, Ali ES, Moseley HN, Liu X
bioRxiv : the preprint server for biology 2025 May 24;
bioRxiv : the preprint server for biology 2025 May 24;
Exosomal SphK1 from colorectal cancer cells promotes cancer cell migration and activates hepatic stellate cells.
Zhang W, Xu C
Molecular medicine reports 2025 Mar;31(3)
Molecular medicine reports 2025 Mar;31(3)
Efficient Fabrication of Human Corneal Stromal Cell Spheroids and Promoting Cell Stemness Based on 3D-Printed Derived PDMS Microwell Platform.
Chen Y, Gu J, Cui Z, Sun X, Liang Y, Duan C, Li X, Su Z, Zhang B, Chen J, Wang Z
Biomolecules 2025 Mar 19;15(3)
Biomolecules 2025 Mar 19;15(3)
Integrative multi-omics reveals the mechanism of ulcerative colitis treated with Ma-Mu-Ran antidiarrheal capsules.
Huang H, Duan B, Huang Z, Wang S, Wen Y, Jiang Q, Chen P, Huang P, Liu J, Zheng S, Ye Y, Zhang D, Wang Q, Huang F, Li J, Han L
Rapid communications in mass spectrometry : RCM 2025 Mar 15;39(5):e9939
Rapid communications in mass spectrometry : RCM 2025 Mar 15;39(5):e9939
The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling.
Lockett AD, Snow A, Adogamhe P, Sysol J, Yadav M, Mubuuke T, Gomes MT, Cook T, Fisher A, Aldred MA, Machado RF
bioRxiv : the preprint server for biology 2025 Jun 11;
bioRxiv : the preprint server for biology 2025 Jun 11;
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway.
Zhang X, Zhang H, Wang J, Chen Y, Lin J, Wang Q, Wu C, Chen H, Lin Y
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e70001
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e70001
SPHK1 enhances olaparib resistance in ovarian cancer through the NFκB/NRF2/ferroptosis pathway.
Teng K, Ma H, Gai P, Zhao X, Qi G
Cell death discovery 2025 Jan 28;11(1):29
Cell death discovery 2025 Jan 28;11(1):29
SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatment.
Zhang J, Ge Q, Du T, Kuang Y, Fan Z, Jia X, Gu W, Chen Z, Wei Z, Shen B
Life science alliance 2025 Feb;8(2)
Life science alliance 2025 Feb;8(2)
Hypoxia-inducible factor 2α overexpression in podocytes ameliorates lipid metabolism disorders in diabetic kidney disease by inhibiting S1P.
Yang X, Wang Q, Nie H, Wang M, Wang Y, Li S, Liu Q, Liu G
Renal failure 2025 Dec;47(1):2568972
Renal failure 2025 Dec;47(1):2568972
Autophagy-dependent secretion of ENO1 mediates chemoresistance of glioblastoma and tumor microenvironment remodeling.
Xie Q, Chen L, Huang Y, Yu Z, Zhu R, Li J, Zhao J, Song Y, Li H, Lu Y
Cell death & disease 2025 Dec 6;17(1):79
Cell death & disease 2025 Dec 6;17(1):79
CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis.
Wang Y, Chen X, You G, Yu S, Chen C, Lian R, Diao L, Li Y, Yin T
Journal of translational medicine 2025 Dec 17;24(1):98
Journal of translational medicine 2025 Dec 17;24(1):98
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Chen H, Duan Z, Jia Q, Zhang X, Xu D, Zheng L, Qi Z, Yang Y, Yang L, Wu C
Molecular neurobiology 2025 Aug;62(8):10834-10855
Molecular neurobiology 2025 Aug;62(8):10834-10855
Hydroxyl safflower yellow A regulates bone-fat balance in osteoporosis by SphK1/S1P/S1PR signaling pathway.
Xu X, Hu X, Zhou S, Liu J, Su Z, Zheng Z, Luo D
Biochemical pharmacology 2025 Aug 20;242(Pt 1):117258
Biochemical pharmacology 2025 Aug 20;242(Pt 1):117258
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids.
Ke MH, Huang SY, Lin WG, Xu ZG, Zheng XX, Liu XB, Cheng YM, Li ZF
World journal of gastrointestinal surgery 2025 Apr 27;17(4):103494
World journal of gastrointestinal surgery 2025 Apr 27;17(4):103494
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization.
Ding X, Zhang X, Cao J, Chen S, Chen Y, Yuan K, Chen B, Yang G, Li S, Yang J, Wang G, Tacke F, Lan T
Cellular and molecular gastroenterology and hepatology 2024;18(6):101406
Cellular and molecular gastroenterology and hepatology 2024;18(6):101406
Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography.
Fang X, Yin Y, Lun H, Liu Y, Zhu S
Journal of pain research 2024;17:609-621
Journal of pain research 2024;17:609-621
Rosmarinic Acid Alleviates Radiation-Induced Pulmonary Fibrosis by Downregulating the tRNA N7-Methylguanosine Modification-Regulated Fibroblast-to-Myofibroblast Transition Through the Exosome Pathway.
Zhang T, Mi J, Qin X, Ouyang Z, Wang Y, Li Z, He S, Hu K, Wang R, Huang W
Journal of inflammation research 2024;17:5567-5586
Journal of inflammation research 2024;17:5567-5586
Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia.
Yu S, Ye Y, Wuren T, Yi H
Frontiers in physiology 2024;15:1359357
Frontiers in physiology 2024;15:1359357
An inducible sphingosine kinase 1 in hepatic stellate cells potentiates liver fibrosis.
Baek JS, Lee JH, Kim JH, Cho SS, Kim YS, Yang JH, Shin EJ, Kang HG, Kim SJ, Ahn SG, Park EY, Baek DJ, Yim SK, Kang KW, Ki SH, Kim KM
Biochemical pharmacology 2024 Nov;229:116520
Biochemical pharmacology 2024 Nov;229:116520
Hydroxysafflor yellow A, a natural food pigment, ameliorates atherosclerosis in ApoE(-/-) mice by inhibiting the SphK1/S1P/S1PR3 pathway.
Liu Y, Piao J, He J, Su Z, Luo Z, Luo D
Food science & nutrition 2024 Nov;12(11):8939-8955
Food science & nutrition 2024 Nov;12(11):8939-8955
Hepatitis B Virus Increases SphK1-S1P Synthesis by Promoting the Availability of the Transcription Factor USF1.
Zhang L, Song YH, Liu J, Zhao YX, Zhou RR, Xu JC, He J, Lu YL, Gan WJ, Lu XS, Li M, Zhou P, Wang L, Han QZ
Journal of immunology (Baltimore, Md. : 1950) 2024 Nov 15;213(10):1499-1507
Journal of immunology (Baltimore, Md. : 1950) 2024 Nov 15;213(10):1499-1507
The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse.
Frost K, Lewis JW, Jones SW, Edwards JR, Naylor AJ, McGettrick HM
International journal of molecular sciences 2024 May 8;25(10)
International journal of molecular sciences 2024 May 8;25(10)
SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.
Chen D, Wu J, Qiu X, Luo S, Huang S, Wei E, Qin M, Huang J, Liu S
Cancer gene therapy 2024 Mar;31(3):410-419
Cancer gene therapy 2024 Mar;31(3):410-419
Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.
Sudhadevi T, Ackerman SJ, Jafri A, Basa P, Ha AW, Natarajan V, Harijith A
American journal of physiology. Lung cellular and molecular physiology 2024 Mar 1;326(3):L377-L392
American journal of physiology. Lung cellular and molecular physiology 2024 Mar 1;326(3):L377-L392
Protocol for the isolation of tumor cell-derived extracellular vesicles followed by in vivo metastasis assessment in a murine ovarian cancer model.
Mittal S, Kumar S, Gupta P, Singh M, Chaluvally-Raghavan P, Pradeep S
STAR protocols 2024 Jun 21;5(2):102943
STAR protocols 2024 Jun 21;5(2):102943
SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.
Zhao T, Ding T, Sun Z, Shao X, Li S, Lu H, Yuan JH, Guo Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417
A role for plasma membrane Ca(2+) ATPases in regulation of cellular Ca(2+) homeostasis by sphingosine kinase-1.
Volk LM, Bruun JE, Trautmann S, Thomas D, Schwalm S, Pfeilschifter J, Zu Heringdorf DM
Pflugers Archiv : European journal of physiology 2024 Dec;476(12):1895-1911
Pflugers Archiv : European journal of physiology 2024 Dec;476(12):1895-1911
Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia-reperfusion injury and remodels sphingosine metabolism.
Xu W, Hou L
Clinical and experimental nephrology 2024 Dec;28(12):1241-1253
Clinical and experimental nephrology 2024 Dec;28(12):1241-1253
A multi-omics approach identifies the key role of disorders of sphingolipid metabolism in Ang II-induced hypertensive cardiomyopathy myocardial remodeling.
Qu Y, Ma D, Wu T, Wang H, Tian Z, Liu X, Wang Y
Scientific reports 2024 Dec 5;14(1):30379
Scientific reports 2024 Dec 5;14(1):30379
Sphk1/S1P pathway promotes blood-brain barrier breakdown after intracerebral hemorrhage through inducing Nlrp3-mediated endothelial cell pyroptosis.
Feng M, An Y, Qin Q, Fong IH, Zhang K, Wang F, Song D, Li M, Yu M, Yeh CT, Chang J, Guo F
Cell death & disease 2024 Dec 23;15(12):926
Cell death & disease 2024 Dec 23;15(12):926
ATF3 regulates SPHK1 in cardiomyocyte injury via endoplasmic reticulum stress.
Chen H, Luo S, Chen H, Zhang C
Immunity, inflammation and disease 2023 Sep;11(9):e998
Immunity, inflammation and disease 2023 Sep;11(9):e998
UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1.
Epshtein Y, Mathew B, Chen W, Jacobson JR
Cells 2023 Oct 5;12(19)
Cells 2023 Oct 5;12(19)
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921
Redox biology 2023 Nov;67:102921
Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia Cells.
Standoli S, Rapino C, Di Meo C, Rudowski A, Kämpfer-Kolb N, Volk LM, Thomas D, Trautmann S, Schreiber Y, Meyer Zu Heringdorf D, Maccarrone M
International journal of molecular sciences 2023 May 9;24(10)
International journal of molecular sciences 2023 May 9;24(10)
Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer.
Zhang E, Ding C, Li S, Aikemu B, Zhou X, Fan X, Sun J, Yang X, Zheng M
Cancer cell international 2023 May 18;23(1):96
Cancer cell international 2023 May 18;23(1):96
A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain.
Liu B, Wu W, Cui L, Zheng X, Li N, Zhang X, Duan G
iScience 2023 Jun 16;26(6):106989
iScience 2023 Jun 16;26(6):106989
The preventive effect of mussel oil on gestational diabetes mellitus in pregnant mice fed by a high-fat and high-sucrose diet.
Li K, Li H, Song X, Kuang X, Liu S, Zhu S, Li D
Food & function 2023 Jan 23;14(2):1198-1208
Food & function 2023 Jan 23;14(2):1198-1208
A comprehensive multiomics approach reveals that high levels of sphingolipids in cardiac cachexia adipose tissue are associated with inflammatory and fibrotic changes.
Qu Y, Wang Y, Wu T, Liu X, Wang H, Ma D
Lipids in health and disease 2023 Dec 1;22(1):211
Lipids in health and disease 2023 Dec 1;22(1):211
Establishment of a Rat Model of Liver Venous Deprivation: Simultaneous Portal and Hepatic Vein Ligation.
Zhang Y, He X, Ma P, Xiong L, Bai W, Zhang G, Xu Y, Song W, Yu K
Journal of clinical and translational hepatology 2023 Apr 28;11(2):393-404
Journal of clinical and translational hepatology 2023 Apr 28;11(2):393-404
LASS2 impairs proliferation of glioma stem cells and migration and invasion of glioma cells mainly via inhibition of EMT and apoptosis promotion.
Zhao WJ, Fan YP, Ou GY, Qiao XY
Journal of Cancer 2022;13(7):2281-2292
Journal of Cancer 2022;13(7):2281-2292
Clonorchis sinensis infection induces hepatobiliary injury via disturbing sphingolipid metabolism and activating sphingosine 1-phosphate receptor 2.
Liu JX, Liu M, Yu GZ, Zhao QQ, Wang JL, Sun YH, Koda S, Zhang B, Yu Q, Yan C, Tang RX, Jiang ZH, Zheng KY
Frontiers in cellular and infection microbiology 2022;12:1011378
Frontiers in cellular and infection microbiology 2022;12:1011378
Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice.
Gan PR, Wang RH, Deng R, Wu H, Bu YH, Chen FY, Dong XT, Ke JT
European journal of pharmacology 2022 Oct 15;933:175271
European journal of pharmacology 2022 Oct 15;933:175271
Metabolomic Analysis Reveals that SPHK1 Promotes Oral Squamous Cell Carcinoma Progression through NF-κB Activation.
Hou CX, Mao GY, Sun QW, Meng Y, Zhu QH, Tang YT, Han W, Sun NN, Song XM, Wang CX, Ye JH
Annals of surgical oncology 2022 Nov;29(12):7386-7399
Annals of surgical oncology 2022 Nov;29(12):7386-7399
Ginkgolide B targets and inhibits creatine kinase B to regulate the CCT/TRiC-SK1 axis and exerts pro-angiogenic activity in middle cerebral artery occlusion mice.
Zhu J, Jin Z, Yang L, Zhao C, Hu J, Chen J, Han Y, Yu P, Luo J, Kong L, Zhang C
Pharmacological research 2022 Jun;180:106240
Pharmacological research 2022 Jun;180:106240
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
Identifying the mechanisms and molecular targets of Hongjingtian injection on treatment of TGFβ1-induced HK-2 cells: coupling network pharmacology with experimental verification.
Sun G, Jiao M, Cui Y, Liang X, Liang X, Zhang S, Guo C
Annals of translational medicine 2022 Dec;10(24):1329
Annals of translational medicine 2022 Dec;10(24):1329
Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse Model.
Li Q, Shi Y, Li X, Yang Y, Zhang X, Xu L, Ma Z, Wang J, Fan L, Wu L
International journal of molecular sciences 2022 Dec 4;23(23)
International journal of molecular sciences 2022 Dec 4;23(23)
CeO(2) nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics.
Cui L, Wang X, Zhao X, Sun B, Xia T, Hu S
Nano today 2022 Aug;45
Nano today 2022 Aug;45
Potential of a sphingosine 1-phosphate receptor antagonist and sphingosine kinase inhibitors as targets for multiple myeloma treatment.
Tanaka Y, Okabe S, Ohyashiki K, Gotoh A
Oncology letters 2022 Apr;23(4):111
Oncology letters 2022 Apr;23(4):111
Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture.
Pan G, Liao M, Dai Y, Li Y, Yan X, Mai W, Liu J, Liao Y, Qiu Z, Zhou Z
Frontiers in cardiovascular medicine 2021;8:748486
Frontiers in cardiovascular medicine 2021;8:748486
SphK2/S1P Promotes Metastasis of Triple-Negative Breast Cancer Through the PAK1/LIMK1/Cofilin1 Signaling Pathway.
Shi W, Ma D, Cao Y, Hu L, Liu S, Yan D, Zhang S, Zhang G, Wang Z, Wu J, Jiang C
Frontiers in molecular biosciences 2021;8:598218
Frontiers in molecular biosciences 2021;8:598218
SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis.
Qin Z, Tong H, Li T, Cao H, Zhu J, Yin S, He W
International journal of molecular medicine 2021 Nov;48(5)
International journal of molecular medicine 2021 Nov;48(5)
Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation.
Chen L, Ye A, Liu X, Lu J, Xie Q, Guo Y, Sun W
Ecotoxicology and environmental safety 2021 Nov;224:112704
Ecotoxicology and environmental safety 2021 Nov;224:112704
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.
Wang X, Yang G
Cell biology international 2021 Apr;45(4):775-784
Cell biology international 2021 Apr;45(4):775-784
POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling.
Shen Z, Feng X, Fang Y, Li Y, Li Z, Zhan Y, Lin M, Li G, Ding Y, Deng H
Cell death & disease 2019 Nov 13;10(11):863
Cell death & disease 2019 Nov 13;10(11):863
Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice.
Qiang GH, Wang ZX, Ji AL, Wu JY, Cao Y, Zhang G, Zhang YY, Jiang CP
Hepatobiliary & pancreatic diseases international : HBPD INT 2019 Jun;18(3):255-265
Hepatobiliary & pancreatic diseases international : HBPD INT 2019 Jun;18(3):255-265
Decreased S1P and SPHK2 are involved in pancreatic acinar cell injury.
Xiao J, Lin H, Liu B, Xia Z, Zhang J, Jin J
Biomarkers in medicine 2019 Jun;13(8):627-637
Biomarkers in medicine 2019 Jun;13(8):627-637
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Liu SQ, Xu CY, Wu WH, Fu ZH, He SW, Qin MB, Huang JA
International journal of oncology 2019 Jan;54(1):41-52
International journal of oncology 2019 Jan;54(1):41-52
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Pang HQ, Yue SJ, Tang YP, Chen YY, Tan YJ, Cao YJ, Shi XQ, Zhou GS, Kang A, Huang SL, Shi YJ, Sun J, Tang ZS, Duan JA
Frontiers in pharmacology 2018;9:165
Frontiers in pharmacology 2018;9:165
Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages.
Qiu Z, Yuan H, Li N, Yang X, Hu X, Su F, Chen B
Molecular medicine reports 2018 Dec;18(6):5399-5408
Molecular medicine reports 2018 Dec;18(6):5399-5408
SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.
Xu CY, Liu SQ, Qin MB, Zhuge CF, Qin L, Qin N, Lai MY, Huang JA
International journal of molecular medicine 2017 May;39(5):1277-1284
International journal of molecular medicine 2017 May;39(5):1277-1284
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
Lu Z, Xiao Z, Liu F, Cui M, Li W, Yang Z, Li J, Ye L, Zhang X
Oncotarget 2016 Jan 5;7(1):241-54
Oncotarget 2016 Jan 5;7(1):241-54
ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner.
Liu X, Ren K, Suo R, Xiong SL, Zhang QH, Mo ZC, Tang ZL, Jiang Y, Peng XS, Yi GH
Journal of physiology and biochemistry 2016 Dec;72(4):657-667
Journal of physiology and biochemistry 2016 Dec;72(4):657-667
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2α and sphingosine kinase 1.
Lu ZP, Xiao ZL, Yang Z, Li J, Feng GX, Chen FQ, Li YH, Feng JY, Gao YE, Ye LH, Zhang XD
Acta pharmacologica Sinica 2015 Oct;36(10):1228-36
Acta pharmacologica Sinica 2015 Oct;36(10):1228-36
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
Lu Z, Zhang W, Gao S, Jiang Q, Xiao Z, Ye L, Zhang X
Biochemical and biophysical research communications 2015 Dec 4-11;468(1-2):8-13
Biochemical and biophysical research communications 2015 Dec 4-11;468(1-2):8-13
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K, Hla T
The Journal of biological chemistry 2003 Nov 21;278(47):47281-90
The Journal of biological chemistry 2003 Nov 21;278(47):47281-90
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPHK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SPHK1. This antibody recognizes human,mouse,rat antigen. The SPHK1 antibody has been validated for the following applications: ELISA, IHC analysis.
