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- References [14]
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- Product number
- 19561-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19561-1-AP, RRID:AB_10950399
- Product name
- Phospho-SPHK1 (Ser225) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Phospho-SPHK1 (Ser225) antibody (Cat. #19561-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 100ul
Submitted references Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia.
Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice.
Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1.
Geniposide alleviates VEGF-induced angiogenesis by inhibiting VEGFR2/PKC/ERK1/2-mediated SphK1 translocation.
Endogenous Ca(2+) release was involved in 50-Hz MF-induced proliferation via Akt-SK1 signal cascade in human amniotic epithelial cells.
Cell fate determined by the activation balance between PKR and SPHK1.
Geniposide downregulates the VEGF/SphK1/S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro.
Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation.
A 50-Hz magnetic-field exposure promotes human amniotic cells proliferation via SphK-S1P-S1PR cascade mediated ERK signaling pathway.
POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling.
Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift.
Involvement of released sphingosine 1-phosphate/sphingosine 1-phosphate receptor axis in skeletal muscle atrophy.
Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation.
Yu S, Ye Y, Wuren T, Yi H
Frontiers in physiology 2024;15:1359357
Frontiers in physiology 2024;15:1359357
Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y
Journal of translational medicine 2024 Jan 10;22(1):43
Journal of translational medicine 2024 Jan 10;22(1):43
Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice.
Gan PR, Wang RH, Deng R, Wu H, Bu YH, Chen FY, Dong XT, Ke JT
European journal of pharmacology 2022 Oct 15;933:175271
European journal of pharmacology 2022 Oct 15;933:175271
Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1.
Gao S, Guo T, Luo S, Zhang Y, Ren Z, Lang X, Hu G, Zuo D, Jia W, Kong D, Yu H, Qiu Y
Biomolecules & therapeutics 2022 Nov 1;30(6):553-561
Biomolecules & therapeutics 2022 Nov 1;30(6):553-561
Geniposide alleviates VEGF-induced angiogenesis by inhibiting VEGFR2/PKC/ERK1/2-mediated SphK1 translocation.
Wang Y, Wu H, Gui BJ, Liu J, Rong GX, Deng R, Bu YH, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154068
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154068
Endogenous Ca(2+) release was involved in 50-Hz MF-induced proliferation via Akt-SK1 signal cascade in human amniotic epithelial cells.
Ye AF, Liu XC, Chen LJ, Xia YP, Yang XB, Sun WJ
Electromagnetic biology and medicine 2022 Apr 3;41(2):142-151
Electromagnetic biology and medicine 2022 Apr 3;41(2):142-151
Cell fate determined by the activation balance between PKR and SPHK1.
Qiao H, Jiang T, Mu P, Chen X, Wen X, Hu Z, Tang S, Wen J, Deng Y
Cell death and differentiation 2021 Jan;28(1):401-418
Cell death and differentiation 2021 Jan;28(1):401-418
Geniposide downregulates the VEGF/SphK1/S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro.
Wang Y, Wu H, Deng R, Dai XJ, Bu YH, Sun MH, Zhang H, Wang MD, Wang RH
Phytotherapy research : PTR 2021 Aug;35(8):4347-4362
Phytotherapy research : PTR 2021 Aug;35(8):4347-4362
Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation.
Chen L, Ye A, Liu X, Lu J, Xie Q, Guo Y, Sun W
Ecotoxicology and environmental safety 2021 Aug 26;224:112704
Ecotoxicology and environmental safety 2021 Aug 26;224:112704
A 50-Hz magnetic-field exposure promotes human amniotic cells proliferation via SphK-S1P-S1PR cascade mediated ERK signaling pathway.
Chen L, Xia Y, Lu J, Xie Q, Ye A, Sun W
Ecotoxicology and environmental safety 2020 May;194:110407
Ecotoxicology and environmental safety 2020 May;194:110407
POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling.
Shen Z, Feng X, Fang Y, Li Y, Li Z, Zhan Y, Lin M, Li G, Ding Y, Deng H
Cell death & disease 2019 Nov 13;10(11):863
Cell death & disease 2019 Nov 13;10(11):863
Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift.
Speirs MMP, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, Andersen JL, Prince JT, Price JC
Oncotarget 2019 Jan 11;10(4):449-479
Oncotarget 2019 Jan 11;10(4):449-479
Involvement of released sphingosine 1-phosphate/sphingosine 1-phosphate receptor axis in skeletal muscle atrophy.
Pierucci F, Frati A, Battistini C, Matteini F, Iachini MC, Vestri A, Penna F, Costelli P, Meacci E
Biochimica et biophysica acta. Molecular basis of disease 2018 Dec;1864(12):3598-3614
Biochimica et biophysica acta. Molecular basis of disease 2018 Dec;1864(12):3598-3614
Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation.
Chowdhury A, Sarkar J, Pramanik PK, Chakraborti T, Chakraborti S
Archives of biochemistry and biophysics 2016 Aug 1;603:91-101
Archives of biochemistry and biophysics 2016 Aug 1;603:91-101
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPHK1-Phospho-Ser225 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human SPHK1-Phospho-Ser225. This antibody recognizes human antigen. The SPHK1-Phospho-Ser225 antibody has been validated for the following applications: ELISA, WB analysis.
