Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [245]
- Comments [0]
- Validations
- Western blot [8]
- Immunohistochemistry [4]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NB100-2331 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-2331, RRID:AB_10001955
- Product name
- Rabbit Polyclonal LC3A Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. This antibody detects both LC3A and LC3B.
- Reactivity
- Human, Mouse, Rat, Canine, Zebrafish
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas.
Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis.
BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury.
Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice.
Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury.
Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages.
Autophagy in Zebrafish Extraocular Muscle Regeneration.
Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model.
Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish.
Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species-induced apoptosis and reduces cell stemness.
Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.
MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.
The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection.
Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy.
Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma.
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy.
Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival.
Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model.
A Rodent Model of Anxiety: The Effect of Perinatal Immune Challenges on Gastrointestinal Inflammation and Integrity.
Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers.
Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo.
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.
Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation.
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer.
Autophagy-lysosomal defect in human CADASIL vascular smooth muscle cells.
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
The programmed DNA elimination and formation of micronuclei in germ line cells of the natural hybridogenetic water frog Pelophylax esculentus.
Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection.
Extracellular DNA promotes colorectal tumor cell survival after cytotoxic chemotherapy.
TRIM50 regulates Beclin 1 proautophagic activity.
Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.
Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney.
Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart.
Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2.
Unraveling mitotic protein networks by 3D multiplexed epitope drug screening.
Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice.
A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.
Monitoring Autophagy in Muscle Stem Cells.
Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy.
Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice.
Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation.
Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice.
(±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice.
Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14L156R is rescued by starvation and inhibition of vacuolar-ATPase.
TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.
Autophagy regulates UBC9 levels during viral-mediated tumorigenesis.
p62 improves AD-like pathology by increasing autophagy.
Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.
Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis.
Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation.
Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics.
Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1.
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress.
β-catenin promotes intracellular bacterial killing via suppression of Pseudomonas aeruginosa-triggered macrophage autophagy.
Protein Kinase Cδ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity.
PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux.
A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.
Inhibitory effects of silibinin on proliferation and lung metastasis of human high metastasis cell line of salivary gland adenoid cystic carcinoma via autophagy induction.
Icariin Attenuates OGD/R-Induced Autophagy via Bcl-2-Dependent Cross Talk between Apoptosis and Autophagy in PC12 Cells.
MAVS maintains mitochondrial homeostasis via autophagy.
Up-Regulated Expression of LAMP2 and Autophagy Activity during Neuroendocrine Differentiation of Prostate Cancer LNCaP Cells.
PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells.
Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma.
CpG-ODN promotes phagocytosis and autophagy through JNK/P38 signal pathway in Staphylococcus aureus-stimulated macrophage.
PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.
Accumulated α-synuclein affects the progression of GM2 gangliosidoses.
Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration.
Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion.
FANCD2 protects against bone marrow injury from ferroptosis.
Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.
mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
Autophagy maintains stemness by preventing senescence.
Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish.
Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.
Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization.
Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function.
Reduction of polyethylenimine-coated iron oxide nanoparticles induced autophagy and cytotoxicity by lactosylation.
Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation.
RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy.
Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells.
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.
HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2.
Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed.
Immunohistochemical detection of autophagy-related microtubule-associated protein 1 light chain 3 (LC3) in the cerebellums of dogs naturally infected with canine distemper virus.
Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation.
Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.
Transforming Growth Factor TGFβ Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas.
Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice.
The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions.
Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes.
Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner.
Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.
Effects of resveratrol on growth and skeletal muscle physiology of juvenile southern flounder.
Autophagy in zebrafish.
The viral restriction factor tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy.
The synergistic effect of SAHA and parthenolide in MDA-MB231 breast cancer cells.
Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways.
Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.
Tamoxifen improves cytopathic effect of oncolytic adenovirus in primary glioblastoma cells mediated through autophagy.
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation.
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction.
Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine.
Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a.
Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin.
Acute, delayed and chronic remote ischemic conditioning is associated with downregulation of mTOR and enhanced autophagy signaling.
MicroRNA-144 is a circulating effector of remote ischemic preconditioning.
Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.
Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.
Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.
Autophagy-related gene expression analysis of wild-type and atg5 gene knockout mouse embryonic fibroblast cells treated with polyethylenimine.
Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity.
Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis.
Hereditary myopathy with early respiratory failure: occurrence in various populations.
Inhibition of autophagy augments the anticancer activity of α-mangostin in chronic myeloid leukemia cells.
Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation.
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.
The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease.
Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation.
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
Fibronectin peptides that bind PDGF-BB enhance survival of cells and tissue under stress.
ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss.
JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes.
MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb.
Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death.
Mitochondrial DNA damage via augmented oxidative stress regulates endoplasmic reticulum stress and autophagy: crosstalk, links and signaling.
MIR376A is a regulator of starvation-induced autophagy.
The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer.
Regulation of endoplasmic reticulum stress in rat cortex by p62/ZIP through the Keap1-Nrf2-ARE signalling pathway after transient focal cerebral ischaemia.
The emerging links between sirtuins and autophagy.
Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability.
A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.
Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer.
Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells.
Manipulation of autophagy by HCMV infection is involved in mTOR and influences the replication of virus.
Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours.
IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments.
Immunohistochemical analysis of macroautophagy: recommendations and limitations.
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.
A modified HSP70 inhibitor shows broad activity as an anticancer agent.
Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model.
The activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells.
Identification of a candidate therapeutic autophagy-inducing peptide.
Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.
Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.
TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells.
ATG proteins mediate efferocytosis and suppress inflammation in mammary involution.
Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies.
Azurophil granule proteins constitute the major mycobactericidal proteins in human neutrophils and enhance the killing of mycobacteria in macrophages.
Englerin a selectively induces necrosis in human renal cancer cells.
Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis.
Vibrio parahaemolyticus ExsE is requisite for initial adhesion and subsequent type III secretion system 1-dependent autophagy in HeLa cells.
E2F-1 lacking the transcriptional activity domain induces autophagy.
Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure.
Exercise induces autophagy in peripheral tissues and in the brain.
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.
TG2 transamidating activity acts as a reostat controlling the interplay between apoptosis and autophagy.
Everolimus triggers cytokine release by macrophages: rationale for stents eluting everolimus and a glucocorticoid.
Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
Hoechst 33342-induced autophagy protected HeLa cells from caspase-independent cell death with the participation of ROS.
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
Cardiac mTOR protects the heart against ischemia-reperfusion injury.
A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice.
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy.
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Autophagic activity in thymus and liver during aging.
Increased autophagic activity in senescent human dental pulp cells.
In vivo and in vitro Leishmania amazonensis infection induces autophagy in macrophages.
Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury.
Protective role of autophagy in branched polyethylenimine (25K)- and poly(L-lysine) (30-70K)-induced cell death.
Single-photon emission computed tomographic imaging of the early time course of therapy-induced cell death using technetium 99m tricarbonyl His-annexin A5 in a colorectal cancer xenograft model.
Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases.
Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
Bacterial toxins can inhibit host cell autophagy through cAMP generation.
Bacterial toxins can inhibit host cell autophagy through cAMP generation.
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway.
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.
Identification of Autographa californica nucleopolyhedrovirus ac93 as a core gene and its requirement for intranuclear microvesicle formation and nuclear egress of nucleocapsids.
Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals.
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis.
Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype.
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease.
Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.
Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases.
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways.
Adenoviruses induce autophagy to promote virus replication and oncolysis.
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Identification of aneuploidy-selective antiproliferation compounds.
Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy.
Ethanol enhances susceptibility to apoptotic cell death via down-regulation of autophagy-related proteins.
Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma.
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells.
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells.
Roles of autophagy in cetuximab-mediated cancer therapy against EGFR.
ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.
Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes.
Entrapment of intracytosolic bacteria by septin cage-like structures.
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.
Autophagy: assays and artifacts.
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
Analyzing autophagy in zebrafish.
Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7.
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Organic particulate material levels in the atmosphere: conditions favoring sensitivity to varying relative humidity and temperature.
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.
Kinetic analysis of autophagosome formation and turnover in primary mouse macrophages.
Modulation of intracellular ROS levels by TIGAR controls autophagy.
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
Transglutaminase 2 is involved in autophagosome maturation.
Transglutaminase 2 is involved in autophagosome maturation.
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos.
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos.
Regulation of autophagy by the p300 acetyltransferase.
Yersinia pestis can reside in autophagosomes and avoid xenophagy in murine macrophages by preventing vacuole acidification.
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes.
Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes.
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization.
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization.
Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain.
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Long-term health effects of aldrin and dieldrin. A study of exposure, health effects and mortality of workers engaged in the manufacture and formulation of the insecticides aldrin and dieldrin.
Li W, Dai Y, Shi B, Yue F, Zou J, Xu G, Jiang X, Wang F, Zhou X, Liu L
Oncogene 2020 May;39(19):3879-3892
Oncogene 2020 May;39(19):3879-3892
Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis.
Szekerczés T, Gógl A, Illyés I, Mandl J, Borka K, Kiss A, Schaff Z, Lendvai G, Werling K
Pathology oncology research : POR 2020 Mar 2;
Pathology oncology research : POR 2020 Mar 2;
BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury.
Sarnyai F, Szekerczés T, Csala M, Sümegi B, Szarka A, Schaff Z, Mandl J
Pathology oncology research : POR 2020 Jul;26(3):1797-1803
Pathology oncology research : POR 2020 Jul;26(3):1797-1803
Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice.
Lindahl M, Chalazonitis A, Palm E, Pakarinen E, Danilova T, Pham TD, Setlik W, Rao M, Võikar V, Huotari J, Kopra J, Andressoo JO, Piepponen PT, Airavaara M, Panhelainen A, Gershon MD, Saarma M
Neurobiology of disease 2020 Feb;134:104696
Neurobiology of disease 2020 Feb;134:104696
Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury.
Yuan JQ, Yuan Y, Pan SS, Cai K
The journal of physiological sciences : JPS 2020 Feb 17;70(1):10
The journal of physiological sciences : JPS 2020 Feb 17;70(1):10
Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages.
Zhang R, Varela M, Forn-Cuní G, Torraca V, van der Vaart M, Meijer AH
Cell death & disease 2020 Apr 24;11(4):277
Cell death & disease 2020 Apr 24;11(4):277
Autophagy in Zebrafish Extraocular Muscle Regeneration.
Saera-Vila A, Kish PE, Kahana A
Methods in molecular biology (Clifton, N.J.) 2019;1854:105-117
Methods in molecular biology (Clifton, N.J.) 2019;1854:105-117
Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model.
Di Pardo A, Pepe G, Castaldo S, Marracino F, Capocci L, Amico E, Madonna M, Giova S, Jeong SK, Park BM, Park BD, Maglione V
Frontiers in molecular neuroscience 2019;12:100
Frontiers in molecular neuroscience 2019;12:100
Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish.
Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X
Disease models & mechanisms 2019 Oct 1;12(10)
Disease models & mechanisms 2019 Oct 1;12(10)
Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species-induced apoptosis and reduces cell stemness.
Liou YF, Chen PN, Chu SC, Kao SH, Chang YZ, Hsieh YS, Chang HR
Environmental toxicology 2019 Nov;34(11):1208-1220
Environmental toxicology 2019 Nov;34(11):1208-1220
Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.
Minakaki G, Canneva F, Chevessier F, Bode F, Menges S, Timotius IK, Kalinichenko LS, Meixner H, Müller CP, Eskofier BM, Casadei N, Riess O, Schröder R, Winkler J, Xiang W, von Hörsten S, Klucken J
Behavioural brain research 2019 May 2;363:199-215
Behavioural brain research 2019 May 2;363:199-215
MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.
Ozturk DG, Kocak M, Akcay A, Kinoglu K, Kara E, Buyuk Y, Kazan H, Gozuacik D
Autophagy 2019 Mar;15(3):375-390
Autophagy 2019 Mar;15(3):375-390
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.
Hoffmann AC, Minakaki G, Menges S, Salvi R, Savitskiy S, Kazman A, Vicente Miranda H, Mielenz D, Klucken J, Winkler J, Xiang W
Scientific reports 2019 Jan 24;9(1):544
Scientific reports 2019 Jan 24;9(1):544
The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection.
Zhang R, Varela M, Vallentgoed W, Forn-Cuni G, van der Vaart M, Meijer AH
PLoS pathogens 2019 Feb;15(2):e1007329
PLoS pathogens 2019 Feb;15(2):e1007329
Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy.
Gregosa A, Vinuesa Á, Todero MF, Pomilio C, Rossi SP, Bentivegna M, Presa J, Wenker S, Saravia F, Beauquis J
Neurobiology of disease 2019 Dec;132:104542
Neurobiology of disease 2019 Dec;132:104542
Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma.
Bryant J, Batis N, Franke AC, Clancey G, Hartley M, Ryan G, Brooks J, Southam AD, Barnes N, Parish J, Roberts S, Khanim F, Spruce R, Mehanna H
Oncotarget 2019 Aug 27;10(50):5229-5244
Oncotarget 2019 Aug 27;10(50):5229-5244
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy.
Yong T, Zhang X, Bie N, Zhang H, Zhang X, Li F, Hakeem A, Hu J, Gan L, Santos HA, Yang X
Nature communications 2019 Aug 23;10(1):3838
Nature communications 2019 Aug 23;10(1):3838
Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival.
Morelli MB, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G
Cancers 2019 Apr 12;11(4)
Cancers 2019 Apr 12;11(4)
Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model.
Hirt J, Porter K, Dixon A, McKinnon S, Liton PB
Cell death discovery 2018;4:14
Cell death discovery 2018;4:14
A Rodent Model of Anxiety: The Effect of Perinatal Immune Challenges on Gastrointestinal Inflammation and Integrity.
Hollins SL, Brock L, Barreto R, Harms L, Dunn A, Garcia-Sobrinho P, Bruce J, Dickson PW, Walker MM, Keely S, Hodgson DM
Neuroimmunomodulation 2018;25(3):163-175
Neuroimmunomodulation 2018;25(3):163-175
Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers.
Nàger M, Sallán MC, Visa A, Pushparaj C, Santacana M, Macià A, Yeramian A, Cantí C, Herreros J
Autophagy 2018;14(4):619-636
Autophagy 2018;14(4):619-636
Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo.
Kustermann M, Manta L, Paone C, Kustermann J, Lausser L, Wiesner C, Eichinger L, Clemen CS, Schröder R, Kestler HA, Sandri M, Rottbauer W, Just S
Autophagy 2018;14(11):1911-1927
Autophagy 2018;14(11):1911-1927
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.
Minakaki G, Menges S, Kittel A, Emmanouilidou E, Schaeffner I, Barkovits K, Bergmann A, Rockenstein E, Adame A, Marxreiter F, Mollenhauer B, Galasko D, Buzás EI, Schlötzer-Schrehardt U, Marcus K, Xiang W, Lie DC, Vekrellis K, Masliah E, Winkler J, Klucken J
Autophagy 2018;14(1):98-119
Autophagy 2018;14(1):98-119
Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation.
Battista RA, Resnati M, Facchi C, Ruggieri E, Cremasco F, Paradiso F, Orfanelli U, Giordano L, Bussi M, Cenci S, Milan E
PloS one 2018;13(8):e0201621
PloS one 2018;13(8):e0201621
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC
Neuron 2018 Sep 19;99(6):1188-1203.e6
Neuron 2018 Sep 19;99(6):1188-1203.e6
Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer.
Lu J, Dong W, He H, Han Z, Zhuo Y, Mo R, Liang Y, Zhu J, Li R, Qu H, Zhang L, Wang S, Ma R, Jia Z, Zhong W
International journal of biological macromolecules 2018 Oct 15;118(Pt A):599-609
International journal of biological macromolecules 2018 Oct 15;118(Pt A):599-609
Autophagy-lysosomal defect in human CADASIL vascular smooth muscle cells.
Hanemaaijer ES, Panahi M, Swaddiwudhipong N, Tikka S, Winblad B, Viitanen M, Piras A, Behbahani H
European journal of cell biology 2018 Nov;97(8):557-567
European journal of cell biology 2018 Nov;97(8):557-567
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
Jeong AL, Ka HI, Han S, Lee S, Lee EW, Soh SJ, Joo HJ, Sumiyasuren B, Park JY, Lim JS, Park JH, Lee MS, Yang Y
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
The programmed DNA elimination and formation of micronuclei in germ line cells of the natural hybridogenetic water frog Pelophylax esculentus.
Chmielewska M, Dedukh D, Haczkiewicz K, Rozenblut-Kościsty B, Kaźmierczak M, Kolenda K, Serwa E, Pietras-Lebioda A, Krasikova A, Ogielska M
Scientific reports 2018 May 18;8(1):7870
Scientific reports 2018 May 18;8(1):7870
Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection.
Palucci I, Matic I, Falasca L, Minerva M, Maulucci G, De Spirito M, Petruccioli E, Goletti D, Rossin F, Piacentini M, Delogu G
Journal of internal medicine 2018 Mar;283(3):303-313
Journal of internal medicine 2018 Mar;283(3):303-313
Extracellular DNA promotes colorectal tumor cell survival after cytotoxic chemotherapy.
Anunobi R, Boone BA, Cheh N, Tang D, Kang R, Loux T, Lotze MT, Zeh HJ
The Journal of surgical research 2018 Jun;226:181-191
The Journal of surgical research 2018 Jun;226:181-191
TRIM50 regulates Beclin 1 proautophagic activity.
Fusco C, Mandriani B, Di Rienzo M, Micale L, Malerba N, Cocciadiferro D, Sjøttem E, Augello B, Squeo GM, Pellico MT, Jain A, Johansen T, Fimia GM, Merla G
Biochimica et biophysica acta. Molecular cell research 2018 Jun;1865(6):908-919
Biochimica et biophysica acta. Molecular cell research 2018 Jun;1865(6):908-919
Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.
Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT
Neurobiology of aging 2018 Jan;61:1-12
Neurobiology of aging 2018 Jan;61:1-12
Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney.
Festa BP, Chen Z, Berquez M, Debaix H, Tokonami N, Prange JA, Hoek GV, Alessio C, Raimondi A, Nevo N, Giles RH, Devuyst O, Luciani A
Nature communications 2018 Jan 11;9(1):161
Nature communications 2018 Jan 11;9(1):161
Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart.
Inomata Y, Nagasaka S, Miyate K, Goto Y, Hino C, Toukairin C, Higashio R, Ishida K, Saino T, Hirose M, Tsumura H, Sanbe A
Biochemical and biophysical research communications 2018 Feb 19;496(4):1141-1147
Biochemical and biophysical research communications 2018 Feb 19;496(4):1141-1147
Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2.
Piacentini M, Baiocchini A, Del Nonno F, Melino G, Barlev NA, Rossin F, D'Eletto M, Falasca L
Cell death & disease 2018 Feb 15;9(3):257
Cell death & disease 2018 Feb 15;9(3):257
Unraveling mitotic protein networks by 3D multiplexed epitope drug screening.
Maier LJ, Kallenberger SM, Jechow K, Waschow M, Eils R, Conrad C
Molecular systems biology 2018 Aug 13;14(8):e8238
Molecular systems biology 2018 Aug 13;14(8):e8238
Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice.
Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K
Journal of neurochemistry 2018 Apr;145(1):80-89
Journal of neurochemistry 2018 Apr;145(1):80-89
A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.
Lim H, Lim YM, Kim KH, Jeon YE, Park K, Kim J, Hwang HY, Lee DJ, Pagire H, Kwon HJ, Ahn JH, Lee MS
Nature communications 2018 Apr 12;9(1):1438
Nature communications 2018 Apr 12;9(1):1438
Monitoring Autophagy in Muscle Stem Cells.
García-Prat L, Muñoz-Cánoves P, Martínez-Vicente M
Methods in molecular biology (Clifton, N.J.) 2017;1556:255-280
Methods in molecular biology (Clifton, N.J.) 2017;1556:255-280
Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy.
Kaverina N, Borovjagin AV, Kadagidze Z, Baryshnikov A, Baryshnikova M, Malin D, Ghosh D, Shah N, Welch DR, Gabikian P, Karseladze A, Cobbs C, Ulasov IV
Autophagy 2017;13(11):1905-1923
Autophagy 2017;13(11):1905-1923
Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice.
Desseille C, Deforges S, Biondi O, Houdebine L, D'amico D, Lamazière A, Caradeuc C, Bertho G, Bruneteau G, Weill L, Bastin J, Djouadi F, Salachas F, Lopes P, Chanoine C, Massaad C, Charbonnier F
Frontiers in molecular neuroscience 2017;10:332
Frontiers in molecular neuroscience 2017;10:332
Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation.
Jiang MY, Han ZD, Li W, Yue F, Ye J, Li B, Cai Z, Lu JM, Dong W, Jiang X, Zhong W, He H, Liu L
Oncotarget 2017 Oct 6;8(46):80295-80302
Oncotarget 2017 Oct 6;8(46):80295-80302
Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice.
Agarwal AK, Tunison K, Dalal JS, Nagamma SS, Hamra FK, Sankella S, Shao X, Auchus RJ, Garg A
Endocrinology 2017 Nov 1;158(11):3954-3973
Endocrinology 2017 Nov 1;158(11):3954-3973
(±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice.
Benvenuto M, Mattera R, Masuelli L, Taffera G, Andracchio O, Tresoldi I, Lido P, Giganti MG, Godos J, Modesti A, Bei R
International journal of food sciences and nutrition 2017 May;68(3):298-312
International journal of food sciences and nutrition 2017 May;68(3):298-312
Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14L156R is rescued by starvation and inhibition of vacuolar-ATPase.
Schulze U, Vollenbröker B, Kühnl A, Granado D, Bayraktar S, Rescher U, Pavenstädt H, Weide T
Biochimica et biophysica acta. Molecular cell research 2017 May;1864(5):749-759
Biochimica et biophysica acta. Molecular cell research 2017 May;1864(5):749-759
TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.
Bae SY, Byun S, Bae SH, Min DS, Woo HA, Lee K
Autophagy 2017 May 4;13(5):820-833
Autophagy 2017 May 4;13(5):820-833
Autophagy regulates UBC9 levels during viral-mediated tumorigenesis.
Mattoscio D, Casadio C, Miccolo C, Maffini F, Raimondi A, Tacchetti C, Gheit T, Tagliabue M, Galimberti VE, De Lorenzi F, Pawlita M, Chiesa F, Ansarin M, Tommasino M, Chiocca S
PLoS pathogens 2017 Mar;13(3):e1006262
PLoS pathogens 2017 Mar;13(3):e1006262
p62 improves AD-like pathology by increasing autophagy.
Caccamo A, Ferreira E, Branca C, Oddo S
Molecular psychiatry 2017 Jun;22(6):865-873
Molecular psychiatry 2017 Jun;22(6):865-873
Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.
Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, Liu L
Cancer research 2017 Jun 1;77(11):2938-2951
Cancer research 2017 Jun 1;77(11):2938-2951
Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis.
Benitez BA, Sands MS
Scientific reports 2017 Jul 24;7(1):6332
Scientific reports 2017 Jul 24;7(1):6332
Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation.
Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J
Nature genetics 2017 Jan;49(1):75-86
Nature genetics 2017 Jan;49(1):75-86
Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics.
Lee SB, Kang JW, Kim SJ, Ahn J, Kim J, Lee SM
British journal of pharmacology 2017 Jan;174(2):195-209
British journal of pharmacology 2017 Jan;174(2):195-209
Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1.
Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N
Biochemical and biophysical research communications 2017 Jan 22;482(4):1334-1340
Biochemical and biophysical research communications 2017 Jan 22;482(4):1334-1340
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress.
Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, Datta D, Symeonidi A, Castellanos A, Welz PS, Caballero JM, Sassone-Corsi P, Muñoz-Cánoves P, Benitah SA
Cell 2017 Aug 10;170(4):678-692.e20
Cell 2017 Aug 10;170(4):678-692.e20
β-catenin promotes intracellular bacterial killing via suppression of Pseudomonas aeruginosa-triggered macrophage autophagy.
Fu Q, Chen K, Zhu Q, Wang W, Huang F, Miao L, Wu X
The Journal of international medical research 2017 Apr;45(2):556-569
The Journal of international medical research 2017 Apr;45(2):556-569
Protein Kinase Cδ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity.
Zhang D, Pan J, Xiang X, Liu Y, Dong G, Livingston MJ, Chen JK, Yin XM, Dong Z
Journal of the American Society of Nephrology : JASN 2017 Apr;28(4):1131-1144
Journal of the American Society of Nephrology : JASN 2017 Apr;28(4):1131-1144
PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux.
Nazim UM, Moon JH, Lee YJ, Seol JW, Park SY
Oncotarget 2017 Apr 18;8(16):26819-26831
Oncotarget 2017 Apr 18;8(16):26819-26831
A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.
Lopez A, Lee SE, Wojta K, Ramos EM, Klein E, Chen J, Boxer AL, Gorno-Tempini ML, Geschwind DH, Schlotawa L, Ogryzko NV, Bigio EH, Rogalski E, Weintraub S, Mesulam MM, Tauopathy Genetics Consortium., Fleming A, Coppola G, Miller BL, Rubinsztein DC
Brain : a journal of neurology 2017 Apr 1;140(4):1128-1146
Brain : a journal of neurology 2017 Apr 1;140(4):1128-1146
Inhibitory effects of silibinin on proliferation and lung metastasis of human high metastasis cell line of salivary gland adenoid cystic carcinoma via autophagy induction.
Jiang C, Jin S, Jiang Z, Wang J
OncoTargets and therapy 2016;9:6609-6618
OncoTargets and therapy 2016;9:6609-6618
Icariin Attenuates OGD/R-Induced Autophagy via Bcl-2-Dependent Cross Talk between Apoptosis and Autophagy in PC12 Cells.
Mo ZT, Li WN, Zhai YR, Gong QH
Evidence-based complementary and alternative medicine : eCAM 2016;2016:4343084
Evidence-based complementary and alternative medicine : eCAM 2016;2016:4343084
MAVS maintains mitochondrial homeostasis via autophagy.
Sun X, Sun L, Zhao Y, Li Y, Lin W, Chen D, Sun Q
Cell discovery 2016;2:16024
Cell discovery 2016;2:16024
Up-Regulated Expression of LAMP2 and Autophagy Activity during Neuroendocrine Differentiation of Prostate Cancer LNCaP Cells.
Morell C, Bort A, Vara-Ciruelos D, Ramos-Torres Á, Altamirano-Dimas M, Díaz-Laviada I, Rodríguez-Henche N
PloS one 2016;11(9):e0162977
PloS one 2016;11(9):e0162977
PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells.
Hossini AM, Quast AS, Plötz M, Grauel K, Exner T, Küchler J, Stachelscheid H, Eberle J, Rabien A, Makrantonaki E, Zouboulis CC
PloS one 2016;11(5):e0154770
PloS one 2016;11(5):e0154770
Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.
Jacob F, Yonis AY, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt MN, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A
PloS one 2016;11(2):e0145937
PloS one 2016;11(2):e0145937
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma.
Liu P, Jin H, Guo Z, Ma J, Zhao J, Li D, Wu H, Gu N
International journal of nanomedicine 2016;11:5003-5014
International journal of nanomedicine 2016;11:5003-5014
CpG-ODN promotes phagocytosis and autophagy through JNK/P38 signal pathway in Staphylococcus aureus-stimulated macrophage.
Wu HM, Wang J, Zhang B, Fang L, Xu K, Liu RY
Life sciences 2016 Sep 15;161:51-9
Life sciences 2016 Sep 15;161:51-9
PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.
Sabha N, Volpatti JR, Gonorazky H, Reifler A, Davidson AE, Li X, Eltayeb NM, Dall'Armi C, Di Paolo G, Brooks SV, Buj-Bello A, Feldman EL, Dowling JJ
The Journal of clinical investigation 2016 Sep 1;126(9):3613-25
The Journal of clinical investigation 2016 Sep 1;126(9):3613-25
Accumulated α-synuclein affects the progression of GM2 gangliosidoses.
Suzuki K, Yamaguchi A, Yamanaka S, Kanzaki S, Kawashima M, Togo T, Katsuse O, Koumitsu N, Aoki N, Iseki E, Kosaka K, Yamaguchi K, Hashimoto M, Aoki I, Hirayasu Y
Experimental neurology 2016 Oct;284(Pt A):38-49
Experimental neurology 2016 Oct;284(Pt A):38-49
Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration.
Saera-Vila A, Kish PE, Louie KW, Grzegorski SJ, Klionsky DJ, Kahana A
Autophagy 2016 Oct 2;12(10):1864-1875
Autophagy 2016 Oct 2;12(10):1864-1875
Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion.
Hong JM, Kim SJ, Lee SM
Toxicology and applied pharmacology 2016 Oct 1;308:1-10
Toxicology and applied pharmacology 2016 Oct 1;308:1-10
FANCD2 protects against bone marrow injury from ferroptosis.
Song X, Xie Y, Kang R, Hou W, Sun X, Epperly MW, Greenberger JS, Tang D
Biochemical and biophysical research communications 2016 Nov 18;480(3):443-449
Biochemical and biophysical research communications 2016 Nov 18;480(3):443-449
Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.
Yamada E, Okada S, Bastie CC, Vatish M, Nakajima Y, Shibusawa R, Ozawa A, Pessin JE, Yamada M
Oncotarget 2016 Nov 15;7(46):74612-74629
Oncotarget 2016 Nov 15;7(46):74612-74629
mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, Boletta A
Nature communications 2016 Mar 2;7:10786
Nature communications 2016 Mar 2;7:10786
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
Piras A, Collin L, Grüninger F, Graff C, Rönnbäck A
Acta neuropathologica communications 2016 Mar 2;4:22
Acta neuropathologica communications 2016 Mar 2;4:22
Autophagy maintains stemness by preventing senescence.
García-Prat L, Martínez-Vicente M, Perdiguero E, Ortet L, Rodríguez-Ubreva J, Rebollo E, Ruiz-Bonilla V, Gutarra S, Ballestar E, Serrano AL, Sandri M, Muñoz-Cánoves P
Nature 2016 Jan 7;529(7584):37-42
Nature 2016 Jan 7;529(7584):37-42
Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish.
Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S
International journal of molecular sciences 2016 Jan 30;17(2)
International journal of molecular sciences 2016 Jan 30;17(2)
Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.
Duarte-Silva S, Silva-Fernandes A, Neves-Carvalho A, Soares-Cunha C, Teixeira-Castro A, Maciel P
Neuroscience 2016 Jan 28;313:162-73
Neuroscience 2016 Jan 28;313:162-73
Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization.
Pomilio C, Pavia P, Gorojod RM, Vinuesa A, Alaimo A, Galvan V, Kotler ML, Beauquis J, Saravia F
Hippocampus 2016 Feb;26(2):194-210
Hippocampus 2016 Feb;26(2):194-210
Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function.
Lu Y, Liu XF, Liu TR, Fan RF, Xu YC, Zhang XZ, Liu LL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1551-1557
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1551-1557
Reduction of polyethylenimine-coated iron oxide nanoparticles induced autophagy and cytotoxicity by lactosylation.
Du J, Zhu W, Yang L, Wu C, Lin B, Wu J, Jin R, Shen T, Ai H
Regenerative biomaterials 2016 Dec;3(4):223-9
Regenerative biomaterials 2016 Dec;3(4):223-9
Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation.
Nuschke A, Rodrigues M, Wells AW, Sylakowski K, Wells A
Stem cell research & therapy 2016 Dec 1;7(1):179
Stem cell research & therapy 2016 Dec 1;7(1):179
RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy.
Erbil S, Oral O, Mitou G, Kig C, Durmaz-Timucin E, Guven-Maiorov E, Gulacti F, Gokce G, Dengjel J, Sezerman OU, Gozuacik D
The Journal of biological chemistry 2016 Aug 5;291(32):16753-65
The Journal of biological chemistry 2016 Aug 5;291(32):16753-65
Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells.
Tan KP, Ho MY, Cho HC, Yu J, Hung JT, Yu AL
Cell death & disease 2016 Aug 25;7(8):e2347
Cell death & disease 2016 Aug 25;7(8):e2347
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Lee HY, Kim J, Quan W, Lee JC, Kim MS, Kim SH, Bae JW, Hur KY, Lee MS
Autophagy 2016 Aug 2;12(8):1390-403
Autophagy 2016 Aug 2;12(8):1390-403
Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.
Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR Jr, Porcelli SA
Nature microbiology 2016 Aug 15;1(9):16133
Nature microbiology 2016 Aug 15;1(9):16133
HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2.
Granato M, Zompetta C, Vescarelli E, Rizzello C, Cardi A, Valia S, Antonelli G, Marchese C, Torrisi MR, Faggioni A, Cirone M
Scientific reports 2016 Aug 1;6:30649
Scientific reports 2016 Aug 1;6:30649
Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed.
Li W, Zou J, Yue F, Song K, Chen Q, McKeehan WL, Wang F, Xu G, Huang H, Yi J, Liu L
Aging cell 2016 Apr;15(2):370-9
Aging cell 2016 Apr;15(2):370-9
Immunohistochemical detection of autophagy-related microtubule-associated protein 1 light chain 3 (LC3) in the cerebellums of dogs naturally infected with canine distemper virus.
Kabak YB, Sozmen M, Yarim M, Guvenc T, Karayigit MO, Gulbahar MY
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2015;90(8):601-7
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2015;90(8):601-7
Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation.
Zhen Y, Li W
Autophagy 2015;11(9):1608-22
Autophagy 2015;11(9):1608-22
Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.
LaPash Daniels CM, Paffenroth E, Austin EV, Glebov K, Lewis D, Walter J, Messing A
PloS one 2015;10(9):e0138132
PloS one 2015;10(9):e0138132
Transforming Growth Factor TGFβ Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas.
Song K, Hu W, Yue F, Zou J, Li W, Chen Q, Yao Q, Sun W, Liu L
PloS one 2015;10(11):e0143150
PloS one 2015;10(11):e0143150
Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice.
Irimia JM, Tagliabracci VS, Meyer CM, Segvich DM, DePaoli-Roach AA, Roach PJ
The Journal of biological chemistry 2015 Sep 11;290(37):22686-98
The Journal of biological chemistry 2015 Sep 11;290(37):22686-98
The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions.
Gorojod RM, Alaimo A, Porte Alcon S, Pomilio C, Saravia F, Kotler ML
Free radical biology & medicine 2015 Oct;87:237-51
Free radical biology & medicine 2015 Oct;87:237-51
Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes.
Chen Q, Yue F, Li W, Zou J, Xu T, Huang C, Zhang Y, Song K, Huang G, Xu G, Huang H, Li J, Liu L
The Journal of biological chemistry 2015 Oct 23;290(43):26051-8
The Journal of biological chemistry 2015 Oct 23;290(43):26051-8
Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner.
Nabissi M, Morelli MB, Amantini C, Liberati S, Santoni M, Ricci-Vitiani L, Pallini R, Santoni G
International journal of cancer 2015 Oct 15;137(8):1855-69
International journal of cancer 2015 Oct 15;137(8):1855-69
Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.
Grossi V, Lucarelli G, Forte G, Peserico A, Matrone A, Germani A, Rutigliano M, Stella A, Bagnulo R, Loconte D, Galleggiante V, Sanguedolce F, Cagiano S, Bufo P, Trabucco S, Maiorano E, Ditonno P, Battaglia M, Resta N, Simone C
Autophagy 2015 Nov 2;11(11):2102-2113
Autophagy 2015 Nov 2;11(11):2102-2113
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.
Clarke AJ, Ellinghaus U, Cortini A, Stranks A, Simon AK, Botto M, Vyse TJ
Annals of the rheumatic diseases 2015 May;74(5):912-20
Annals of the rheumatic diseases 2015 May;74(5):912-20
Effects of resveratrol on growth and skeletal muscle physiology of juvenile southern flounder.
Wilson WN, Baumgarner BL, Watanabe WO, Alam MS, Kinsey ST
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2015 May;183:27-35
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2015 May;183:27-35
Autophagy in zebrafish.
Varga M, Fodor E, Vellai T
Methods (San Diego, Calif.) 2015 Mar;75:172-80
Methods (San Diego, Calif.) 2015 Mar;75:172-80
The viral restriction factor tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy.
Zou J, Li W, Misra A, Yue F, Song K, Chen Q, Guo G, Yi J, Kimata JT, Liu L
The Journal of biological chemistry 2015 Mar 13;290(11):7269-79
The Journal of biological chemistry 2015 Mar 13;290(11):7269-79
The synergistic effect of SAHA and parthenolide in MDA-MB231 breast cancer cells.
Carlisi D, Lauricella M, D'Anneo A, Buttitta G, Emanuele S, di Fiore R, Martinez R, Rolfo C, Vento R, Tesoriere G
Journal of cellular physiology 2015 Jun;230(6):1276-89
Journal of cellular physiology 2015 Jun;230(6):1276-89
Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways.
Cai-McRae X, Zhong H, Karantza V
Oncogene 2015 Jun 4;34(23):2968-77
Oncogene 2015 Jun 4;34(23):2968-77
Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.
Gan M, Moussaud S, Jiang P, McLean PJ
Neurobiology of aging 2015 Feb;36(2):1209-20
Neurobiology of aging 2015 Feb;36(2):1209-20
Tamoxifen improves cytopathic effect of oncolytic adenovirus in primary glioblastoma cells mediated through autophagy.
Ulasov IV, Shah N, Kaverina NV, Lee H, Lin B, Lieber A, Kadagidze ZG, Yoon JG, Schroeder B, Hothi P, Ghosh D, Baryshnikov AY, Cobbs CS
Oncotarget 2015 Feb 28;6(6):3977-87
Oncotarget 2015 Feb 28;6(6):3977-87
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation.
Wei Y, An Z, Zou Z, Sumpter R, Su M, Zang X, Sinha S, Gaestel M, Levine B
eLife 2015 Feb 18;4
eLife 2015 Feb 18;4
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D
Molecular pharmacology 2015 Dec;88(6):1045-54
Molecular pharmacology 2015 Dec;88(6):1045-54
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Altuntas S, Rossin F, Marsella C, D'Eletto M, Diaz-Hidalgo L, Farrace MG, Campanella M, Antonioli M, Fimia GM, Piacentini M
Oncotarget 2015 Dec 29;6(42):44941-54
Oncotarget 2015 Dec 29;6(42):44941-54
PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction.
Muhammad E, Levitas A, Singh SR, Braiman A, Ofir R, Etzion S, Sheffield VC, Etzion Y, Carrier L, Parvari R
Human molecular genetics 2015 Dec 20;24(25):7227-40
Human molecular genetics 2015 Dec 20;24(25):7227-40
Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine.
Lin CW, Jan MS, Kuo JH
Molecular pharmaceutics 2015 Aug 3;12(8):2858-68
Molecular pharmaceutics 2015 Aug 3;12(8):2858-68
Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a.
Wang T, Martin S, Papadopulos A, Harper CB, Mavlyutov TA, Niranjan D, Glass NR, Cooper-White JJ, Sibarita JB, Choquet D, Davletov B, Meunier FA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 15;35(15):6179-94
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 15;35(15):6179-94
Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin.
Zou J, Yue F, Li W, Song K, Jiang X, Yi J, Liu L
PloS one 2014;9(4):e94903
PloS one 2014;9(4):e94903
Acute, delayed and chronic remote ischemic conditioning is associated with downregulation of mTOR and enhanced autophagy signaling.
Rohailla S, Clarizia N, Sourour M, Sourour W, Gelber N, Wei C, Li J, Redington AN
PloS one 2014;9(10):e111291
PloS one 2014;9(10):e111291
MicroRNA-144 is a circulating effector of remote ischemic preconditioning.
Li J, Rohailla S, Gelber N, Rutka J, Sabah N, Gladstone RA, Wei C, Hu P, Kharbanda RK, Redington AN
Basic research in cardiology 2014;109(5):423
Basic research in cardiology 2014;109(5):423
Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.
Heijnen HF, van Wijk R, Pereboom TC, Goos YJ, Seinen CW, van Oirschot BA, van Dooren R, Gastou M, Giles RH, van Solinge W, Kuijpers TW, Gazda HT, Bierings MB, Da Costa L, MacInnes AW
PLoS genetics 2014;10(5):e1004371
PLoS genetics 2014;10(5):e1004371
Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.
Cicchini M, Chakrabarti R, Kongara S, Price S, Nahar R, Lozy F, Zhong H, Vazquez A, Kang Y, Karantza V
Autophagy 2014;10(11):2036-52
Autophagy 2014;10(11):2036-52
Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.
Lim YM, Lim H, Hur KY, Quan W, Lee HY, Cheon H, Ryu D, Koo SH, Kim HL, Kim J, Komatsu M, Lee MS
Nature communications 2014 Sep 26;5:4934
Nature communications 2014 Sep 26;5:4934
Autophagy-related gene expression analysis of wild-type and atg5 gene knockout mouse embryonic fibroblast cells treated with polyethylenimine.
Lin CW, Jan MS, Kuo JH
Molecular pharmaceutics 2014 Sep 2;11(9):3002-8
Molecular pharmaceutics 2014 Sep 2;11(9):3002-8
Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity.
Xiong R, Siegel D, Ross D
Toxicology and applied pharmacology 2014 Oct 15;280(2):285-95
Toxicology and applied pharmacology 2014 Oct 15;280(2):285-95
Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis.
Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E
Autophagy 2014 Oct 1;10(10):1827-43
Autophagy 2014 Oct 1;10(10):1827-43
Hereditary myopathy with early respiratory failure: occurrence in various populations.
Palmio J, Evilä A, Chapon F, Tasca G, Xiang F, Brådvik B, Eymard B, Echaniz-Laguna A, Laporte J, Kärppä M, Mahjneh I, Quinlivan R, Laforêt P, Damian M, Berardo A, Taratuto AL, Bueri JA, Tommiska J, Raivio T, Tuerk M, Gölitz P, Chevessier F, Sewry C, Norwood F, Hedberg C, Schröder R, Edström L, Oldfors A, Hackman P, Udd B
Journal of neurology, neurosurgery, and psychiatry 2014 Mar;85(3):345-53
Journal of neurology, neurosurgery, and psychiatry 2014 Mar;85(3):345-53
Inhibition of autophagy augments the anticancer activity of α-mangostin in chronic myeloid leukemia cells.
Chen JJ, Long ZJ, Xu DF, Xiao RZ, Liu LL, Xu ZF, Qiu SX, Lin DJ, Liu Q
Leukemia & lymphoma 2014 Mar;55(3):628-38
Leukemia & lymphoma 2014 Mar;55(3):628-38
Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation.
Schonewolf CA, Mehta M, Schiff D, Wu H, Haffty BG, Karantza V, Jabbour SK
World journal of gastrointestinal oncology 2014 Mar 15;6(3):74-82
World journal of gastrointestinal oncology 2014 Mar 15;6(3):74-82
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP
Nature communications 2014 Mar 11;5:3430
Nature communications 2014 Mar 11;5:3430
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.
Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F
Biochimica et biophysica acta 2014 Jul;1842(7):1144-53
Biochimica et biophysica acta 2014 Jul;1842(7):1144-53
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.
Budina-Kolomets A, Balaburski GM, Bondar A, Beeharry N, Yen T, Murphy ME
Cancer biology & therapy 2014 Feb;15(2):194-9
Cancer biology & therapy 2014 Feb;15(2):194-9
The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
Oliverio S, Corazzari M, Sestito C, Piredda L, Ippolito G, Piacentini M
Amino acids 2014 Dec;46(12):2767-76
Amino acids 2014 Dec;46(12):2767-76
Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease.
Duarte-Silva S, Neves-Carvalho A, Soares-Cunha C, Teixeira-Castro A, Oliveira P, Silva-Fernandes A, Maciel P
Cerebellum (London, England) 2014 Dec;13(6):713-27
Cerebellum (London, England) 2014 Dec;13(6):713-27
Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation.
Nuschke A, Rodrigues M, Stolz DB, Chu CT, Griffith L, Wells A
Stem cell research & therapy 2014 Dec 17;5(6):140
Stem cell research & therapy 2014 Dec 17;5(6):140
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
Barmada SJ, Serio A, Arjun A, Bilican B, Daub A, Ando DM, Tsvetkov A, Pleiss M, Li X, Peisach D, Shaw C, Chandran S, Finkbeiner S
Nature chemical biology 2014 Aug;10(8):677-85
Nature chemical biology 2014 Aug;10(8):677-85
Fibronectin peptides that bind PDGF-BB enhance survival of cells and tissue under stress.
Lin F, Zhu J, Tonnesen MG, Taira BR, McClain SA, Singer AJ, Clark RAF
The Journal of investigative dermatology 2014 Apr;134(4):1119-1127
The Journal of investigative dermatology 2014 Apr;134(4):1119-1127
ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss.
Lozy F, Cai-McRae X, Teplova I, Price S, Reddy A, Bhanot G, Ganesan S, Vazquez A, Karantza V
Autophagy 2014 Apr;10(4):662-76
Autophagy 2014 Apr;10(4):662-76
JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes.
Drerup CM, Nechiporuk AV
PLoS genetics 2013;9(2):e1003303
PLoS genetics 2013;9(2):e1003303
MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb.
Wang J, Yang K, Zhou L, Minhaowu, Wu Y, Zhu M, Lai X, Chen T, Feng L, Li M, Huang C, Zhong Q, Huang X
PLoS pathogens 2013;9(10):e1003697
PLoS pathogens 2013;9(10):e1003697
Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death.
Martin S, Harper CB, May LM, Coulson EJ, Meunier FA, Osborne SL
PloS one 2013;8(3):e60152
PloS one 2013;8(3):e60152
Mitochondrial DNA damage via augmented oxidative stress regulates endoplasmic reticulum stress and autophagy: crosstalk, links and signaling.
Yuzefovych LV, LeDoux SP, Wilson GL, Rachek LI
PloS one 2013;8(12):e83349
PloS one 2013;8(12):e83349
MIR376A is a regulator of starvation-induced autophagy.
Korkmaz G, Tekirdag KA, Ozturk DG, Kosar A, Sezerman OU, Gozuacik D
PloS one 2013;8(12):e82556
PloS one 2013;8(12):e82556
The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.
Sanjurjo L, Amézaga N, Vilaplana C, Cáceres N, Marzo E, Valeri M, Cardona PJ, Sarrias MR
PloS one 2013;8(11):e79670
PloS one 2013;8(11):e79670
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
Devereaux K, Dall'Armi C, Alcazar-Roman A, Ogasawara Y, Zhou X, Wang F, Yamamoto A, De Camilli P, Di Paolo G
PloS one 2013;8(10):e76405
PloS one 2013;8(10):e76405
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
Xie X, White EP, Mehnert JM
PloS one 2013;8(1):e55096
PloS one 2013;8(1):e55096
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer.
Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Corominas-Faja B, Cuyàs E, López-Bonet E, Martin-Castillo B, Joven J, Menendez JA
Scientific reports 2013;3:2469
Scientific reports 2013;3:2469
Regulation of endoplasmic reticulum stress in rat cortex by p62/ZIP through the Keap1-Nrf2-ARE signalling pathway after transient focal cerebral ischaemia.
Wang W, Kang J, Li H, Su J, Wu J, Xu Y, Yu H, Xiang X, Yi H, Lu Y, Sun L
Brain injury 2013;27(7-8):924-33
Brain injury 2013;27(7-8):924-33
The emerging links between sirtuins and autophagy.
Lee IH, Yun J, Finkel T
Methods in molecular biology (Clifton, N.J.) 2013;1077:259-71
Methods in molecular biology (Clifton, N.J.) 2013;1077:259-71
Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability.
Zou J, Yue F, Jiang X, Li W, Yi J, Liu L
The Biochemical journal 2013 Sep 15;454(3):447-57
The Biochemical journal 2013 Sep 15;454(3):447-57
A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.
Budina-Kolomets A, Hontz RD, Pimkina J, Murphy ME
Autophagy 2013 Oct;9(10):1553-65
Autophagy 2013 Oct;9(10):1553-65
Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer.
D'Anneo A, Carlisi D, Lauricella M, Puleio R, Martinez R, Di Bella S, Di Marco P, Emanuele S, Di Fiore R, Guercio A, Vento R, Tesoriere G
Cell death & disease 2013 Oct 31;4:e891
Cell death & disease 2013 Oct 31;4:e891
Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells.
Hollomon MG, Gordon N, Santiago-O'Farrill JM, Kleinerman ES
BMC cancer 2013 Oct 26;13:500
BMC cancer 2013 Oct 26;13:500
Manipulation of autophagy by HCMV infection is involved in mTOR and influences the replication of virus.
Zhao J, Li Z, Wang M, Zhang Z, Ma H, Chang J, Gao D, Wang S
Acta biochimica et biophysica Sinica 2013 Nov;45(11):979-81
Acta biochimica et biophysica Sinica 2013 Nov;45(11):979-81
Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours.
Seront E, Boidot R, Bouzin C, Karroum O, Jordan BF, Gallez B, Machiels JP, Feron O
British journal of cancer 2013 Nov 12;109(10):2597-606
British journal of cancer 2013 Nov 12;109(10):2597-606
IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments.
Grkovic S, O'Reilly VC, Han S, Hong M, Baxter RC, Firth SM
Oncogene 2013 May 9;32(19):2412-20
Oncogene 2013 May 9;32(19):2412-20
Immunohistochemical analysis of macroautophagy: recommendations and limitations.
Martinet W, Schrijvers DM, Timmermans JP, Bult H, De Meyer GR
Autophagy 2013 Mar;9(3):386-402
Autophagy 2013 Mar;9(3):386-402
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.
Jiang TF, Zhang YJ, Zhou HY, Wang HM, Tian LP, Liu J, Ding JQ, Chen SD
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2013 Mar;8(1):356-69
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2013 Mar;8(1):356-69
A modified HSP70 inhibitor shows broad activity as an anticancer agent.
Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, Murphy ME
Molecular cancer research : MCR 2013 Mar;11(3):219-29
Molecular cancer research : MCR 2013 Mar;11(3):219-29
Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model.
Choi BY, Jang BG, Kim JH, Seo JN, Wu G, Sohn M, Chung TN, Suh SW
Neurobiology of disease 2013 Jun;54:382-91
Neurobiology of disease 2013 Jun;54:382-91
The activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells.
Xiong R, Siegel D, Ross D
Chemico-biological interactions 2013 Jul 5;204(2):116-24
Chemico-biological interactions 2013 Jul 5;204(2):116-24
Identification of a candidate therapeutic autophagy-inducing peptide.
Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B
Nature 2013 Feb 14;494(7436):201-6
Nature 2013 Feb 14;494(7436):201-6
Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.
Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M
Biochimica et biophysica acta 2013 Aug;1832(8):1249-59
Biochimica et biophysica acta 2013 Aug;1832(8):1249-59
Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.
Eaves-Pyles T, Patel J, Arigi E, Cong Y, Cao A, Garg N, Dhiman M, Pyles RB, Arulanandam B, Miller AL, Popov VL, Soong L, Carlsen ED, Coletta C, Szabo C, Almeida IC
Molecular medicine (Cambridge, Mass.) 2013 Aug 28;19:263-75
Molecular medicine (Cambridge, Mass.) 2013 Aug 28;19:263-75
TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells.
Chen MC, Chen CH, Liu YN, Wang HP, Pan SL, Teng CM
Cancer letters 2013 Aug 19;336(2):370-8
Cancer letters 2013 Aug 19;336(2):370-8
ATG proteins mediate efferocytosis and suppress inflammation in mammary involution.
Teplova I, Lozy F, Price S, Singh S, Barnard N, Cardiff RD, Birge RB, Karantza V
Autophagy 2013 Apr;9(4):459-75
Autophagy 2013 Apr;9(4):459-75
Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.
Rowe I, Chiaravalli M, Mannella V, Ulisse V, Quilici G, Pema M, Song XW, Xu H, Mari S, Qian F, Pei Y, Musco G, Boletta A
Nature medicine 2013 Apr;19(4):488-93
Nature medicine 2013 Apr;19(4):488-93
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
Claerhout S, Dutta B, Bossuyt W, Zhang F, Nguyen-Charles C, Dennison JB, Yu Q, Yu S, Balázsi G, Lu Y, Mills GB
PloS one 2012;7(6):e39400
PloS one 2012;7(6):e39400
Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies.
Momma K, Noguchi S, Malicdan MC, Hayashi YK, Minami N, Kamakura K, Nonaka I, Nishino I
PloS one 2012;7(12):e52002
PloS one 2012;7(12):e52002
Azurophil granule proteins constitute the major mycobactericidal proteins in human neutrophils and enhance the killing of mycobacteria in macrophages.
Jena P, Mohanty S, Mohanty T, Kallert S, Morgelin M, Lindstrøm T, Borregaard N, Stenger S, Sonawane A, Sørensen OE
PloS one 2012;7(12):e50345
PloS one 2012;7(12):e50345
Englerin a selectively induces necrosis in human renal cancer cells.
Sulzmaier FJ, Li Z, Nakashige ML, Fash DM, Chain WJ, Ramos JW
PloS one 2012;7(10):e48032
PloS one 2012;7(10):e48032
Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis.
Chiou SK, Hoa N, Ge L, Jadus MR
Gastroenterology research and practice 2012;2012:897678
Gastroenterology research and practice 2012;2012:897678
Vibrio parahaemolyticus ExsE is requisite for initial adhesion and subsequent type III secretion system 1-dependent autophagy in HeLa cells.
Erwin DP, Nydam SD, Call DR
Microbiology (Reading, England) 2012 Sep;158(Pt 9):2303-2314
Microbiology (Reading, England) 2012 Sep;158(Pt 9):2303-2314
E2F-1 lacking the transcriptional activity domain induces autophagy.
Garcia-Garcia A, Rodriguez-Rocha H, Tseng MT, Montes de Oca-Luna R, Zhou HS, McMasters KM, Gomez-Gutierrez JG
Cancer biology & therapy 2012 Sep;13(11):1091-101
Cancer biology & therapy 2012 Sep;13(11):1091-101
Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure.
Garcia AG, Wilson RM, Heo J, Murthy NR, Baid S, Ouchi N, Sam F
American journal of physiology. Heart and circulatory physiology 2012 Sep 1;303(5):H587-96
American journal of physiology. Heart and circulatory physiology 2012 Sep 1;303(5):H587-96
Exercise induces autophagy in peripheral tissues and in the brain.
He C, Sumpter R Jr, Levine B
Autophagy 2012 Oct;8(10):1548-51
Autophagy 2012 Oct;8(10):1548-51
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.
Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS
Human molecular genetics 2012 Nov 15;21(22):4888-903
Human molecular genetics 2012 Nov 15;21(22):4888-903
TG2 transamidating activity acts as a reostat controlling the interplay between apoptosis and autophagy.
Rossin F, D'Eletto M, Macdonald D, Farrace MG, Piacentini M
Amino acids 2012 May;42(5):1793-802
Amino acids 2012 May;42(5):1793-802
Everolimus triggers cytokine release by macrophages: rationale for stents eluting everolimus and a glucocorticoid.
Martinet W, Verheye S, De Meyer I, Timmermans JP, Schrijvers DM, Van Brussel I, Bult H, De Meyer GR
Arteriosclerosis, thrombosis, and vascular biology 2012 May;32(5):1228-35
Arteriosclerosis, thrombosis, and vascular biology 2012 May;32(5):1228-35
Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
Yamada E, Bastie CC, Koga H, Wang Y, Cuervo AM, Pessin JE
Cell reports 2012 May 31;1(5):557-69
Cell reports 2012 May 31;1(5):557-69
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J
Autophagy 2012 May 1;8(5):754-66
Autophagy 2012 May 1;8(5):754-66
Hoechst 33342-induced autophagy protected HeLa cells from caspase-independent cell death with the participation of ROS.
Zheng F, Yang WJ, Sun KJ, Wan XM, Man N, Wen LP
Free radical research 2012 Jun;46(6):740-9
Free radical research 2012 Jun;46(6):740-9
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
Liang X, De Vera ME, Buchser WJ, Romo de Vivar Chavez A, Loughran P, Beer Stolz D, Basse P, Wang T, Van Houten B, Zeh HJ 3rd, Lotze MT
Cancer research 2012 Jun 1;72(11):2791-801
Cancer research 2012 Jun 1;72(11):2791-801
Cardiac mTOR protects the heart against ischemia-reperfusion injury.
Aoyagi T, Kusakari Y, Xiao CY, Inouye BT, Takahashi M, Scherrer-Crosbie M, Rosenzweig A, Hara K, Matsui T
American journal of physiology. Heart and circulatory physiology 2012 Jul;303(1):H75-85
American journal of physiology. Heart and circulatory physiology 2012 Jul;303(1):H75-85
A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice.
Choi KE, Hall CL, Sun JM, Wei L, Mohamad O, Dix TA, Yu SP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jul;26(7):2799-810
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jul;26(7):2799-810
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy.
Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT, Goedert M
Brain : a journal of neurology 2012 Jul;135(Pt 7):2169-77
Brain : a journal of neurology 2012 Jul;135(Pt 7):2169-77
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK
Science translational medicine 2012 Jul 25;4(144):144ra103
Science translational medicine 2012 Jul 25;4(144):144ra103
Autophagic activity in thymus and liver during aging.
Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K
Age (Dordrecht, Netherlands) 2012 Feb;34(1):75-85
Age (Dordrecht, Netherlands) 2012 Feb;34(1):75-85
Increased autophagic activity in senescent human dental pulp cells.
Li L, Zhu YQ, Jiang L, Peng W
International endodontic journal 2012 Dec;45(12):1074-9
International endodontic journal 2012 Dec;45(12):1074-9
In vivo and in vitro Leishmania amazonensis infection induces autophagy in macrophages.
Cyrino LT, Araújo AP, Joazeiro PP, Vicente CP, Giorgio S
Tissue & cell 2012 Dec;44(6):401-8
Tissue & cell 2012 Dec;44(6):401-8
Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury.
Nakagawa S, Nishihara K, Inui K, Masuda S
European journal of pharmacology 2012 Dec 5;696(1-3):143-54
European journal of pharmacology 2012 Dec 5;696(1-3):143-54
Protective role of autophagy in branched polyethylenimine (25K)- and poly(L-lysine) (30-70K)-induced cell death.
Lin CW, Jan MS, Kuo JH, Hsu LJ, Lin YS
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012 Dec 18;47(5):865-74
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012 Dec 18;47(5):865-74
Single-photon emission computed tomographic imaging of the early time course of therapy-induced cell death using technetium 99m tricarbonyl His-annexin A5 in a colorectal cancer xenograft model.
Vangestel C, Van de Wiele C, Mees G, Mertens K, Staelens S, Reutelingsperger C, Pauwels P, Van Damme N, Peeters M
Molecular imaging 2012 Apr;11(2):135-47
Molecular imaging 2012 Apr;11(2):135-47
Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases.
de Pablo-Latorre R, Saide A, Polishhuck EV, Nusco E, Fraldi A, Ballabio A
Human molecular genetics 2012 Apr 15;21(8):1770-81
Human molecular genetics 2012 Apr 15;21(8):1770-81
Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.
Zhang X, Yuan Q, Tang W, Gu J, Osei K, Wang J
PloS one 2011;6(11):e27647
PloS one 2011;6(11):e27647
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
Ohmi K, Zhao HZ, Neufeld EF
PloS one 2011;6(11):e27461
PloS one 2011;6(11):e27461
Bacterial toxins can inhibit host cell autophagy through cAMP generation.
Shahnazari S, Namolovan A, Mogridge J, Kim PK, Brumell JH
Autophagy 2011 Sep;7(9):957-65
Autophagy 2011 Sep;7(9):957-65
Bacterial toxins can inhibit host cell autophagy through cAMP generation.
Shahnazari S, Namolovan A, Mogridge J, Kim PK, Brumell JH
Autophagy 2011 Sep;7(9):957-65
Autophagy 2011 Sep;7(9):957-65
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway.
Meng Q, Cai D
The Journal of biological chemistry 2011 Sep 16;286(37):32324-32
The Journal of biological chemistry 2011 Sep 16;286(37):32324-32
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.
Kuo TC, Chen CT, Baron D, Onder TT, Loewer S, Almeida S, Weismann CM, Xu P, Houghton JM, Gao FB, Daley GQ, Doxsey S
Nature cell biology 2011 Sep 11;13(10):1214-23
Nature cell biology 2011 Sep 11;13(10):1214-23
Identification of Autographa californica nucleopolyhedrovirus ac93 as a core gene and its requirement for intranuclear microvesicle formation and nuclear egress of nucleocapsids.
Yuan M, Huang Z, Wei D, Hu Z, Yang K, Pang Y
Journal of virology 2011 Nov;85(22):11664-74
Journal of virology 2011 Nov;85(22):11664-74
Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals.
Tomaras GD, Binley JM, Gray ES, Crooks ET, Osawa K, Moore PL, Tumba N, Tong T, Shen X, Yates NL, Decker J, Wibmer CK, Gao F, Alam SM, Easterbrook P, Abdool Karim S, Kamanga G, Crump JA, Cohen M, Shaw GM, Mascola JR, Haynes BF, Montefiori DC, Morris L
Journal of virology 2011 Nov;85(21):11502-19
Journal of virology 2011 Nov;85(21):11502-19
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Zois CE, Giatromanolaki A, Sivridis E, Papaiakovou M, Kainulainen H, Koukourakis MI
Autophagy 2011 Nov;7(11):1371-8
Autophagy 2011 Nov;7(11):1371-8
Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis.
D'Agostino C, Nogalska A, Cacciottolo M, Engel WK, Askanas V
Acta neuropathologica 2011 Nov;122(5):627-36
Acta neuropathologica 2011 Nov;122(5):627-36
Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype.
Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Martin-Castillo B, Vellon L, Menendez JA
Cell cycle (Georgetown, Tex.) 2011 Nov 15;10(22):3871-85
Cell cycle (Georgetown, Tex.) 2011 Nov 15;10(22):3871-85
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.
Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL
BMC cell biology 2011 May 5;12:17
BMC cell biology 2011 May 5;12:17
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease.
Dammer EB, Na CH, Xu P, Seyfried NT, Duong DM, Cheng D, Gearing M, Rees H, Lah JJ, Levey AI, Rush J, Peng J
The Journal of biological chemistry 2011 Mar 25;286(12):10457-65
The Journal of biological chemistry 2011 Mar 25;286(12):10457-65
Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.
Xie R, Nguyen S, McKeehan K, Wang F, McKeehan WL, Liu L
The Journal of biological chemistry 2011 Mar 25;286(12):10367-77
The Journal of biological chemistry 2011 Mar 25;286(12):10367-77
Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases.
Jorge CD, Ventura R, Maycock C, Outeiro TF, Santos H, Costa J
Neurochemical research 2011 Jun;36(6):1005-11
Neurochemical research 2011 Jun;36(6):1005-11
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways.
Mostowy S, Sancho-Shimizu V, Hamon MA, Simeone R, Brosch R, Johansen T, Cossart P
The Journal of biological chemistry 2011 Jul 29;286(30):26987-95
The Journal of biological chemistry 2011 Jul 29;286(30):26987-95
Adenoviruses induce autophagy to promote virus replication and oncolysis.
Rodriguez-Rocha H, Gomez-Gutierrez JG, Garcia-Garcia A, Rao XM, Chen L, McMasters KM, Zhou HS
Virology 2011 Jul 20;416(1-2):9-15
Virology 2011 Jul 20;416(1-2):9-15
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.
Hsu HS, Huang PI, Chang YL, Tzao C, Chen YW, Shih HC, Hung SC, Chen YC, Tseng LM, Chiou SH
Cancer 2011 Jul 1;117(13):2970-85
Cancer 2011 Jul 1;117(13):2970-85
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH
Autophagy 2011 Jan;7(1):17-26
Autophagy 2011 Jan;7(1):17-26
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH
Autophagy 2011 Jan;7(1):17-26
Autophagy 2011 Jan;7(1):17-26
Identification of aneuploidy-selective antiproliferation compounds.
Tang YC, Williams BR, Siegel JJ, Amon A
Cell 2011 Feb 18;144(4):499-512
Cell 2011 Feb 18;144(4):499-512
Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy.
Dortet L, Mostowy S, Samba-Louaka A, Gouin E, Nahori MA, Wiemer EA, Dussurget O, Cossart P
PLoS pathogens 2011 Aug;7(8):e1002168
PLoS pathogens 2011 Aug;7(8):e1002168
Ethanol enhances susceptibility to apoptotic cell death via down-regulation of autophagy-related proteins.
von Haefen C, Sifringer M, Menk M, Spies CD
Alcoholism, clinical and experimental research 2011 Aug;35(8):1381-91
Alcoholism, clinical and experimental research 2011 Aug;35(8):1381-91
Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma.
Jiang S, Li Y, Zhu YH, Wu XQ, Tang J, Li Z, Feng GK, Deng R, Li DD, Luo RZ, Zhang MF, Qin W, Wang X, Jia WH, Zhu XF
Cancer science 2011 Aug;102(8):1568-75
Cancer science 2011 Aug;102(8):1568-75
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.
Lichtenberg M, Mansilla A, Zecchini VR, Fleming A, Rubinsztein DC
Cell death & disease 2011 Aug 25;2:e196
Cell death & disease 2011 Aug 25;2:e196
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Fukaya T, Takagi H, Sato Y, Sato K, Eizumi K, Taya H, Shin T, Chen L, Dong C, Azuma M, Yagita H, Malissen B, Sato K
Blood 2010 Sep 30;116(13):2266-76
Blood 2010 Sep 30;116(13):2266-76
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells.
Yoon S, Woo SU, Kang JH, Kim K, Kwon MH, Park S, Shin HJ, Gwak HS, Chwae YJ
Autophagy 2010 Nov;6(8):1125-38
Autophagy 2010 Nov;6(8):1125-38
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells.
Yoon S, Woo SU, Kang JH, Kim K, Kwon MH, Park S, Shin HJ, Gwak HS, Chwae YJ
Autophagy 2010 Nov;6(8):1125-38
Autophagy 2010 Nov;6(8):1125-38
Roles of autophagy in cetuximab-mediated cancer therapy against EGFR.
Li X, Lu Y, Pan T, Fan Z
Autophagy 2010 Nov;6(8):1066-77
Autophagy 2010 Nov;6(8):1066-77
ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.
Homer CR, Richmond AL, Rebert NA, Achkar JP, McDonald C
Gastroenterology 2010 Nov;139(5):1630-41, 1641.e1-2
Gastroenterology 2010 Nov;139(5):1630-41, 1641.e1-2
Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes.
Fujimoto K, Ford EL, Tran H, Wice BM, Crosby SD, Dorn GW 2nd, Polonsky KS
The Journal of clinical investigation 2010 Nov;120(11):4031-9
The Journal of clinical investigation 2010 Nov;120(11):4031-9
Entrapment of intracytosolic bacteria by septin cage-like structures.
Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P
Cell host & microbe 2010 Nov 18;8(5):433-44
Cell host & microbe 2010 Nov 18;8(5):433-44
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.
Zhou X, Wang L, Hasegawa H, Amin P, Han BX, Kaneko S, He Y, Wang F
Proceedings of the National Academy of Sciences of the United States of America 2010 May 18;107(20):9424-9
Proceedings of the National Academy of Sciences of the United States of America 2010 May 18;107(20):9424-9
Autophagy: assays and artifacts.
Barth S, Glick D, Macleod KF
The Journal of pathology 2010 Jun;221(2):117-24
The Journal of pathology 2010 Jun;221(2):117-24
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S
Human molecular genetics 2010 Jun 15;19(12):2445-55
Human molecular genetics 2010 Jun 15;19(12):2445-55
Analyzing autophagy in zebrafish.
He C, Klionsky DJ
Autophagy 2010 Jul;6(5):642-4
Autophagy 2010 Jul;6(5):642-4
Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7.
Zwerger M, Kolb T, Richter K, Karakesisoglou I, Herrmann H
Molecular biology of the cell 2010 Jan 15;21(2):354-68
Molecular biology of the cell 2010 Jan 15;21(2):354-68
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, Xing G, Zhao Y, Lin CH, Tsai SF, Fidler IJ, Hung MC
Science signaling 2010 Feb 9;3(108):ra9
Science signaling 2010 Feb 9;3(108):ra9
Organic particulate material levels in the atmosphere: conditions favoring sensitivity to varying relative humidity and temperature.
Pankow JF
Proceedings of the National Academy of Sciences of the United States of America 2010 Apr 13;107(15):6682-6
Proceedings of the National Academy of Sciences of the United States of America 2010 Apr 13;107(15):6682-6
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V
PloS one 2010 Apr 1;5(4):e9979
PloS one 2010 Apr 1;5(4):e9979
Kinetic analysis of autophagosome formation and turnover in primary mouse macrophages.
Swanson MS, Byrne BG, Dubuisson JF
Methods in enzymology 2009;452:383-402
Methods in enzymology 2009;452:383-402
Modulation of intracellular ROS levels by TIGAR controls autophagy.
Bensaad K, Cheung EC, Vousden KH
The EMBO journal 2009 Oct 7;28(19):3015-26
The EMBO journal 2009 Oct 7;28(19):3015-26
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS
The Journal of biological chemistry 2009 Oct 2;284(40):27664-73
The Journal of biological chemistry 2009 Oct 2;284(40):27664-73
Transglutaminase 2 is involved in autophagosome maturation.
D'Eletto M, Farrace MG, Falasca L, Reali V, Oliverio S, Melino G, Griffin M, Fimia GM, Piacentini M
Autophagy 2009 Nov;5(8):1145-54
Autophagy 2009 Nov;5(8):1145-54
Transglutaminase 2 is involved in autophagosome maturation.
D'Eletto M, Farrace MG, Falasca L, Reali V, Oliverio S, Melino G, Griffin M, Fimia GM, Piacentini M
Autophagy 2009 Nov;5(8):1145-54
Autophagy 2009 Nov;5(8):1145-54
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos.
He C, Bartholomew CR, Zhou W, Klionsky DJ
Autophagy 2009 May;5(4):520-6
Autophagy 2009 May;5(4):520-6
Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos.
He C, Bartholomew CR, Zhou W, Klionsky DJ
Autophagy 2009 May;5(4):520-6
Autophagy 2009 May;5(4):520-6
Regulation of autophagy by the p300 acetyltransferase.
Lee IH, Finkel T
The Journal of biological chemistry 2009 Mar 6;284(10):6322-8
The Journal of biological chemistry 2009 Mar 6;284(10):6322-8
Yersinia pestis can reside in autophagosomes and avoid xenophagy in murine macrophages by preventing vacuole acidification.
Pujol C, Klein KA, Romanov GA, Palmer LE, Cirota C, Zhao Z, Bliska JB
Infection and immunity 2009 Jun;77(6):2251-61
Infection and immunity 2009 Jun;77(6):2251-61
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T
Proceedings of the National Academy of Sciences of the United States of America 2008 Mar 4;105(9):3374-9
Proceedings of the National Academy of Sciences of the United States of America 2008 Mar 4;105(9):3374-9
Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes.
Swerdlow S, McColl K, Rong Y, Lam M, Gupta A, Distelhorst CW
Autophagy 2008 Jul;4(5):612-20
Autophagy 2008 Jul;4(5):612-20
Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes.
Swerdlow S, McColl K, Rong Y, Lam M, Gupta A, Distelhorst CW
Autophagy 2008 Jul;4(5):612-20
Autophagy 2008 Jul;4(5):612-20
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization.
Mercer CA, Kaliappan A, Dennis PB
Autophagy 2008 Feb;4(2):185-94
Autophagy 2008 Feb;4(2):185-94
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization.
Mercer CA, Kaliappan A, Dennis PB
Autophagy 2008 Feb;4(2):185-94
Autophagy 2008 Feb;4(2):185-94
Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain.
Nie X, Nishitani C, Yamazoe M, Ariki S, Takahashi M, Shimizu T, Mitsuzawa H, Sawada K, Smith K, Crouch E, Nagae H, Takahashi H, Kuroki Y
Biochemistry 2008 Dec 2;47(48):12878-85
Biochemistry 2008 Dec 2;47(48):12878-85
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J
Proceedings of the National Academy of Sciences of the United States of America 2007 Nov 27;104(48):19023-8
Proceedings of the National Academy of Sciences of the United States of America 2007 Nov 27;104(48):19023-8
Long-term health effects of aldrin and dieldrin. A study of exposure, health effects and mortality of workers engaged in the manufacture and formulation of the insecticides aldrin and dieldrin.
de Jong G
Toxicology letters 1991 Apr;Suppl:1-206
Toxicology letters 1991 Apr;Suppl:1-206
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LC3A Antibody [NB100-2331] - Analysis of heart tissue lysates from mice which were subjected or not to 48 hours of starvation. The signal was developed using ECL method and this LC3 antibody was found to detect both forms of LC3, i.e. LC3-I and LC3-II. As expected, the levels of LC3-II form were higher in the heart tissue lysates from starved mice.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LC3A Antibody [NB100-2331] - Detection of HRP conjugated autophagic LC3 in mouse ES cell lysate. The atg5-/- lane (ES cells, cultured to form embryonic bodies, that are deficient in conversion of LC3-1 to LC3-11) demonstrates the specificity of NB 100-2331, as there is no detection of LC3-11. Photo courtesy of Dr. Beth Levine, UT Southwestern Medical Center.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: LC3A Antibody [NB100-2331] - Image shows a specific band for LC3 in 0.5 mg/mL of Neuro2A lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LC3A Antibody [NB100-2331] - Analysis in human brain lyaste.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LC3A Antibody [NB100-2331] - Analysis in human cell lysates.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LC3A Antibody [NB100-2331] - LC3A expression in Mouse macrophage cell line RAW 264.7. Image from verified customer review.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LC3A Antibody [NB100-2331] - Autophagy mobilized during differentiation of immortalized human mesenchymal stem cells (ihMSCs). Cultured ihMSCs were stimulated to undergo osteogenesis to form osteoblasts for 30 days at 21% and 4% oxygen. LC3I and LC3II levels were assessed via immunoblot every 10 days and normalized to beta-actin to derive average LC3II band densities. Image collected and cropped by CiteAb from the following publication (http://stemcellres.com/content/5/6/140), licensed under a CC-BY licence.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LC3A Antibody [NB100-2331] - High autophagosome concentration is consumed during early immortalized human mesenchymal stem cell differentiation. Immortalized human mesenchymal stem cells were differentiated under osteogenic conditions (see Materials and methods) and assayed for changes in LC3I and LC3II during a 72-hour window. Cells were differentiated under standard conditions (top) or with addition of 5 uM rapamycin (middle) or 5 nM bafilomycin (bottom) for the first 3 hours of differentiation to modulate autophagy. Immunoblots were performed for LC3 at the indicated time points to assess autophagosome degradation via relative changes in LC3II (lower band; 17 kDa). Studies were repeated three times with similar trends seen consistently. Image collected and cropped by CiteAb from the following publication (http://stemcellres.com/content/5/6/140), licensed under a CC-BY licence.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: LC3A Antibody [NB100-2331] - Analysis in mouse renal tissue. Image from verifed customer review.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: LC3A Antibody [NB100-2331] - Staining in mouse meniscus and cartilage. Image from verified customer review.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: LC3A Antibody [NB100-2331] - Staining of human brain, cerebral cortex, cell processes in gray matter.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: LC3A Antibody [NB100-2331] - Rapamycin increases autophagy in brains of PDAPP mice. Representative epifluorescent (c200x) image of hippocampal CA1 in control- and rapamycin-fed transgenic PDAPP mice stained with an anti-LC3 antibody. An increase in LC3-immunoreactive puncta was observed in CA1 projections of transgenic PDAPP mice following rapamycin administration. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0009979) licensed under a CC-BY licence.
