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LearnABIN2849519
antibody from antibodies-online
Targeting: MAP1LC3A
ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- ABIN2849519 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-LC3 (APG8A) (AA 1-30), (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- AA 1-30, N-Term
- Antibody clone number
- RB7609
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1.
Forkhead box protein O3 transcription factor negatively regulates autophagy in human cancer cells by inhibiting forkhead box protein O1 expression and cytosolic accumulation.
Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain.
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Identification and anti-human glioblastoma activity of tagitinin C from Tithonia diversifolia methanolic extract.
IGF-I stimulates Rab7-RILP interaction during neuronal autophagy.
Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.
Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent.
Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease.
The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair.
c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.
Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.
Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression.
Autophagy protects neuron from Abeta-induced cytotoxicity.
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection.
Superoxide is the major reactive oxygen species regulating autophagy.
Autophagy: dual roles in life and death?
Autophagy in metazoans: cell survival in the land of plenty.
Autophagy in health and disease: a double-edged sword.
LC3 conjugation system in mammalian autophagy.
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, Lotz MK, Ochi M
Arthritis research & therapy 2015 Oct 13;17:285
Arthritis research & therapy 2015 Oct 13;17:285
Forkhead box protein O3 transcription factor negatively regulates autophagy in human cancer cells by inhibiting forkhead box protein O1 expression and cytosolic accumulation.
Zhu WL, Tong H, Teh JT, Wang M
PloS one 2014;9(12):e115087
PloS one 2014;9(12):e115087
Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain.
Zhang E, Yi MH, Ko Y, Kim HW, Seo JH, Lee YH, Lee W, Kim DW
Brain research 2013 Jun 26;1519:31-9
Brain research 2013 Jun 26;1519:31-9
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Déglon N, Pereira de Almeida L
Brain : a journal of neurology 2011 May;134(Pt 5):1400-15
Brain : a journal of neurology 2011 May;134(Pt 5):1400-15
Identification and anti-human glioblastoma activity of tagitinin C from Tithonia diversifolia methanolic extract.
Lee MY, Liao MH, Tsai YN, Chiu KH, Wen HC
Journal of agricultural and food chemistry 2011 Mar 23;59(6):2347-55
Journal of agricultural and food chemistry 2011 Mar 23;59(6):2347-55
IGF-I stimulates Rab7-RILP interaction during neuronal autophagy.
Bains M, Zaegel V, Mize-Berge J, Heidenreich KA
Neuroscience letters 2011 Jan 20;488(2):112-7
Neuroscience letters 2011 Jan 20;488(2):112-7
Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.
Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, Yokota Y, Fukamoto K, Mutou Y, Kobayashi Y, Yorifuji H
Journal of electron microscopy 2010;59(6):495-501
Journal of electron microscopy 2010;59(6):495-501
Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.
Wang M, Hossain MS, Tan W, Coolman B, Zhou J, Liu S, Casey PJ
Oncogene 2010 Sep 2;29(35):4959-70
Oncogene 2010 Sep 2;29(35):4959-70
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent.
Geng Y, Kohli L, Klocke BJ, Roth KA
Neuro-oncology 2010 May;12(5):473-81
Neuro-oncology 2010 May;12(5):473-81
Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease.
Ma JF, Huang Y, Chen SD, Halliday G
Neuropathology and applied neurobiology 2010 Jun;36(4):312-9
Neuropathology and applied neurobiology 2010 Jun;36(4):312-9
The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair.
Li B, Castano AP, Hudson TE, Nowlin BT, Lin SL, Bonventre JV, Swanson KD, Duffield JS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):4767-81
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):4767-81
c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.
Li X, Ma Q, Wang J, Liu X, Yang Y, Zhao H, Wang Y, Jin Y, Zeng J, Li J, Song L, Li X, Li P, Qian X, Cao C
Cell death and differentiation 2010 Aug;17(8):1277-87
Cell death and differentiation 2010 Aug;17(8):1277-87
Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.
Cirstea D, Hideshima T, Rodig S, Santo L, Pozzi S, Vallet S, Ikeda H, Perrone G, Gorgun G, Patel K, Desai N, Sportelli P, Kapoor S, Vali S, Mukherjee S, Munshi NC, Anderson KC, Raje N
Molecular cancer therapeutics 2010 Apr;9(4):963-75
Molecular cancer therapeutics 2010 Apr;9(4):963-75
Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression.
Bohensky J, Leshinsky S, Srinivas V, Shapiro IM
Pediatric nephrology (Berlin, Germany) 2010 Apr;25(4):633-42
Pediatric nephrology (Berlin, Germany) 2010 Apr;25(4):633-42
Autophagy protects neuron from Abeta-induced cytotoxicity.
Hung SY, Huang WP, Liou HC, Fu WM
Autophagy 2009 May;5(4):502-10
Autophagy 2009 May;5(4):502-10
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection.
English L, Chemali M, Duron J, Rondeau C, Laplante A, Gingras D, Alexander D, Leib D, Norbury C, Lippé R, Desjardins M
Nature immunology 2009 May;10(5):480-7
Nature immunology 2009 May;10(5):480-7
Superoxide is the major reactive oxygen species regulating autophagy.
Chen Y, Azad MB, Gibson SB
Cell death and differentiation 2009 Jul;16(7):1040-52
Cell death and differentiation 2009 Jul;16(7):1040-52
Autophagy: dual roles in life and death?
Baehrecke EH
Nature reviews. Molecular cell biology 2005 Jun;6(6):505-10
Nature reviews. Molecular cell biology 2005 Jun;6(6):505-10
Autophagy in metazoans: cell survival in the land of plenty.
Lum JJ, DeBerardinis RJ, Thompson CB
Nature reviews. Molecular cell biology 2005 Jun;6(6):439-48
Nature reviews. Molecular cell biology 2005 Jun;6(6):439-48
Autophagy in health and disease: a double-edged sword.
Shintani T, Klionsky DJ
Science (New York, N.Y.) 2004 Nov 5;306(5698):990-5
Science (New York, N.Y.) 2004 Nov 5;306(5698):990-5
LC3 conjugation system in mammalian autophagy.
Tanida I, Ueno T, Kominami E
The international journal of biochemistry & cell biology 2004 Dec;36(12):2503-18
The international journal of biochemistry & cell biology 2004 Dec;36(12):2503-18
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, Zhao S, Liu JO, Yu L
The Journal of biological chemistry 2003 Aug 1;278(31):29278-87
The Journal of biological chemistry 2003 Aug 1;278(31):29278-87
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