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antibody from antibodies-online
Targeting: MAP1LC3A
ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [3]
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- Product number
- ABIN2849553 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 89-120), (C-Term), (cleaved) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 89-120, C-Term, cleaved
- Antibody clone number
- RB38908
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
- Handling
- Avoid freeze-thaw cycles.
Submitted references Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress.
Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms.
Chaperone molecules concentrate together with the ubiquitin-proteasome system inside particulate cytoplasmic structures: possible role in metabolism of misfolded proteins.
IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages.
Autophagy proteins in prostate cancer: relation with anaerobic metabolism and Gleason score.
Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice.
Patterns of autophagy in urothelial cell carcinomas--the significance of "stone-like" structures (SLS) in transurethral resection biopsies.
LC3 immunostaining pitfalls.
A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.
Immunohistochemical analysis of macroautophagy: recommendations and limitations.
Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas.
Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas.
Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.
Inhibition of the host translation shutoff response by herpes simplex virus 1 triggers nuclear envelope-derived autophagy.
Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.
LC3A-positive "stone-like" structures in cutaneous squamous cell carcinomas.
Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1.
Autophagy in endometrial carcinomas and prognostic relevance of 'stone-like' structures (SLS): what is destined for the atypical endometrial hyperplasia?
Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine.
The gluttonous side of malignant melanoma: basic and clinical implications of macroautophagy.
Autophagy patterns and prognosis in uveal melanomas.
Pancreatic cancers require autophagy for tumor growth.
Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas.
LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas.
Autophagy: dual roles in life and death?
Autophagy in metazoans: cell survival in the land of plenty.
Autophagy in health and disease: a double-edged sword.
LC3 conjugation system in mammalian autophagy.
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
Kong J, Whelan KA, Laczkó D, Dang B, Caro Monroig A, Soroush A, Falcone J, Amaravadi RK, Rustgi AK, Ginsberg GG, Falk GW, Nakagawa H, Lynch JP
Molecular carcinogenesis 2016 Nov;55(11):1526-1541
Molecular carcinogenesis 2016 Nov;55(11):1526-1541
Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms.
Pecci A, Necchi V, Barozzi S, Vitali A, Boveri E, Elena C, Bernasconi P, Noris P, Solcia E
Journal of hematology & oncology 2015 Jun 18;8:71
Journal of hematology & oncology 2015 Jun 18;8:71
Chaperone molecules concentrate together with the ubiquitin-proteasome system inside particulate cytoplasmic structures: possible role in metabolism of misfolded proteins.
Vanoli A, Necchi V, Barozzi S, Manca R, Pecci A, Solcia E
Histochemistry and cell biology 2015 Aug;144(2):179-84
Histochemistry and cell biology 2015 Aug;144(2):179-84
IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages.
Assani K, Tazi MF, Amer AO, Kopp BT
PloS one 2014;9(5):e96681
PloS one 2014;9(5):e96681
Autophagy proteins in prostate cancer: relation with anaerobic metabolism and Gleason score.
Giatromanolaki A, Sivridis E, Mendrinos S, Koutsopoulos AV, Koukourakis MI
Urologic oncology 2014 Jan;32(1):39.e11-8
Urologic oncology 2014 Jan;32(1):39.e11-8
Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice.
Armani A, Cinti F, Marzolla V, Morgan J, Cranston GA, Antelmi A, Carpinelli G, Canese R, Pagotto U, Quarta C, Malorni W, Matarrese P, Marconi M, Fabbri A, Rosano G, Cinti S, Young MJ, Caprio M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Aug;28(8):3745-57
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Aug;28(8):3745-57
Patterns of autophagy in urothelial cell carcinomas--the significance of "stone-like" structures (SLS) in transurethral resection biopsies.
Sivridis E, Koukourakis MI, Mendrinos SE, Touloupidis S, Giatromanolaki A
Urologic oncology 2013 Oct;31(7):1254-60
Urologic oncology 2013 Oct;31(7):1254-60
LC3 immunostaining pitfalls.
Koukourakis MI, Giatromanolaki A, Zois CE, Sivridis E
Histopathology 2013 May;62(6):962-3
Histopathology 2013 May;62(6):962-3
A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.
Khweek AA, Caution K, Akhter A, Abdulrahman BA, Tazi M, Hassan H, Majumdar N, Doran A, Guirado E, Schlesinger LS, Shuman H, Amer AO
European journal of immunology 2013 May;43(5):1333-44
European journal of immunology 2013 May;43(5):1333-44
Immunohistochemical analysis of macroautophagy: recommendations and limitations.
Martinet W, Schrijvers DM, Timmermans JP, Bult H, De Meyer GR
Autophagy 2013 Mar;9(3):386-402
Autophagy 2013 Mar;9(3):386-402
Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas.
Giatromanolaki A, Koukourakis MI, Pouliliou S, Gatter KC, Pezzella F, Harris AL, Sivridis E
Hematology/oncology and stem cell therapy 2013 Mar;6(1):20-5
Hematology/oncology and stem cell therapy 2013 Mar;6(1):20-5
Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas.
Karpathiou G, Sivridis E, Koukourakis M, Mikroulis D, Bouros D, Froudarakis M, Bougioukas G, Maltezos E, Giatromanolaki A
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2013 Jul;121(7):592-604
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2013 Jul;121(7):592-604
Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.
Abdulrahman BA, Khweek AA, Akhter A, Caution K, Tazi M, Hassan H, Zhang Y, Rowland PD, Malhotra S, Aeffner F, Davis IC, Valvano MA, Amer AO
The Journal of biological chemistry 2013 Jan 18;288(3):2049-58
The Journal of biological chemistry 2013 Jan 18;288(3):2049-58
Inhibition of the host translation shutoff response by herpes simplex virus 1 triggers nuclear envelope-derived autophagy.
Radtke K, English L, Rondeau C, Leib D, Lippé R, Desjardins M
Journal of virology 2013 Apr;87(7):3990-7
Journal of virology 2013 Apr;87(7):3990-7
Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.
Tang J, Deng R, Luo RZ, Shen GP, Cai MY, Du ZM, Jiang S, Yang MT, Fu JH, Zhu XF
Breast cancer research and treatment 2012 Jul;134(2):549-60
Breast cancer research and treatment 2012 Jul;134(2):549-60
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Zois CE, Giatromanolaki A, Sivridis E, Papaiakovou M, Kainulainen H, Koukourakis MI
Autophagy 2011 Nov;7(11):1371-8
Autophagy 2011 Nov;7(11):1371-8
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.
Abdulrahman BA, Khweek AA, Akhter A, Caution K, Kotrange S, Abdelaziz DH, Newland C, Rosales-Reyes R, Kopp B, McCoy K, Montione R, Schlesinger LS, Gavrilin MA, Wewers MD, Valvano MA, Amer AO
Autophagy 2011 Nov;7(11):1359-70
Autophagy 2011 Nov;7(11):1359-70
LC3A-positive "stone-like" structures in cutaneous squamous cell carcinomas.
Sivridis E, Giatromanolaki A, Karpathiou G, Karpouzis A, Kouskoukis C, Koukourakis MI
The American Journal of dermatopathology 2011 May;33(3):285-90
The American Journal of dermatopathology 2011 May;33(3):285-90
Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1.
Sivridis E, Koukourakis MI, Mendrinos SE, Karpouzis A, Fiska A, Kouskoukis C, Giatromanolaki A
Melanoma research 2011 Jun;21(3):188-95
Melanoma research 2011 Jun;21(3):188-95
Autophagy in endometrial carcinomas and prognostic relevance of 'stone-like' structures (SLS): what is destined for the atypical endometrial hyperplasia?
Sivridis E, Giatromanolaki A, Liberis V, Koukourakis MI
Autophagy 2011 Jan;7(1):74-82
Autophagy 2011 Jan;7(1):74-82
Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine.
Zois CE, Giatromanolaki A, Kainulainen H, Botaitis S, Torvinen S, Simopoulos C, Kortsaris A, Sivridis E, Koukourakis MI
Biochemical and biophysical research communications 2011 Jan 7;404(1):552-8
Biochemical and biophysical research communications 2011 Jan 7;404(1):552-8
The gluttonous side of malignant melanoma: basic and clinical implications of macroautophagy.
Checinska A, Soengas MS
Pigment cell & melanoma research 2011 Dec;24(6):1116-32
Pigment cell & melanoma research 2011 Dec;24(6):1116-32
Autophagy patterns and prognosis in uveal melanomas.
Giatromanolaki AN, Charitoudis GS, Bechrakis NE, Kozobolis VP, Koukourakis MI, Foerster MH, Sivridis EL
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Aug;24(8):1036-45
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Aug;24(8):1036-45
Pancreatic cancers require autophagy for tumor growth.
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC
Genes & development 2011 Apr 1;25(7):717-29
Genes & development 2011 Apr 1;25(7):717-29
Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas.
Giatromanolaki A, Koukourakis MI, Harris AL, Polychronidis A, Gatter KC, Sivridis E
Journal of clinical pathology 2010 Oct;63(10):867-72
Journal of clinical pathology 2010 Oct;63(10):867-72
LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas.
Sivridis E, Koukourakis MI, Zois CE, Ledaki I, Ferguson DJ, Harris AL, Gatter KC, Giatromanolaki A
The American journal of pathology 2010 May;176(5):2477-89
The American journal of pathology 2010 May;176(5):2477-89
Autophagy: dual roles in life and death?
Baehrecke EH
Nature reviews. Molecular cell biology 2005 Jun;6(6):505-10
Nature reviews. Molecular cell biology 2005 Jun;6(6):505-10
Autophagy in metazoans: cell survival in the land of plenty.
Lum JJ, DeBerardinis RJ, Thompson CB
Nature reviews. Molecular cell biology 2005 Jun;6(6):439-48
Nature reviews. Molecular cell biology 2005 Jun;6(6):439-48
Autophagy in health and disease: a double-edged sword.
Shintani T, Klionsky DJ
Science (New York, N.Y.) 2004 Nov 5;306(5698):990-5
Science (New York, N.Y.) 2004 Nov 5;306(5698):990-5
LC3 conjugation system in mammalian autophagy.
Tanida I, Ueno T, Kominami E
The international journal of biochemistry & cell biology 2004 Dec;36(12):2503-18
The international journal of biochemistry & cell biology 2004 Dec;36(12):2503-18
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, Zhao S, Liu JO, Yu L
The Journal of biological chemistry 2003 Aug 1;278(31):29278-87
The Journal of biological chemistry 2003 Aug 1;278(31):29278-87
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