DCABH-204

antibody from Creative Diagnostics

Targeting: ATG7 APG7L, DKFZp434N0735, GSA7

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DCABH-204

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-204, RRID:AB_2474272

Product name

Rabbit Anti-ACACA monoclonal antibody, clone TU64-19

Antibody type

Monoclonal

Description

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCÏ« (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCÉÇ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCÏ« is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme's short-term regulatory mechanism. The gene encoding ACCÏ« maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCÉÇ is homologous to that of the ACCÏ«, except for an additional peptide of about 150 amino acids at the N-terminus.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TU64-19

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.