ALDH8A1

This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018]

Description

Aldehyde dehydrogenase 8 family member A1

Tissue specificity

Group enriched (kidney, liver)

Subcell location

Nucleoplasm, Centrosome

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (134917393 - 134950115)

Ensembl ID

ENSG00000118514  (ver. 103.38)

Orthologs

Mouse Aldh8a1: ENSMUSG00000037542

UniProt

Q9H2A2

neXtProt

NX_Q9H2A2

Human splice variants
Mouse splice variants

Protein structure