HPA024354

antibody from Atlas Antibodies

Targeting: DNAH17 DNAHL1, DNEL2, FLJ40457

Immunocytochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

HPA024354

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA024354, RRID:AB_1847911

Product name

Anti-DNAH17

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human DNAH17, Gene description: dynein, axonemal, heavy chain 17, Alternative Gene Names: DNAHL1, DNEL2, FLJ40457, Validated applications: ICC, Uniprot ID: Q9UFH2, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Identification of IQCH as a calmodulin-associated protein required for sperm motility in humans

Cavarocchi E, Sayou C, Lorès P, Cazin C, Stouvenel L, El Khouri E, Coutton C, Kherraf Z, Patrat C, Govin J, Thierry-Mieg N, Whitfield M, Ray P, Dulioust E, Touré A
iScience 2023;26(8):107354

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Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice

Tu C, Cong J, Zhang Q, He X, Zheng R, Yang X, Gao Y, Wu H, Lv M, Gu Y, Lu S, Liu C, Tian S, Meng L, Wang W, Tan C, Nie H, Li D, Zhang H, Gong F, Hu L, Lu G, Xu W, Lin G, Zhang F, Cao Y, Tan Y
The American Journal of Human Genetics 2021;108(8):1466-1477

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Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.

Aprea I, Raidt J, Höben IM, Loges NT, Nöthe-Menchen T, Pennekamp P, Olbrich H, Kaiser T, Biebach L, Tüttelmann F, Horvath J, Schubert M, Krallmann C, Kliesch S, Omran H
PLoS genetics 2021 Feb;17(2):e1009306

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CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.

Dougherty GW, Mizuno K, Nöthe-Menchen T, Ikawa Y, Boldt K, Ta-Shma A, Aprea I, Minegishi K, Pang YP, Pennekamp P, Loges NT, Raidt J, Hjeij R, Wallmeier J, Mussaffi H, Perles Z, Elpeleg O, Rabert F, Shiratori H, Letteboer SJ, Horn N, Young S, Strünker T, Stumme F, Werner C, Olbrich H, Takaoka K, Ide T, Twan WK, Biebach L, Große-Onnebrink J, Klinkenbusch JA, Praveen K, Bracht DC, Höben IM, Junger K, Gützlaff J, Cindrić S, Aviram M, Kaiser T, Memari Y, Dzeja PP, Dworniczak B, Ueffing M, Roepman R, Bartscherer K, Katsanis N, Davis EE, Amirav I, Hamada H, Omran H
Nature communications 2020 Nov 2;11(1):5520

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Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia

Whitfield M, Thomas L, Bequignon E, Schmitt A, Stouvenel L, Montantin G, Tissier S, Duquesnoy P, Copin B, Chantot S, Dastot F, Faucon C, Barbotin A, Loyens A, Siffroi J, Papon J, Escudier E, Amselem S, Mitchell V, Touré A, Legendre M
The American Journal of Human Genetics 2019;105(1):198-212

Immunocytochemistry

Supportive validation

Submitted by

Atlas Antibodies (provider)

Main image

Experimental details

Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm & plasma membrane.

Sample type

Human