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- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12868-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12868-1-AP, RRID:AB_2209712
- Product name
- TRAF5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRAF5 antibody (Cat. #12868-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Immunomodulatory effects of bacterial lysates on the IL-17 signaling pathway in an asthma mouse model.
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury.
Exploring the Anti-Colorectal Cancer Mechanism of Norcantharidin Through TRAF5/NF-κB Pathway Regulation and Folate-Targeted Liposomal Delivery.
Chemically Modified PPARγ mRNA Unleashes Adipogenic Potential in 3T3-L1-Predipocytes: An Approach for Accelerated Wound Healing.
TRAF2 associates with cullin neddylation complex assembly.
CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway.
Microbial chaperonin 60 inhibits osteoclast differentiation by interfering with RANK/RANKL binding and overexpression of lipocalin2.
IL-17 promotes melanoma through TRAF2 as a scaffold protein recruiting PIAS2 and ELAVL1 to induce EPHA5.
Integrated analysis identifies low microRNA-215 expression as associated with a poor prognosis of patients with colorectal cancer through the IKβ-α signaling pathway.
Down-regulated HDAC3 elevates microRNA-495-3p to restrain epithelial-mesenchymal transition and oncogenicity of melanoma cells via reducing TRAF5.
TRAF5 protects against myocardial ischemia reperfusion injury via AKT signaling.
Decreased miR-218-5p Levels as a Serum Biomarker in Bone Metastasis of Prostate Cancer.
Effects of antisense lncRNA PCBP1-AS1 on biological behaviors of vulvar squamous carcinoma cells by regulating TRAF5 and NF-κB expression.
Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Gao M, Wang X, Yin L, Wei X, Li F
The Journal of asthma : official journal of the Association for the Care of Asthma 2026 Feb;63(2):159-168
The Journal of asthma : official journal of the Association for the Care of Asthma 2026 Feb;63(2):159-168
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury.
Leng J, Cao Z, Li L, Hu D, Luo Y, Tu B, Cao X, Tao R, Jiang Y, Tie H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Nov 6;74(1):156
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Nov 6;74(1):156
Exploring the Anti-Colorectal Cancer Mechanism of Norcantharidin Through TRAF5/NF-κB Pathway Regulation and Folate-Targeted Liposomal Delivery.
Zhang F, Chen X, Qiao C, Yang S, Zhai Y, Zhang J, Chai K, Wang H, Zhou J, Guo M, Lu P, Wu J
International journal of molecular sciences 2025 Feb 9;26(4)
International journal of molecular sciences 2025 Feb 9;26(4)
Chemically Modified PPARγ mRNA Unleashes Adipogenic Potential in 3T3-L1-Predipocytes: An Approach for Accelerated Wound Healing.
Luo Z, Lu Y, Zheng S, Liu K, Fu W, Pan Y
International journal of medical sciences 2024;21(13):2480-2493
International journal of medical sciences 2024;21(13):2480-2493
TRAF2 associates with cullin neddylation complex assembly.
Wang T, Zhang Q, Xu Y, Yan R, Pan Y, Xuan Y, Shen M, Chen X, Zhu H, Ke X, Qu Y, Zhang X
The FEBS journal 2024 Oct;291(20):4473-4488
The FEBS journal 2024 Oct;291(20):4473-4488
CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway.
Hou X, Qu X, Chen W, Sang X, Ye Y, Wang C, Guo Y, Shi H, Yang C, Zhu K, Zhang Y, Xu H, Lv L, Zhang D, Hou L
Journal of neuroinflammation 2024 Jun 5;21(1):148
Journal of neuroinflammation 2024 Jun 5;21(1):148
Microbial chaperonin 60 inhibits osteoclast differentiation by interfering with RANK/RANKL binding and overexpression of lipocalin2.
Cho JY, Woo HE, Yeom J, An M, Ma S, Yim DJ, Kim SH, Lim YH
Biochimica et biophysica acta. Molecular cell research 2024 Dec;1871(8):119850
Biochimica et biophysica acta. Molecular cell research 2024 Dec;1871(8):119850
IL-17 promotes melanoma through TRAF2 as a scaffold protein recruiting PIAS2 and ELAVL1 to induce EPHA5.
Du J, Du Y, Chen L, Liu H
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119547
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119547
Integrated analysis identifies low microRNA-215 expression as associated with a poor prognosis of patients with colorectal cancer through the IKβ-α signaling pathway.
Wang Z, Jiang X, Li Q, Jin Y, Liu X, Wang F, Mao Y, Hua D
Translational cancer research 2020 Sep;9(9):5233-5244
Translational cancer research 2020 Sep;9(9):5233-5244
Down-regulated HDAC3 elevates microRNA-495-3p to restrain epithelial-mesenchymal transition and oncogenicity of melanoma cells via reducing TRAF5.
Ma Y, Duan J, Hao X
Journal of cellular and molecular medicine 2020 Nov;24(22):12933-12944
Journal of cellular and molecular medicine 2020 Nov;24(22):12933-12944
TRAF5 protects against myocardial ischemia reperfusion injury via AKT signaling.
Xu W, Zhang L, Ma S, Zhang Y, Cai Z, Zhang K, Jin D
European journal of pharmacology 2020 Jul 5;878:173092
European journal of pharmacology 2020 Jul 5;878:173092
Decreased miR-218-5p Levels as a Serum Biomarker in Bone Metastasis of Prostate Cancer.
Peng P, Chen T, Wang Q, Zhang Y, Zheng F, Huang S, Tang Y, Yang C, Ding W, Ren D, Huang Z, Guo Y
Oncology research and treatment 2019;42(4):165-185
Oncology research and treatment 2019;42(4):165-185
Effects of antisense lncRNA PCBP1-AS1 on biological behaviors of vulvar squamous carcinoma cells by regulating TRAF5 and NF-κB expression.
Wang H, Ouyang L, Gao S
Translational cancer research 2019 Aug;8(4):1578-1590
Translational cancer research 2019 Aug;8(4):1578-1590
Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.
Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters 2017 Nov 1;408:60-70
Cancer letters 2017 Nov 1;408:60-70
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 12868-1-AP(TRAF5 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRAF5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRAF5. This antibody recognizes human, mouse, rat antigen. The TRAF5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
