Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 17504-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17504-1-AP, RRID:AB_2097393
- Product name
- EIF4A3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EIF4A3 antibody (Cat. #17504-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CircSPI1 acts as an oncogene in acute myeloid leukemia through antagonizing SPI1 and interacting with microRNAs.
Local translation in nuclear condensate amyloid bodies.
eIF4A3 regulates the TFEB-mediated transcriptional response via GSK3B to control autophagy.
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation.
hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3.
Comprehensive analysis of biological networks and the eukaryotic initiation factor 4A-3 gene as pivotal in hepatocellular carcinoma.
Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2'-O-methylation via NOP58 recruitment in colorectal cancer.
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells.
Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.
LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer.
mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion.
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.
Y14 governs p53 expression and modulates DNA damage sensitivity.
The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation.
TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.
A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement.
A proteomic approach to discover and compare interacting partners of papillomavirus E2 proteins from diverse phylogenetic groups.
A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging.
Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.
An atlas of chromatoid body components.
Wang X, Jin P, Zhang Y, Wang K
Cell death & disease 2021 Mar 19;12(4):297
Cell death & disease 2021 Mar 19;12(4):297
Local translation in nuclear condensate amyloid bodies.
Theodoridis PR, Bokros M, Marijan D, Balukoff NC, Wang D, Kirk CC, Budine TD, Goldsmith HD, Wang M, Audas TE, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
eIF4A3 regulates the TFEB-mediated transcriptional response via GSK3B to control autophagy.
Sakellariou D, Tiberti M, Kleiber TH, Blazquez L, López AR, Abildgaard MH, Lubas M, Bartek J, Papaleo E, Frankel LB
Cell death and differentiation 2021 Dec;28(12):3344-3356
Cell death and differentiation 2021 Dec;28(12):3344-3356
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation.
Feng J, Ren X, Fu H, Li D, Chen X, Zu X, Liu Q, Wu M
Molecular therapy. Nucleic acids 2021 Dec 3;26:473-487
Molecular therapy. Nucleic acids 2021 Dec 3;26:473-487
hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3.
Wang X, Chen M, Fang L
Molecular therapy. Nucleic acids 2021 Dec 3;26:122-134
Molecular therapy. Nucleic acids 2021 Dec 3;26:122-134
Comprehensive analysis of biological networks and the eukaryotic initiation factor 4A-3 gene as pivotal in hepatocellular carcinoma.
Lin Y, Liang R, Mao Y, Ye J, Mai R, Gao X, Liu Z, Wainwright T, Li Q, Luo M, Ge L, Li Y, Zou D
Journal of cellular biochemistry 2020 Oct;121(10):4094-4107
Journal of cellular biochemistry 2020 Oct;121(10):4094-4107
Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2'-O-methylation via NOP58 recruitment in colorectal cancer.
Wu H, Qin W, Lu S, Wang X, Zhang J, Sun T, Hu X, Li Y, Chen Q, Wang Y, Zhao H, Piao H, Zhang R, Wei M
Molecular cancer 2020 May 22;19(1):95
Molecular cancer 2020 May 22;19(1):95
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Tang W, Wang D, Shao L, Liu X, Zheng J, Xue Y, Ruan X, Yang C, Liu L, Ma J, Li Z, Liu Y
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells.
Qi W, Li Z, Xia L, Dai J, Zhang Q, Wu C, Xu S
Scientific reports 2019 Nov 7;9(1):16185
Scientific reports 2019 Nov 7;9(1):16185
Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.
Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ
RNA (New York, N.Y.) 2019 Mar;25(3):352-363
RNA (New York, N.Y.) 2019 Mar;25(3):352-363
LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer.
Luo K, Geng J, Zhang Q, Xu Y, Zhou X, Huang Z, Shi KQ, Pan C, Wu J
Journal of experimental & clinical cancer research : CR 2019 Jun 11;38(1):249
Journal of experimental & clinical cancer research : CR 2019 Jun 11;38(1):249
mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion.
Kim WK, Yun S, Kwon Y, You KT, Shin N, Kim J, Kim H
Scientific reports 2017 Nov 20;7(1):15833
Scientific reports 2017 Nov 20;7(1):15833
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.
Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C
Cell research 2017 Mar;27(3):315-328
Cell research 2017 Mar;27(3):315-328
Y14 governs p53 expression and modulates DNA damage sensitivity.
Lu CC, Lee CC, Tseng CT, Tarn WY
Scientific reports 2017 Mar 31;7:45558
Scientific reports 2017 Mar 31;7:45558
The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation.
Rodor J, Pan Q, Blencowe BJ, Eyras E, Cáceres JF
RNA (New York, N.Y.) 2016 Sep;22(9):1411-26
RNA (New York, N.Y.) 2016 Sep;22(9):1411-26
TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins.
Prpar Mihevc S, Baralle M, Buratti E, Rogelj B
Scientific reports 2016 Sep 26;6:33996
Scientific reports 2016 Sep 26;6:33996
A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement.
Chuang TW, Lee KM, Lou YC, Lu CC, Tarn WY
The Journal of biological chemistry 2016 Apr 15;291(16):8565-74
The Journal of biological chemistry 2016 Apr 15;291(16):8565-74
A proteomic approach to discover and compare interacting partners of papillomavirus E2 proteins from diverse phylogenetic groups.
Jang MK, Anderson DE, van Doorslaer K, McBride AA
Proteomics 2015 Jun;15(12):2038-50
Proteomics 2015 Jun;15(12):2038-50
A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging.
Fletcher BR, Hill GS, Long JM, Gallagher M, Shapiro ML, Rapp PR
Neurobiology of learning and memory 2014 Nov;115:58-67
Neurobiology of learning and memory 2014 Nov;115:58-67
Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.
Melero R, Uchiyama A, Castaño R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O
Structure (London, England : 1993) 2014 Aug 5;22(8):1105-1119
Structure (London, England : 1993) 2014 Aug 5;22(8):1105-1119
An atlas of chromatoid body components.
Meikar O, Vagin VV, Chalmel F, Sõstar K, Lardenois A, Hammell M, Jin Y, Da Ros M, Wasik KA, Toppari J, Hannon GJ, Kotaja N
RNA (New York, N.Y.) 2014 Apr;20(4):483-95
RNA (New York, N.Y.) 2014 Apr;20(4):483-95
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 17504-1-AP(EIF4A3 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using EIF4A3 antibody 17504-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-EIF4A3 (IP:17504-1-AP, 3ug; Detection:17504-1-AP 1:1000) with mouse heart tissue lysate 5000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 17504-1-AP(EIF4A3 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue