BS60293

antibody from Bioworld Technology, Inc
Targeting: IL22RA2 CRF2-S1, IL-22BP
Provider product page for BS60293

Antibody data

Product number
BS60293 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL 22RÏ«2 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human IL-22RÏ«2.
Description
IL-22RÏ«2 (interleukin-22 receptor Ï«-2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2 soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22RÏ«2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is four- to ten-fold higher than that of the membrane bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22RÏ«2 prevents the binding to the IL-22 membrane bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22RÏ«2 may be important in regulating inflammatory responses. In addition, IL-22RÏ«2 can be induced by lipopolysaccharide (LPS).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL22RA2 protein structure - BS60293 shown in red.