26689-1-AP

antibody from Proteintech Group

Targeting: CCN1 CYR61, GIG1, IGFBP10

Provider product page for 26689-1-AP

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Immunocytochemistry

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Antibody data

Antibody Data
Antigen structure
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Product number: 26689-1-AP - Provider product page
Provider: Proteintech Group
Product name: CYR61/CCN1 antibody
Antibody type: Polyclonal
Description: KD/KO validated CYR61/CCN1 antibody (Cat. #26689-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CCN1 protein structure - 26689-1-AP shown in red.

Submitted references O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.

Dai S, Wan X, Xia L, Xu L, Xie C, Wang G, Tang J
Cell death & disease 2026 Mar 15;17(1)

Phosphoethanolamine cytidylyltransferase 2 exerts an anti-tumor role in clear cell renal cell carcinoma by modulating the hippo/YAP1 signaling pathway in a PPP2R1A-dependent manner.

Nan N, Guo H, Huang Y, Chen J, Qiang X
Toxicology and applied pharmacology 2026 Jun;511:117786

Novel senescence inducer ICA-11c, a derivative of icaritin, YAP-dependently suppresses hepatocellular carcinoma cells.

Chen HF, Shen S, Wang SL, Ye L, Li JC, Cao WL, Hou ZL, Jia JH, Liu QB, Yao GD, Song SJ
Chemico-biological interactions 2026 Jan 5;423:111814

ECM Protein CYR61 Promotes Migration and Osteoblastic Differentiation of Irradiation BMSCs via Migrasomes.

Yan C, Sun W, Chen Z, Liu L, Zhou P, Gu Y, Wu G, Wang K
Stem cells international 2025;2025:8825935

ACTN2, regulated by PRDM9, affects the growth and inflammation of vascular smooth muscle cells by interacting with PDLIM1 in intracranial aneurysms.

Zhang G, Zhao J, Yu Z, Liu H
Frontiers in molecular neuroscience 2025;18:1606973

Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation.

Guo W, Zhang C, Zhou Q, Chen T, Xu X, Zhang J, Yu X, Wu H, Zhang X, Ma L, Qian K, Klionsky DJ, Kang R, Kroemer G, Yu Y, Tang D, Wang J
Developmental cell 2025 Sep 8;60(17):2294-2312.e11

Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells.

Sicairos B, Zhou J, Hu Z, Zhang Q, Shi WQ, Du Y
ACS omega 2025 Sep 2;10(34):38522-38530

HOMER3 orchestrates SRC-YAP1 activity that promotes tumor cell growth and antagonizes anti-tumor immunotherapy in prostate cancer.

Tong T, Lei H, Huang M, Yang Z, Dai X, Zou H, Guo Y, Luo J, Teng Q, Cao F, Pang J, Li P
Oncogene 2025 Oct;44(41):3895-3908

The S1PR1-CCN1 axis drives endothelial-to-mesenchymal transition and vascular instability in brain arteriovenous malformations.

Li G, Zhang H, Liu M, Liu Y, Shen S, Li S, Zhu W
European journal of medical research 2025 Nov 25;30(1):1175

MISP promotes the progression of lung adenocarcinoma through Inhibition of the Hippo signaling pathway.

Cheng Y, Shen Y, Fang W, Duan S, Wang Y, Dai X, Chen Y
Discover oncology 2025 Nov 17;16(1):2116

Targeted Nanoencapsulation of Tunicamycin Reduces Toxicity While Improving its Therapeutic Effectiveness in Pancreatic Cancer Cells.

Dutta D, Upadhyay S, De A, Haque I, Breier AH, De A, Mettman DJ, Kambhampati S, Quadir M, Diaz F, Banerjee SK, Bossmann SH, Banerjee S
Research square 2025 May 23;

CCN1 derived from vascular endothelial cells impairs cognitive function in Alzheimer's disease model mice.

Hirabayashi S, Uyeda A, Manabe I, Yonezu Y, Saito T, Saido TC, Misawa H, Ogasawara Y, Kinoshita K, Muramatsu R
Journal of pharmacological sciences 2025 Mar;157(3):146-155

YAP1 facilitates the pathogenesis of psoriasis via modulating keratinocyte proliferation and inflammation.

Huang C, Li W, Shen C, Jiang B, Zhang K, Li X, Zhong W, Li Z, Chen Z, Chen C, Jian X, Liu X, Huang H, Yang L, Yu B
Cell death & disease 2025 Mar 19;16(1):186

LncRNA MKLN1-AS promotes glioma tumorigenesis and growth via activating the Hippo pathway through miR-126-5p/TEAD1 axis.

Chen S, Tu S, Huang Y, Lin H, Wang Y, Dai X
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):6787-6799

CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer.

Fan H, Zhao H, Gao L, Dong Y, Zhang P, Yu P, Ji Y, Chen ZS, Liang X, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500589

Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells.

Dutta D, Upadhyay SP, De A, Haque I, Breier AH, De A, Mettman DJ, Kambhampati S, Quadir M, Diaz F, Banerjee SK, Bossmann SH, Banerjee S
Molecular therapy. Oncology 2025 Dec 18;33(4):201047

Plasminogen activator inhibitor 1 promotes aortic aging-like pathophysiology in humans and mice.

Khoddam A, Kalousdian A, Eren M, Soberanes S, Decker A, Lux EJ, Zywicki BW, Dinh B, Boztepe B, Cheema BS, Cuda CM, Abdala-Valencia H, Sivakumar A, Miyata T, Wilsbacher LD, Vaughan DE
The Journal of clinical investigation 2025 Dec 1;135(23)

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non-Small Cell Lung Cancer.

Zhang F, Huang B, Xu Y, Cao G, Shen M, Liu C, Luo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2415814

CDK4/6-mediated phosphorylation of DUB3 promotes YAP1 stability and hepatocellular carcinoma progression.

Huang L, Yuan W, Li X, Liu Y, Wan R, Ma X, Liu T, Liang J, Zhu Y
Cell death discovery 2025 Apr 30;11(1):212

Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.

Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85

CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway.

Hu K, Xie L, Wu W, Zhang J, Li Y, He J, Zhang Y, Lu D, Koeffler HP, Lin L, Yin D
International journal of biological sciences 2024;20(8):3140-3155

CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation.

Zeng X, Tang J, Zhang Q, Wang C, Qi J, Wei Y, Xu J, Yang K, Zhou Z, Wu H, Luo J, Jiang Y, Song Z, Wu J, Wu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2401588

Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells.

Sicairos B, Zhou J, Hu Z, Zhang Q, Shi WQ, Du Y
bioRxiv : the preprint server for biology 2024 Sep 3;

YAP-LAMB3 axis dictates cellular resistance of pancreatic ductal adenocarcinoma cells to gemcitabine.

Li Y, Wang X, Yu H, Cao J, Xie J, Zhou J, Feng Z, Chen W
Molecular carcinogenesis 2024 Oct;63(10):1953-1966

Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E-deficient mice.

Xu MY, Xu JJ, Kang LJ, Liu ZH, Su MM, Zhao WQ, Wang ZH, Sun L, Xiao JB, Evans PC, Tian XY, Wang L, Huang Y, Liang XM, Weng JP, Xu SW
Acta pharmacologica Sinica 2024 Nov;45(11):2277-2289

YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression.

Li X, Zhong H, Shi Q, Ruan R, Huang C, Wen Q, Zeng S, Xia Y, Zeng Q, Xiong J, Wang S, Chen J, Lei W, Deng J
Cellular and molecular life sciences : CMLS 2024 Mar 17;81(1):143

YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes.

Chen H, Shang Y, Li X, Wang R
Cell cycle (Georgetown, Tex.) 2024 Jan;23(1):83-91

TGN-020 Alleviate Inflammation and Apoptosis After Cerebral Ischemia-Reperfusion Injury in Mice Through Glymphatic and ERK1/2 Signaling Pathway.

Li X, Xie Z, Zhou Q, Tan X, Meng W, Pang Y, Huang L, Ding Z, Hu Y, Li R, Huang G, Li H
Molecular neurobiology 2024 Feb;61(2):1175-1186

Modulation of the hippo-YAP pathway by cyclic stretch in rat type 2 alveolar epithelial cells-a proof-of-concept study.

Ran X, Müller S, Brunssen C, Huhle R, Scharffenberg M, Schnabel C, Koch T, Gama de Abreu M, Morawietz H, Ferreira JMC, Wittenstein J
Frontiers in physiology 2023;14:1253810

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

Guo Y, Cui Y, Li Y, Jin X, Wang D, Lei M, Chen F, Liu Y, Xu J, Yao G, Zeng G, Chen X
Cancer communications (London, England) 2023 May;43(5):582-612

CCN1 secreted by human adipose-derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway.

Yang Y, Li S, Sun X, Zhang L, Chen M, Fu H
International wound journal 2023 May;20(5):1667-1677

miR-183-5p overexpression orchestrates collective invasion in salivary adenoid cystic carcinoma through the FAT1/YAP1 signaling pathway.

Chen BJ, Jiang J, Li T, Jiang HJ, Liang XH, Tang YL
Biochemical and biophysical research communications 2023 May 7;655:127-137

Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.

Pusec CM, Ilievski V, De Jesus A, Farooq Z, Zapater JL, Sweis N, Ismail H, Khan MW, Ardehali H, Cordoba-Chacon J, Layden BT
Scientific reports 2023 May 17;13(1):8034

MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.

Sun Y, Jin X, Meng J, Guo F, Chen T, Zhao X, Wu H, Ren D
The EMBO journal 2023 Dec 1;42(23):e114558

CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma.

Chen S, Xu Y, Yang B
Functional & integrative genomics 2023 Aug 8;23(3):270

USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ.

Yuan P, Feng Z, Huang H, Wang G, Chen Z, Xu G, Xie Z, Jie Z, Zhao X, Ma Q, Wang S, Shen Y, Huang Y, Han Y, Ye H, Wang J, Shi P, Sun X
International journal of biological sciences 2022;18(8):3122-3136

Patient-driven discovery of CCN1 to rescue cutaneous wound healing in diabetes via the intracellular EIF3A/CCN1/ATG7 signaling by nanoparticle-enabled delivery.

Jiang JS, Zang J, Ru Y, Luo Y, Song JK, Luo Y, Fei XY, Zhang Z, Zhang Y, Yang D, Zhou M, Chen QL, Bai Y, Li YY, Kuai L, Li B
Biomaterials 2022 Sep;288:121698

Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1.

Shi H, Zhang Y, Wang Y, Fang P, Liu Y, Li W
Toxicology and applied pharmacology 2022 Mar 15;439:115926

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Ferrand N, Fert A, Morichon R, Radosevic-Robin N, Zaoui M, Sabbah M
Cancers 2022 Mar 14;14(6)

Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex.

Terry BK, Park R, Cho SH, Crino PB, Kim S
Human molecular genetics 2022 Jun 22;31(12):1979-1996

RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1.

Huang Y, Zou Y, Jie Z
Experimental and therapeutic medicine 2022 Feb;23(2):118

Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.

Li H, Li T, Wang H, He X, Li Y, Wen S, Peng R, Nie Y, Lu Y, Yang H, Ye Y, Shi G, Chen Y
Frontiers in cardiovascular medicine 2021;8:689318

AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.

Fang P, Deng WJ, Fan N, Shi J, Shi HY, Ou L, Pan JL, Yang SY
Environmental toxicology 2021 Nov;36(11):2225-2235

Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.

Xu G, Seng Z, Zhang M, Qu J
Environmental toxicology 2021 Dec;36(12):2500-2511

The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.

Liu T, Yang Y, Xie Z, Luo Q, Yang D, Liu X, Zhao H, Wei Q, Liu Y, Li L, Wang Y, Wang F, Yu J, Xu J, Yu J, Yi P
Molecular therapy. Nucleic acids 2021 Dec 3;26:388-400

MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.

Yan F, Wang Q, Xia M, Ru Y, Hu W, Yan G, Xiong X, Zhang M, Wang J, Li Q, Zhang B, Wang H, Lin W, Wu G, Li X
Cancer biology & medicine 2021 Dec 22;19(6):818-35

A translational program that suppresses metabolism to shield the genome.

Balukoff NC, Ho JJD, Theodoridis PR, Wang M, Bokros M, Llanio LM, Krieger JR, Schatz JH, Lee S
Nature communications 2020 Nov 13;11(1):5755

Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.

Miao X, Zhang N
Experimental and molecular pathology 2020 Dec;117:104546

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Sun J, Zhang W, Tan Z, Zheng C, Tang Y, Ke X, Zhang Y, Liu Y, Li P, Hu Q, Wang H, Mao P, Zheng Z
Virulence 2020 Dec;11(1):113-131

Downregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1.

Wang J, Li H, Xia C, Yang X, Dai B, Tao K, Dou K
OncoTargets and therapy 2019;12:869-882

A Novel Electrochemiluminescent Immunoassay Based on Target Transformation Assisted with Catalyzed Hairpin Assembly Amplification for the Ultrasensitive Bioassay.

Lei HX, Niu CC, Li T, Wan YF, Liang WB, Yuan R, Liao P
ACS applied materials & interfaces 2019 Aug 28;11(34):31427-31433

Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.

Li M, Chen J, Yu X, Xu S, Li D, Zheng Q, Yin Y
Cells 2019 Apr 17;8(4)

Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.

Gao M, Chen M, Li C, Xu M, Liu Y, Cong M, Sang N, Liu S
Cell discovery 2018;4:5

Quantitative Proteomics Implicates Rictor/mTORC2 in Cell Adhesion.

Wang H, Shao X, He Q, Wang C, Xia L, Yue D, Qin G, Jia C, Chen R
Journal of proteome research 2018 Oct 5;17(10):3360-3369

EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy.

Xia H, Dai X, Yu H, Zhou S, Fan Z, Wei G, Tang Q, Gong Q, Bi F
Cell death & disease 2018 Feb 15;9(3):269

Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior.

Man QW, Ma YQ, Liu JY, Zhao Y, Liu B, Zhao YF
BioMed research international 2017;2017:4624890

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