M00239

antibody from Boster Biological Technology

Targeting: LGR5 FEX, GPR49, GPR67, HG38

Western blot (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

M00239

Provider

Boster Biological Technology

Product name

Anti-LGR5/GPR49 Rabbit Monoclonal Antibody

Antibody type

Monoclonal

Description

Monoclonal antibody for GPR49/LGR5 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IP, WB. Reactive species: Human, Mouse, Rat GPR49/LGR5 information: Molecular Weight: 99998 MW; Subcellular Localization: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653); Tissue Specificity: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Antibody clone number

CHF-12

Vial size

100ug/vial

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage

At -20°C for one year. Avoid repeated freezing and thawing.

References

Submitted references

Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf--lammasome Activation, and Reversing Gut Microbiota Disorder.

Huang S, Huang Y, Lin W, Wang L, Yang Y, Li P, Xiao L, Chen Y, Chu Q, Yuan X
Oxidative medicine and cellular longevity 2022;2022:2586305

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Prevention and Alleviation of Dextran Sulfate Sodium Salt-Induced Inflammatory Bowel Disease in Mice With Bacillus subtilis-Fermented Milk via Inhibition of the Inflammatory Responses and Regulation of the Intestinal Flora.

Zhang X, Tong Y, Lyu X, Wang J, Wang Y, Yang R
Frontiers in microbiology 2020;11:622354

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Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation.

Zhou C, Fang X, Xu J, Gao J, Zhang L, Zhao J, Meng Y, Zhou W, Han X, Bai Y, Li Z, Zou D
Gut microbes 2020 Nov 9;12(1):1782156