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LearnNBP1-77020
antibody from Novus Biologicals
Targeting: CFLAR
c-FLIP, CASH, CASP8AP1, Casper, cFLIP, CLARP, FLAME, FLIP, I-FLICE, MRIT
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [2]
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- Product number
- NBP1-77020 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-77020, RRID:AB_11035561
- Product name
- Rabbit Polyclonal FLIP Antibody
- Antibody type
- Polyclonal
- Description
- Ion exchange chromatography. FLIP has short form (FLIPS) and long form (FLIPL) and antibody recognizes the FLIPL only.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
A defect in central tolerance in NOD mice.
Molecular determinants of response to TRAIL in killing of normal and cancer cells.
Kim JH, Gupta SC, Park B, Yadav VR, Aggarwal BB
Molecular nutrition & food research 2012 Mar;56(3):454-65
Molecular nutrition & food research 2012 Mar;56(3):454-65
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB
Molecular pharmacology 2011 Feb;79(2):279-89
Molecular pharmacology 2011 Feb;79(2):279-89
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB
Molecular pharmacology 2006 Jan;69(1):195-206
Molecular pharmacology 2006 Jan;69(1):195-206
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Ichikawa H, Takada Y, Murakami A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Ichikawa H, Takada Y, Murakami A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
Takada Y, Andreeff M, Aggarwal BB
Blood 2005 Jul 15;106(2):641-9
Blood 2005 Jul 15;106(2):641-9
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
Takada Y, Khuri FR, Aggarwal BB
The Journal of biological chemistry 2004 Jun 18;279(25):26287-99
The Journal of biological chemistry 2004 Jun 18;279(25):26287-99
A defect in central tolerance in NOD mice.
Kishimoto H, Sprent J
Nature immunology 2001 Nov;2(11):1025-31
Nature immunology 2001 Nov;2(11):1025-31
Molecular determinants of response to TRAIL in killing of normal and cancer cells.
Kim K, Fisher MJ, Xu SQ, el-Deiry WS
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Feb;6(2):335-46
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Feb;6(2):335-46
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: FLIP Antibody [NBP1-77020] - Western blot analysis of FLIP in NIH/3T3 whole cell lysate with FLIP antibody at 1:500 dilution.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: FLIP Antibody [NBP1-77020] - Analysis of FLIP in K562 cell lysate with FLIP antibody at (A) 1 and (B) 2 ug/ml.
