Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 16208-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16208-1-AP, RRID:AB_2147370
- Product name
- MTF2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MTF2 antibody (Cat. #16208-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Polycomb Factor PHF19 Controls Cell Growth and Differentiation Toward Erythroid Pathway in Chronic Myeloid Leukemia Cells.
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation.
Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.
RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells.
Cell Signaling Coordinates Global PRC2 Recruitment and Developmental Gene Expression in Murine Embryonic Stem Cells.
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells.
Polycomb-like 2 regulates PRC2 components to affect proliferation in glioma cells.
Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression.
G-tract RNA removes Polycomb repressive complex 2 from genes.
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.
Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity.
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding.
Polycomb-like proteins link the PRC2 complex to CpG islands.
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.
García-Montolio M, Ballaré C, Blanco E, Gutiérrez A, Aranda S, Gómez A, Kok CH, Yeung DT, Hughes TP, Vizán P, Di Croce L
Frontiers in cell and developmental biology 2021;9:655201
Frontiers in cell and developmental biology 2021;9:655201
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation.
Conway E, Rossi F, Fernandez-Perez D, Ponzo E, Ferrari KJ, Zanotti M, Manganaro D, Rodighiero S, Tamburri S, Pasini D
Molecular cell 2021 Sep 2;81(17):3526-3541.e8
Molecular cell 2021 Sep 2;81(17):3526-3541.e8
Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
Petracovici A, Bonasio R
Molecular cell 2021 Jun 17;81(12):2625-2639.e5
Molecular cell 2021 Jun 17;81(12):2625-2639.e5
Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.
Youmans DT, Gooding AR, Dowell RD, Cech TR
Molecular cell 2021 Feb 4;81(3):488-501.e9
Molecular cell 2021 Feb 4;81(3):488-501.e9
RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells.
Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR
Nature genetics 2020 Sep;52(9):931-938
Nature genetics 2020 Sep;52(9):931-938
Cell Signaling Coordinates Global PRC2 Recruitment and Developmental Gene Expression in Murine Embryonic Stem Cells.
Aljazi MB, Gao Y, Wu Y, Mias GI, He J
iScience 2020 Nov 20;23(11):101646
iScience 2020 Nov 20;23(11):101646
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
Chen S, Jiao L, Liu X, Yang X, Liu X
Molecular cell 2020 Mar 19;77(6):1265-1278.e7
Molecular cell 2020 Mar 19;77(6):1265-1278.e7
PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells.
Jain P, Ballare C, Blanco E, Vizan P, Di Croce L
eLife 2020 Mar 10;9
eLife 2020 Mar 10;9
Polycomb-like 2 regulates PRC2 components to affect proliferation in glioma cells.
Wang F, Gao Y, Lv Y, Wu Y, Guo Y, Du F, Wang S, Yu J, Cao X, Li PA
Journal of neuro-oncology 2020 Jun;148(2):259-271
Journal of neuro-oncology 2020 Jun;148(2):259-271
Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression.
Tamburri S, Lavarone E, Fernández-Pérez D, Conway E, Zanotti M, Manganaro D, Pasini D
Molecular cell 2020 Feb 20;77(4):840-856.e5
Molecular cell 2020 Feb 20;77(4):840-856.e5
G-tract RNA removes Polycomb repressive complex 2 from genes.
Beltran M, Tavares M, Justin N, Khandelwal G, Ambrose J, Foster BM, Worlock KB, Tvardovskiy A, Kunzelmann S, Herrero J, Bartke T, Gamblin SJ, Wilson JR, Jenner RG
Nature structural & molecular biology 2019 Oct;26(10):899-909
Nature structural & molecular biology 2019 Oct;26(10):899-909
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.
Healy E, Mucha M, Glancy E, Fitzpatrick DJ, Conway E, Neikes HK, Monger C, Van Mierlo G, Baltissen MP, Koseki Y, Vermeulen M, Koseki H, Bracken AP
Molecular cell 2019 Nov 7;76(3):437-452.e6
Molecular cell 2019 Nov 7;76(3):437-452.e6
Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity.
Lavarone E, Barbieri CM, Pasini D
Nature communications 2019 Apr 11;10(1):1679
Nature communications 2019 Apr 11;10(1):1679
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP
Molecular cell 2018 May 3;70(3):408-421.e8
Molecular cell 2018 May 3;70(3):408-421.e8
MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding.
Perino M, van Mierlo G, Karemaker ID, van Genesen S, Vermeulen M, Marks H, van Heeringen SJ, Veenstra GJC
Nature genetics 2018 Jul;50(7):1002-1010
Nature genetics 2018 Jul;50(7):1002-1010
Polycomb-like proteins link the PRC2 complex to CpG islands.
Li H, Liefke R, Jiang J, Kurland JV, Tian W, Deng P, Zhang W, He Q, Patel DJ, Bulyk ML, Shi Y, Wang Z
Nature 2017 Sep 14;549(7671):287-291
Nature 2017 Sep 14;549(7671):287-291
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.
Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF
PLoS genetics 2012;8(3):e1002576
PLoS genetics 2012;8(3):e1002576
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 16208-1-AP(MTF2 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 16208-1-AP(MTF2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 16208-1-AP(MTF2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue