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- Antibody Data
- Antigen structure
- References [14]
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- Product number
- 12451-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12451-1-AP, RRID:AB_2089636
- Product name
- DBT antibody
- Antibody type
- Polyclonal
- Description
- DBT antibody (Cat. #12451-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.
Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly.
Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism.
Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer.
Contribution of Brain Intrinsic Branched-Chain Amino Acid Metabolism in a Novel Mouse Model of Maple Syrup Urine Disease.
Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis.
Construction and validation of a bioinformatics‑based screen for cuproptosis‑related genes and risk model for Alzheimer's disease.
Comprehensive molecular analyses of cuproptosis-related genes with regard to prognosis, immune landscape, and response to immune checkpoint blockers in lung adenocarcinoma.
Overexpression of DBT suppresses the aggressiveness of renal clear cell carcinoma and correlates with immune infiltration.
Branched-chain amino acids promote thrombocytopoiesis by activating mTOR signaling.
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance.
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia.
Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury.
Kiermayer C, Erdelen R, Schriever SC, Böhm R, Prehn C, Artati A, Kleinert M, Miller M, Dyar KA, Schmid RM, Pfluger PT, Adamski J, Brielmeier M
Redox biology 2026 Jun;93:104165
Redox biology 2026 Jun;93:104165
Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly.
Haggadone MD, Goldspiel BP, O'Farrell A, Kiledjian NT, Knight M, Smith TR, Anderson E, Vázquez Marrero VR, Boyer MA, Xu PJ, Scaglione M, Powers ZM, Queriault C, Wu A, Yang Q, O'Riordan MX, Raj A, Mesaros C, Conn CS, Shin S, Bailis W
bioRxiv : the preprint server for biology 2026 Jan 20;
bioRxiv : the preprint server for biology 2026 Jan 20;
Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism.
Rome K, Hall E, Wu A, Bailis W
bioRxiv : the preprint server for biology 2026 Jan 17;
bioRxiv : the preprint server for biology 2026 Jan 17;
Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer.
Li Z, Liu Z, Lin M, Pan H, Liu Y, Liu Y, Xie Y, Zhang J, Guan S, Li Y, Zhu M, Fang Y, Shen Z, Deng H
Journal of experimental & clinical cancer research : CR 2025 May 28;44(1):164
Journal of experimental & clinical cancer research : CR 2025 May 28;44(1):164
Contribution of Brain Intrinsic Branched-Chain Amino Acid Metabolism in a Novel Mouse Model of Maple Syrup Urine Disease.
Kuhs AC, Ohl L, Thurston T, Singh J, Bhuyan S, Grandinette S, Xu J, Siemsgluess SA, Jakher Y, Ahrens-Nicklas RC
Journal of inherited metabolic disease 2025 Mar;48(2):e70003
Journal of inherited metabolic disease 2025 Mar;48(2):e70003
Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis.
Noji MC, Demetriadou C, Landis M, Pennise J, Pinheiro LV, Jaccard A, Chatoff A, Drummond J, Guo K, Azor R, Robertson MR, Kawakami R, Marcinkiewicz MM, Tobias JW, Snyder NW, Feldser D, Arany Z, Wellen KE
bioRxiv : the preprint server for biology 2025 Jun 15;
bioRxiv : the preprint server for biology 2025 Jun 15;
Construction and validation of a bioinformatics‑based screen for cuproptosis‑related genes and risk model for Alzheimer's disease.
Hu R, Xiao Z, Qiao M, Liu C, Wu G, Wang Y, Dong M, Huang Z
Molecular medicine reports 2024 Nov;30(5)
Molecular medicine reports 2024 Nov;30(5)
Comprehensive molecular analyses of cuproptosis-related genes with regard to prognosis, immune landscape, and response to immune checkpoint blockers in lung adenocarcinoma.
Li R, Tong R, Zhang JL, Zhang Z, Deng M, Hou G
Journal of cancer research and clinical oncology 2024 May 9;150(5):246
Journal of cancer research and clinical oncology 2024 May 9;150(5):246
Overexpression of DBT suppresses the aggressiveness of renal clear cell carcinoma and correlates with immune infiltration.
Zhang C, Huang G, Yang J, Jiang Y, Huang R, Ye Z, Huang Y, Hu H, Xi X
Frontiers in immunology 2023;14:1197011
Frontiers in immunology 2023;14:1197011
Branched-chain amino acids promote thrombocytopoiesis by activating mTOR signaling.
Jiang H, Zhang L, Yang M, Li G, Ding C, Xin M, Dai J, Sun X, Fan X, Sun H, Liu J, Xu Y
Journal of thrombosis and haemostasis : JTH 2023 Nov;21(11):3224-3235
Journal of thrombosis and haemostasis : JTH 2023 Nov;21(11):3224-3235
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance.
Blair MC, Neinast MD, Jang C, Chu Q, Jung JW, Axsom J, Bornstein MR, Thorsheim C, Li K, Hoshino A, Yang S, Roth Flach RJ, Zhang BB, Rabinowitz JD, Arany Z
Nature metabolism 2023 Apr;5(4):589-606
Nature metabolism 2023 Apr;5(4):589-606
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z
Cell metabolism 2022 Nov 1;34(11):1749-1764.e7
Cell metabolism 2022 Nov 1;34(11):1749-1764.e7
Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia.
Tong WH, Ollivierre H, Noguchi A, Ghosh MC, Springer DA, Rouault TA
Heliyon 2022 Aug;8(8):e10371
Heliyon 2022 Aug;8(8):e10371
Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury.
Blum JE, Gheller BJ, Benvie A, Field MS, Panizza E, Vacanti NM, Berry D, Thalacker-Mercer A
The Journal of nutrition 2021 Nov 2;151(11):3313-3328
The Journal of nutrition 2021 Nov 2;151(11):3313-3328
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DBT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DBT. This antibody recognizes human, mouse, rat antigen. The DBT antibody has been validated for the following applications: ELISA, WB analysis.
