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- Antibody Data
- Antigen structure
- References [6]
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- Product number
- AF1617 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Frizzled-5 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human Frizzled-5 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) Frizzled-1, rmFrizzled-2, rmFrizzled-3, rmFrizzled-6, rmFrizzled-7, and rmFrizzled-8 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
AAC50385- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation.
Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways.
WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity.
WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Evidence for altered Wnt signaling in psoriatic skin.
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.
Ramírez VT, Ramos-Fernández E, Henríquez JP, Lorenzo A, Inestrosa NC
The Journal of biological chemistry 2016 Sep 2;291(36):19092-107
The Journal of biological chemistry 2016 Sep 2;291(36):19092-107
Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways.
Tsai HL, Deng WP, Lai WF, Chiu WT, Yang CB, Tsai YH, Hwang SM, Renshaw PF
PloS one 2014;9(8):e104937
PloS one 2014;9(8):e104937
WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity.
Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ
PloS one 2011;6(8):e22920
PloS one 2011;6(8):e22920
WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G
Cellular signalling 2011 Mar;23(3):550-4
Cellular signalling 2011 Mar;23(3):550-4
Evidence for altered Wnt signaling in psoriatic skin.
Gudjonsson JE, Johnston A, Stoll SW, Riblett MB, Xing X, Kochkodan JJ, Ding J, Nair RP, Aphale A, Voorhees JJ, Elder JT
The Journal of investigative dermatology 2010 Jul;130(7):1849-59
The Journal of investigative dermatology 2010 Jul;130(7):1849-59
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.
Magdesian MH, Carvalho MM, Mendes FA, Saraiva LM, Juliano MA, Juliano L, Garcia-Abreu J, Ferreira ST
The Journal of biological chemistry 2008 Apr 4;283(14):9359-68
The Journal of biological chemistry 2008 Apr 4;283(14):9359-68
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